(+/-)-Taxifolin
| Internal ID | 8fc79b4a-7f59-4416-ba89-9a64fbbadbdf |
| Taxonomy | Phenylpropanoids and polyketides > Flavonoids > Flavans > Flavanones > Flavanonols |
| IUPAC Name | 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-2,3-dihydrochromen-4-one |
| SMILES (Canonical) | C1=CC(=C(C=C1C2C(C(=O)C3=C(C=C(C=C3O2)O)O)O)O)O |
| SMILES (Isomeric) | C1=CC(=C(C=C1C2C(C(=O)C3=C(C=C(C=C3O2)O)O)O)O)O |
| InChI | InChI=1S/C15H12O7/c16-7-4-10(19)12-11(5-7)22-15(14(21)13(12)20)6-1-2-8(17)9(18)3-6/h1-5,14-19,21H |
| InChI Key | CXQWRCVTCMQVQX-UHFFFAOYSA-N |
| Popularity | 1,214 references in papers |
| Molecular Formula | C15H12O7 |
| Molecular Weight | 304.25 g/mol |
| Exact Mass | 304.05830272 g/mol |
| Topological Polar Surface Area (TPSA) | 127.00 Ų |
| XlogP | 1.50 |
| 215257-15-1 |
| 98006-93-0 |
| 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxychroman-4-one |
| NSC2801 |
| (-)-Dihydroquercetin |
| CHEBI:38747 |
| 2-(3,4-Dihydroxyphenyl)-3,5,7-trihydroxy-2,3-dihydro-4H-chromen-4-one |
| NSC-2801 |
| 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-2,3-dihydrochromen-4-one |
| (?)-Taxifolin |
| There are more than 10 synonyms. If you wish to see them all click here. |
| Target | Value | Probability (raw) | Probability (%) |
|---|---|---|---|
| No predicted properties yet! | |||
Proven Targets:
| CHEMBL ID | UniProt ID | Name | Min activity | Assay type | Source |
|---|---|---|---|---|---|
| CHEMBL1293255 | P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD+] |
3548.1 nM |
Potency |
via CMAUP
|
| CHEMBL256 | P0DMS8 | Adenosine A3 receptor |
34100 nM |
Ki |
PMID: 8576921
|
| CHEMBL1293236 | P46063 | ATP-dependent DNA helicase Q1 |
35481.3 nM |
Potency |
via CMAUP
|
| CHEMBL1293237 | P54132 | Bloom syndrome protein |
4466.8 nM 4466.8 nM |
Potency Potency |
via CMAUP
via CMAUP |
| CHEMBL3729 | P22748 | Carbonic anhydrase IV |
9098.2 nM |
Ki |
PMID: 26498393
|
| CHEMBL2326 | P43166 | Carbonic anhydrase VII |
493.1 nM 493.1 nM |
Ki Ki |
PMID: 26498393
via Super-PRED |
| CHEMBL3242 | O43570 | Carbonic anhydrase XII |
32.5 nM 32.5 nM |
Ki Ki |
PMID: 26498393
via Super-PRED |
| CHEMBL340 | P08684 | Cytochrome P450 3A4 |
25118.9 nM 25118.9 nM |
Potency Potency |
via CMAUP
via CMAUP |
| CHEMBL2392 | P06746 | DNA polymerase beta |
1888.8 nM |
Potency |
via CMAUP
|
| CHEMBL1293278 | O75496 | Geminin |
31622.8 nM |
Potency |
via CMAUP
|
| CHEMBL1293226 | B2RXH2 | Lysine-specific demethylase 4D-like |
10000 nM 8912.5 nM |
Potency Potency |
via CMAUP
via CMAUP |
| CHEMBL4040 | P28482 | MAP kinase ERK2 |
31.6 nM |
Potency |
via Super-PRED
|
| CHEMBL4393 | P39900 | Matrix metalloproteinase 12 |
5750 nM |
IC50 |
PMID: 22658537
|
| CHEMBL280 | P45452 | Matrix metalloproteinase 13 |
34600 nM |
IC50 |
PMID: 22658537
|
| CHEMBL283 | P08254 | Matrix metalloproteinase 3 |
33910 nM |
IC50 |
PMID: 22658537
|
| CHEMBL321 | P14780 | Matrix metalloproteinase 9 |
32020 nM |
IC50 |
PMID: 22658537
|
| CHEMBL333 | P08253 | Matrix metalloproteinase-2 |
22620 nM |
IC50 |
PMID: 22658537
|
| CHEMBL1293224 | P10636 | Microtubule-associated protein tau |
15848.9 nM |
Potency |
via CMAUP
|
| CHEMBL1293232 | Q16637 | Survival motor neuron protein |
35481.3 nM |
Potency |
via CMAUP
|
Predicted Targets (via Super-PRED):
| CHEMBL ID | UniProt ID | Name | Probability | Model accuracy |
|---|---|---|---|---|
| CHEMBL5619 | P27695 | DNA-(apurinic or apyrimidinic site) lyase | 98.51% | 91.11% |
| CHEMBL1951 | P21397 | Monoamine oxidase A | 97.02% | 91.49% |
| CHEMBL1806 | P11388 | DNA topoisomerase II alpha | 92.37% | 89.00% |
| CHEMBL3108638 | O15164 | Transcription intermediary factor 1-alpha | 91.82% | 95.56% |
| CHEMBL3038477 | P67870 | Casein kinase II alpha/beta | 90.14% | 99.23% |
| CHEMBL1860 | P10827 | Thyroid hormone receptor alpha | 90.12% | 99.15% |
| CHEMBL1929 | P47989 | Xanthine dehydrogenase | 88.44% | 96.12% |
| CHEMBL3401 | O75469 | Pregnane X receptor | 86.15% | 94.73% |
| CHEMBL3194 | P02766 | Transthyretin | 86.06% | 90.71% |
| CHEMBL2581 | P07339 | Cathepsin D | 83.85% | 98.95% |
| CHEMBL3137262 | O60341 | LSD1/CoREST complex | 82.64% | 97.09% |
| CHEMBL4203 | Q9HAZ1 | Dual specificity protein kinase CLK4 | 82.26% | 94.45% |
| CHEMBL1293249 | Q13887 | Kruppel-like factor 5 | 80.91% | 86.33% |
| CHEMBL3251 | P19838 | Nuclear factor NF-kappa-B p105 subunit | 80.86% | 96.09% |
| CHEMBL5697 | Q9GZT9 | Egl nine homolog 1 | 80.72% | 93.40% |
Below are displayed all the plants proven (via scientific papers) to contain this
compound!
To see more specific details click the taxa you are interested in.
To see more specific details click the taxa you are interested in.
| PubChem | 471 |
| NPASS | NPC36835 |
| ChEMBL | CHEMBL337309 |
| LOTUS | LTS0040950 |
| wikiData | Q104972046 |