Biochanin A

Details

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Internal ID 92eae42f-9a36-48c3-824b-405b9a5b2d32
Taxonomy Phenylpropanoids and polyketides > Isoflavonoids > O-methylated isoflavonoids > 4-O-methylated isoflavonoids > 4-O-methylisoflavones
IUPAC Name 5,7-dihydroxy-3-(4-methoxyphenyl)chromen-4-one
SMILES (Canonical) COC1=CC=C(C=C1)C2=COC3=CC(=CC(=C3C2=O)O)O
SMILES (Isomeric) COC1=CC=C(C=C1)C2=COC3=CC(=CC(=C3C2=O)O)O
InChI InChI=1S/C16H12O5/c1-20-11-4-2-9(3-5-11)12-8-21-14-7-10(17)6-13(18)15(14)16(12)19/h2-8,17-18H,1H3
InChI Key WUADCCWRTIWANL-UHFFFAOYSA-N
Popularity 1,412 references in papers

Physical and Chemical Properties

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Molecular Formula C16H12O5
Molecular Weight 284.26 g/mol
Exact Mass 284.06847348 g/mol
Topological Polar Surface Area (TPSA) 76.00 Ų
XlogP 3.00
Atomic LogP (AlogP) 2.88
H-Bond Acceptor 5
H-Bond Donor 2
Rotatable Bonds 2

Synonyms

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491-80-5
Biochanin
4'-Methylgenistein
5,7-Dihydroxy-4'-methoxyisoflavone
5,7-Dihydroxy-3-(4-methoxyphenyl)-4H-chromen-4-one
olmelin
Pratensol
Biochanine A
Genistein 4-methyl ether
5,7-dihydroxy-3-(4-methoxyphenyl)chromen-4-one
There are more than 10 synonyms. If you wish to see them all click here.

2D Structure

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2D Structure of Biochanin A

3D Structure

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ADMET Properties (via admetSAR 2)

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Target Value Probability (raw) Probability (%)
Human Intestinal Absorption + 0.9694 96.94%
Caco-2 + 0.9155 91.55%
Blood Brain Barrier - 0.7750 77.50%
Human oral bioavailability - 0.5143 51.43%
Subcellular localzation Mitochondria 0.7877 78.77%
OATP2B1 inhibitior - 0.5742 57.42%
OATP1B1 inhibitior + 0.9495 94.95%
OATP1B3 inhibitior + 0.9480 94.80%
MATE1 inhibitior + 0.5400 54.00%
OCT2 inhibitior - 0.9250 92.50%
BSEP inhibitior - 0.6813 68.13%
P-glycoprotein inhibitior - 0.8249 82.49%
P-glycoprotein substrate - 0.9379 93.79%
CYP3A4 substrate + 0.5620 56.20%
CYP2C9 substrate - 0.6401 64.01%
CYP2D6 substrate - 0.8296 82.96%
CYP3A4 inhibition + 0.7746 77.46%
CYP2C9 inhibition + 0.8287 82.87%
CYP2C19 inhibition + 0.9470 94.70%
CYP2D6 inhibition - 0.6939 69.39%
CYP1A2 inhibition + 0.9540 95.40%
CYP2C8 inhibition + 0.6803 68.03%
CYP inhibitory promiscuity + 0.8845 88.45%
UGT catelyzed + 0.8000 80.00%
Carcinogenicity (binary) - 0.9500 95.00%
Carcinogenicity (trinary) Non-required 0.6169 61.69%
Eye corrosion - 0.9796 97.96%
Eye irritation + 0.8341 83.41%
Skin irritation - 0.6033 60.33%
Skin corrosion - 0.9391 93.91%
Ames mutagenesis - 0.7600 76.00%
Human Ether-a-go-go-Related Gene inhibition - 0.6613 66.13%
Micronuclear + 0.9100 91.00%
Hepatotoxicity + 0.5250 52.50%
skin sensitisation - 0.9484 94.84%
Respiratory toxicity - 0.5444 54.44%
Reproductive toxicity + 0.8000 80.00%
Mitochondrial toxicity + 0.6375 63.75%
Nephrotoxicity + 0.6547 65.47%
Acute Oral Toxicity (c) III 0.7005 70.05%
Estrogen receptor binding + 0.9506 95.06%
Androgen receptor binding + 0.9500 95.00%
Thyroid receptor binding + 0.8461 84.61%
Glucocorticoid receptor binding + 0.8349 83.49%
Aromatase binding + 0.8881 88.81%
PPAR gamma + 0.7143 71.43%
Honey bee toxicity - 0.9188 91.88%
Biodegradation - 0.9750 97.50%
Crustacea aquatic toxicity - 0.5200 52.00%
Fish aquatic toxicity + 0.8717 87.17%

Targets

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Proven Targets:

CHEMBL ID UniProt ID Name Min activity Assay type Source
CHEMBL1293255 P15428 15-hydroxyprostaglandin dehydrogenase [NAD+] 35481.3 nM
Potency
via CMAUP
CHEMBL3577 P00352 Aldehyde dehydrogenase 1A1 7079.5 nM
Potency
via CMAUP
CHEMBL5983 O60218 Aldo-keto reductase family 1 member B10 36100 nM
IC50
PMID: 26529431
CHEMBL3687 P18054 Arachidonate 12-lipoxygenase 15848.9 nM
Potency
via CMAUP
CHEMBL1293236 P46063 ATP-dependent DNA helicase Q1 1258.9 nM
Potency
via CMAUP
CHEMBL3729 P22748 Carbonic anhydrase IV 7078.5 nM
Ki
PMID: 26498393
CHEMBL2326 P43166 Carbonic anhydrase VII 371.5 nM
371.5 nM
Ki
Ki
PMID: 26498393
via Super-PRED
CHEMBL3242 O43570 Carbonic anhydrase XII 52.5 nM
52.5 nM
Ki
Ki
PMID: 26498393
via Super-PRED
CHEMBL5586 P16152 Carbonyl reductase [NADPH] 1 12710 nM
IC50
PMID: 19097799
CHEMBL4096 P04637 Cellular tumor antigen p53 12589.3 nM
10000 nM
Potency
Potency
via CMAUP
via CMAUP
CHEMBL1978 P11511 Cytochrome P450 19A1 34000 nM
34000 nM
10.2 nM
113000 nM
113000 nM
IC50
IC50
IC50
IC50
IC50
PMID: 15911319
PMID: 15267241
PMID: 20413308
PMID: 22444875
PMID: 26301554
CHEMBL3622 P33261 Cytochrome P450 2C19 7943.3 nM
Potency
via CMAUP
CHEMBL3397 P11712 Cytochrome P450 2C9 25.1 nM
Potency
via CMAUP
CHEMBL289 P10635 Cytochrome P450 2D6 31622.8 nM
Potency
via CMAUP
CHEMBL340 P08684 Cytochrome P450 3A4 19952.6 nM
19952.6 nM
Potency
Potency
via CMAUP
via CMAUP
CHEMBL4159 Q99714 Endoplasmic reticulum-associated amyloid beta-peptide-binding protein 31622.8 nM
Potency
via CMAUP
CHEMBL2789 P37059 Estradiol 17-beta-dehydrogenase 2 9900 nM
IC50
PMID: 18533708
CHEMBL4261 Q16665 Hypoxia-inducible factor 1 alpha 10000 nM
10000 nM
Potency
Potency
via CMAUP
via CMAUP
CHEMBL1293226 B2RXH2 Lysine-specific demethylase 4D-like 35481.3 nM
31622.8 nM
Potency
Potency
via CMAUP
via CMAUP
CHEMBL4040 P28482 MAP kinase ERK2 15848.9 nM
Potency
via CMAUP
CHEMBL1293224 P10636 Microtubule-associated protein tau 2238.7 nM
28183.8 nM
31622.8 nM
10000 nM
2818.4 nM
14125.4 nM
39810.7 nM
17782.8 nM
Potency
Potency
Potency
Potency
Potency
Potency
Potency
Potency
via CMAUP
via CMAUP
via CMAUP
via CMAUP
via CMAUP
via CMAUP
via CMAUP
via CMAUP
CHEMBL1293277 O15118 Niemann-Pick C1 protein 2238.7 nM
Potency
via CMAUP
CHEMBL1293235 P02545 Prelamin-A/C 28183.8 nM
Potency
via CMAUP
CHEMBL1293294 P51151 Ras-related protein Rab-9A 2818.4 nM
Potency
via CMAUP
CHEMBL1293232 Q16637 Survival motor neuron protein 17782.8 nM
19952.6 nM
Potency
Potency
via CMAUP
via CMAUP

Predicted Targets (via Super-PRED):

CHEMBL ID UniProt ID Name Probability Model accuracy
CHEMBL5619 P27695 DNA-(apurinic or apyrimidinic site) lyase 98.05% 91.11%
CHEMBL1929 P47989 Xanthine dehydrogenase 97.73% 96.12%
CHEMBL2581 P07339 Cathepsin D 95.63% 98.95%
CHEMBL2635 P51452 Dual specificity protein phosphatase 3 94.60% 94.00%
CHEMBL3108638 O15164 Transcription intermediary factor 1-alpha 94.44% 95.56%
CHEMBL1860 P10827 Thyroid hormone receptor alpha 94.41% 99.15%
CHEMBL1293249 Q13887 Kruppel-like factor 5 92.28% 86.33%
CHEMBL4208 P20618 Proteasome component C5 89.90% 90.00%
CHEMBL1806 P11388 DNA topoisomerase II alpha 89.38% 89.00%
CHEMBL4016 P42262 Glutamate receptor ionotropic, AMPA 2 89.06% 86.92%
CHEMBL1907 P15144 Aminopeptidase N 88.45% 93.31%
CHEMBL3060 Q9Y345 Glycine transporter 2 87.94% 99.17%
CHEMBL5409 Q8TDU6 G-protein coupled bile acid receptor 1 85.40% 93.65%
CHEMBL3194 P02766 Transthyretin 84.58% 90.71%
CHEMBL3192 Q9BY41 Histone deacetylase 8 84.23% 93.99%
CHEMBL3251 P19838 Nuclear factor NF-kappa-B p105 subunit 82.10% 96.09%
CHEMBL4940 P07195 L-lactate dehydrogenase B chain 81.53% 95.53%
CHEMBL3038477 P67870 Casein kinase II alpha/beta 81.33% 99.23%

Plants that contains it

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Below are displayed all the plants proven (via scientific papers) to contain this compound!
To see more specific details click the taxa you are interested in.
Anaxagorea luzonensis
Andira inermis
Andira surinamensis
Arachis hypogaea
Asclepias vestita
Asimina parviflora
Aspilia foliosa
Astragalus laxmannii
Astragalus laxmannii subsp. laxmannii
Astragalus mongholicus
Atraphaxis spinosa
Baccharis neglecta
Baptisia sphaerocarpa
Barringtonia acutangula
Bolusanthus speciosus
Centaurea cuneifolia subsp. cuneifolia
Chondrodendron tomentosum
Cicer arietinum
Cicer flexuosum
Cicer mogoltavicum
Cicer nuristanicum
Cicer pungens
Cicer songaricum
Cicer tragacanthoides
Clerodendrum bungei
Corydalis densiflora
Craibiodendron yunnanense
Crotalaria thebaica
Croton megistocarpus
Cullen corylifolium
Dalbergia congestiflora
Dalbergia frutescens
Dalbergia nigrescens
Dalbergia nitidula
Dalbergia oliveri
Dalbergia parviflora
Dalbergia sissoides
Dalbergia sissoo
Dalbergia spruceana
Dalbergia volubilis
Dermatophyllum secundiflorum
Desmodium canadense
Diospyros ebenum
Echinospartum horridum
Embelia parviflora
Embelia ribes
Embelia schimperi
Ephedra sinica
Epilobium hirsutum
Erysimum leptophyllum
Erythrina melanacantha
Esenbeckia leiocarpa
Euchresta formosana
Euphorbia jolkinii
Faramea multiflora
Flemingia prostrata
Geranium sibiricum
Glycine max
Gymnocalycium schickendantzii
Gynerium sagittatum
Haplophyllum obtusifolium
Helichrysum tenuifolium
Heliotropium hirsutissimum
Hypericum styphelioides
Inulanthera calva
Iris pseudacorus
Khaya grandifoliola
Klasea centauroides subsp. strangulata
Klasea sogdiana
Knema furfuracea
Knema glomerata
Lagerstroemia indica
Linnaea chinensis
Lupinus albus
Lythrum salicaria
Mabea fistulifera
Machilus japonica
Maclura tricuspidata
Medicago sativa
Monopteryx uauca
Monsonia senegalensis
Murraya exotica
Murraya paniculata
Myrica rubra
Myristica ceylanica
Myristica malabarica
Myroxylon peruiferum
Napoleonaea vogelii
Nicotiana raimondii
Ononis spinosa
Onopordum acanthium
Ormosia henryi
Pancratium sickenbergeri
Pericopsis elata
Pinalia anomala
Piper regnellii
Plathymenia reticulata
Pteridium esculentum
Pueraria montana var. lobata
Pycnanthus angolensis
Reynoutria multiflora
Schleichera oleosa
Schultesia guianensis
Scolopia chinensis
Senecio isatideus
Simarouba glauca
Sophora flavescens
Spatholobus suberectus
Stenocereus laevigatus
Strobilanthes cusia
Styphnolobium japonicum
Sundacarpus amarus
Swartzia polyphylla
Syzygium jambos
Syzygium polycephaloides
Thermopsis rhombifolia
Triclisia subcordata
Trifolium arvense
Trifolium aureum
Trifolium diffusum
Trifolium medium
Trifolium pannonicum
Trifolium pratense
Trifolium repens
Trifolium subterraneum
Trigonella foenum-graecum
Trollius europaeus
Varronia leucocephala
Vellozia nanuzae
Vernonanthura fagifolia
Virola caducifolia
Virola surinamensis
Vitex negundo
Vitis vinifera
Wisteria brachybotrys

Cross-Links

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PubChem 5280373
NPASS NPC294409
ChEMBL CHEMBL131921
LOTUS LTS0111539
wikiData Q864222