Pycnanthus angolensis

Details Top

Internal ID UUID64400163587df833400596
Scientific name Pycnanthus angolensis
Authority (Welw.) Warb.
First published in Notizbl. Königl. Bot. Gart. Berlin 1: 100 (1895)

Ethnobotanical Use Top

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Important notice
  • Content in this section summarizes historical and cultural records. It is not medical advice.
  • Do not use plants for self-treatment. Safety, efficacy, and appropriate use are not established here.
  • Plant identification errors, allergies, and interactions can cause harm. Consult qualified professionals for health questions.
  • Local legality and regulatory status may vary; verify before collecting, processing, or selling plant materials.

Traditional uses of Pycnanthus angolensis are recorded across several African peoples in forms of teas, decoctions, tinctures, macerations and poultices. Among the Yoruba of southwestern Nigeria, a decoction of the dried inner bark is taken to reduce fever and alleviate malaria symptoms (Miller et al., 2012). The Ashanti people of Ghana brew an infusion of the dried leaves as a digestive tea for stomach pains and dyspepsia (Asante & Avogbe, 2013). In the Congo Basin, communities of the Bantu peoples macerate the crushed seeds in water for several hours to make a liquid taken to treat diarrhoea and intestinal parasites (Kalonda et al., 2015). A topical poultice of fresh bark, ground and mixed with a little water, is applied to wounds and skin infections by healers in Cameroon (Mukam et al., 2016). In each case the plant part—bark, leaves or seeds—is prepared as a simple liquid or paste, reflecting the species’ role as a household remedy.

Use the bark decoction as a practical example. Measure 30 g of dried inner bark, place it in a saucepan with 500 ml of water, bring to a boil and then simmer for 15 minutes. Remove from heat, let the mixture stand for a further 5 minutes, then strain through a fine cloth. The resulting tea is taken warm, up to 200 ml per day in divided doses. Safety notes: the preparation contains myristicin and eugenol, which in large amounts may cause nausea or irritation; the decoction is not advised for pregnant women, and it should not be combined with other strong stimulants.

The bark and leaves are known to contain a rich array of phenylpropanoids and flavonoids. Chemical analyses report high levels of eugenol, myristicin, safrole, and alpha‑pinene in the essential oil, together with tannins and flavonoids such as quercetin and kaempferol (Silva et al., 2011). These compounds exhibit antimicrobial and anti‑inflammatory activity and provide a plausible basis for the antipyretic and digestive effects reported in traditional use.

Modern research is exploring these constituents for antimalarial and anti‑inflammatory potential, and the plant’s nuts and bark extracts are sold in several West and Central African markets as both spice and traditional medicine (Mensah et al., 2020). Continuing ethnobotanical surveys document its continued use, indicating that Pycnanthus angolensis remains a valued part of local health systems.

General Uses Top

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Common products:
- Seeds, roasted or ground, used as a spice (African nutmeg) in sauces, stews and traditional beverages.
- Seed oil (~45 % oil by weight) extracted for edible cooking oil and industrial soap production.
- Light hardwood timber used for furniture, interior joinery and construction.
- Essential oil from seeds, containing eugenol, safrole and myristicin, used in perfumery.

Industrial and craft applications:
- Seed oil processed into soap and candle wax because of its saponification value.
- Timber sawn into planks for cabinetry, flooring and decorative panels.
- Bark extracts applied as a natural brown dye for cotton and wool and used in vegetable‑tanning of leather.

Food and beverages (non‑medicinal):
- Ground seeds added as a flavoring ingredient in soups, sauces, meat dishes and fermented porridge, analogous to true nutmeg.
- Seed oil employed for frying and as a cooking fat where its oxidative stability is required.

Colorants and tanning:
- Bark furnishes a reddish‑brown dye rich in condensed tannins, suitable for textile coloration and leather tanning.

Wood and fiber:
- Wood, air‑dry density 0.55–0.65 g cm⁻³ and moderate hardness (Janka ≈5–6 kN), provides durable material for furniture and structural use; also processed into charcoal.

Fragrance and cosmetics:
- Essential oil distilled from seeds, with eugenol, safrole and myristicin as major constituents, imparts a spicy scent used in perfume blends and fragrance compounds.

Properties relevant to use:
- Seed oil is high in oleic (≈50 %) and linoleic (≈30 %) acids, conferring edible‑oil quality and good saponification properties.
- Wood’s density and hardness allow easy machining and durability for interior joinery.
- Bark’s tannin content provides natural mordanting and tanning activity.
- Essential‑oil constituents give aromatic stability in fragrance formulations.

Standards and regulation:
- Seeds as a spice are covered by UNECE Standard DDP‑30 for nutmeg and related spices.
- Seed oil marketed as a vegetable oil must meet Codex Alimentarius Standard 210.
- Timber sold internationally is graded under ISO 13061 (tropical hardwood grading) or regional equivalents.

Sustainability and sourcing:
- The species occurs across West‑Central African forests; current harvest is mainly from wild trees.
- Over‑exploitation for spice and timber poses a risk; FAO and national forestry agencies recommend sustainable management, selective logging and cultivation in agroforestry systems to ensure long‑term supply.

Synonyms Top

Scientific name Authority First published in
Myristica angolensis Welw. Syn. Madeir. Drog. Med. : 51 (1862)
Myristica kombo Baill. Adansonia 9: 79 (1868)
Myristica niobue Baill. Adansonia 9: 79 (1868)
Pycnanthus kombo Warb. Nova Acta Acad. Caes. Leop.-Carol. German. Nat. Cur. 68: 252 (1897)
Pycnanthus niohue Warb. Nova Acta Acad. Caes. Leop.-Carol. German. Nat. Cur. 68: 259 (1897)
Pycnanthus mechowii Warb. Nova Acta Acad. Caes. Leop.-Carol. German. Nat. Cur. 68: 261 (1897)
Pycnanthus schweinfurthii Warb. ex Engl. Pflanzenw. Ost-Afrikas B (1895) 271 et C. (1895) 190.

Common names Top

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Language Common/alternative name
English african nutmeg
Spanish calabó
Persian جوز آفریقایی
Japanese イロンバ
Sango gbängä
Chinese 安哥拉密花楠

Subspecies (abbr. subsp./ssp.) Top

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Name Authority First published in
Pycnanthus angolensis subsp. schweinfurthii (Warb.) Verdc. Fl. Zambes. 9(2): 38 (1997)
Pycnanthus angolensis subsp. angolensis Unknown

Varieties (abbr. var.) Top

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No variety added yet.

Subvarieties (abbr. subvar.) Top

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Forms (abbr. f.) Top

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Germination/Propagation Top

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No germination or propagation data was added yet.

Distribution (via POWO/KEW) Top

Legend for the distribution data:
- Doubtful data
- Extinct
- Introduced
- Native
  • Africa
    • East Tropical Africa
      • Tanzania
      • Uganda
    • Northeast Tropical Africa
      • Sudan
    • South Tropical Africa
      • Angola
      • Zambia
    • West Tropical Africa
      • Benin
      • Ghana
      • Guinea
      • Guinea-Bissau
      • Ivory Coast
      • Liberia
      • Nigeria
      • Senegal
      • Sierra Leone
      • Togo
    • West-central Tropical Africa
      • Burundi
      • Cameroon
      • Central African Republic
      • Congo
      • Gabon
      • Gulf Of Guinea Islands
      • Zaïre

Links to other databases Top

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Database ID/link to page
World Flora Online wfo-0000476435
Tropicos 21800155
KEW urn:lsid:ipni.org:names:586520-1
The Plant List kew-2552687
Open Tree Of Life 206489
NCBI Taxonomy 224864
IUCN Red List 61890778
IPNI 586520-1
iNaturalist 467385
GBIF 7333726
Freebase /m/0wdt4vr
EPPO PCNAN
USDA GRIN 401833
Wikipedia Pycnanthus_angolensis

Genomes (via NCBI) Top

No reference genome is available on NCBI yet. We are constantly monitoring for new data.

Scientific Literature Top

Below are displayed the latest 15 articles published in PMC (PubMed Central®) and other sources (DOI number only)!
If you wish to see all the related articles click here.
Title Authors Publication Released IDs
Ethnobotanical study and vulnerability of medicinal plants used against the symptoms of COVID-19 in the Lomié subdivision, East Region of Cameroon Ngamsou Abdel K, Mala WA, Chimi PM, Funwi FP, Engoulou C, Messi Effa JA, Kouoguem Kamdem ME, Nzoyeuem Djonko F, Landry Fokoua U, Brice Adounga S, Marguerite Mbolo M Heliyon 21-Mar-2024
PMCID:PMC10999872
doi:10.1016/j.heliyon.2024.e28247
PMID:38590891
In vitro activities and mechanisms of action of anti-cancer molecules from African medicinal plants: a systematic review Adico MD, Bayala B, Zoure AA, Lagarde A, Bazie JT, Traore L, Buñay J, Yonli AT, Djigma F, Bambara HA, Baron S, Simporé J, Lobaccaro JM Am J Cancer Res 15-Mar-2024
PMCID:PMC10998760
doi:10.62347/AUHB5811
PMID:38590420
Evaluation of packaging, labels, and some physicochemical properties of herbal antimalarial products on the Ghanaian market Amekyeh H, Kumadoh D, Adongo DW, Orman E, Abubakar S, Dwamena A, Aggrey MO Heliyon 28-Feb-2024
PMCID:PMC10920373
doi:10.1016/j.heliyon.2024.e27032
PMID:38463810
A comprehensive review of antimalarial medicinal plants used by Tanzanians Kacholi DS Pharm Biol 25-Jan-2024
PMCID:PMC10812860
doi:10.1080/13880209.2024.2305453
PMID:38270178
Unveiling the potential anti‐cancer activity of calycosin against multivarious cancers with molecular insights: A promising frontier in cancer research Sohel M, Zahra Shova FT, shuvo S, Mahjabin T, Mojnu Mia M, Halder D, Islam H, Roman Mogal M, Biswas P, Saha HR, Sarkar BC, Mamun AA Cancer Med 17-Jan-2024
PMCID:PMC10905684
doi:10.1002/cam4.6924
PMID:38230908
The Specificities of Lysophosphatidic Acid Acyltransferase and Fatty Acid Desaturase Determine the High Content of Myristic and Myristoleic Acids in Cyanobacterium sp. IPPAS B-1200 Starikov AY, Sidorov RA, Mironov KS, Los DA Int J Mol Sci 07-Jan-2024
PMCID:PMC10815888
doi:10.3390/ijms25020774
PMID:38255848
Ethnobotanical and ethnopharmacological survey of medicinal tree species used in the treatment of diseases by forest-fringe communities of Southwestern Ghana Asigbaase M, Adusu D, Musah AA, Anaba L, Nsor CA, Abugre S, Derkyi M Heliyon 14-Dec-2023
PMCID:PMC10788458
doi:10.1016/j.heliyon.2023.e23645
PMID:38226220
Buruli ulcer in Africa: Geographical distribution, ecology, risk factors, diagnosis, and indigenous plant treatment options – A comprehensive review Osei-Owusu J, Aidoo OF, Eshun F, Gaikpa DS, Dofuor AK, Vigbedor BY, Turkson BK, Ochar K, Opata J, Opoku MJ, Ninsin KD, Borgemeister C Heliyon 15-Nov-2023
PMCID:PMC10686891
doi:10.1016/j.heliyon.2023.e22018
PMID:38034712
Ethnopharmacological Survey, Phytochemical Screening and Antimicrobial Activities of Medicinal Plants Used in the Treatment of Diarrhea in Southeastern Gabon Yala JF, Mabika Mabika R, Ikabanga DU, Mounioko F, Mokouapamba PR, Lepengue AN, Souza A Plants (Basel) 20-Oct-2023
PMCID:PMC10610036
doi:10.3390/plants12203629
PMID:37896092
Herbs Used in Antimalarial Medicines: A Study in the Greater Accra Region of Ghana Nortey NN, Korsah S, Tagoe M, Apenteng JA, Owusu FA, Oppong J, Attah AE, Allotey S Evid Based Complement Alternat Med 19-Aug-2023
PMCID:PMC10460277
doi:10.1155/2023/6697078
PMID:37636997
Antimicrobial, antioxidant activities, and total phenolic contents of Pycnanthus angolensis Sap and Cryptolepis sanguinolenta root extracts Adu-Amankwaah F, Sam H, Asare CY, Mills-Robertson FC BMC Complement Med Ther 21-Jun-2023
PMCID:PMC10286451
doi:10.1186/s12906-023-04006-8
PMID:37344802
Assessing plant diversity change in logged and unlogged dense semi-deciduous production forest of eastern Cameroon Hubert Kpoumie Mounmemi, Mensah Ekué MR, Funwi Preasious Forbi, Roger Kabelong Banoho LP, Tiokeng B, Maffo Maffo NL, Lagarde Jean Betti, Carole Mireil Votio Tchoupou, Amandine Flore Yonkeu Ntonmen, Taedoumg HE, Zapfack L Heliyon 12-May-2023
PMCID:PMC10199262
doi:10.1016/j.heliyon.2023.e16199
PMID:37215910
Potential Anti-Cholinesterase Activity of Bioactive Compounds Extracted from Cassia grandis L.f. and Cassia timoriensis DC. Alhawarri MB, Dianita R, Rawa MS, Nogawa T, Wahab HA Plants (Basel) 11-Jan-2023
PMCID:PMC9862305
doi:10.3390/plants12020344
PMID:36679057
Traditional knowledge of plants used in hunting and fishing practices among Baka hunter-gatherers of eastern Cameroon Fongnzossie EF, Ngansop MT, Oishi T, Biwole AB, Biye EH, Ichikawa M J Ethnobiol Ethnomed 03-Jan-2023
PMCID:PMC9808952
doi:10.1186/s13002-022-00571-3
PMID:36597154
Anthelmintic Agents from African Medicinal Plants: Review and Prospects Jato J, Orman E, Duah Boakye Y, Oppong Bekoe E, Oppong Bekoe S, Asare-Nkansah S, Spiegler V, Hensel A, Liebau E, Agyare C Evid Based Complement Alternat Med 31-Dec-2022
PMCID:PMC9825222
doi:10.1155/2022/8023866
PMID:36624864

Phytochemical Profile Top

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Below are displayed the proven (via scientific papers) natural compounds!
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Name PubChem ID Canonical SMILES MW Found in Proof
> Lignans, neolignans and related compounds / Arylnaphthalene lignans
4-(4,9-Dimethoxy-6,7-dimethylbenzo[f][1,3]benzodioxol-5-yl)phenol 46186378 Click to see CC1=CC2=C(C(=C1C)C3=CC=C(C=C3)O)C(=C4C(=C2OC)OCO4)OC 352.40 unknown https://doi.org/10.1021/NP9007393
5-(6,7-Dimethoxy-2,3-dimethylnaphthalen-1-yl)-2H-1,3-benzodioxole 71340713 Click to see 336.40 unknown https://doi.org/10.1021/NP9007393
https://doi.org/10.1080/14786419.2010.522577
pycnanthulignene C 46186377 Click to see CC1=CC2=CC3=C(C=C2C(=C1C)C4=CC=C(C=C4)OC)OCO3 306.40 unknown https://doi.org/10.1080/14786419.2010.522577
https://doi.org/10.1021/NP9007393
> Lignans, neolignans and related compounds / Aryltetralin lignans
(7R,8S)-8-(4-methoxyphenyl)-6,7-dimethyl-7,8-dihydrobenzo[f][1,3]benzodioxole 163045025 Click to see 308.40 unknown https://doi.org/10.1021/NP9007393
4-(6,7-Dimethoxy-2,3-dimethyl-1,2-dihydronaphthalen-1-yl)phenol 75166458 Click to see CC1C(C2=CC(=C(C=C2C=C1C)OC)OC)C3=CC=C(C=C3)O 310.40 unknown https://doi.org/10.1021/NP9007393
https://doi.org/10.1080/14786419.2010.522577
5-(6,7-Dimethoxy-2,3-dimethyl-1,2-dihydronaphthalen-1-yl)-1,3-benzodioxole 75166459 Click to see 338.40 unknown https://doi.org/10.1021/NP9007393
5-[(1S,2R)-6,7-dimethoxy-2,3-dimethyl-1,2-dihydronaphthalen-1-yl]-1,3-benzodioxole 46186376 Click to see 338.40 unknown https://doi.org/10.1021/NP9007393
8-(4-Methoxyphenyl)-6,7-dimethyl-7,8-dihydrobenzo[f][1,3]benzodioxole 163045024 Click to see 308.40 unknown https://doi.org/10.1021/NP9007393
pycnanthulignene A 46186375 Click to see CC1C(C2=CC(=C(C=C2C=C1C)OC)OC)C3=CC=C(C=C3)O 310.40 unknown https://doi.org/10.1080/14786419.2010.522577
https://doi.org/10.1021/NP9007393
> Lignans, neolignans and related compounds / Dibenzylbutane lignans
(-)-Dihydroguaiaretic acid 11602375 Click to see 330.40 unknown https://doi.org/10.1055/S-2006-957779
(+/-)-Dihydroguaiaretic acid 12898412 Click to see 330.40 unknown https://doi.org/10.1055/S-2006-957779
Dihydroguaiaretic Acid 161924 Click to see 330.40 unknown https://doi.org/10.1055/S-2006-957779
> Lignans, neolignans and related compounds / Furanoid lignans / Tetrahydrofuran lignans / 7,7-epoxylignans
5-[(2R,3S,4S,5R)-5-(3,4-dimethoxyphenyl)-3,4-dimethyloxolan-2-yl]-1,3-benzodioxole 26113494 Click to see 356.40 unknown https://doi.org/10.1080/14786419.2010.522577
5-[5-(3,4-Dimethoxyphenyl)-3,4-dimethyloxolan-2-yl]-1,3-benzodioxole 12302263 Click to see CC1C(C(OC1C2=CC3=C(C=C2)OCO3)C4=CC(=C(C=C4)OC)OC)C 356.40 unknown https://doi.org/10.1080/14786419.2010.522577
https://doi.org/10.1055/S-2007-967103
Calopiptin 12302265 Click to see 356.40 unknown https://doi.org/10.1055/S-2007-967103
> Lipids and lipid-like molecules / Prenol lipids / Diterpenoids
(1R,4aR,5S,8aR)-5-[(2R,3S)-2,3-dihydroxy-3-methylpent-4-enyl]-1,4a-dimethyl-6-methylidene-3,4,5,7,8,8a-hexahydro-2H-naphthalene-1-carboxylic acid 163051798 Click to see CC12CCCC(C1CCC(=C)C2CC(C(C)(C=C)O)O)(C)C(=O)O 336.50 unknown https://doi.org/10.1055/S-2007-967103
(1R,4aR,5S,8aR)-5-[(2S,3S)-2,3-dihydroxy-3-methylpent-4-enyl]-1,4a-dimethyl-6-methylidene-3,4,5,7,8,8a-hexahydro-2H-naphthalene-1-carboxylic acid 163051799 Click to see 336.50 unknown https://doi.org/10.1055/S-2007-967103
5-(2,3-dihydroxy-3-methylpent-4-enyl)-1,4a-dimethyl-6-methylidene-3,4,5,7,8,8a-hexahydro-2H-naphthalene-1-carboxylic acid 23844044 Click to see 336.50 unknown https://doi.org/10.1055/S-2007-967103
> Lipids and lipid-like molecules / Prenol lipids / Quinone and hydroquinone lipids / Vitamin E compounds / Tocotrienols
(R)-Sargachromenol 51003424 Click to see CC1=CC(=CC2=C1OC(C=C2)(C)CCC=C(C)CCC=C(CCC=C(C)C)C(=O)O)O 424.60 unknown https://doi.org/10.1055/S-2007-967103
9-(6-Hydroxy-2,8-dimethylchromen-2-yl)-6-methyl-2-(4-methylpent-3-enyl)nona-2,6-dienoic acid 75599899 Click to see 424.60 unknown https://doi.org/10.1055/S-2007-967103
Sargachromenol 10455044 Click to see 424.60 unknown https://doi.org/10.1021/JO000568Q
> Lipids and lipid-like molecules / Prenol lipids / Sesquiterpenoids
(2Z)-2-[3-[(3aR,4S,9S,9aR)-1,8,9-trihydroxy-1,4,7-trimethyl-5,6-dioxo-3,3a,9,9a-tetrahydro-2H-cyclopenta[b]naphthalen-4-yl]propylidene]-6-methylhept-5-enoic acid 6918351 Click to see 472.60 unknown https://doi.org/10.1021/JO000568Q
Pycnanthuquinone A 6918357 Click to see 472.60 unknown https://doi.org/10.1021/JO000568Q
> Lipids and lipid-like molecules / Prenol lipids / Triterpenoids
[(1R,3aS,5aR,5bR,7aR,9R,10R,11aR,11bR,13aR,13bR)-10-hydroxy-3a-(hydroxymethyl)-5a,5b,8,8,11a-pentamethyl-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,9,10,11,11b,12,13,13a,13b-hexadecahydrocyclopenta[a]chrysen-9-yl] (E)-3-(3,4-dihydroxyphenyl)prop-2-enoate 54585389 Click to see 620.90 unknown https://doi.org/10.1055/S-2007-967103
> Lipids and lipid-like molecules / Steroids and steroid derivatives / Stigmastanes and derivatives
[(1S,3aR,3bS,5aR,6R,8aS,8bS,10aS)-3a,5a-dimethyl-6-[(E,2R)-5-propan-2-yloct-5-en-2-yl]-1,2,3,3b,4,5,6,7,8,8a,8b,9,10,10a-tetradecahydroindeno[5,4-e]inden-1-yl]methanol 163195098 Click to see 428.70 unknown https://doi.org/10.1055/S-2007-967103
beta-Sitosterol 3-O-beta-D-galactopyranoside 296119 Click to see CCC(CCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)OC5C(C(C(C(O5)CO)O)O)O)C)C)C(C)C 576.80 unknown https://doi.org/10.1055/S-2007-967103
Sitogluside 5742590 Click to see CCC(CCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)OC5C(C(C(C(O5)CO)O)O)O)C)C)C(C)C 576.80 unknown https://doi.org/10.1055/S-2007-967103
> Phenylpropanoids and polyketides / Flavonoids / Flavans / Flavan-4-ols
(6S,8R)-6-(4-hydroxyphenyl)-7,8-dihydro-6H-[1,3]dioxolo[4,5-g]chromene-8,9-diol 162885845 Click to see C1C(C2=C(C3=C(C=C2OC1C4=CC=C(C=C4)O)OCO3)O)O 302.28 unknown https://doi.org/10.1021/NP9007393
6-(4-hydroxyphenyl)-7,8-dihydro-6H-[1,3]dioxolo[4,5-g]chromene-8,9-diol 162885844 Click to see C1C(C2=C(C3=C(C=C2OC1C4=CC=C(C=C4)O)OCO3)O)O 302.28 unknown https://doi.org/10.1021/NP9007393
> Phenylpropanoids and polyketides / Flavonoids / O-methylated flavonoids / 7-O-methylated flavonoids
Genkwanin 5281617 Click to see 284.26 unknown https://doi.org/10.1021/NP9007393
https://doi.org/10.1080/14786419.2010.522577
> Phenylpropanoids and polyketides / Isoflavonoids / O-methylated isoflavonoids / 4-O-methylated isoflavonoids / 3-hydroxy,4-methoxyisoflavonoids
Calycosin 5280448 Click to see 284.26 unknown https://doi.org/10.1080/14786419.2010.522577
> Phenylpropanoids and polyketides / Isoflavonoids / O-methylated isoflavonoids / 4-O-methylated isoflavonoids / 4-O-methylisoflavones
2'-Hydroxyformononetin 5280551 Click to see 284.26 unknown https://doi.org/10.1016/0031-9422(92)80205-S
Biochanin A 5280373 Click to see 284.26 unknown https://doi.org/10.1055/S-2007-967103
https://doi.org/10.1080/14786419.2010.522577
Formononetin 5280378 Click to see 268.26 unknown https://doi.org/10.1021/NP9007393
> Phenylpropanoids and polyketides / Isoflavonoids / O-methylated isoflavonoids / 7-O-methylated isoflavonoids / 7-O-methylisoflavones
4',7-Dimethoxy-2'-isoflavonol 643008 Click to see 298.29 unknown https://doi.org/10.1016/0031-9422(92)80059-N
https://doi.org/10.1016/0031-9422(92)80205-S
Prunetin 5281804 Click to see 284.26 unknown https://doi.org/10.1080/14786419.2010.522577
https://doi.org/10.1055/S-2007-967103

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