Tyramine
| Internal ID | 1629815e-706f-4618-a24a-d50d5ba927d4 |
| Taxonomy | Benzenoids > Benzene and substituted derivatives > Phenethylamines |
| IUPAC Name | 4-(2-aminoethyl)phenol |
| SMILES (Canonical) | C1=CC(=CC=C1CCN)O |
| SMILES (Isomeric) | C1=CC(=CC=C1CCN)O |
| InChI | InChI=1S/C8H11NO/c9-6-5-7-1-3-8(10)4-2-7/h1-4,10H,5-6,9H2 |
| InChI Key | DZGWFCGJZKJUFP-UHFFFAOYSA-N |
| Popularity | 13,572 references in papers |
| Molecular Formula | C8H11NO |
| Molecular Weight | 137.18 g/mol |
| Exact Mass | 137.084063974 g/mol |
| Topological Polar Surface Area (TPSA) | 46.20 Ų |
| XlogP | 1.10 |
| Atomic LogP (AlogP) | 0.89 |
| H-Bond Acceptor | 2 |
| H-Bond Donor | 2 |
| Rotatable Bonds | 2 |
| 51-67-2 |
| 4-(2-Aminoethyl)phenol |
| p-Tyramine |
| 4-Hydroxyphenethylamine |
| Uteramine |
| 2-(4-Hydroxyphenyl)ethylamine |
| Tocosine |
| Tyrosamine |
| Tyramin |
| Systogene |
| There are more than 10 synonyms. If you wish to see them all click here. |
| Target | Value | Probability (raw) | Probability (%) |
|---|---|---|---|
| Human Intestinal Absorption | + | 0.9967 | 99.67% |
| Caco-2 | + | 0.9637 | 96.37% |
| Blood Brain Barrier | - | 0.6000 | 60.00% |
| Human oral bioavailability | - | 0.7000 | 70.00% |
| Subcellular localzation | Lysosomes | 0.5368 | 53.68% |
| OATP2B1 inhibitior | - | 1.0000 | 100.00% |
| OATP1B1 inhibitior | + | 0.9413 | 94.13% |
| OATP1B3 inhibitior | + | 0.9535 | 95.35% |
| MATE1 inhibitior | - | 0.9800 | 98.00% |
| OCT2 inhibitior | - | 0.6500 | 65.00% |
| BSEP inhibitior | - | 0.9345 | 93.45% |
| P-glycoprotein inhibitior | - | 0.9893 | 98.93% |
| P-glycoprotein substrate | - | 0.8844 | 88.44% |
| CYP3A4 substrate | - | 0.7771 | 77.71% |
| CYP2C9 substrate | - | 1.0000 | 100.00% |
| CYP2D6 substrate | + | 0.6209 | 62.09% |
| CYP3A4 inhibition | - | 0.8495 | 84.95% |
| CYP2C9 inhibition | - | 0.9361 | 93.61% |
| CYP2C19 inhibition | - | 0.9044 | 90.44% |
| CYP2D6 inhibition | - | 0.9231 | 92.31% |
| CYP1A2 inhibition | - | 0.9045 | 90.45% |
| CYP2C8 inhibition | + | 0.6034 | 60.34% |
| CYP inhibitory promiscuity | - | 0.7840 | 78.40% |
| UGT catelyzed | + | 0.8000 | 80.00% |
| Carcinogenicity (binary) | - | 0.6110 | 61.10% |
| Carcinogenicity (trinary) | Non-required | 0.7249 | 72.49% |
| Eye corrosion | + | 0.9424 | 94.24% |
| Eye irritation | + | 0.9442 | 94.42% |
| Skin irritation | + | 0.8021 | 80.21% |
| Skin corrosion | + | 0.8926 | 89.26% |
| Ames mutagenesis | - | 0.7300 | 73.00% |
| Human Ether-a-go-go-Related Gene inhibition | - | 0.8152 | 81.52% |
| Micronuclear | - | 0.7200 | 72.00% |
| Hepatotoxicity | - | 0.5500 | 55.00% |
| skin sensitisation | + | 0.4905 | 49.05% |
| Respiratory toxicity | + | 0.6444 | 64.44% |
| Reproductive toxicity | + | 0.5444 | 54.44% |
| Mitochondrial toxicity | + | 0.8625 | 86.25% |
| Nephrotoxicity | - | 0.8059 | 80.59% |
| Acute Oral Toxicity (c) | II | 0.6377 | 63.77% |
| Estrogen receptor binding | - | 0.6992 | 69.92% |
| Androgen receptor binding | - | 0.5288 | 52.88% |
| Thyroid receptor binding | - | 0.7864 | 78.64% |
| Glucocorticoid receptor binding | - | 0.7783 | 77.83% |
| Aromatase binding | - | 0.8127 | 81.27% |
| PPAR gamma | - | 0.6713 | 67.13% |
| Honey bee toxicity | - | 0.9401 | 94.01% |
| Biodegradation | - | 0.6750 | 67.50% |
| Crustacea aquatic toxicity | + | 0.6100 | 61.00% |
| Fish aquatic toxicity | - | 0.9480 | 94.80% |
Proven Targets:
| CHEMBL ID | UniProt ID | Name | Min activity | Assay type | Source |
|---|---|---|---|---|---|
| CHEMBL3577 | P00352 | Aldehyde dehydrogenase 1A1 |
39810.7 nM |
Potency |
via CMAUP
|
| CHEMBL3622 | P33261 | Cytochrome P450 2C19 |
39810.7 nM |
Potency |
via CMAUP
|
| CHEMBL1287622 | Q9Y468 | Lethal(3)malignant brain tumor-like protein 1 |
12589.3 nM |
Potency |
via CMAUP
|
| CHEMBL1293226 | B2RXH2 | Lysine-specific demethylase 4D-like |
35481.3 nM |
Potency |
via CMAUP
|
| CHEMBL1899 | P46098 | Serotonin 3a (5-HT3a) receptor |
26000 nM |
EC50 |
PMID: 18033297
|
| CHEMBL5857 | Q96RJ0 | Trace amine-associated receptor 1 |
731 nM 881.84 nM |
EC50 IC50 |
via Super-PRED
via CMAUP |
Predicted Targets (via Super-PRED):
| CHEMBL ID | UniProt ID | Name | Probability | Model accuracy |
|---|---|---|---|---|
| CHEMBL5619 | P27695 | DNA-(apurinic or apyrimidinic site) lyase | 94.08% | 91.11% |
| CHEMBL3251 | P19838 | Nuclear factor NF-kappa-B p105 subunit | 92.89% | 96.09% |
| CHEMBL3492 | P49721 | Proteasome Macropain subunit | 87.89% | 90.24% |
| CHEMBL242 | Q92731 | Estrogen receptor beta | 87.77% | 98.35% |
| CHEMBL4203 | Q9HAZ1 | Dual specificity protein kinase CLK4 | 86.97% | 94.45% |
| CHEMBL3230 | O95977 | Sphingosine 1-phosphate receptor Edg-6 | 86.31% | 94.01% |
| CHEMBL3060 | Q9Y345 | Glycine transporter 2 | 84.50% | 99.17% |
| CHEMBL4793 | Q86TI2 | Dipeptidyl peptidase IX | 83.34% | 96.95% |
| CHEMBL3038469 | P24941 | CDK2/Cyclin A | 82.50% | 91.38% |
| CHEMBL2288 | Q13526 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | 81.60% | 91.71% |
| CHEMBL4101 | P17612 | cAMP-dependent protein kinase alpha-catalytic subunit | 80.63% | 82.86% |
Below are displayed all the plants proven (via scientific papers) to contain this
compound!
To see more specific details click the taxa you are interested in.
To see more specific details click the taxa you are interested in.
| PubChem | 5610 |
| NPASS | NPC125732 |
| ChEMBL | CHEMBL11608 |
| LOTUS | LTS0111335 |
| wikiData | Q165930 |