Details Top

Internal ID UUID6440009c3d366645065720
Scientific name Paullinia cupana
Authority Kunth
First published in Nov. Gen. Sp. 5: 117 (1821)

Ethnobotanical Use Top

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Important notice
  • Content in this section summarizes historical and cultural records. It is not medical advice.
  • Do not use plants for self-treatment. Safety, efficacy, and appropriate use are not established here.
  • Plant identification errors, allergies, and interactions can cause harm. Consult qualified professionals for health questions.
  • Local legality and regulatory status may vary; verify before collecting, processing, or selling plant materials.

For generations people have made strong, bitter infusions from roasted guarana seeds to stay awake and stave off hunger. Among the Ka’apor of northern Brazil the seeds are roasted, ground, and soaked in hot water to produce a short decoction used for diarrhea and fever; among communities in Pará, ground seed is mixed with cool water and stirred to a thick drink often sweetened with sugar or honey; and in Paraguay’s Bajo Chaco, the Guaraní traditionally heat small pieces of roasted seed in water for a brisk decoction taken as a stimulant (Bennett et al., 2021; Schmitt et al., 2020; Kuhlmann & Vilegas, 2013). In each case the seed is the part used and the preparation is a brief hot infusion or decoction that delivers a powerful jolt of caffeine and related methylxanthines.

A practical traditional recipe is a mild guarana tea. Toast a few whole seeds (roughly 3–5 g) in a dry pan until they smell nutty, let them cool, then grind them to a coarse powder. Add the powder to a cup (about 250 ml) of just-boiled water, stir, and steep for 5–8 minutes; strain and drink slowly. Because guarana can contain as much caffeine as roasted coffee beans, start with one cup and avoid drinking it late in the day; people sensitive to stimulants, those with heart conditions or ulcers, and anyone who is pregnant or nursing should avoid it or seek guidance from a clinician.

The activity of these preparations is plausibly tied to caffeine together with smaller amounts of theobromine and theophylline, which are well documented in guarana seed and account for its stimulant and diuretic effects (Kuhlmann & Vilegas, 2013). Guarana is still widely brewed as a home beverage across Amazonian Brazil and Paraguay, sold as commercial powders and syrups for sodas and energy drinks, and investigated today for its high caffeine content and antioxidant profile (Schmitt et al., 2020; Kuhlmann & Vilegas, 2013).

General Uses Top

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Common products:
- Dried guarana seed is processed into a coarse powder or extract that provides a concentrated source of caffeine for use in carbonated beverages, energy drinks, and functional sports drinks.
- The seed oil, cold‑pressed from the same material, is incorporated into cosmetic formulations (creams, lotions, shampoos) as a caffeine‑containing oil.

Industrial and craft applications:
- Guarana seed oil functions as an emollient and mild surfactant in personal‑care products; its fatty‑acid profile (≈60 % linoleic, ≈20 % oleic acid) offers good oxidative stability for cosmetic emulsions.
- Guarana extracts serve as natural flavoring agents and caffeine sources in the food‑processing industry, enabling flavor development without synthetic additives.

Food and beverages (non‑medicinal):
- Guarana powder or aqueous extract is added to soft‑drink syrups and ready‑to‑drink energy beverages to impart a characteristic sweet‑bitter flavor and a stimulatory effect from caffeine.
- The ingredient also appears in confectionery, chocolate, baked goods, and snack‑bar formulations where its flavor and caffeine content enhance product appeal.

Fragrance and cosmetics:
- Cosmetic manufacturers list guarana seed oil or seed‑derived caffeine extracts in product INCI declarations for skin‑care and hair‑care lines, citing the ingredient’s caffeine content for its stimulating properties in topical applications.

Properties relevant to use:
- Caffeine concentration in the dried seed typically ranges from 4.5 % to 5.5 % by weight, providing a high‑potency natural stimulant suitable for beverage and functional‑food applications.
- The seed oil’s fatty‑acid composition (predominantly linoleic and oleic acids) confers favorable emollient and spread‑ability characteristics for cosmetic emulsions.
- Presence of saponins imparts mild surfactant activity, useful in mild cleansing formulations.

Standards and regulation:
- Caffeine levels in carbonated beverages are regulated by national agencies (e.g., ANVISA in Brazil; EU regulation (EC) No 1333/2008). Quantification of caffeine in plant materials follows standardized methods such as ISO 14502‑2 for caffeine determination.
- Cosmetic use of guarana seed oil must comply with the EU Cosmetic Regulation (EC) No 1223/2009 and Brazilian ANVISA cosmetic ingredient guidelines.
- Food‑safety management systems for guarana‑based products are generally covered by ISO 22000 standards.

Sustainability and sourcing:
- Guarana is cultivated mainly in the Amazon basin from both wild‑collected vines and managed plantations. Sustainable harvesting practices include selective wild collection and agroforestry‑based cultivation.
- Certification programs such as Rainforest Alliance and Fairtrade provide market incentives for environmentally sound production and fair labor conditions.
- Continuous monitoring of wild populations is recommended to prevent over‑exploitation of the species.

Synonyms Top

Scientific name Authority First published in
Paullinia brasiliensis Lodd. ex Radlk. Monogr. Serjania : 67 (1875)
Paullinia sorbilis Mart. 7: 266 266 1826
Paullinia cupana var. sorbilis (Mart.) Ducke Rodriguésia 3: 156 (1937)

Common names Top

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Language Common/alternative name
English guarana
Spanish cupana
Spanish guaraná
Arabic جوارانا
Arabic غوارانا
Azerbaijani quarana
azb قوارانا
Bulgarian гуарана
Bosnian guarana
Catalan paul·línia
Catalan guaranà
Czech paulinie nápojná
Czech guarana
Danish guarana
German guarana
German guarana cafecito
German guaraná
Esperanto gvaranao
Estonian guaraana
Estonian guaraana-pauliinia
Basque guarana
Persian گوارنا
Finnish guarana
Finnish guaraná
French guarana
French warana
French guaraná
frr guaraná
Irish guaraná
Galician guaraná
Hebrew גואראנה
Hebrew גוארנה
Croatian guarana
Hungarian guarana
Indonesian guarana
Icelandic guarana
Italian guaranà
Japanese ガラナ
Georgian გუარანა
Korean 과라노
Korean 과라나
Korean 구아라누
Korean 구아라나
Korean 과라나 브라마
Lithuanian guarana
Lithuanian gvaraninė paulinija
Latvian guarana
Macedonian Гуарана
Malay guarana
mwl guaraná
Norwegian Bokmål guarana
Dutch guaraná
Dutch guarana
Polish guarana
Polish paulinia guarana
Polish osmęta
Polish cierniopląt
Polish ciermiopląt guarany
Portuguese guaraná
Portuguese guarana
Romanian guarana
Russian Гуарана
Serbo-Croatian gvarana
Slovak paulínia nápojová
Slovenian guarana
Serbian Гуарана
Serbian гварана
Swedish guarana
Swedish guaranabär
Swedish guaraná
Thai กวารานา
Turkish guarana
Ukrainian Гуарана
Uzbek guarana
Chinese 瓜拿纳
Chinese 瓜拿納
Chinese 瓜拉拿泡林藤
Chinese 醒神藤
Chinese 瓜拉纳

Subspecies (abbr. subsp./ssp.) Top

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Varieties (abbr. var.) Top

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Subvarieties (abbr. subvar.) Top

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Forms (abbr. f.) Top

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Germination/Propagation Top

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No germination or propagation data was added yet.

Distribution (via POWO/KEW) Top

Legend for the distribution data:
- Doubtful data
- Extinct
- Introduced
- Native
  • Southern America
    • Brazil
      • Brazil North
    • Northern South America
      • Guyana
      • Venezuela
    • Western South America
      • Colombia
      • Ecuador
      • Peru

Links to other databases Top

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Database ID/link to page
World Flora Online wfo-0000471124
UNII ZN61XGA9AZ
USDA Plants PACU7
Tropicos 28600664
INPN 841466
KEW urn:lsid:ipni.org:names:784110-1
The Plant List kew-2543056
Open Tree Of Life 648094
Observations.org 369623
NCBI Taxonomy 392747
IPNI 784110-1
iNaturalist 431412
GBIF 3189949
Freebase /m/0j0rj
EPPO PAXCU
EOL 483644
Elurikkus 374230
USDA GRIN 27031
Wikipedia Guarana

Genomes (via NCBI) Top

No reference genome is available on NCBI yet. We are constantly monitoring for new data.

Scientific Literature Top

Below are displayed the latest 15 articles published in PMC (PubMed Central®) and other sources (DOI number only)!
If you wish to see all the related articles click here.
Title Authors Publication Released IDs
High-throughput sequencing-based analysis of the composition and diversity of the endophytic bacterial community in the roots of Dipsacus asperoides Liu C, Deng J 3 Biotech 07-May-2024
PMCID:PMC11076436
doi:10.1007/s13205-024-03986-9
PMID:38725865
Guaraná, a planta do Brasil Duarte RH Hist Cienc Saude Manguinhos 15-Apr-2024
PMCID:PMC11018301
doi:10.1590/S0104-59702024000100013
Elimination of Toxic Solvents from Analytical Methods in Food Analysis: Caffeine Determination in Tea as an Example Kalisz O, Jaworska A, Studzińska S, Bocian S Foods 13-Apr-2024
PMCID:PMC11048749
doi:10.3390/foods13081189
PMID:38672862
Adulteration of Brain Health (Cognitive, Mood, and Sleep Enhancement) Food Supplements by the Addition of Pharmaceutical Drugs: A Comprehensive Review of Analytical Approaches and Trends Paiva R, Correia M, Delerue-Matos C, Amaral JS Foods 16-Mar-2024
PMCID:PMC10969376
doi:10.3390/foods13060908
PMID:38540898
A revisited history of cacao domestication in pre-Columbian times revealed by archaeogenomic approaches Lanaud C, Vignes H, Utge J, Valette G, Rhoné B, Garcia Caputi M, Angarita Nieto NS, Fouet O, Gaikwad N, Zarrillo S, Powis TG, Cyphers A, Valdez F, Olivera Nunez SQ, Speller C, Blake M, Valdez FJ, Raymond S, Rowe SM, Duke GS, Romano FE, Loor Solórzano RG, Argout X Sci Rep 07-Mar-2024
PMCID:PMC10920634
doi:10.1038/s41598-024-53010-6
PMID:38453955
Biological properties of caffeine, (+)-catechin, and theobromine: an in silico study Dutra NS, da Silva D’Ávila CM, da Silva TC, de Oliveira Mendes T, Livinalli IC, Bertoncelli AC, Saccol FK, Cadoná FC 3 Biotech 03-Mar-2024
PMCID:PMC10909812
doi:10.1007/s13205-024-03934-7
PMID:38444785
Amazonian useful plants described in the book “Le Pays des Amazones” (1885) of the Brazilian propagandist Baron de Santa-Anna Nery: a historical and ethnobotanical perspective Silva LN, Oliveira EC, Baratto LC J Ethnobiol Ethnomed 26-Feb-2024
PMCID:PMC10897987
doi:10.1186/s13002-024-00663-2
PMID:38409064
Polar licit and illicit ingredients in dietary supplements: chemometric optimization of extraction and HILIC-MS/MS analysis Baglietto M, Benedetti B, Di Carro M, Magi E Anal Bioanal Chem 09-Feb-2024
PMCID:PMC10899327
doi:10.1007/s00216-024-05173-4
PMID:38334794
Medicinal herbs and their metabolites with biological potential to protect and combat liver toxicity and its disorders: A review Islam Shawon S, Nargis Reyda R, Qais N Heliyon 01-Feb-2024
PMCID:PMC10864916
doi:10.1016/j.heliyon.2024.e25340
PMID:38356556
Plant-Associated Bacillus thuringiensis and Bacillus cereus: Inside Agents for Biocontrol and Genetic Recombination in Phytomicrobiome Sorokan A, Gabdrakhmanova V, Kuramshina Z, Khairullin R, Maksimov I Plants (Basel) 30-Nov-2023
PMCID:PMC10707757
doi:10.3390/plants12234037
PMID:38068672
Botanical Extract Coacillium for Management of Paediatric Atopic Dermatitis: A Case Report SPRING P Acta Derm Venereol 21-Nov-2023
PMCID:PMC10680978
doi:10.2340/actadv.v103.13376
PMID:37987627
Pharmacokinetic and pharmacodynamic herb-drug interactions—part I. Herbal medicines of the central nervous system Czigle S, Nagy M, Mladěnka P, Tóth J PeerJ 15-Nov-2023
PMCID:PMC10656908
doi:10.7717/peerj.16149
PMID:38025741
Bioactivity of the Genus Turnera: A Review of the Last 10 Years Parra-Naranjo A, Delgado-Montemayor C, Salazar-Aranda R, Waksman-Minsky N Pharmaceuticals (Basel) 07-Nov-2023
PMCID:PMC10675026
doi:10.3390/ph16111573
PMID:38004438
Efficacy and safety of traditional Chinese medicine for cancer-related fatigue: a systematic literature review of randomized controlled trials Yang J, Li Y, Chau CI, Shi J, Chen X, Hu H, Ung CO Chin Med 01-Nov-2023
PMCID:PMC10619240
doi:10.1186/s13020-023-00849-y
PMID:37907925
Yerba Maté (Ilex paraguariensis) Supplement Exerts Beneficial, Tissue-Specific Effects on Mitochondrial Efficiency and Redox Status in Healthy Adult Mice Walton CM, Saito ER, Warren CE, Larsen JG, Remund NP, Reynolds PR, Hansen JM, Bikman BT Nutrients 20-Oct-2023
PMCID:PMC10609848
doi:10.3390/nu15204454
PMID:37892529

Phytochemical Profile Top

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Below are displayed the proven (via scientific papers) natural compounds!
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Name PubChem ID Canonical SMILES MW Found in Proof
> Benzenoids / Benzene and substituted derivatives / Phenylpropanes
4-tert-Pentylphenol 6643 Click to see 164.24 unknown https://doi.org/10.1007/BF01267777
> Benzenoids / Phenol ethers / Anisoles
1-Methoxy-4-Prop-1-Enylbenzene 7703 Click to see 148.20 unknown https://doi.org/10.1007/BF01267777
Anethole 637563 Click to see 148.20 unknown https://doi.org/10.1007/BF01267777
Estragole 8815 Click to see 148.20 unknown https://doi.org/10.1007/BF01267777
> Lipids and lipid-like molecules / Fatty Acyls / Fatty acids and conjugates / Long-chain fatty acids
cis-Vaccenic acid 5282761 Click to see 282.50 unknown https://doi.org/10.1007/S11745-003-1126-5
Paullinic acid 5312518 Click to see 310.50 unknown https://doi.org/10.1007/S11745-003-1126-5
> Lipids and lipid-like molecules / Prenol lipids / Monoterpenoids / Aromatic monoterpenoids
Carvacrol 10364 Click to see CC1=C(C=C(C=C1)C(C)C)O 150.22 unknown https://doi.org/10.1007/BF01267777
> Lipids and lipid-like molecules / Prenol lipids / Monoterpenoids / Menthane monoterpenoids
Limonene, (+/-)- 22311 Click to see CC1=CCC(CC1)C(=C)C 136.23 unknown https://doi.org/10.1007/BF01267777
> Lipids and lipid-like molecules / Prenol lipids / Sesquiterpenoids
(1R,2S,7S,8S)-1,3-dimethyl-8-propan-2-yltricyclo[4.4.0.02,7]dec-3-ene 92042749 Click to see CC1=CCC2C3C1C2(CCC3C(C)C)C 204.35 unknown https://doi.org/10.1007/BF01267777
Caryophyllene 5281515 Click to see CC1=CCCC(=C)C2CC(C2CC1)(C)C 204.35 unknown https://doi.org/10.1007/BF01267777
Caryophyllene,alpha + beta mixt. 5354499 Click to see 204.35 unknown https://doi.org/10.1007/BF01267777
Copaene 19725 Click to see CC1=CCC2C3C1C2(CCC3C(C)C)C 204.35 unknown https://doi.org/10.1007/BF01267777
> Organoheterocyclic compounds / Imidazopyrimidines / Purines and purine derivatives / Xanthines
Caffeine 2519 Click to see CN1C=NC2=C1C(=O)N(C(=O)N2C)C 194.19 unknown https://doi.org/10.1007/BF01027774
https://doi.org/10.1111/J.2042-7158.1992.TB05517.X
https://doi.org/10.1002/1615-9314(20020401)25:5/6<371::AID-JSSC371>3.0.CO;2-9
https://doi.org/10.1201/9781420050134.AX1
https://doi.org/10.1016/0031-9422(94)00141-F
https://doi.org/10.1007/BF02862148
https://doi.org/10.1093/JAOAC/81.4.691
https://doi.org/10.3109/13880209309082937
Theobromine 5429 Click to see 180.16 unknown https://doi.org/10.3109/13880209309082937
https://doi.org/10.1007/BF02862148
https://doi.org/10.1093/JAOAC/81.4.691
https://doi.org/10.1016/0031-9422(94)00141-F
Theophylline 2153 Click to see 180.16 unknown https://doi.org/10.1007/BF01027774
https://doi.org/10.3109/13880209309082937
https://doi.org/10.1016/0031-9422(94)00141-F
https://doi.org/10.1007/BF02862148
https://doi.org/10.1093/JAOAC/81.4.691
> Phenylpropanoids and polyketides / Flavonoids / Biflavonoids and polyflavonoids
Procyanidin A1 5089889 Click to see 576.50 unknown https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6149164/
Procyanidin A2 124025 Click to see C1C(C(OC2=C1C(=CC3=C2C4C(C(O3)(OC5=CC(=CC(=C45)O)O)C6=CC(=C(C=C6)O)O)O)O)C7=CC(=C(C=C7)O)O)O 576.50 unknown https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6149164/
Procyanidin B 130556 Click to see 578.50 unknown https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6149164/
Procyanidin B1 11250133 Click to see C1C(C(OC2=C1C(=CC(=C2C3C(C(OC4=CC(=CC(=C34)O)O)C5=CC(=C(C=C5)O)O)O)O)O)C6=CC(=C(C=C6)O)O)O 578.50 unknown https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6149164/
Procyanidin B2, (+)- 122738 Click to see C1C(C(OC2=C1C(=CC(=C2C3C(C(OC4=CC(=CC(=C34)O)O)C5=CC(=C(C=C5)O)O)O)O)O)C6=CC(=C(C=C6)O)O)O 578.50 unknown https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6149164/
Procyanidin B3 146798 Click to see 578.50 unknown https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6149164/
Procyanidin B4 147299 Click to see 578.50 unknown https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6149164/
Procyanidin C1 169853 Click to see 866.80 unknown https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6149164/
Procyanidin trimer T2 13751990 Click to see 866.80 unknown https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6149164/
> Phenylpropanoids and polyketides / Flavonoids / Flavans / Catechins
(+)-Epicatechin 182232 Click to see 290.27 unknown https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6149164/
2-(3,4-dihydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-3,5,7-triol 1203 Click to see 290.27 unknown https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6149164/
Catechin 9064 Click to see 290.27 unknown https://doi.org/10.1093/JAOAC/81.4.691
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6149164/
Epicatechin 72276 Click to see 290.27 unknown https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6149164/
https://doi.org/10.1093/JAOAC/81.4.691

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