gamma-Linolenic acid
| Internal ID | 9f691905-817c-4212-844f-4e9283a021b6 |
| Taxonomy | Lipids and lipid-like molecules > Fatty Acyls > Lineolic acids and derivatives |
| IUPAC Name | (6Z,9Z,12Z)-octadeca-6,9,12-trienoic acid |
| SMILES (Canonical) | CCCCCC=CCC=CCC=CCCCCC(=O)O |
| SMILES (Isomeric) | CCCCC/C=C\C/C=C\C/C=C\CCCCC(=O)O |
| InChI | InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/b7-6-,10-9-,13-12- |
| InChI Key | VZCCETWTMQHEPK-QNEBEIHSSA-N |
| Popularity | 3,886 references in papers |
| Molecular Formula | C18H30O2 |
| Molecular Weight | 278.40 g/mol |
| Exact Mass | 278.224580195 g/mol |
| Topological Polar Surface Area (TPSA) | 37.30 Ų |
| XlogP | 5.90 |
| Atomic LogP (AlogP) | 5.66 |
| H-Bond Acceptor | 1 |
| H-Bond Donor | 1 |
| Rotatable Bonds | 13 |
| GAMOLENIC ACID |
| 506-26-3 |
| (6Z,9Z,12Z)-octadeca-6,9,12-trienoic acid |
| (Z,Z,Z)-6,9,12-Octadecatrienoic acid |
| Ligla |
| (6,9,12)-linolenic acid |
| gamma Linolenic Acid |
| 6,9,12-Octadecatrienoic acid, (Z,Z,Z)- |
| CCRIS 7668 |
| .gamma.-Linolenic Acid |
| There are more than 10 synonyms. If you wish to see them all click here. |
| Target | Value | Probability (raw) | Probability (%) |
|---|---|---|---|
| Human Intestinal Absorption | + | 0.9947 | 99.47% |
| Caco-2 | + | 0.5236 | 52.36% |
| Blood Brain Barrier | + | 0.8250 | 82.50% |
| Human oral bioavailability | + | 0.5429 | 54.29% |
| Subcellular localzation | Plasma membrane | 0.5465 | 54.65% |
| OATP2B1 inhibitior | - | 0.8522 | 85.22% |
| OATP1B1 inhibitior | - | 0.6946 | 69.46% |
| OATP1B3 inhibitior | - | 0.5698 | 56.98% |
| MATE1 inhibitior | - | 0.9600 | 96.00% |
| OCT2 inhibitior | - | 0.9000 | 90.00% |
| BSEP inhibitior | + | 0.6225 | 62.25% |
| P-glycoprotein inhibitior | - | 0.7950 | 79.50% |
| P-glycoprotein substrate | - | 0.9580 | 95.80% |
| CYP3A4 substrate | - | 0.6862 | 68.62% |
| CYP2C9 substrate | + | 0.6276 | 62.76% |
| CYP2D6 substrate | - | 0.8766 | 87.66% |
| CYP3A4 inhibition | - | 0.9295 | 92.95% |
| CYP2C9 inhibition | - | 0.8972 | 89.72% |
| CYP2C19 inhibition | - | 0.9467 | 94.67% |
| CYP2D6 inhibition | - | 0.9545 | 95.45% |
| CYP1A2 inhibition | + | 0.9107 | 91.07% |
| CYP2C8 inhibition | - | 0.9103 | 91.03% |
| CYP inhibitory promiscuity | - | 0.9349 | 93.49% |
| UGT catelyzed | - | 0.0000 | 0.00% |
| Carcinogenicity (binary) | - | 0.7035 | 70.35% |
| Carcinogenicity (trinary) | Non-required | 0.7021 | 70.21% |
| Eye corrosion | + | 0.9611 | 96.11% |
| Eye irritation | + | 0.8105 | 81.05% |
| Skin irritation | + | 0.8622 | 86.22% |
| Skin corrosion | + | 0.6450 | 64.50% |
| Ames mutagenesis | - | 0.9500 | 95.00% |
| Human Ether-a-go-go-Related Gene inhibition | + | 0.6726 | 67.26% |
| Micronuclear | - | 1.0000 | 100.00% |
| Hepatotoxicity | + | 0.5375 | 53.75% |
| skin sensitisation | + | 0.8676 | 86.76% |
| Respiratory toxicity | - | 0.6111 | 61.11% |
| Reproductive toxicity | - | 0.7866 | 78.66% |
| Mitochondrial toxicity | + | 0.5625 | 56.25% |
| Nephrotoxicity | - | 0.7723 | 77.23% |
| Acute Oral Toxicity (c) | IV | 0.8289 | 82.89% |
| Estrogen receptor binding | + | 0.5433 | 54.33% |
| Androgen receptor binding | - | 0.8513 | 85.13% |
| Thyroid receptor binding | + | 0.5982 | 59.82% |
| Glucocorticoid receptor binding | - | 0.6226 | 62.26% |
| Aromatase binding | - | 0.5900 | 59.00% |
| PPAR gamma | + | 0.8862 | 88.62% |
| Honey bee toxicity | - | 0.9964 | 99.64% |
| Biodegradation | + | 0.6500 | 65.00% |
| Crustacea aquatic toxicity | + | 0.6600 | 66.00% |
| Fish aquatic toxicity | + | 0.9649 | 96.49% |
Proven Targets:
| CHEMBL ID | UniProt ID | Name | Min activity | Assay type | Source |
|---|---|---|---|---|---|
| CHEMBL4081 | P13726 | Coagulation factor III |
30000 nM |
IC50 |
PMID: 9834151
|
| CHEMBL4422 | O14842 | Free fatty acid receptor 1 |
4620 nM 240 nM |
EC50 EC50 |
PMID: 26774923
via Super-PRED |
| CHEMBL1287622 | Q9Y468 | Lethal(3)malignant brain tumor-like protein 1 |
35481.3 nM |
Potency |
via CMAUP
|
| CHEMBL239 | Q07869 | Peroxisome proliferator-activated receptor alpha |
270 nM 270 nM 270 nM |
IC50 IC50 IC50 |
via Super-PRED
DOI: 10.1007/s00044-012-0285-6 DOI: 10.1007/s00044-008-9102-7 |
| CHEMBL3979 | Q03181 | Peroxisome proliferator-activated receptor delta |
750 nM 750 nM |
IC50 IC50 |
via Super-PRED
DOI: 10.1007/s00044-012-0285-6 |
| CHEMBL235 | P37231 | Peroxisome proliferator-activated receptor gamma |
2200 nM |
IC50 |
DOI: 10.1007/s00044-012-0285-6
|
Predicted Targets (via Super-PRED):
| CHEMBL ID | UniProt ID | Name | Probability | Model accuracy |
|---|---|---|---|---|
| CHEMBL3060 | Q9Y345 | Glycine transporter 2 | 97.65% | 99.17% |
| CHEMBL2581 | P07339 | Cathepsin D | 96.76% | 98.95% |
| CHEMBL230 | P35354 | Cyclooxygenase-2 | 93.23% | 89.63% |
| CHEMBL3251 | P19838 | Nuclear factor NF-kappa-B p105 subunit | 93.07% | 96.09% |
| CHEMBL1781 | P11387 | DNA topoisomerase I | 92.27% | 97.00% |
| CHEMBL4769 | O95749 | Geranylgeranyl pyrophosphate synthetase | 91.51% | 92.08% |
| CHEMBL221 | P23219 | Cyclooxygenase-1 | 88.67% | 90.17% |
| CHEMBL2265 | P23141 | Acyl coenzyme A:cholesterol acyltransferase | 84.40% | 85.94% |
| CHEMBL3359 | P21462 | Formyl peptide receptor 1 | 82.54% | 93.56% |
| CHEMBL4793 | Q86TI2 | Dipeptidyl peptidase IX | 81.76% | 96.95% |
Below are displayed all the plants proven (via scientific papers) to contain this
compound!
To see more specific details click the taxa you are interested in.
To see more specific details click the taxa you are interested in.
| PubChem | 5280933 |
| NPASS | NPC5413 |
| ChEMBL | CHEMBL464982 |
| LOTUS | LTS0160094 |
| wikiData | Q415885 |