Details Top

Internal ID UUID64400ca2b3586728909460
Scientific name Berberis aquifolium
Authority Pursh
First published in Fl. Amer. Sept. 1: 219 (1813)

Ethnobotanical Use Top

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Important notice
  • Content in this section summarizes historical and cultural records. It is not medical advice.
  • Do not use plants for self-treatment. Safety, efficacy, and appropriate use are not established here.
  • Plant identification errors, allergies, and interactions can cause harm. Consult qualified professionals for health questions.
  • Local legality and regulatory status may vary; verify before collecting, processing, or selling plant materials.

Among the Nlaka’pamux of British Columbia, the root bark was boiled in water to make a decoction for gastrointestinal upset (Turner & Hebda, 1992). The Coast Salish of Washington applied a poultice of crushed bark to wounds (Moerman, 1998). Early European‑American settlers in the Pacific Northwest prepared a bitter tea from the dried bark as a tonic (Heller, 1998). The Tlingit of Alaska steeped the root bark as an infusion to relieve diarrhea (Moerman, 1998), and the same bark was macerated in alcohol to create a tincture for topical skin complaints (Moerman, 1998). These uses are recorded in ethnobotanical surveys that document infusions, decoctions, poultices and macerations of the root bark and, occasionally, the leaf.

To prepare a mild tea, measure 1 teaspoon (≈2 g) of dried root bark and add to 250 mL (1 cup) of just‑boiled water. Cover and steep 10–15 minutes, then strain. The resulting beverage can be taken once or twice daily. Safety: the tea contains berberine and should be avoided in pregnancy; do not exceed three cups per day and consult a health professional if you are on blood‑pressure or anticoagulant medication.

The active constituents of Berberis aquifolium are well‑established isoquinoline alkaloids—berberine, berbamine, palmatine and jatrorrhizine—along with minor flavonoids. These compounds give the plant its characteristic bitterness and have been linked in ethnobotanical accounts to antimicrobial, anti‑inflammatory and mild cholagogue actions.

Modern research continues to investigate berberine’s metabolic and antimicrobial properties, and Oregon‑grape extracts are available as tinctures, capsules and dried herb for topical use. Many herbalists still brew the traditional tea for digestive support, reflecting a living bridge between historic practice and contemporary herbal science.

General Uses Top

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Food and beverages (non-medicinal):
Ripe berries of Berberis aquifolium are edible; they are very tart and acidic and are used for making jams and jellies and as a souring or flavoring agent in culinary preparations (USDA, Wild Flowers of North America; Turner and Szczawinski, Edible Wild Fruits and Nuts of Canada; Pojar and MacKinnon, Plants of the Pacific Northwest Coast). The fruit is generally not consumed raw due to acidity.

Colorants and tanning:
The roots and stems contain berberine and related isoquinoline alkaloids; they yield yellow and brown dyes on protein fibers and mordanted wool (USDA Dye Plants Database; Genders, A Book of Dyeing; Wilkinson, Wild Flowers as Dye Plants).

Synonyms Top

Scientific name Authority First published in
Mahonia brevipes Rehder Stand. Cycl. Hort. 4: 1971 (1916)
Mahonia diversifolia Sweet Brit. Fl. Gard. 4: t. 94 (1831)
Mahonia latifolia hort. ex Dippel Handb. Laubholzk. 3: 109 (1893)
Mahonia aquifolium (Pursh) Nutt. Gen. N. Amer. Pl. 1: 212 (1818)
Mahonia moseriana Moser ex H.Martinet Jardin 1895: 128 (1895)
Mahonia wagneri (Jouin) Rehder J. Arnold Arbor. 1: 142 (1919)
Mahonia murrayana hort. ex Dippel Handb. Laubholzk. 3: 109 (1893)
Mahonia undulata Ahrendt J. Linn. Soc., Bot. 57: 338 (1961)
Mahonia moseri Ahrendt J. Linn. Soc., Bot. 57: 337 (1961)
Mahonia pinnata var. hortensis Fedde Bot. Jahrb. Syst. 31: 88 (1901)
Odostemon brevipes A.Heller Cat. N. Amer. Pl. , ed. 3: 128 (1912)
Berberis aquifolium var. juglandifolia Rehder Mitt. Deutsch. Dendrol. Ges. 21: 184 (1912 publ. 1913)
Berberis aquifolium var. lyallii (Ahrendt) Marroq. & Laferr. J. Arizona-Nevada Acad. Sci. 30: 53 (1997)
Berberis brevipes Greene Ottawa Naturalist 15: 42 (1901)
Berberis fasciculata Schult.f. Syst. Veg., ed. 15 bis [Roemer & Schultes] 7(1): 17. 1829
Berberis pinnata Banks ex DC. Syst. Nat. [Candolle] 2: 20. 1821 [late May 1821]
Berberis pinnata var. hortensis (Fedde) Marroq. & Laferr. J. Arizona-Nevada Acad. Sci. 30: 54 (1997)
Mahonia aquifolium var. nutkana DC. Syst. Nat. 2: 20 (1821)
Odostemon nutkanus Rydb. Bull. Torrey Bot. Club 33: 141 (1906)
Odostemon aquifolium (Pursh) Rydb. Bull. Torrey Bot. Club 33: 141 (1906)
Mahonia aquifolium var. juglandifolia Jouin Mitt. Deutsch. Dendrol. Ges. 19: 88 (1910 publ. 1911)
Mahonia pinnata var. wagneri Jouin Mitt. Deutsch. Dendrol. Ges. 19: 90 (1910 publ. 1911)
Berberis pinnata var. wagneri Rehder Mitt. Deutsch. Dendrol. Ges. 21: 184 (1912 publ. 1913)
Mahonia aquifolium var. lyallii Ahrendt J. Linn. Soc., Bot. 57: 336 (1961)
Berberis aquifolium var. nutkana (DC.) Marroq. & Laferr. J. Arizona-Nevada Acad. Sci. 30: 53 (1997)
Mahonia aquifolium f. albovariegata Schwer. Mitt. Deutsch. Dendrol. Ges. 17: 216 (1908)
Mahonia aquifolium f. amabilis Schwer. Mitt. Deutsch. Dendrol. Ges. 17: 216 (1908)
Mahonia aquifolium f. aucubifolia Schwer. Mitt. Deutsch. Dendrol. Ges. 17: 216 (1908)
Mahonia aquifolium f. aureovariegata Schwer. Mitt. Deutsch. Dendrol. Ges. 17: 216 (1908)
Mahonia aquifolium f. lutescens Schwer. Mitt. Deutsch. Dendrol. Ges. 17: 216 (1908)

Common names Top

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Language Common/alternative name
English piper's oregon-grape
English holly-leaf oregon-grape
English holly-leaved barberry
English hollyleaved barberry
English oregon grapeholly
English oregon holly
English oregon holly grape
English oregongrape
English shining oregon-grape
English tall oregon-grape
Arabic عنب الجبل
Danish høj oregon-drue
Japanese ヒイラギメギ
Dutch mahonie
Russian Барбарис падуболистный

Subspecies (abbr. subsp./ssp.) Top

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Varieties (abbr. var.) Top

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Subvarieties (abbr. subvar.) Top

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Forms (abbr. f.) Top

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Germination/Propagation Top

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Alternate between 4°C and 20°C for 3 months each, over several cycles, with an extended germination period.
Pulpy Coat Inhibits Germination: Seeds with a pulpy or fleshy outer coat need to have this material removed by soaking and rinsing in clean water daily for about a week. The inhibitory substances in the pulp are thus washed away, and germination rates improve.
Sow seeds immediately as their viability decreases rapidly, or they best germinate when fresh. If stored, seeds might need temperature cycling and patience to germinate.
wash off pulpy coat completely in daily detergent washes

Distribution (via POWO/KEW) Top

Legend for the distribution data:
- Doubtful data
- Extinct
- Introduced
- Native
  • Australasia
    • Australia
      • New South Wales
      • South Australia
      • Tasmania
  • Europe
    • Eastern Europe
      • Central European Russia
      • Krym
      • Ukraine
    • Middle Europe
      • Austria
      • Belgium
      • Czechoslovakia
      • Germany
      • Hungary
      • Netherlands
      • Poland
    • Northern Europe
      • Denmark
      • Finland
      • Great Britain
      • Norway
      • Sweden
    • Southeastern Europe
      • Bulgaria
      • Romania
    • Southwestern Europe
      • France
      • Spain
  • Northern America
    • Eastern Canada
      • Ontario
      • Québec
    • Northeastern U.S.A.
      • Michigan
      • Vermont
    • Northwestern U.S.A.
      • Idaho
      • Montana
      • Oregon
      • Washington
    • Southwestern U.S.A.
      • California
      • Nevada
    • Western Canada
      • British Columbia

Links to other databases Top

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Database ID/link to page
World Flora Online wfo-0000562782
Canadensys 3663
Tropicos 3500167
KEW urn:lsid:ipni.org:names:31334-2
The Plant List kew-2673426
Missouri Botanical Garden 277780
Open Tree Of Life 793093
Observations.org 7028
NCBI Taxonomy 203270
Nature Serve 2.136078
IPNI 31334-2
iNaturalist 126887
GBIF 3033868
Calflora (Californian flora) 1067
USDA GRIN 6814
Wikipedia Mahonia_aquifolium
Plantarium 105224

Genomes (via NCBI) Top

Below is displayed the reference genome only!
If you wish to browse all genomes for this plant click here.
Accession Assembly
Name Level Submitter Released Coverage Size
GCA_965233575.2 dmBerAqui1.hap1.2 Chromosome WELLCOME SANGER INSTITUTE 2026-04-27 49 0.95 Gb

Scientific Literature Top

Below are displayed the latest 15 articles published in PMC (PubMed Central®) and other sources (DOI number only)!
If you wish to see all the related articles click here.
Title Authors Publication Released IDs
UV-Triggered Drug Release from Mesoporous Titanium Nanoparticles Loaded with Berberine Hydrochloride: Enhanced Antibacterial Activity Zuo F, Wang B, Wang L, He J, Qiu X Molecules 03-Apr-2024
PMCID:PMC11013668
doi:10.3390/molecules29071607
PMID:38611885
Commodity risk assessment of Cornus alba and Cornus sanguinea plants from the UK Bragard C, Baptista P, Chatzivassiliou E, Di Serio F, Gonthier P, Jaques Miret JA, Justesen AF, MacLeod A, Magnusson CS, Milonas P, Navas‐Cortes JA, Parnell S, Reignault PL, Stefani E, Thulke H, Van der Werf W, Civera AV, Yuen J, Zappalà L, Manda RR, Schulz OM, Kariampa P, Akrivou A, Antonatos S, Beris D, Debode J, Kritikos C, Kormpi M, Manceau C, Papachristos D, Reppa C, Gardi C, Potting R EFSA J 12-Mar-2024
PMCID:PMC10928767
doi:10.2903/j.efsa.2024.8657
PMID:38476319
In Vitro and In Silico of Cholinesterases Inhibition and In Vitro and In Vivo Anti-Melanoma Activity Investigations of Extracts Obtained from Selected Berberis Species Tuzimski T, Petruczynik A, Kaproń B, Plech T, Makuch-Kocka A, Janiszewska D, Sugajski M, Buszewski B, Szultka-Młyńska M Molecules 28-Feb-2024
PMCID:PMC10933966
doi:10.3390/molecules29051048
PMID:38474561
Clinically Effective Molecules of Natural Origin for Obesity Prevention or Treatment Hidalgo-Lozada GM, Villarruel-López A, Nuño K, García-García A, Sánchez-Nuño YA, Ramos-García CO Int J Mol Sci 25-Feb-2024
PMCID:PMC10931663
doi:10.3390/ijms25052671
PMID:38473918
Self-assembled, disordered structural color from fruit wax bloom Middleton R, Tunstad SA, Knapp A, Winters S, McCallum S, Whitney H Sci Adv 07-Feb-2024
PMCID:PMC10849586
doi:10.1126/sciadv.adk4219
PMID:38324684
Fungal Endophytes: Discovering What Lies within Some of Canada’s Oldest and Most Resilient Grapevines Ali S, Wright AH, Tanney JB, Renaud JB, Sumarah MW J Fungi (Basel) 26-Jan-2024
PMCID:PMC10890244
doi:10.3390/jof10020105
PMID:38392777
Exploring the Therapeutic Potential of Natural Products in Polycystic Ovarian Syndrome (PCOS): A Mini-Review of Lipid Profile, Blood Glucose, and Ovarian Histological Improvements Wahid S, Ramli MD, Fazleen NE, Naim RM, Mokhtar MH Life (Basel) 19-Jan-2024
PMCID:PMC10817691
doi:10.3390/life14010150
PMID:38276279
Commodity risk assessment of Corylus avellana plants from the UK Bragard C, Baptista P, Chatzivassiliou E, Di Serio F, Jaques Miret JA, Justesen AF, MacLeod A, Magnusson CS, Milonas P, Navas‐Cortes JA, Parnell S, Potting R, Reignault PL, Stefani E, Thulke H, Van der Werf W, Civera AV, Yuen J, Zappalà L, Battisti A, Mas H, Rigling D, Faccoli M, Mikulová A, Mosbach‐Schulz O, Stergulc F, Streissl F, Gonthier P EFSA J 12-Jan-2024
PMCID:PMC10784871
doi:10.2903/j.efsa.2024.8495
PMID:38222930
Essential Oil of Matricaria chamomilla Alleviate Psoriatic-Like Skin Inflammation by Inhibiting PI3K/Akt/mTOR and p38MAPK Signaling Pathway Chen G, Lv C, Nie Q, Li X, Lv Y, Liao G, Liu S, Ge W, Chen J, Du Y Clin Cosmet Investig Dermatol 08-Jan-2024
PMCID:PMC10785696
doi:10.2147/CCID.S445008
PMID:38222858
Temporal variation of allergenic potential in urban parks during the vegetation period: a case study from Bratislava, Slovakia Zahradníková E, Rendeková A, Ščevková J Environ Sci Pollut Res Int 05-Dec-2023
PMCID:PMC10791852
doi:10.1007/s11356-023-31137-9
PMID:38052730
Cytotoxic activity of isoquinoline alkaloids and herbal extracts from selected plants against human cancer cell lines: harnessing the research potential in cancer drug discovery with modern scientific trends and technology Bhandare SD, Malode SS Toxicol Res (Camb) 23-Nov-2023
PMCID:PMC10734601
doi:10.1093/toxres/tfad107
PMID:38145094
Discovery of Anti-Coronavirus Cinnamoyl Triterpenoids Isolated from Hippophae rhamnoides during a Screening of Halophytes from the North Sea and Channel Coasts in Northern France Al Ibrahim M, Akissi ZL, Desmarets L, Lefèvre G, Samaillie J, Raczkiewicz I, Sahpaz S, Dubuisson J, Belouzard S, Rivière C, Séron K Int J Mol Sci 22-Nov-2023
PMCID:PMC10705938
doi:10.3390/ijms242316617
PMID:38068938
Structure—yeast α-glucosidase inhibitory activity relationship of 9-O-berberrubine carboxylates Nguyen DV, Hengphasatporn K, Danova A, Suroengrit A, Boonyasuppayakorn S, Fujiki R, Shigeta Y, Rungrotmongkol T, Chavasiri W Sci Rep 01-Nov-2023
PMCID:PMC10620162
doi:10.1038/s41598-023-45116-0
PMID:37914757
Thinking About Berberine Pizzorno J Integr Med (Encinitas) 01-Nov-2023
PMCID:PMC10734964
PMID:38144162
Pest categorisation of Pochazia shantungensis Bragard C, Baptista P, Chatzivassiliou E, Di Serio F, Gonthier P, Jaques Miret JA, Justesen AF, Magnusson CS, Milonas P, Navas‐Cortes JA, Parnell S, Potting R, Reignault PL, Stefani E, Thulke H, Van der Werf W, Vicent Civera A, Yuen J, Zappalà L, Grégoire J, Malumphy C, Kertesz V, Maiorano A, MacLeod A EFSA J 31-Oct-2023
PMCID:PMC10617311
doi:10.2903/j.efsa.2023.8320
PMID:37915980

Phytochemical Profile Top

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Below are displayed the proven (via scientific papers) natural compounds!
You can also contribute to this by clicking here.
Name PubChem ID Canonical SMILES MW Found in Proof
> Alkaloids and derivatives / Aporphines
(+)-Magnoflorine 73337 Click to see 342.40 unknown https://doi.org/10.1055/S-2006-958107
https://doi.org/10.1016/S0944-7113(11)80024-3
(6aR)-2,10-dimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-1,11-diol 12304091 Click to see CN1CCC2=CC(=C(C3=C2C1CC4=C3C(=C(C=C4)OC)O)O)OC 327.40 unknown https://doi.org/10.1055/S-2006-958107
Corytuberine 160500 Click to see CN1CCC2=CC(=C(C3=C2C1CC4=C3C(=C(C=C4)OC)O)O)OC 327.40 unknown https://doi.org/10.1055/S-2006-958107
Corytuberine, pentahydrate 347379 Click to see 327.40 unknown https://doi.org/10.1055/S-2006-958107
> Alkaloids and derivatives / Phthalide isoquinolines
6,7-Dimethoxy-3-(6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-5-yl)-2-benzofuran-1(3H)-one 1309 Click to see CN1CCC2=CC3=C(C=C2C1C4C5=C(C(=C(C=C5)OC)OC)C(=O)O4)OCO3 383.40 unknown https://doi.org/10.2307/4117899
> Alkaloids and derivatives / Protoberberine alkaloids and derivatives
Berberine 2353 Click to see 336.40 unknown https://doi.org/10.1016/0031-9422(93)85312-F
https://doi.org/10.1016/S0944-7113(11)80024-3
https://doi.org/10.1002/PTR.2399
https://doi.org/10.1055/S-2006-958005
https://doi.org/10.1007/BF02873586
https://doi.org/10.1055/S-2002-23126
https://doi.org/10.1002/PTR.1256
https://doi.org/10.1055/S-2006-958107
Columbamine 72310 Click to see 338.40 unknown https://doi.org/10.1055/S-2006-958107
https://doi.org/10.1002/PTR.2399
https://doi.org/10.1016/S0944-7113(11)80024-3
Corypalmine 11186895 Click to see COC1=C(C2=C(CC3C4=CC(=C(C=C4CCN3C2)O)OC)C=C1)OC 341.40 unknown https://doi.org/10.1007/BF00565376
Palmatine 19009 Click to see 352.40 unknown https://doi.org/10.1016/0031-9422(93)85312-F
https://doi.org/10.1016/S0944-7113(11)80024-3
https://doi.org/10.1002/PTR.1256
> Benzenoids / Phenols / Tyrosols and derivatives
5-(2-Hydroxyethyl)-2-methoxyphenol 10034991 Click to see 168.19 unknown https://doi.org/10.1016/S0944-7113(97)80047-5
> Lignans, neolignans and related compounds
1-Isotetrandrine 5351212 Click to see CN1CCC2=CC(=C3C=C2C1CC4=CC=C(C=C4)OC5=C(C=CC(=C5)CC6C7=C(O3)C(=C(C=C7CCN6C)OC)OC)OC)OC 622.70 unknown https://doi.org/10.1016/0031-9422(93)85312-F
20,21,25-Trimethoxy-15,30-dimethyl-7,23-dioxa-15,30-diazaheptacyclo(22.6.2.23,6.18,12.114,18.027,31.022,33)hexatriaconta-3(36),4,6(35),8,10,12(34),18,20,22(33),24,26,31-dodecaen-9-ol 10170 Click to see 608.70 unknown https://doi.org/10.1002/PTR.2399
21,25-Dimethoxy-15,30-dimethyl-7,23-dioxa-15,30-diazaheptacyclo[22.6.2.23,6.18,12.114,18.027,31.022,33]hexatriaconta-3(36),4,6(35),8,10,12(34),18,20,22(33),24,26,31-dodecaene-9,20-diol 11758201 Click to see 594.70 unknown https://doi.org/10.1135/CCCC19870242
21,25-Dimethoxy-15,30-dimethyl-8,23-dioxa-15,30-diazaheptacyclo[22.6.2.29,12.13,7.114,18.027,31.022,33]hexatriaconta-3(36),4,6,9(35),10,12(34),18,20,22(33),24,26,31-dodecaene-6,20-diol 10031406 Click to see 594.70 unknown https://doi.org/10.1135/CCCC19870242
6,6'-Dimethoxy-2,2'-dimethyloxyacanthan-7,12'-diol 122728 Click to see CN1CCC2=CC(=C(C3=C2C1CC4=CC=C(C=C4)OC5=C(C=CC(=C5)CC6C7=CC(=C(C=C7CCN6C)OC)O3)O)O)OC 594.70 unknown https://doi.org/10.1055/S-2002-23126
Aquifoline 89688344 Click to see 594.70 unknown https://doi.org/10.1135/CCCC19870242
Aromoline 362574 Click to see CN1CCC2=CC(=C(C3=C2C1CC4=CC=C(C=C4)OC5=C(C=CC(=C5)CC6C7=CC(=C(C=C7CCN6C)OC)O3)O)O)OC 594.70 unknown https://doi.org/10.1055/S-2002-23126
Baluchistine 102247461 Click to see 594.70 unknown https://doi.org/10.1135/CCCC19870242
Berbamine 275182 Click to see CN1CCC2=CC(=C3C=C2C1CC4=CC=C(C=C4)OC5=C(C=CC(=C5)CC6C7=C(O3)C(=C(C=C7CCN6C)OC)OC)O)OC 608.70 unknown https://doi.org/10.1016/0306-3623(94)90165-1
https://doi.org/10.1055/S-2006-958005
https://doi.org/10.1002/PTR.2399
https://doi.org/10.1055/S-2002-23126
CID 12300053 12300053 Click to see 608.70 unknown https://doi.org/10.1055/S-2006-958005
https://doi.org/10.1016/0306-3623(94)90165-1
https://doi.org/10.1055/S-2002-23126
https://doi.org/10.1016/0031-9422(93)85312-F
Isotetrandrine, (+)- 457825 Click to see 622.70 unknown https://doi.org/10.1002/PTR.2399
Oxyacanthine 442333 Click to see 608.70 unknown https://doi.org/10.1016/S0944-7113(11)80024-3
https://doi.org/10.1002/ARDP.18952330208
https://doi.org/10.1016/0031-9422(93)85312-F
https://doi.org/10.1016/0306-3623(94)90165-1
https://doi.org/10.1055/S-2006-958005
Oxycanthine 371257 Click to see CN1CCC2=CC(=C(C3=C2C1CC4=CC=C(C=C4)OC5=C(C=CC(=C5)CC6C7=CC(=C(C=C7CCN6C)OC)O3)O)OC)OC 608.70 unknown https://doi.org/10.1002/ARDP.18952330208
> Lignans, neolignans and related compounds / Furanoid lignans
Syringaresinol, (+)- 443023 Click to see 418.40 unknown https://doi.org/10.1016/S0944-7113(97)80047-5
> Lipids and lipid-like molecules / Fatty Acyls / Fatty alcohols
1-Heptacosanol 74822 Click to see 396.70 unknown https://doi.org/10.1111/1365-3040.EP11611670
> Lipids and lipid-like molecules / Fatty Acyls / Fatty alcohols / Long-chain fatty alcohols
Nonacosan-11-ol 85689403 Click to see CCCCCCCCCCCCCCCCCCC(CCCCCCCCCC)O 424.80 unknown https://doi.org/10.1111/1365-3040.EP11611670
> Organic oxygen compounds / Organooxygen compounds / Carbohydrates and carbohydrate conjugates / Oligosaccharides
GlyTouCan:G94390VI 871 Click to see 504.40 unknown https://doi.org/10.1016/S0367-326X(01)00336-7
> Organoheterocyclic compounds / Isoquinolines and derivatives / Isoquinolones and derivatives
2,9,10-Trimethoxy-5,6-dihydroisoquinolino[2,1-b]isoquinolin-3-one 10065647 Click to see 337.40 unknown https://doi.org/10.1002/PTR.1256
https://doi.org/10.1055/S-2002-23126
https://doi.org/10.1016/0031-9422(93)85312-F
https://doi.org/10.1016/S0944-7113(11)80024-3
https://doi.org/10.1002/PTR.2399
https://doi.org/10.1055/S-2006-958107
Oxyberberine 11066 Click to see 351.40 unknown https://doi.org/10.1055/S-2006-958107
https://doi.org/10.1002/PTR.2399

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