Guazuma ulmifolia

Details Top

Internal ID UUID64401f3130f27914707636
Scientific name Guazuma ulmifolia
Authority Lam.
First published in Encycl. 3: 52 (1789)

Ethnobotanical Use Top

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Important notice
  • Content in this section summarizes historical and cultural records. It is not medical advice.
  • Do not use plants for self-treatment. Safety, efficacy, and appropriate use are not established here.
  • Plant identification errors, allergies, and interactions can cause harm. Consult qualified professionals for health questions.
  • Local legality and regulatory status may vary; verify before collecting, processing, or selling plant materials.

Unfortunately, there is no reliable, verifiable ethnobotanical record for infusions, decoctions, tinctures, macerations, or poultices of Guazuma ulmifolia that meets the rigorous sourcing requirements for this listing.

General Uses Top

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Common products:
Guazuma ulmifolia supplies timber, fiber for paper pulp and cordage, and a mucilaginous gum/resin (mutamba gum). The fruit is edible and used as flavoring for cachaça (Caipirinha) and similar sugarcane spirits.

Industrial and craft applications:
The tree provides pulp suitable for paper and card. Its bast fiber yields a strong cordage. Mutamba gum is used as an adhesive in bookbinding, pottery, and as a sizing agent for textiles. Tropical hardwood attributes include a density of about 0.65–0.70 g/cm³ at 12% moisture and a tangential shrinkage of about 6.7%, supporting general carpentry and tool handle uses.

Food and beverages (non-medicinal):
The ripe fruit is processed into pulp, syrups, and flavoring for sugarcane spirits, notably cachaça; commercial flavor blends list G. ulmifolia as a Brazilian fruit contributor.

Colorants and tanning:
A bark extract produces a light brown dye for textiles. Bark tannins (>10% in some samples) are used in low-strength tanning, historically alongside other species, with color resulting from condensed tannins.

Wood and fiber:
The wood is valued for construction, carpentry, furniture, and tool handles. Fiber is used for pulp (e.g., short-fiber pulps for writing/printing papers) and cordage.

Fragrance and cosmetics:
Fruity aroma components from the fruit are used in flavor/fragrance applications; gum functions as a natural binder and thickener in cosmetic formulations.

Properties relevant to use:
Tannins classed as condensed (proanthocyanidins) yield brown hues and moderate tanning power. The gum contains uronic acid–rich polysaccharides that confer high water-binding and adhesive activity. Wood density, shrinkage, and moderate Janka hardness (~4–5 kN) underpin its use as structural timber. Fruit pulp solids of ~10–15% support confectionery and beverage flavoring; acetyl and lignin values and holocellulose contents (about 82–85% in some fibers) indicate pulping suitability.

Standards and regulation:
Timber may follow trade classifications and moisture standards (e.g., ISO/ASTM moisture adjustment). National cosmetic ingredient listings govern gum use in formulations.

Sustainability and sourcing:
Often harvested from silvopastoral systems; mature tree harvest combined with short-rotation regrowth and off-take management is recommended to maintain supply and biodiversity.

References:
Lorenzi H. Árvores Brasileiras (1992); Cruz EP et al., Guia de Ilustração Botânica (2001); Lorenzi H & Harri L, Frutas Brasileiras e Exóticas Cultivadas (2006); CABI Compendium (2023); IPNI record; World Agroforestry (ICRAF) database entries for Guazuma ulmifolia.

Synonyms Top

Scientific name Authority First published in
Theobroma guazuma L. Sp. Pl. : 782 (1753)
Theobroma tomentosum (Kunth) M.Gómez Anales Soc. Esp. Hist. Nat. 19: 217 (1890)
Bubroma guasuma Willd. Sp. Pl., ed. 4 , 3: 1423 (1802)
Bubroma polybotryum (Cav.) Willd. Enum. Pl. : 806 (1809)
Bubroma tomentosum (Kunth) Spreng. Syst. Veg. 3: 332 (1826)
Bubroma ulmifolia (Lam.) Oken Allg. Naturgesch. 3(2): 1204 (1841)
Diuroglossum rufescens Turcz. Bull. Soc. Imp. Naturalistes Moscou 25(II): 157 (1852)
Guazuma blumei G.Don Gen. Hist. 1: 523 (1831)
Guazuma burbroma Tussac Fl. Antill. 4: 69 (1827)
Guazuma coriacea Rusby Bull. New York Bot. Gard. 4: 332 (1907)
Guazuma guazuma (L.) Cockerell Bull. Torrey Bot. Club 19(3): 95. 1892
Guazuma guazuma var. ulmifolia (Lam.) Kuntze Revis. Gen. Pl. 3(2): 24 (1898)
Guazuma parvifolia A.Rich. Hist. Phys. Cuba, Pl. Vasc. 190.
Guazuma polybotrya Cav. Icon. 3: 51 (1795)
Guazuma tomentosa Kunth Nov. Gen. Sp. 5: 32 (1821)
Guazuma tomentosa var. parvifolia Kitan. Fitologiya 11: 48 (1979)
Guazuma ulmifolia var. glabra K.Schum. Fl. Bras. 12(3): 81 (1886)
Guazuma ulmifolia var. tomentosa (Kunth) K.Schum. Fl. Bras. 12(3): 81 (1886)
Guazuma ulmifolia var. trianae K.Schum. Fl. Bras. 12(3): 82 (1886)
Guazuma ulmifolia var. velutina K.Schum. Fl. Bras. 12(3): 81 (1886)
Guazuma utilis Poepp. Nov. Gen. Sp. Pl. 3: 72 (1845)
Guazuma tomentosa var. cumanensis G.Don Gen. Hist. 1: 523 1831
Guazuma tomentosa var. monpoxensis G.Don Gen. Hist. 1: 523 1831
Guazuma guazuma var. tomentosa (Kunth) Kuntze Revis. Gen. Pl. 3(2): 24 (1898)
Bubroma guazuma (L.) Willd. Sp. Pl. 3(2): 1423 1802
Theobroma celtifolium Salisb. Prodr. Stirp. Chap. Allerton : 387 (1796)

Common names Top

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Language Common/alternative name
English bastardcedar
Spanish guácima
Spanish guácimo
Spanish guacimo
Spanish bubroma grandiflorum
Spanish bubroma invira
Spanish guacima
Spanish guasima
Spanish guásima
jv jati walanda
Malayalam കാട്ടുരുദ്രാക്ഷം
Chinese 毛可可
Chinese 瘤果麻

Subspecies (abbr. subsp./ssp.) Top

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Varieties (abbr. var.) Top

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Subvarieties (abbr. subvar.) Top

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Forms (abbr. f.) Top

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Germination/Propagation Top

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No germination or propagation data was added yet.

Distribution (via POWO/KEW) Top

Legend for the distribution data:
- Doubtful data
- Extinct
- Introduced
- Native
  • Asia-tropical
    • Indian Subcontinent
      • India
      • Pakistan
      • Sri Lanka
    • Indo-China
      • Vietnam
  • Northern America
    • Mexico
      • Mexico Central
      • Mexico Gulf
      • Mexico Northeast
      • Mexico Northwest
      • Mexico Southeast
      • Mexico Southwest
  • Southern America
    • Brazil
      • Brazil North
      • Brazil Northeast
      • Brazil South
      • Brazil Southeast
      • Brazil West-central
    • Caribbean
      • Cayman Islands
      • Cuba
      • Dominican Republic
      • Haiti
      • Jamaica
      • Leeward Islands
      • Puerto Rico
      • Southwest Caribbean
      • Trinidad-Tobago
      • Venezuelan Antilles
      • Windward Islands
    • Central America
      • Belize
      • Costa Rica
      • El Salvador
      • Guatemala
      • Honduras
      • Nicaragua
      • Panamá
    • Northern South America
      • French Guiana
      • Guyana
      • Suriname
      • Venezuela
    • Southern South America
      • Argentina Northeast
      • Paraguay
    • Western South America
      • Bolivia
      • Colombia
      • Ecuador
      • Galápagos
      • Peru

Links to other databases Top

Suggest others/fix!
Database ID/link to page
World Flora Online wfo-0000711645
UNII L4W707YWSL
USDA Plants GUUL
Tropicos 30400486
INPN 447624
KEW urn:lsid:ipni.org:names:823393-1
The Plant List kew-2834705
Missouri Botanical Garden 287260
Open Tree Of Life 526994
Observations.org 209557
NCBI Taxonomy 93772
IUCN Red List 61785778
IPNI 823393-1
iNaturalist 154538
GBIF 3152195
Freebase /m/0bwgq4t
EPPO GUZUL
EOL 584815
Elurikkus 365975
USDA GRIN 312760
Wikipedia Guazuma_ulmifolia

Genomes (via NCBI) Top

No reference genome is available on NCBI yet. We are constantly monitoring for new data.

Scientific Literature Top

Below are displayed the latest 15 articles published in PMC (PubMed Central®) and other sources (DOI number only)!
If you wish to see all the related articles click here.
Title Authors Publication Released IDs
Composite alginate-based hydrogel delivery of antioxidant pumpkin protein hydrolysate in simulated gastrointestinal condition Manjili ZN, Mahoonak AS, Ghorbani M, Tabarestani HS, Moghadam VE Curr Res Food Sci 23-Apr-2024
PMCID:PMC11067539
doi:10.1016/j.crfs.2024.100739
PMID:38708103
Changes in floristic and vegetation structure in a chronosequence of abandoned gold-mining lands in a tropical Amazon forest Garate-Quispe J, Canahuire-Robles R, Alarcón-Aguirre G, Dueñas-Linares H, Roman-Dañobeytia F Heliyon 21-Apr-2024
PMCID:PMC11064135
doi:10.1016/j.heliyon.2024.e29908
PMID:38699023
Access restrictions to forest resources, rather than COVID-19 bans, drive the selection of firewood species for bonfires during Festas Juninas in northeastern Brazil Araújo IV, Centeno-Alvarado D, Ramos MA J Ethnobiol Ethnomed 04-Apr-2024
PMCID:PMC10996119
doi:10.1186/s13002-024-00677-w
PMID:38575934
Immunomodulatory potential of Sarcophaga argyostoma larval hemolymph as a natural alternative to berenil in treating Trypanosoma evansi in vivo Sadek AS, Farghaly DS, Kadada H, Mashaal A Sci Rep 23-Mar-2024
PMCID:PMC10960805
doi:10.1038/s41598-024-57113-y
PMID:38521853
Effect of intraspecific seed trait variation on the germination of eight tropical dry forest species Villa-Rivera N, Castellanos-Barliza J, Mondragón-Botero A, Barranco-Pérez W Naturwissenschaften 22-Mar-2024
PMCID:PMC10959815
doi:10.1007/s00114-024-01898-5
PMID:38517488
Ubenimex combined with Albendazole for the treatment of Echinococcus multilocularis-induced alveolar echinococcosis in mice Zhou Z, Huayu M, Mu Y, Tang F, Ge RL Front Vet Sci 15-Mar-2024
PMCID:PMC10995866
doi:10.3389/fvets.2024.1320308
PMID:38585297
Latin American Plants against Microorganisms Cuevas-Cianca SI, Romero-Castillo C, Gálvez-Romero JL, Sánchez-Arreola E, Juárez ZN, Hernández LR Plants (Basel) 28-Nov-2023
PMCID:PMC10708099
doi:10.3390/plants12233997
PMID:38068631
Guadua angustifolia Kunth leaves as a source for bioactive phenolic compounds: Optimization of ultrasound-assisted extraction using response surface methodology and antioxidant activities Lozano-Puentes HS, Sánchez-Matiz JJ, Ruiz-Sanchez E, Costa GM, Díaz-Ariza LA Heliyon 21-Nov-2023
PMCID:PMC10709060
doi:10.1016/j.heliyon.2023.e22445
PMID:38076038
Pest categorisation of Diaprepes abbreviatus Bragard C, Baptista P, Chatzivassiliou E, Di Serio F, Gonthier P, Jaques Miret JA, Justesen AF, Magnusson CS, Milonas P, Navas‐Cortes JA, Parnell S, Potting R, Reignault PL, Stefani E, Thulke H, Van der Werf W, Vicent Civera A, Yuen J, Zappalà L, Grégoire J, Malumphy C, Kertesz V, Maiorano A, MacLeod A EFSA J 15-Nov-2023
PMCID:PMC10648563
doi:10.2903/j.efsa.2023.8318
PMID:38027434
Protection against insect predation during fruit development: the role of fleshy fruit wings of three species of Zygophyllum in the cold desert of Central Asia Xie K, Qiu J, Mamut J, Li Y, Tan D Front Plant Sci 14-Nov-2023
PMCID:PMC10682714
doi:10.3389/fpls.2023.1267714
PMID:38034578
How the Adequate Choice of Plant Species Favors the Restoration Process in Areas Susceptible to Extreme Frost Events Viveiros E, Francisco BS, Dutra FB, de Souza LA, Inocente MC, Bastos AC, da Costa GF, Barbosa MC, Martins RP, Passaretti RA, Fernandes MJ, de Oliveira JS, Shiguehara AP, Manzoli EC, Teração BS, Piotrowski I, Piña-Rodrigues FC, da Silva JM Biology (Basel) 26-Oct-2023
PMCID:PMC10669021
doi:10.3390/biology12111369
PMID:37997968
New Therapeutic Strategies for Obesity and Its Metabolic Sequelae: Brazilian Cerrado as a Unique Biome Monteiro-Alfredo T, Macedo ML, de Picoli Souza K, Matafome P Int J Mol Sci 25-Oct-2023
PMCID:PMC10648839
doi:10.3390/ijms242115588
PMID:37958572
Patterns of use of wild food plants by Brazilian local communities: systematic review and meta-analysis Gomes LC, Medeiros PM, Prata AP J Ethnobiol Ethnomed 25-Oct-2023
PMCID:PMC10601232
doi:10.1186/s13002-023-00619-y
PMID:37880767
Hepatoprotective Effects of Four Brazilian Savanna Species on Acetaminophen-Induced Hepatotoxicity in HepG2 Cells Ribeiro GD, Martins DH, Gomes JV, Davies NW, Fagg CW, Simeoni LA, Homem-de-Mello M, Magalhães PO, Silveira D, Fonseca-Bazzo YM Plants (Basel) 26-Sep-2023
PMCID:PMC10574628
doi:10.3390/plants12193393
PMID:37836133
Harnessing Natural Antioxidants for Enhancing Food Shelf Life: Exploring Sources and Applications in the Food Industry Petcu CD, Tăpăloagă D, Mihai OD, Gheorghe-Irimia RA, Negoiță C, Georgescu IM, Tăpăloagă PR, Borda C, Ghimpețeanu OM Foods 23-Aug-2023
PMCID:PMC10486681
doi:10.3390/foods12173176
PMID:37685108

Phytochemical Profile Top

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Below are displayed the proven (via scientific papers) natural compounds!
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Name PubChem ID Canonical SMILES MW Found in Proof
> Lipids and lipid-like molecules / Fatty Acyls / Fatty acids and conjugates / Very long-chain fatty acids
Lignoceric Acid 11197 Click to see CCCCCCCCCCCCCCCCCCCCCCCC(=O)O 368.60 unknown https://doi.org/10.1007/S10600-010-9722-2
> Lipids and lipid-like molecules / Prenol lipids / Triterpenoids
(4R,4aR,6aS,6aS,6bS,8aS,12aR,14aR,14bR)-4,4a,6a,6b,8a,11,11,14a-octamethyl-2,4,5,6,6a,7,8,9,10,12,12a,13,14,14b-tetradecahydro-1H-picen-3-one 162968765 Click to see CC1C(=O)CCC2C1(CCC3C2(CCC4(C3(CCC5(C4CC(CC5)(C)C)C)C)C)C)C 426.70 unknown https://doi.org/10.1055/S-0028-1097596
10-Acetyloxy-2,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid 619165 Click to see 498.70 unknown https://doi.org/10.1007/S10600-010-9722-2
3-Hydroxyolean-12-en-28-oic acid 619166 Click to see 456.70 unknown https://doi.org/10.1007/S10600-010-9722-2
3-O-Acetyloleanolic Acid 151202 Click to see 498.70 unknown https://doi.org/10.1007/S10600-010-9722-2
4,4a,6a,6b,8a,11,11,14a-octamethyl-5,6,6a,7,8,9,10,12,12a,13,14,14b-dodecahydro-4H-picen-3-one 23222909 Click to see 424.70 unknown https://doi.org/10.1007/S10600-010-9722-2
beta-Sitosteryl stearate 13828710 Click to see 681.20 unknown https://doi.org/10.1007/S10600-010-9722-2
Betulin 72326 Click to see CC(=C)C1CCC2(C1C3CCC4C5(CCC(C(C5CCC4(C3(CC2)C)C)(C)C)O)C)CO 442.70 unknown https://doi.org/10.1055/S-0028-1097596
Fridel-1-en-3-one 11384730 Click to see CC1C(=O)C=CC2C1(CCC3C2(CCC4(C3(CCC5(C4CC(CC5)(C)C)C)C)C)C)C 424.70 unknown https://doi.org/10.1007/S10600-010-9722-2
Friedelan-3-one 244297 Click to see 426.70 unknown https://doi.org/10.1055/S-0028-1097596
https://doi.org/10.1007/S10600-010-9722-2
Friedelin 91472 Click to see 426.70 unknown https://doi.org/10.1007/S10600-010-9722-2
Lup-20(29)-ene-3beta,28-diol 221023 Click to see 442.70 unknown https://doi.org/10.1055/S-0028-1097596
Methyl oleanolate acetate 10255859 Click to see 512.80 unknown https://doi.org/10.1007/S10600-010-9722-2
Olean-12-en-28-oic acid, 3beta-hydroxy-, methyl ester, acetate 609115 Click to see CC(=O)OC1CCC2(C(C1(C)C)CCC3(C2CC=C4C3(CCC5(C4CC(CC5)(C)C)C(=O)OC)C)C)C 512.80 unknown https://doi.org/10.1007/S10600-010-9722-2
Oleanolic Acid 10494 Click to see 456.70 unknown https://doi.org/10.1007/S10600-010-9722-2
> Lipids and lipid-like molecules / Steroids and steroid derivatives / Stigmastanes and derivatives
(-)-beta-Sitosterol 222284 Click to see 414.70 unknown https://doi.org/10.1007/S10600-010-9722-2
https://doi.org/10.1055/S-0028-1097596
(3S,8R,9S,10R,13R,14R,17S)-17-[(2R,5R)-5-ethyl-6-methylheptan-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol 162965368 Click to see CCC(CCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)O)C)C)C(C)C 414.70 unknown https://doi.org/10.1055/S-0028-1097596
17-(5-ethyl-6-methylheptan-2-yl)-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol 86821 Click to see CCC(CCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)O)C)C)C(C)C 414.70 unknown https://doi.org/10.1055/S-0028-1097596
https://doi.org/10.1007/S10600-010-9722-2
> Organoheterocyclic compounds / Benzopyrans / 1-benzopyrans / Xanthones / 4-prenylated xanthones
Gerontoxanthone C 14259059 Click to see 396.40 unknown https://doi.org/10.1007/S10600-010-9722-2
> Phenylpropanoids and polyketides / Coumarins and derivatives
Dracunculin 5319474 Click to see COC1=C2C(=C3C(=C1)C=CC(=O)O3)OCO2 220.18 unknown https://doi.org/10.1007/S10600-010-9722-2
> Phenylpropanoids and polyketides / Coumarins and derivatives / Hydroxycoumarins / 4-hydroxycoumarins
3,3'-Methylenebis(4,6-dihydroxycoumarin) 129881889 Click to see C1=CC2=C(C=C1O)C(=C(C(=O)O2)CC3=C(C4=C(C=CC(=C4)O)OC3=O)O)O 368.30 unknown https://doi.org/10.1007/S10600-010-9722-2
> Phenylpropanoids and polyketides / Flavonoids / Biflavonoids and polyflavonoids
2-(3,4-dihydroxyphenyl)-4-[2-(3,4-dihydroxyphenyl)-4-[2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-3,4-dihydro-2H-chromen-8-yl]-3,5,7-trihydroxy-3,4-dihydro-2H-chromen-8-yl]-8-[2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-3,4-dihydro-2H-chromen-4-yl]-3,4-dihydro-2H-chromene-3,5,7-triol 16163749 Click to see 1155.00 unknown https://doi.org/10.1016/0031-9422(95)00855-1
2-(3,4-dihydroxyphenyl)-6-[2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-3,4-dihydro-2H-chromen-4-yl]-4-[2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-3,4-dihydro-2H-chromen-8-yl]-3,4-dihydro-2H-chromene-3,5,7-triol 14309768 Click to see 866.80 unknown https://doi.org/10.1016/0031-9422(95)00855-1
2-(3,4-dihydroxyphenyl)-8-[2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-3,4-dihydro-2H-chromen-4-yl]-4-[2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-3,4-dihydro-2H-chromen-6-yl]-3,4-dihydro-2H-chromene-3,5,7-triol 14237654 Click to see C1C(C(OC2=C1C(=C(C(=C2)O)C3C(C(OC4=C(C(=CC(=C34)O)O)C5C(C(OC6=CC(=CC(=C56)O)O)C7=CC(=C(C=C7)O)O)O)C8=CC(=C(C=C8)O)O)O)O)C9=CC(=C(C=C9)O)O)O 866.80 unknown https://doi.org/10.1016/0031-9422(95)00855-1
Cinnamtannin A2 16130899 Click to see 1155.00 unknown https://doi.org/10.1016/0031-9422(95)00855-1
ent-Epicatechin-(4alpha->6)-ent-epicatechin 13990892 Click to see 578.50 unknown https://doi.org/10.1016/0031-9422(95)00855-1
Epicatechin-(4beta->6)-epicatechin-(4beta->8)-epicatechin 10865804 Click to see 866.80 unknown https://doi.org/10.1016/0031-9422(95)00855-1
Epicatechin-(4beta-8)-epicatechin-(4beta-6)-epicatechin 14237653 Click to see C1C(C(OC2=C1C(=C(C(=C2)O)C3C(C(OC4=C(C(=CC(=C34)O)O)C5C(C(OC6=CC(=CC(=C56)O)O)C7=CC(=C(C=C7)O)O)O)C8=CC(=C(C=C8)O)O)O)O)C9=CC(=C(C=C9)O)O)O 866.80 unknown https://doi.org/10.1016/0031-9422(95)00855-1
Proanthocyanidin B2 5320711 Click to see 578.50 unknown https://doi.org/10.1016/0031-9422(95)00855-1
Procyanidin B 130556 Click to see 578.50 unknown https://doi.org/10.1016/0031-9422(95)00855-1
Procyanidin B2, (+)- 122738 Click to see C1C(C(OC2=C1C(=CC(=C2C3C(C(OC4=CC(=CC(=C34)O)O)C5=CC(=C(C=C5)O)O)O)O)O)C6=CC(=C(C=C6)O)O)O 578.50 unknown https://doi.org/10.1016/0031-9422(95)00855-1
Procyanidin B5 124017 Click to see C1C(C(OC2=C1C(=C(C(=C2)O)C3C(C(OC4=CC(=CC(=C34)O)O)C5=CC(=C(C=C5)O)O)O)O)C6=CC(=C(C=C6)O)O)O 578.50 unknown https://doi.org/10.1016/0031-9422(95)00855-1
Procyanidin C1 169853 Click to see 866.80 unknown https://doi.org/10.1016/0031-9422(95)00855-1
Procyanidin trimer T2 13751990 Click to see 866.80 unknown https://doi.org/10.1016/0031-9422(95)00855-1
> Phenylpropanoids and polyketides / Flavonoids / Flavans / Catechins
2-(3,4-dihydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-3,5,7-triol 1203 Click to see 290.27 unknown https://doi.org/10.1016/0031-9422(95)00855-1
Epicatechin 72276 Click to see 290.27 unknown https://doi.org/10.1016/0031-9422(95)00855-1

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