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Internal ID UUID643fe2a4b4a33464695458
Scientific name Marrubium cylleneum
Authority Boiss. & Heldr.
First published in Diagn. Pl. Orient. , ser. 2, 4: 51 (1859)

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Synonyms Top

Scientific name Authority First published in
Marrubium velutinum subsp. cylleneum (Boiss. & Heldr.) Nyman Consp. Fl. Eur. 582. 1881 (1881)
Marrubium candidissimum subsp. cylleneum (Boiss. & Heldr.) Nyman Consp. Fl. Eur. Suppl. 2: 253. 1890 (1890)

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Distribution (via POWO/KEW) Top

Legend for the distribution data:
- Doubtful data
- Extinct
- Introduced
- Native

Links to other databases Top

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Database ID/link to page
World Flora Online wfo-0000236585
Tropicos 100220098
KEW urn:lsid:ipni.org:names:449874-1
The Plant List kew-120838
Open Tree Of Life 6081181
Observations.org 119721
NCBI Taxonomy 2291699
IPNI 449874-1
iNaturalist 410580
GBIF 3881846
EPPO MAQCY
Elurikkus 432732
CMAUP NPO23987

Genomes (via NCBI) Top

No reference genome is available on NCBI yet. We are constantly monitoring for new data.

Scientific Literature Top

Below are displayed the latest 15 articles published in PMC (PubMed Central®) and other sources (DOI number only)!
If you wish to see all the related articles click here.
Title Authors Publication Released IDs
Paving the way towards effective plant-based inhibitors of hyaluronidase and tyrosinase: a critical review on a structure–activity relationship Gębalski J, Graczyk F, Załuski D J Enzyme Inhib Med Chem 26-Apr-2022
PMCID:PMC9045780
doi:10.1080/14756366.2022.2061966
PMID:35470749
Contribution to the Orophilous Cushion-Like Vegetation of Central-Southern and Insular Greece Musarella CM, Brullo S, del Galdo GG Plants (Basel) 30-Nov-2020
PMCID:PMC7760968
doi:10.3390/plants9121678
PMID:33266088
Cytotoxic activity of methanolic fractions of different Marrubium spp. against melanoma cells is independent of antioxidant activity and total phenolic content Kozyra M, Korga A, Ostrowska M, Humeniuk E, Adamczuk G, Gieroba R, Makuch‐Kocka A, Dudka J FEBS Open Bio 02-Dec-2019
PMCID:PMC6943230
doi:10.1002/2211-5463.12755
PMID:31691511
A comprehensive review on tyrosinase inhibitors Zolghadri S, Bahrami A, Hassan Khan MT, Munoz-Munoz J, Garcia-Molina F, Garcia-Canovas F, Saboury AA J Enzyme Inhib Med Chem 03-Jan-2019
PMCID:PMC6327992
doi:10.1080/14756366.2018.1545767
PMID:30734608
Identification of Three Dalbergia Species Based on Differences in Extractive Components Yin X, Huang A, Zhang S, Liu R, Ma F Molecules 28-Aug-2018
PMCID:PMC6225358
doi:10.3390/molecules23092163
PMID:30154322
Inhibitory Effects of Physalis alkekengi L., Alcea rosea L., Bunium persicum B. Fedtsch. and Marrubium vulgare L. on Mushroom Tyrosinase Namjoyan F, Jahangiri A, Azemi ME, Arkian E, Mousavi H Jundishapur J Nat Pharm Prod 20-Feb-2015
PMCID:PMC4386320
doi:10.17795/jjnpp-23356
PMID:25866725
Bis-spirolabdane Diterpenoids from Leonotis nepetaefolia Li J, Fronczek FR, Ferreira D, Burandt CL Jr, Setola V, Roth BL, Zjawiony JK J Nat Prod 04-Apr-2012
PMCID:PMC3338874
doi:10.1021/np3000156
PMID:22475308
The Hunt for Natural Skin Whitening Agents Smit N, Vicanova J, Pavel S Int J Mol Sci 10-Dec-2009
PMCID:PMC2801997
doi:10.3390/ijms10125326
PMID:20054473
Cytotoxicity and immunomodulating characteristics of labdane diterpenes from Marrubium cylleneum and Marrubium velutinum. Karioti A, Skopeliti M, Tsitsilonis O, Heilmann J, Skaltsa H Phytochemistry 01-Jun-2007
doi:10.1016/J.PHYTOCHEM.2007.03.027
PMID:17475293
Identification of tyrosinase inhibitors from Marrubium velutinum and Marrubium cylleneum. Karioti A, Protopappa A, Megoulas N, Skaltsa H Bioorg Med Chem 01-Apr-2007
doi:10.1016/J.BMC.2007.01.035
PMID:17287127
Labdane diterpenes from Marrubium velutinum and Marrubium cylleneum. Karioti A, Heilmann J, Skaltsa H Phytochemistry 01-May-2005
doi:10.1016/J.PHYTOCHEM.2005.02.029
PMID:15896376
Effects of the Flavonoid Pilloin Isolated from Marrubium cylleneum on Mitogen-Induced Lymphocyte Transformation Fotios Michelis, Ekaterini Tiligada, Helen Skaltsa, Diamanto Lazari, Alexios-Leandros Skaltsounis, Andreas Delitheos Informa UK Limited 04-Mar-2003
doi:10.1076/PHBI.40.4.245.8472

Phytochemical Profile Top

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Below are displayed the proven (via scientific papers) natural compounds!
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Name PubChem ID Canonical SMILES MW Found in Proof
> Lipids and lipid-like molecules / Prenol lipids / Monoterpenoids / Menthane monoterpenoids
(6S)-6-hydroxy-3-methyl-6-propan-2-ylcyclohex-2-en-1-one 101674118 Click to see CC1=CC(=O)C(CC1)(C(C)C)O 168.23 unknown via CMAUP database
[(1S,4S)-1-methyl-3-oxo-4-propan-2-ylcyclohexyl] acetate 101644387 Click to see CC(C)C1CCC(CC1=O)(C)OC(=O)C 212.28 unknown via CMAUP database
2-[(4R)-4-methylcyclohexen-1-yl]propan-2-ol 11367124 Click to see CC1CCC(=CC1)C(C)(C)O 154.25 unknown via CMAUP database
2-Cyclohexen-1-one, 2-(1-hydroxy-1-methylethyl)-5-methyl-, (5R)- 11062797 Click to see CC1CC=C(C(=O)C1)C(C)(C)O 168.23 unknown via CMAUP database
cis-Pulegol 10080594 Click to see CC1CCC(=C(C)C)C(C1)O 154.25 unknown via CMAUP database
> Organic acids and derivatives / Carboxylic acids and derivatives / Amino acids, peptides, and analogues / Alpha amino acids and derivatives / Proline and derivatives
D-proline betaine 7016562 Click to see C[N+]1(CCCC1C(=O)[O-])C 143.18 unknown via CMAUP database
> Organic oxygen compounds / Organooxygen compounds / Carbohydrates and carbohydrate conjugates / Oligosaccharides
6'-Glucosyl-martynoside 44429858 Click to see CC1C(C(C(C(O1)OC2C(C(OC(C2OC(=O)C=CC3=CC(=C(C=C3)O)OC)COC4C(C(C(C(O4)CO)O)O)O)OCCC5=CC(=C(C=C5)OC)O)O)O)O)O 814.80 unknown https://doi.org/10.1016/J.BMC.2007.01.035
> Organoheterocyclic compounds / Lactones / Gamma butyrolactones
(1S,4R,8R,9S,10S,12S)-4,8,10-trimethylspiro[2-oxatricyclo[6.3.1.04,12]dodecane-9,5'-oxolane]-2',3-dione 162896480 Click to see CC1CC2C3C(CCCC3(C14CCC(=O)O4)C)(C(=O)O2)C 292.40 unknown https://doi.org/10.1016/J.PHYTOCHEM.2007.03.027
13-epicyllenin A 44254085 Click to see CC1CC2C3C(CCCC3(C14CCC5(O4)CC(OC5)O)C)(C(=O)O2)C 350.40 unknown https://doi.org/10.1016/J.PHYTOCHEM.2005.02.029
13,15-diepicyllenin A 46883140 Click to see CC1CC2C3C(CCCC3(C14CCC5(O4)CC(OC5)O)C)(C(=O)O2)C 350.40 unknown https://doi.org/10.1016/J.PHYTOCHEM.2005.02.029
4,8,10-Trimethylspiro[2-oxatricyclo[6.3.1.04,12]dodecane-9,5'-oxolane]-2',3-dione 73318049 Click to see CC1CC2C3C(CCCC3(C14CCC(=O)O4)C)(C(=O)O2)C 292.40 unknown https://doi.org/10.1016/J.PHYTOCHEM.2007.03.027
CID 163014799 163014799 Click to see CC1CC2C3C(CCCC3(C14CCC5(O4)CC(OC5)OC)C)(C(=O)O2)C 364.50 unknown https://doi.org/10.1016/J.PHYTOCHEM.2007.03.027
CID 163014800 163014800 Click to see CC1CC2C3C(CCCC3(C14CCC5(O4)CC(OC5)OC)C)(C(=O)O2)C 364.50 unknown https://doi.org/10.1016/J.PHYTOCHEM.2007.03.027
CID 72983502 72983502 Click to see CC1CC2C3C(CCCC3(C14CCC5(O4)CC(OC5)OC)C)(C(=O)O2)C 364.50 unknown https://doi.org/10.1016/J.PHYTOCHEM.2007.03.027
CID 74156862 74156862 Click to see CC1CC2C3C(CCCC3(C14CCC5(O4)CC(OC5)O)C)(C(=O)O2)C 350.40 unknown https://doi.org/10.1016/J.PHYTOCHEM.2005.02.029
Marrubiin 73401 Click to see CC1CC2C3C(CCCC3(C1(CCC4=COC=C4)O)C)(C(=O)O2)C 332.40 unknown https://doi.org/10.1016/J.PHYTOCHEM.2005.02.029
Marrubin 235392 Click to see CC1CC2C3C(CCCC3(C1(CCC4=COC=C4)O)C)(C(=O)O2)C 332.40 unknown https://doi.org/10.1016/J.PHYTOCHEM.2005.02.029
> Organoheterocyclic compounds / Pyrans / Pyranones and derivatives
Kojic acid 3840 Click to see C1=C(OC=C(C1=O)O)CO 142.11 unknown https://doi.org/10.1016/J.BMC.2007.01.035
> Phenylpropanoids and polyketides / Cinnamic acids and derivatives / Hydroxycinnamic acids and derivatives / Hydroxycinnamic acids
3-(3-Hydroxy-4-methoxy-phenyl)-acrylic acid 92126 Click to see COC1=C(C=C(C=C1)C=CC(=O)O)O 194.18 unknown https://doi.org/10.1016/J.BMC.2007.01.035
3-(4-Hydroxy-3-methoxyphenyl)prop-2-enoic acid 709 Click to see COC1=C(C=CC(=C1)C=CC(=O)O)O 194.18 unknown https://doi.org/10.1016/J.BMC.2007.01.035
4-Hydroxycinnamic acid 322 Click to see C1=CC(=CC=C1C=CC(=O)O)O 164.16 unknown https://doi.org/10.1016/J.BMC.2007.01.035
Ferulic acid 445858 Click to see COC1=C(C=CC(=C1)C=CC(=O)O)O 194.18 unknown via CMAUP database
Isoferulic acid 736186 Click to see COC1=C(C=C(C=C1)C=CC(=O)O)O 194.18 unknown via CMAUP database
p-Coumaric acid 637542 Click to see C1=CC(=CC=C1C=CC(=O)O)O 164.16 unknown https://doi.org/10.1016/J.BMC.2007.01.035
> Phenylpropanoids and polyketides / Flavonoids / Flavones
5,6,7,8,4'-Pentahydroxyflavone 96506 Click to see C1=CC(=CC=C1C2=CC(=O)C3=C(C(=C(C(=C3O2)O)O)O)O)O 302.23 unknown https://doi.org/10.1016/J.BMC.2007.01.035
Apigenin 5280443 Click to see C1=CC(=CC=C1C2=CC(=O)C3=C(C=C(C=C3O2)O)O)O 270.24 unknown https://doi.org/10.1076/PHBI.40.4.245.8472
> Phenylpropanoids and polyketides / Flavonoids / Flavones / Flavonols
Quercetin 5280343 Click to see C1=CC(=C(C=C1C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)O)O)O 302.23 unknown https://doi.org/10.1016/J.BMC.2007.01.035
> Phenylpropanoids and polyketides / Flavonoids / Flavonoid glycosides / Flavonoid 3-O-p-coumaroyl glycosides
[6-[2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-4-oxochromen-3-yl]oxy-3,4,5-trihydroxyoxan-2-yl]methyl 3-(4-hydroxyphenyl)prop-2-enoate 72992711 Click to see C1=CC(=CC=C1C=CC(=O)OCC2C(C(C(C(O2)OC3=C(OC4=CC(=CC(=C4C3=O)O)O)C5=CC(=C(C=C5)O)O)O)O)O)O 610.50 unknown https://doi.org/10.1016/J.BMC.2007.01.035
[6-[5,7-Dihydroxy-2-(4-hydroxyphenyl)-4-oxochromen-3-yl]oxy-3,4,5-trihydroxyoxan-2-yl]methyl 3-(4-hydroxyphenyl)prop-2-enoate 57369598 Click to see C1=CC(=CC=C1C=CC(=O)OCC2C(C(C(C(O2)OC3=C(OC4=CC(=CC(=C4C3=O)O)O)C5=CC=C(C=C5)O)O)O)O)O 594.50 unknown https://doi.org/10.1016/J.BMC.2007.01.035
Helichrysoside 5317991 Click to see C1=CC(=CC=C1C=CC(=O)OCC2C(C(C(C(O2)OC3=C(OC4=CC(=CC(=C4C3=O)O)O)C5=CC(=C(C=C5)O)O)O)O)O)O 610.50 unknown https://doi.org/10.1016/J.BMC.2007.01.035
Tiliroside 5320686 Click to see C1=CC(=CC=C1C=CC(=O)OCC2C(C(C(C(O2)OC3=C(OC4=CC(=CC(=C4C3=O)O)O)C5=CC=C(C=C5)O)O)O)O)O 594.50 unknown via CMAUP database
> Phenylpropanoids and polyketides / Flavonoids / Flavonoid glycosides / Flavonoid O-glycosides
Luteolin 5-glucoside 5317471 Click to see C1=CC(=C(C=C1C2=CC(=O)C3=C(O2)C=C(C=C3OC4C(C(C(C(O4)CO)O)O)O)O)O)O 448.40 unknown https://doi.org/10.1016/J.BMC.2007.01.035
> Phenylpropanoids and polyketides / Flavonoids / Flavonoid glycosides / Flavonoid O-glycosides / Flavonoid-3-O-glycosides
5,7-Dihydroxy-2-(4-hydroxyphenyl)-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-4-one 5462193 Click to see C1=CC(=CC=C1C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)OC4C(C(C(C(O4)CO)O)O)O)O 448.40 unknown https://doi.org/10.1016/J.BMC.2007.01.035
Astragalin 5282102 Click to see C1=CC(=CC=C1C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)OC4C(C(C(C(O4)CO)O)O)O)O 448.40 unknown https://doi.org/10.1016/J.BMC.2007.01.035
Rutin 5280805 Click to see CC1C(C(C(C(O1)OCC2C(C(C(C(O2)OC3=C(OC4=CC(=CC(=C4C3=O)O)O)C5=CC(=C(C=C5)O)O)O)O)O)O)O)O 610.50 unknown https://doi.org/10.1016/J.BMC.2007.01.035
> Phenylpropanoids and polyketides / Flavonoids / Flavonoid glycosides / Flavonoid O-glycosides / Flavonoid-7-O-glycosides
[3,5-Dihydroxy-2-[5-hydroxy-2-(4-hydroxyphenyl)-4-oxochromen-7-yl]oxy-6-(hydroxymethyl)oxan-4-yl] 3-(4-hydroxyphenyl)prop-2-enoate 74977535 Click to see C1=CC(=CC=C1C=CC(=O)OC2C(C(OC(C2O)OC3=CC(=C4C(=C3)OC(=CC4=O)C5=CC=C(C=C5)O)O)CO)O)O 578.50 unknown https://doi.org/10.1016/J.BMC.2007.01.035
2-(3,4-dihydroxyphenyl)-5-hydroxy-7-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-4-one 13093776 Click to see C1=CC(=C(C=C1C2=CC(=O)C3=C(C=C(C=C3O2)OC4C(C(C(C(O4)CO)O)O)O)O)O)O 448.40 unknown https://doi.org/10.1016/J.BMC.2007.01.035
3''-O-(4-Hydroxycinnamoyl)cosmosiin 44429738 Click to see C1=CC(=CC=C1C=CC(=O)OC2C(C(OC(C2O)OC3=CC(=C4C(=C3)OC(=CC4=O)C5=CC=C(C=C5)O)O)CO)O)O 578.50 unknown https://doi.org/10.1016/J.BMC.2007.01.035
Luteolin 7-galactoside 5291488 Click to see C1=CC(=C(C=C1C2=CC(=O)C3=C(C=C(C=C3O2)OC4C(C(C(C(O4)CO)O)O)O)O)O)O 448.40 unknown https://doi.org/10.1016/J.BMC.2007.01.035
Luteolin 7-O-glucoside 5280637 Click to see C1=CC(=C(C=C1C2=CC(=O)C3=C(C=C(C=C3O2)OC4C(C(C(C(O4)CO)O)O)O)O)O)O 448.40 unknown https://doi.org/10.1016/J.BMC.2007.01.035
Thermopsoside 11294177 Click to see COC1=C(C=CC(=C1)C2=CC(=O)C3=C(C=C(C=C3O2)OC4C(C(C(C(O4)CO)O)O)O)O)O 462.40 unknown https://doi.org/10.1076/PHBI.40.4.245.8472
> Phenylpropanoids and polyketides / Flavonoids / O-methylated flavonoids / 6-O-methylated flavonoids
Pectolinarigenin 5320438 Click to see COC1=CC=C(C=C1)C2=CC(=O)C3=C(O2)C=C(C(=C3O)OC)O 314.29 unknown https://doi.org/10.1076/PHBI.40.4.245.8472
> Phenylpropanoids and polyketides / Flavonoids / O-methylated flavonoids / 7-O-methylated flavonoids
Pilloin 5320496 Click to see COC1=C(C=C(C=C1)C2=CC(=O)C3=C(C=C(C=C3O2)OC)O)O 314.29 unknown https://doi.org/10.1076/PHBI.40.4.245.8472
Salvigenin 161271 Click to see COC1=CC=C(C=C1)C2=CC(=O)C3=C(C(=C(C=C3O2)OC)OC)O 328.30 unknown https://doi.org/10.1076/PHBI.40.4.245.8472

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