Oxyresveratrol
| Internal ID | f483d2fa-ace3-45e5-bb33-c822c249a333 |
| Taxonomy | Phenylpropanoids and polyketides > Stilbenes |
| IUPAC Name | 4-[(E)-2-(3,5-dihydroxyphenyl)ethenyl]benzene-1,3-diol |
| SMILES (Canonical) | C1=CC(=C(C=C1O)O)C=CC2=CC(=CC(=C2)O)O |
| SMILES (Isomeric) | C1=CC(=C(C=C1O)O)/C=C/C2=CC(=CC(=C2)O)O |
| InChI | InChI=1S/C14H12O4/c15-11-4-3-10(14(18)8-11)2-1-9-5-12(16)7-13(17)6-9/h1-8,15-18H/b2-1+ |
| InChI Key | PDHAOJSHSJQANO-OWOJBTEDSA-N |
| Popularity | 176 references in papers |
| Molecular Formula | C14H12O4 |
| Molecular Weight | 244.24 g/mol |
| Exact Mass | 244.07355886 g/mol |
| Topological Polar Surface Area (TPSA) | 80.90 Ų |
| XlogP | 2.80 |
| Atomic LogP (AlogP) | 2.68 |
| H-Bond Acceptor | 4 |
| H-Bond Donor | 4 |
| Rotatable Bonds | 2 |
| 29700-22-9 |
| Hydroxyresveratrol |
| Tetrahydroxystilbene |
| trans-oxyresveratrol |
| (E)-4-(3,5-Dihydroxystyryl)benzene-1,3-diol |
| 4-[(E)-2-(3,5-dihydroxyphenyl)ethenyl]benzene-1,3-diol |
| 4721-07-7 |
| 4-[2-(3,5-dihydroxyphenyl)ethenyl]benzene-1,3-diol |
| OXYLRESVERATROL |
| 2,3',4,5'-Tetrahydroxystilbene |
| There are more than 10 synonyms. If you wish to see them all click here. |
| Target | Value | Probability (raw) | Probability (%) |
|---|---|---|---|
| Human Intestinal Absorption | + | 0.9762 | 97.62% |
| Caco-2 | + | 0.7736 | 77.36% |
| Blood Brain Barrier | - | 0.7000 | 70.00% |
| Human oral bioavailability | - | 0.6000 | 60.00% |
| Subcellular localzation | Mitochondria | 0.6978 | 69.78% |
| OATP2B1 inhibitior | - | 0.5678 | 56.78% |
| OATP1B1 inhibitior | + | 0.9223 | 92.23% |
| OATP1B3 inhibitior | + | 0.9544 | 95.44% |
| MATE1 inhibitior | - | 0.9800 | 98.00% |
| OCT2 inhibitior | - | 0.9338 | 93.38% |
| BSEP inhibitior | - | 0.7294 | 72.94% |
| P-glycoprotein inhibitior | - | 0.9482 | 94.82% |
| P-glycoprotein substrate | - | 0.9720 | 97.20% |
| CYP3A4 substrate | - | 0.6651 | 66.51% |
| CYP2C9 substrate | - | 0.5955 | 59.55% |
| CYP2D6 substrate | - | 0.6927 | 69.27% |
| CYP3A4 inhibition | + | 0.7134 | 71.34% |
| CYP2C9 inhibition | + | 0.9190 | 91.90% |
| CYP2C19 inhibition | + | 0.8449 | 84.49% |
| CYP2D6 inhibition | - | 0.9195 | 91.95% |
| CYP1A2 inhibition | + | 0.9515 | 95.15% |
| CYP2C8 inhibition | + | 0.6014 | 60.14% |
| CYP inhibitory promiscuity | + | 0.9090 | 90.90% |
| UGT catelyzed | + | 0.7000 | 70.00% |
| Carcinogenicity (binary) | - | 0.7172 | 71.72% |
| Carcinogenicity (trinary) | Non-required | 0.6573 | 65.73% |
| Eye corrosion | - | 0.9663 | 96.63% |
| Eye irritation | + | 0.9923 | 99.23% |
| Skin irritation | + | 0.6322 | 63.22% |
| Skin corrosion | - | 0.7359 | 73.59% |
| Ames mutagenesis | - | 0.6200 | 62.00% |
| Human Ether-a-go-go-Related Gene inhibition | - | 0.7933 | 79.33% |
| Micronuclear | + | 0.6500 | 65.00% |
| Hepatotoxicity | - | 0.5195 | 51.95% |
| skin sensitisation | + | 0.8957 | 89.57% |
| Respiratory toxicity | - | 0.7222 | 72.22% |
| Reproductive toxicity | + | 0.5889 | 58.89% |
| Mitochondrial toxicity | - | 0.7250 | 72.50% |
| Nephrotoxicity | + | 0.4703 | 47.03% |
| Acute Oral Toxicity (c) | III | 0.7754 | 77.54% |
| Estrogen receptor binding | + | 0.9085 | 90.85% |
| Androgen receptor binding | + | 0.7694 | 76.94% |
| Thyroid receptor binding | + | 0.7700 | 77.00% |
| Glucocorticoid receptor binding | + | 0.8625 | 86.25% |
| Aromatase binding | + | 0.8977 | 89.77% |
| PPAR gamma | + | 0.9344 | 93.44% |
| Honey bee toxicity | - | 0.8445 | 84.45% |
| Biodegradation | - | 0.9250 | 92.50% |
| Crustacea aquatic toxicity | + | 0.5100 | 51.00% |
| Fish aquatic toxicity | + | 0.9874 | 98.74% |
Proven Targets:
| CHEMBL ID | UniProt ID | Name | Min activity | Assay type | Source |
|---|---|---|---|---|---|
| CHEMBL221 | P23219 | Cyclooxygenase-1 |
1400 nM |
IC50 |
PMID: 11858749
|
| CHEMBL2231 | P04798 | Cytochrome P450 1A1 |
15000 nM |
IC50 |
PMID: 11754588
|
| CHEMBL4878 | Q16678 | Cytochrome P450 1B1 |
34000 nM 34000 nM |
IC50 IC50 |
PMID: 11754588
PMID: 27265259 |
| CHEMBL333 | P08253 | Matrix metalloproteinase-2 |
27600 nM |
IC50 |
PMID: 22658537
|
| CHEMBL1973 | P14679 | Tyrosinase |
12700 nM |
IC50 |
PMID: 16919455
|
Predicted Targets (via Super-PRED):
| CHEMBL ID | UniProt ID | Name | Probability | Model accuracy |
|---|---|---|---|---|
| CHEMBL5619 | P27695 | DNA-(apurinic or apyrimidinic site) lyase | 98.12% | 91.11% |
| CHEMBL3194 | P02766 | Transthyretin | 97.75% | 90.71% |
| CHEMBL3108638 | O15164 | Transcription intermediary factor 1-alpha | 91.30% | 95.56% |
| CHEMBL1951 | P21397 | Monoamine oxidase A | 88.77% | 91.49% |
| CHEMBL1293249 | Q13887 | Kruppel-like factor 5 | 87.68% | 86.33% |
| CHEMBL1929 | P47989 | Xanthine dehydrogenase | 85.76% | 96.12% |
| CHEMBL1075094 | Q16236 | Nuclear factor erythroid 2-related factor 2 | 85.64% | 96.00% |
| CHEMBL242 | Q92731 | Estrogen receptor beta | 84.20% | 98.35% |
| CHEMBL2288 | Q13526 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | 84.12% | 91.71% |
| CHEMBL3401 | O75469 | Pregnane X receptor | 83.40% | 94.73% |
| CHEMBL4208 | P20618 | Proteasome component C5 | 83.24% | 90.00% |
| CHEMBL1806 | P11388 | DNA topoisomerase II alpha | 82.56% | 89.00% |
| CHEMBL2581 | P07339 | Cathepsin D | 82.44% | 98.95% |
| CHEMBL1860 | P10827 | Thyroid hormone receptor alpha | 80.41% | 99.15% |
Below are displayed all the plants proven (via scientific papers) to contain this
compound!
To see more specific details click the taxa you are interested in.
To see more specific details click the taxa you are interested in.
| PubChem | 5281717 |
| NPASS | NPC292452 |
| ChEMBL | CHEMBL43065 |
| LOTUS | LTS0044764 |
| wikiData | Q7116143 |