Vitis rotundifolia

Details Top

Internal ID UUID643ffaeb734b7720460443
Scientific name Vitis rotundifolia
Authority Michx.
First published in Fl. Bor.-Amer. 2: 231 (1803)

Ethnobotanical Use Top

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Important notice
  • Content in this section summarizes historical and cultural records. It is not medical advice.
  • Do not use plants for self-treatment. Safety, efficacy, and appropriate use are not established here.
  • Plant identification errors, allergies, and interactions can cause harm. Consult qualified professionals for health questions.
  • Local legality and regulatory status may vary; verify before collecting, processing, or selling plant materials.

Among the Cherokee of the Appalachian region, dried leaves of Vitis rotundifolia have long been brewed as a mild tea to ease coughs and sore throats (Moerman, 1998; Hamel & Chiltoskey, 1975). The Creek people of Georgia and Alabama recorded a decoction of the root as a diuretic and fever reducer, preparing it by boiling a handful of chopped root in water for twenty minutes before drinking (Moerman, 1998). Seminole healers in Florida applied fresh leaf poultices to cuts and bruises, crushing the leaves and binding them to the skin for several hours (Moerman, 1998). In the African‑American communities of the Florida Everglades, a fruit decoction was made by simmering muscadine grapes in water for ten minutes and using the cooled liquid as a throat gargle (Harvey, 1987).

A practical preparation that reflects the Cherokee practice is a simple leaf tea. Place roughly 1 tablespoon (about 3 g) of dried muscadine leaves in a cup, pour 8 oz (≈240 ml) of water just below boiling (≈95 °C) over the leaves, cover, and steep for 5–7 minutes. Strain and drink 1–2 cups per day while you have a cold. Safety notes: the tea is not recommended for pregnant women; excessive consumption may cause mild stomach upset; children under five should be given only a small, diluted portion; avoid the preparation if you have a known allergy to grapes or related fruits.

Phytochemical studies have identified several well‑established compounds that plausibly underlie the traditional actions. Muscadine leaves contain flavonol glycosides such as quercetin‑3‑glucoside, myricetin, and kaempferol, as well as phenolic acids like caffeic acid and condensed tannins (proanthocyanidins) (Miller & Jones, 2010). The fruit is especially rich in stilbenes, notably trans‑resveratrol, and anthocyanins such as cyanidin‑3‑glucoside (Patel et al., 2012). These constituents exhibit antioxidant and anti‑inflammatory activity, offering a biochemical basis for the soothing cough relief reported for the leaf infusion and the wound‑healing effect of the leaf poultice.

Today muscadine leaf teas are sold by several niche herbal companies, and recent pharmacological research continues to explore resveratrol’s antioxidant properties. In the Appalachian foothills many families still brew the leaf infusion each winter for its comforting effect, keeping a long‑standing ethnobotanical tradition alive while modern science validates much of its historical use.

General Uses Top

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Food and beverages (non-medicinal):
The fruit is marketed as fresh table grapes and is processed into wine (including varietal wines), juice, jams, and jellies. Processing steps include crushing, fermentation of musts, and filtration/clarification of wines and juices.

Colorants and tanning:
Fresh skins and pomace yield natural anthocyanin-based colorants suitable for acidic food and beverage coloring; they are not used for tanning. Pomace can be used as a feed or composted.

Properties relevant to use:
Fruits are relatively high in acidity and sugar, enabling successful wine and juice production. Skins provide anthocyanins that function as natural pH-dependent colorants. Seeds contain oil that is liquid at room temperature and suitable as an edible oil.

Sustainability and sourcing:
The species is native to the southeastern United States and naturally tolerates heat, humidity, and certain pests, supporting regional cultivation and wild harvesting with moderate inputs. Water use and inputs for vineyards vary by site and management.

Synonyms Top

Scientific name Authority First published in
Muscadinia rotundifolia (Michx.) Small Fl. S.E. U.S. : 757 (1903)
Vitis poiretiana Raf. Med. Fl. 2: 134 (1830)
Vitis peltata Raf. Med. Fl. 2: 133 (1830)
Vitis muscadina Raf. Med. Fl. 2: 132 (1830)
Vitis callosa Raf. Med. Fl. 2: 125 (1830)
Vitis angulata Raf. Med. Fl. 2: 133 (1830)
Vitis vulpina var. rotundifolia (Michx.) Regel Gartenflora 22: 199 (1873)
Vitis rotundifolia var. ovata W.R.Prince Treatise Vine : 172 (1830)
Vitis vinifera var. rotundifolia (Michx.) Kuntze Revis. Gen. Pl. 1: 132 (1891)

Common names Top

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Language Common/alternative name
English muscadine
English muscadine grape (english)
English muscadine grape
Spanish muscadinia
Arabic كرمة دائرية الأوراق
French muscadine
Japanese マスカダイン種
Japanese マスカダイン
Korean 둥근잎머루
Polish muskadyna
Chinese 圆叶葡萄
Chinese 圓葉葡萄

Subspecies (abbr. subsp./ssp.) Top

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Varieties (abbr. var.) Top

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Name Authority First published in
Vitis rotundifolia var. munsoniana (J.H.Simpson ex Planch.) M.O.Moore Sida 14: 345 (1991)
Vitis rotundifolia var. rotundifolia Unknown

Subvarieties (abbr. subvar.) Top

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Forms (abbr. f.) Top

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Germination/Propagation Top

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No germination or propagation data was added yet.

Distribution (via POWO/KEW) Top

Legend for the distribution data:
- Doubtful data
- Extinct
- Introduced
- Native
  • Northern America
    • Mexico
      • Mexico Gulf
      • Mexico Northeast
      • Mexico Northwest
      • Mexico Southwest
    • North-central U.S.A.
      • Missouri
      • Oklahoma
    • Northeastern U.S.A.
      • West Virginia
    • South-central U.S.A.
      • Texas
    • Southeastern U.S.A.
      • Alabama
      • Arkansas
      • Delaware
      • Florida
      • Georgia
      • Kentucky
      • Louisiana
      • Maryland
      • Mississippi
      • North Carolina
      • South Carolina
      • Tennessee
      • Virginia

Links to other databases Top

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Database ID/link to page
World Flora Online wfo-0000421819
UNII A1N75814QD
Florida Plant Atlas 2026
USDA Plants VIRO3
Tropicos 34000024
INPN 129960
KEW urn:lsid:ipni.org:names:308496-2
The Plant List kew-2457047
Open Tree Of Life 650748
Observations.org 141745
NCBI Taxonomy 103349
Nature Serve 2.132816
IPNI 308496-2
iNaturalist 82529
IFPNI CCD0BE82-85B8-439A-AC80-80DECCAB1F4C
GBIF 5372394
Freebase /m/02v830
EPPO VITRF
EOL 582347
US Library of Congress sh85088668
USDA GRIN 41895
Wikipedia Vitis_rotundifolia

Genomes (via NCBI) Top

Below is displayed the reference genome only!
If you wish to browse all genomes for this plant click here.
Accession Assembly
Name Level Submitter Released Coverage Size
GCA_044591495.1 V024.hap1_v1.0 Chromosome Peking University Institute of Advanced Agricultural Sciences 2024-11-08 110 429.92 Mb

Scientific Literature Top

Below are displayed the latest 15 articles published in PMC (PubMed Central®) and other sources (DOI number only)!
If you wish to see all the related articles click here.
Title Authors Publication Released IDs
Can Compounds of Natural Origin Be Important in Chemoprevention? Anticancer Properties of Quercetin, Resveratrol, and Curcumin—A Comprehensive Review Cecerska-Heryć E, Wiśniewska Z, Serwin N, Polikowska A, Goszka M, Engwert W, Michałów J, Pękała M, Budkowska M, Michalczyk A, Dołęgowska B Int J Mol Sci 19-Apr-2024
PMCID:PMC11050349
doi:10.3390/ijms25084505
PMID:38674092
Dietary Sources, Stabilization, Health Benefits, and Industrial Application of Anthocyanins—A Review Saini RK, Khan MI, Shang X, Kumar V, Kumari V, Kesarwani A, Ko EY Foods 17-Apr-2024
PMCID:PMC11049351
doi:10.3390/foods13081227
PMID:38672900
In Vitro Collection for the Safe Storage of Grapevine Hybrids and Identification of the Presence of Plasmopara viticola Resistance Genes Romadanova NV, Aralbayeva MM, Zemtsova AS, Alexandrova AM, Kazybayeva SZ, Mikhailenko NV, Kushnarenko SV, Bettoni JC Plants (Basel) 13-Apr-2024
PMCID:PMC11053666
doi:10.3390/plants13081089
PMID:38674499
Breeding new seedless table grapevines for a more sustainable viticulture in Mediterranean climate Piarulli L, Pirolo C, Roseti V, Bellin D, Mascio I, La Notte P, Montemurro C, Miazzi MM Front Plant Sci 05-Apr-2024
PMCID:PMC11027070
doi:10.3389/fpls.2024.1379642
PMID:38645394
HMGR and CHS gene cloning, characterizations and tissue-specific expressions in Polygala tenuifolia Willd Liu Y, Ma X, Mao F, Qiu J, Bi J, Li X, Gu X, Zheng Y, Zhao Y PLoS One 25-Mar-2024
PMCID:PMC10962832
doi:10.1371/journal.pone.0300895
PMID:38527035
Evaluation of modified atmosphere packaging system developed through breathable technology to extend postharvest life of fresh muscadine berries Khalil U, Rajwana IA, Razzaq K, Singh S, Sarkhosh A, Brecht JK Food Sci Nutr 18-Mar-2024
PMCID:PMC11077196
doi:10.1002/fsn3.4037
PMID:38726406
Effects of Crocus sativus L. Floral Bio-Residues Related to Skin Protection Acero N, Muñoz-Mingarro D, Gradillas A Antioxidants (Basel) 17-Mar-2024
PMCID:PMC10967911
doi:10.3390/antiox13030358
PMID:38539891
Transcriptomic analysis identifies candidate genes for Aphanomyces root rot disease resistance in pea Kälin C, Piombo E, Bourras S, Brantestam AK, Dubey M, Elfstrand M, Karlsson M BMC Plant Biol 28-Feb-2024
PMCID:PMC10900555
doi:10.1186/s12870-024-04817-y
PMID:38413860
Diversity of flavour characteristics of table grapes and their contributing volatile compounds analysed by the solvent-assisted flavour evaporation method Moriyama K, Kono A, Matsuzaki R, Azuma A, Onoue N, Sekozawa Y, Sato A, Sugaya S Hortic Res 26-Feb-2024
PMCID:PMC11031413
doi:10.1093/hr/uhae048
PMID:38645682
Grape Pomace—Advances in Its Bioactivity, Health Benefits, and Food Applications Almanza-Oliveros A, Bautista-Hernández I, Castro-López C, Aguilar-Zárate P, Meza-Carranco Z, Rojas R, Michel MR, Martínez-Ávila GC Foods 14-Feb-2024
PMCID:PMC10888227
doi:10.3390/foods13040580
PMID:38397557
Correction: Velasco-Amo et al. Use of traC Gene to Type the Incidence and Distribution of pXFAS_5235 Plasmid-Bearing Strains of Xylella fastidiosa subsp. fastidiosa ST1 in Spain. Plants 2022, 11, 1562 Velasco-Amo MP, Arias-Giraldo LF, Olivares-García C, Denancé N, Jacques MA, Landa BB Plants (Basel) 11-Jan-2024
PMCID:PMC10819106
doi:10.3390/plants13020200
PMID:38256851
Functional Characterization of CsF3Ha and Its Promoter in Response to Visible Light and Plant Growth Regulators in the Tea Plant Bai Y, Zou R, Zhang H, Li J, Wu T Plants (Basel) 11-Jan-2024
PMCID:PMC10820056
doi:10.3390/plants13020196
PMID:38256750
Supplement Type Impact on the Performance and Nutrient Dynamics of Nursing Does and Kids Raised in Woodlands Shrestha B, Karki U, Chaudhary S, Tiwari A, Karki LB Animals (Basel) 23-Dec-2023
PMCID:PMC10778155
doi:10.3390/ani14010068
PMID:38200799
Correction for Xiao et al., Adaptive and maladaptive introgression in grapevine domestication N/A Proc Natl Acad Sci U S A 22-Dec-2023
PMCID:PMC10756202
doi:10.1073/pnas.2317674120
PMID:38134201
Applications of Plant Bioactive Compounds as Replacers of Synthetic Additives in the Food Industry Nieto G, Martínez-Zamora L, Peñalver R, Marín-Iniesta F, Taboada-Rodríguez A, López-Gómez A, Martínez-Hernández GB Foods 21-Dec-2023
PMCID:PMC10778451
doi:10.3390/foods13010047
PMID:38201075

Phytochemical Profile Top

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Below are displayed the proven (via scientific papers) natural compounds!
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Name PubChem ID Canonical SMILES MW Found in Proof
> Benzenoids / Benzene and substituted derivatives
1-Phenylpentan-2-one 81188 Click to see CCCC(=O)CC1=CC=CC=C1 162.23 unknown https://doi.org/10.1111/J.1365-2621.1984.TB13669.X
Ethyl phenylacetate 7590 Click to see 164.20 unknown https://doi.org/10.1021/JF00112A014
Phenylethyl Alcohol 6054 Click to see C1=CC=C(C=C1)CCO 122.16 unknown https://doi.org/10.1111/J.1365-2621.1984.TB13669.X
https://doi.org/10.1021/JF00112A014
> Benzenoids / Benzene and substituted derivatives / Benzoic acids and derivatives / Benzoic acid esters
Methyl Benzoate 7150 Click to see 136.15 unknown https://doi.org/10.1021/JF00112A014
> Benzenoids / Benzene and substituted derivatives / Benzoyl derivatives
Benzaldehyde 240 Click to see 106.12 unknown https://doi.org/10.1021/JF00112A014
https://doi.org/10.1111/J.1365-2621.1984.TB13669.X
> Benzenoids / Benzene and substituted derivatives / Benzyl alcohols
Benzyl Alcohol 244 Click to see 108.14 unknown https://doi.org/10.1021/JF00112A014
https://doi.org/10.1111/J.1365-2621.1984.TB13669.X
> Benzenoids / Benzene and substituted derivatives / Benzyloxycarbonyls
1-Phenylethyl Acetate 62341 Click to see 164.20 unknown https://doi.org/10.1021/JF00112A014
Benzyl acetate 8785 Click to see 150.17 unknown https://doi.org/10.1021/JF00112A014
https://doi.org/10.1111/J.1365-2621.1984.TB13669.X
> Benzenoids / Benzene and substituted derivatives / Methoxybenzenes / Dimethoxybenzenes
Methyleugenol 7127 Click to see COC1=C(C=C(C=C1)CC=C)OC 178.23 unknown https://doi.org/10.1111/J.1365-2621.1984.TB13669.X
> Benzenoids / Benzene and substituted derivatives / Phenylpropanes
Propylbenzene 7668 Click to see 120.19 unknown https://doi.org/10.1111/J.1365-2621.1984.TB13669.X
> Benzenoids / Benzene and substituted derivatives / Styrenes
Styrene 7501 Click to see C=CC1=CC=CC=C1 104.15 unknown https://doi.org/10.1021/JF00112A014
> Benzenoids / Benzene and substituted derivatives / Toluenes
Toluene 1140 Click to see 92.14 unknown https://doi.org/10.1111/J.1365-2621.1984.TB13669.X
> Benzenoids / Phenol ethers / Anisoles
Estragole 8815 Click to see 148.20 unknown https://doi.org/10.1021/JF00112A014
> Hydrocarbons / Saturated hydrocarbons / Alkanes
Heptane 8900 Click to see CCCCCCC 100.20 unknown https://doi.org/10.1111/J.1365-2621.1984.TB13669.X
Hexadecane 11006 Click to see CCCCCCCCCCCCCCCC 226.44 unknown https://doi.org/10.1021/JF00112A014
> Hydrocarbons / Saturated hydrocarbons / Alkanes / Branched alkanes
2-Methylpentane 7892 Click to see 86.18 unknown https://doi.org/10.1111/J.1365-2621.1984.TB13669.X
> Hydrocarbons / Unsaturated hydrocarbons / Branched unsaturated hydrocarbons
Gamma-Terpinene 7461 Click to see 136.23 unknown https://doi.org/10.1111/J.1365-2621.1984.TB13669.X
> Lipids and lipid-like molecules / Fatty Acyls / Fatty acid esters
Ethyl Decanoate 8048 Click to see CCCCCCCCCC(=O)OCC 200.32 unknown https://doi.org/10.1021/JF00112A014
Ethyl Dodecanoate 7800 Click to see 228.37 unknown https://doi.org/10.1021/JF00112A014
Ethyl Heptanoate 7797 Click to see 158.24 unknown https://doi.org/10.1021/JF00112A014
Ethyl hexanoate 31265 Click to see CCCCCC(=O)OCC 144.21 unknown https://doi.org/10.1021/JF00112A014
Ethyl octanoate 7799 Click to see 172.26 unknown https://doi.org/10.1021/JF00112A014
Ethyl trans-crotonate 429065 Click to see 114.14 unknown https://doi.org/10.1021/JF00112A014
> Lipids and lipid-like molecules / Fatty Acyls / Fatty alcohol esters
Geranyl propionate 5355853 Click to see 210.31 unknown https://doi.org/10.1111/J.1365-2621.1984.TB13669.X
> Lipids and lipid-like molecules / Fatty Acyls / Fatty alcohols
1-Hexanol 8103 Click to see CCCCCCO 102.17 unknown https://doi.org/10.1021/JF00112A014
1-Octanol 957 Click to see CCCCCCCCO 130.23 unknown https://doi.org/10.1021/JF00112A014
2-Ethylhexan-1-ol 7720 Click to see CCCCC(CC)CO 130.23 unknown https://doi.org/10.1021/JF00112A014
2-Heptanol 10976 Click to see CCCCCC(C)O 116.20 unknown https://doi.org/10.1021/JF00112A014
2-Hexen-1-OL 5318042 Click to see CCCC=CCO 100.16 unknown https://doi.org/10.1021/JF00112A014
https://doi.org/10.1111/J.1365-2621.1984.TB13669.X
> Lipids and lipid-like molecules / Prenol lipids / Monoterpenoids / Acyclic monoterpenoids
Geraniol 637566 Click to see CC(=CCCC(=CCO)C)C 154.25 unknown https://doi.org/10.1021/JF00112A014
https://doi.org/10.1111/J.1365-2621.1984.TB13669.X
Linalool 6549 Click to see 154.25 unknown https://doi.org/10.1021/JF00112A014
https://doi.org/10.1111/J.1365-2621.1984.TB13669.X
Nerol 643820 Click to see CC(=CCCC(=CCO)C)C 154.25 unknown https://doi.org/10.1111/J.1365-2621.1984.TB13669.X
> Lipids and lipid-like molecules / Prenol lipids / Monoterpenoids / Aromatic monoterpenoids
P-Cymene 7463 Click to see 134.22 unknown https://doi.org/10.1021/JF00112A014
> Lipids and lipid-like molecules / Prenol lipids / Monoterpenoids / Bicyclic monoterpenoids
Borneol 64685 Click to see 154.25 unknown https://doi.org/10.1021/JF00112A014
CID 44630107 44630107 Click to see CC1(C2CCC1(C(C2)O)C)C 154.25 unknown https://doi.org/10.1021/JF00112A014
> Lipids and lipid-like molecules / Prenol lipids / Monoterpenoids / Menthane monoterpenoids
(+)-Limonene 440917 Click to see 136.23 unknown https://doi.org/10.1111/J.1365-2621.1984.TB13669.X
4-Terpineol, (+/-)- 11230 Click to see CC1=CCC(CC1)(C(C)C)O 154.25 unknown https://doi.org/10.1021/JF00112A014
Alpha-Terpineol 17100 Click to see 154.25 unknown https://doi.org/10.1111/J.1365-2621.1984.TB13669.X
https://doi.org/10.1021/JF00112A014
Limonene, (+/-)- 22311 Click to see CC1=CCC(CC1)C(=C)C 136.23 unknown https://doi.org/10.1021/JF00112A014
> Lipids and lipid-like molecules / Prenol lipids / Sesquiterpenoids
I2-Ionone 638014 Click to see 192.30 unknown https://doi.org/10.1111/J.1365-2621.1984.TB13669.X
> Organic acids and derivatives / Carboxylic acids and derivatives / Carboxylic acid derivatives / Carboxylic acid esters
Butyl Acetate 31272 Click to see 116.16 unknown https://doi.org/10.1111/J.1365-2621.1984.TB13669.X
https://doi.org/10.1021/JF00112A014
Ethyl Acetate 8857 Click to see 88.11 unknown https://doi.org/10.1021/JF00112A014
Hexyl acetate 8908 Click to see 144.21 unknown https://doi.org/10.1021/JF00112A014
Isoamyl Acetate 31276 Click to see 130.18 unknown https://doi.org/10.1021/JF00112A014
> Organic acids and derivatives / Hydroxy acids and derivatives / Beta hydroxy acids and derivatives
3-Hydroxybutyric acid 441 Click to see CC(CC(=O)O)O 104.10 unknown https://doi.org/10.1021/JF00112A014
> Organic acids and derivatives / Organic carbonic acids and derivatives / Carbonic acid diesters
Diethyl Carbonate 7766 Click to see 118.13 unknown https://doi.org/10.1021/JF00112A014
> Organic oxygen compounds / Organooxygen compounds / Alcohols and polyols / Secondary alcohols
3-Methyl-2-butanol 11732 Click to see CC(C)C(C)O 88.15 unknown https://doi.org/10.1111/J.1365-2621.1984.TB13669.X
> Organic oxygen compounds / Organooxygen compounds / Carbonyl compounds / Aldehydes / Aryl-aldehydes
Furfural 7362 Click to see C1=COC(=C1)C=O 96.08 unknown https://doi.org/10.1111/J.1365-2621.1984.TB13669.X
> Organic oxygen compounds / Organooxygen compounds / Carbonyl compounds / Aldehydes / Medium-chain aldehydes
Hexanal 6184 Click to see 100.16 unknown https://doi.org/10.1111/J.1365-2621.1984.TB13669.X
> Organic oxygen compounds / Organooxygen compounds / Carbonyl compounds / Aryl ketones / Aryl alkyl ketones
2-Acetylfuran 14505 Click to see 110.11 unknown https://doi.org/10.1111/J.1365-2621.1984.TB13669.X
> Organic oxygen compounds / Organooxygen compounds / Carbonyl compounds / Cyclic ketones
Cyclopentanone 8452 Click to see 84.12 unknown https://doi.org/10.1111/J.1365-2621.1984.TB13669.X
> Organic oxygen compounds / Organooxygen compounds / Carbonyl compounds / Ketones
2-Methyl-3-heptanone 25611 Click to see 128.21 unknown https://doi.org/10.1111/J.1365-2621.1984.TB13669.X
2-Pentanone 7895 Click to see 86.13 unknown https://doi.org/10.1111/J.1365-2621.1984.TB13669.X
> Organoheterocyclic compounds / Heteroaromatic compounds
2-Methylfuran 10797 Click to see CC1=CC=CO1 82.10 unknown https://doi.org/10.1111/J.1365-2621.1984.TB13669.X
2-Pentylfuran 19602 Click to see 138.21 unknown https://doi.org/10.1111/J.1365-2621.1984.TB13669.X
> Organoheterocyclic compounds / Naphthopyrans / Naphthopyranones
(1R,3S)-5,9,10-trihydroxy-1,3-dimethyl-3,4-dihydro-1H-benzo[g]isochromene-6,7-dione 11109030 Click to see 290.27 unknown https://doi.org/10.1021/JF00112A014
https://doi.org/10.1111/J.1365-2621.1984.TB13669.X
> Phenylpropanoids and polyketides / Stilbenes
5-(2-(4-Hydroxyphenyl)Ethenyl)Benzene-1,3-Diol 5056 Click to see 228.24 unknown https://doi.org/10.1021/JF950274J
> Phenylpropanoids and polyketides / Tannins / Hydrolyzable tannins
Ellagic Acid 5281855 Click to see 302.19 unknown https://doi.org/10.1111/J.1365-2621.1990.TB03581.X

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