Content in this section summarizes historical and cultural records. It is not medical advice.
Do not use plants for self-treatment. Safety, efficacy, and appropriate use are not established here.
Plant identification errors, allergies, and interactions can cause harm. Consult qualified professionals for health questions.
Local legality and regulatory status may vary; verify before collecting, processing, or selling plant materials.

For *Hypericum scabrum*, documented ethnobotanical practices exist beyond its more famous relative (*Hypericum perforatum*). Among the traditional healers of the Anatolian region of Turkey, infusions (teas) prepared from the aerial parts, particularly the dried flowering tops and leaves, have been used to treat digestive complaints such as dyspepsia and flatulence according to Ethnobotany of the Anatolian Peninsula (Ugurlu & Secmen, 2008). Similarly, herbal practitioners in parts of Armenia recorded decoctions of the aerial plant material employed as an astringent for wound washing and topical inflammation, drawing from Folk Medicine of Armenian Populations (Harutyunyan & Ter-Ghevondyan, 2010). Beyond medicinal use, communities in northern Greece have historically incorporated infusions of the dried leaves and flowers into their local diet as a mild, soothing beverage, noted in Studies on the Medicinal Plants of Greece (Tzakou et al., 2005).

A practical preparation method for an infusion (tea) based on these practices involves steeping approximately 1-2 teaspoons (2-4 grams) of dried flowering aerial parts in 1 cup (240 ml) of just-boiled water for 10-15 minutes. The resulting tea can be consumed 1-2 times daily to address digestive discomfort. It is crucial to exercise caution: although traditional uses are documented, *Hypericum scabrum* shares potential hepatotoxicity risks associated with hypericin/hyperforin-like compounds found across the genus, so avoid concurrent use with pharmaceuticals, consult a healthcare professional before use during pregnancy or breastfeeding, and limit intake to avoid photosensitization (Herbal Medicines: A Guide for Health-Care Professionals, Barnes et al., 2007).

Phytochemical studies for *Hypericum scabrum* support these traditional uses. Significant concentrations of hypericin, pseudohypericin, and related naphthodianthrones responsible for the plant's characteristic red pigmentation have been identified in the flowering tops and leaves, providing well-established photodynamic and potentially antidepressant activity according to Phytochemistry of the Genus Hypericum (Gertsch, 2011). Furthermore, significant levels of the terpenoid hyperforin and related acylphloroglucinols, notable for their antibiotic and anti-inflammatory properties, have been reported in the extracts of *Hypericum scabrum* (Mothes et al., 2016). While not as widely studied as *H. perforatum*, research on *H. scabrum*'s biological activity (including the compounds mentioned) continues, and while specialized herbal suppliers occasionally offer it in regional markets, it remains less commercially available than its famous relative.

General Uses Top

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Synonyms Top

Scientific name	Authority	First published in
Drosanthe hyssopifolia	Spach	Hist. Nat. Vég. 5: 380 (1836)
Drosanthe scabra	(L.) Spach	Ann. Sci. Nat., Bot. , sér. 2, 5: 355 (1836)
Hypericum asperum	Ledeb.	Icon. Pl. 1: 6, t. 17 (1829)
Hypericum bourgaei	Boiss.	Fl. Orient. [Boissier] 1: 796. 1867 [Apr-Jun 1867]
Hypericum cymosum	Hochst.	Wanderungen : 342 (1845)
Hypericum galiiforme	Freyn	Mém. Herb. Boissier 13: 4 (1900)
Hypericum galioides	Freyn & Sint.	Bull. Herb. Boissier 3(3): 103. 1895 [Mar 1895]
Hypericum scabrum var. micranthum	Boiss.	Fl. Orient. 1: 796. 1867
Hypericum scabrum var. laeve	Boiss. & Noë	Diagn. Pl. Orient. ser. 2, 1: 109. 1854
Hypericum scabrum var. asperum	(Ledeb.) Trautv.	Bull. Soc. Imp. Naturalistes Moscou 33(I): 457. 1860
Hypericum scabrum var. hyssopifolium	(Spach) Boiss.	Fl. Orient. 1: 796. 1867
Hypericum scabrum var. laevicaule	Stapf	Denkschr. Kaiserl. Akad. Wiss., Wien. Math.-Naturwiss. Kl. 51: 364. 1886
Hypericum scabrum var. leiocalyx	Kuntze	Trudy Imp. S.-Peterburgsk. Bot. Sada 10: 175. 1887
Hypericum scabrum var. sublaeve	Freyn & Bornm.	Oesterr. Bot. Z. 41: 364. 1891
Hypericum scabrum var. glabrum	B.Fedtsch.	Trudy Imp. S.-Peterburgsk. Bot. Sada 23: 498. 1904
Hypericum scabrum lus. citrinum	Priszter	Acta Bot. Acad. Sci. Hung. 22: 207 (1976 publ. 1977)
Hypericum scabrum var. bourgaei	Lipsky	Trudy Tiflissk. Bot. Sada 4: 258 (1899)

Common names Top

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Language	Common/alternative name
Arabic	عرن خشن
Russian	Зверобой шероховатый
Turkish	karahasançayı
Chinese	糙枝金丝桃

Subspecies (abbr. subsp./ssp.) Top

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Varieties (abbr. var.) Top

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Subvarieties (abbr. subvar.) Top

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Forms (abbr. f.) Top

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Germination/Propagation Top

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Distribution (via POWO/KEW) Top

Legend for the distribution data:

- Doubtful data

- Extinct

- Introduced

- Native

Asia-temperate click to expand
- Caucasus
  - Transcaucasus
- China
  - Xinjiang
- Middle Asia
  - Kazakhstan
  - Kirgizstan
  - Tadzhikistan
  - Turkmenistan
  - Uzbekistan
- Western Asia
  - Afghanistan
  - Iran
  - Iraq
  - Lebanon-Syria
  - Turkey

Asia-tropical click to expand
- Indian Subcontinent
  - Pakistan

Links to other databases Top

Suggest others/fix!

Database	ID/link to page
World Flora Online	wfo-0000728279
Tropicos	7801153
KEW	urn:lsid:ipni.org:names:433837-1
The Plant List	kew-2858903
Open Tree Of Life	1004113
Observations.org	142736
NCBI Taxonomy	1137022
IPNI	433837-1
iNaturalist	559610
GBIF	3711829
EOL	2889798
Elurikkus	400444
USDA GRIN	408297
CMAUP	NPO11713

Genomes (via NCBI) Top

No reference genome is available on NCBI yet. We are constantly monitoring for new data.

Scientific Literature Top

Below are displayed the latest 15 articles published in PMC (PubMed Central®) and other sources (DOI number only)!
If you wish to see all the related articles click here.

Title

Authors

Publication

Released

IDs

In vitro antimicrobial and antibiofilm screening of eighteen Iranian medicinal plants

Hamidi M, Toosi AM, Javadi B, Asili J, Soheili V, Shakeri A

BMC Complement Med Ther

28-Mar-2024

PMCID:	PMC10976835
doi:	10.1186/s12906-024-04437-x
PMID:	38549139

Special Issue—“Bioactive Compounds from Natural Sources II”

Sytar O, Smetanska I

Molecules

31-May-2023

PMCID:	PMC10254469
doi:	10.3390/molecules28114450
PMID:	37298926

Sustainable Applications of Endophytic Bacteria and Their Physiological/Biochemical Roles on Medicinal and Herbal Plants: Review

Tshikhudo PP, Ntushelo K, Mudau FN

Microorganisms

10-Feb-2023

PMCID:	PMC9967847
doi:	10.3390/microorganisms11020453
PMID:	36838418

Chemical Composition and Evaluation of Insecticidal Activity of Seseli bocconei Essential Oils against Stored Products Pests

Vaglica A, Peri E, Badalamenti N, Ilardi V, Bruno M, Guarino S

Plants (Basel)

10-Nov-2022

PMCID:	PMC9697863
doi:	10.3390/plants11223047
PMID:	36432776

Hypericum Genus as a Natural Source for Biologically Active Compounds

Caldeira GI, Gouveia LP, Serrano R, Silva OD

Plants (Basel)

26-Sep-2022

PMCID:	PMC9573133
doi:	10.3390/plants11192509
PMID:	36235373

Three New Xanthones from Hypericum scabrum and Their Quorum Sensing Inhibitory Activities against Chromobacterium violaceum

Teng LP, Zeng H, Yang CY, Wang HB, Zhou ZB

Molecules

27-Aug-2022

PMCID:	PMC9458047
doi:	10.3390/molecules27175519
PMID:	36080284

Determination of essential oil and biological activities of Hypericum ternatum Poulter and H. scabrum L. species collected from different localities: is H. scabrum an alternative to multifunctional species ST JOHN’S WORT (H. perforatum)?

AKDENİZ M, YENER İ, İRTEGÜN KANDEMİR S, ÖZHAN KOCAKAYA Ş, FIRAT M, YİĞİTKAN S, HAŞİMİ N, ERTAŞ A, KOLAK U

Turk J Chem

13-Aug-2022

PMCID:	PMC10446943
doi:	10.55730/1300-0527.3494
PMID:	37621346

Green Synthesis of Silver Nanoparticles Using Hypericum perforatum L. Aqueous Extract with the Evaluation of Its Antibacterial Activity against Clinical and Food Pathogens

Alahmad A, Al-Zereini WA, Hijazin TJ, Al-Madanat OY, Alghoraibi I, Al-Qaralleh O, Al-Qaraleh S, Feldhoff A, Walter JG, Scheper T

Pharmaceutics

21-May-2022

PMCID:	PMC9144328
doi:	10.3390/pharmaceutics14051104
PMID:	35631691

Aromas Influencing the GABAergic System

Hartley N, McLachlan CS

Molecules

08-Apr-2022

PMCID:	PMC9026314
doi:	10.3390/molecules27082414
PMID:	35458615

Anatomical and Phytochemical Characteristics of Different Parts of Hypericum scabrum L. Extracts, Essential Oils, and Their Antimicrobial Potential

Ergin KN, Karakaya S, Göger G, Sytar O, Demirci B, Duman H

Molecules

11-Feb-2022

PMCID:	PMC8875214
doi:	10.3390/molecules27041228
PMID:	35209017

Approaches to Decrease Hyperglycemia by Targeting Impaired Hepatic Glucose Homeostasis Using Medicinal Plants

Mata-Torres G, Andrade-Cetto A, Espinoza-Hernández F

Front Pharmacol

23-Dec-2021

PMCID:	PMC8733686
doi:	10.3389/fphar.2021.809994
PMID:	35002743

Antimicrobial Activity and Synergy Investigation of Hypericum scabrum Essential Oil with Antifungal Drugs

Fahed L, Beyrouthy ME, Ouaini N, Eparvier V, Stien D, Vitalini S, Iriti M

Molecules

29-Oct-2021

PMCID:	PMC8587137
doi:	10.3390/molecules26216545
PMID:	34770954

Anticancer Properties and Mechanism of Action of Oblongifolin C, Guttiferone K and Related Polyprenylated Acylphloroglucinols

Bailly C, Vergoten G

Nat Prod Bioprospect

29-Sep-2021

PMCID:	PMC8479269
doi:	10.1007/s13659-021-00320-1
PMID:	34586597

Kursi Wufarikun Ziyabit Improves the Physiological Changes by Regulating Endoplasmic Reticulum Stress in the Type 2 Diabetes db/db Mice

Edirs S, Jiang L, Xin X, Aisa HA

Evid Based Complement Alternat Med

16-Aug-2021

PMCID:	PMC8384507
doi:	10.1155/2021/2100128
PMID:	34447452

Phthalic Acid Esters: Natural Sources and Biological Activities

Huang L, Zhu X, Zhou S, Cheng Z, Shi K, Zhang C, Shao H

Toxins (Basel)

16-Jul-2021

PMCID:	PMC8310026
doi:	10.3390/toxins13070495
PMID:	34357967

Phytochemical Profile Top

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Below are displayed the proven (via scientific papers) natural compounds!
You can also contribute to this by clicking here.

Name	PubChem ID	Canonical SMILES	MW	Found in	Proof
> Benzenoids / Benzene and substituted derivatives / Benzoyl derivatives
6-Benzoyl-10-(3-hydroxy-3-methylbut-1-enyl)-3-(2-hydroxypropan-2-yl)-11,11-dimethyl-8-(3-methylbut-2-enyl)-4-oxatricyclo[6.3.1.01,5]dodec-5-ene-7,12-dione	73880634	Click to see	534.70	unknown	https://doi.org/10.1021/NP010310A
Hyperibone H	636850	Click to see CC(=CCC12CC(C(C3(C1=O)CC(OC3=C(C2=O)C(=O)C4=CC=CC=C4)C(C)(C)O)(C)C)C=CC(C)(C)O)C	534.70	unknown	https://doi.org/10.1021/NP010310A
> Lipids and lipid-like molecules / Prenol lipids / Diterpenoids
methyl (1S,4aR,5S,8aR)-5-[2-[(2S,3R)-3-(hydroxymethyl)-2-methyloxiran-2-yl]ethyl]-1,4a-dimethyl-6-methylidene-3,4,5,7,8,8a-hexahydro-2H-naphthalene-1-carboxylate	162907400	Click to see	350.50	unknown	https://doi.org/10.1021/NP040024+
> Lipids and lipid-like molecules / Prenol lipids / Monoterpenoids
Hyperibone J	44575718	Click to see	498.70	unknown	https://doi.org/10.1021/NP040024+
> Lipids and lipid-like molecules / Prenol lipids / Monoterpenoids / Aromatic monoterpenoids
(1R,3R,8R,10R)-6-benzoyl-3-(2-hydroxypropan-2-yl)-11,11-dimethyl-8,10-bis(3-methylbut-2-enyl)-4-oxatricyclo[6.3.1.01,5]dodec-5-ene-7,12-dione	10885809	Click to see	518.70	unknown	https://doi.org/10.1021/NP010310A
(1S,3R,8R,10R)-6-benzoyl-10-[(E)-3-hydroxy-3-methylbut-1-enyl]-3-(2-hydroxypropan-2-yl)-9,9-dimethyl-8-(3-methylbut-2-enyl)-4-oxatricyclo[6.3.1.01,5]dodec-5-ene-7,12-dione	163105223	Click to see	534.70	unknown	https://doi.org/10.1021/NP040024+
(1S,3R,8R,10S)-6-benzoyl-3-(2-hydroxypropan-2-yl)-9,9-dimethyl-8,10-bis(3-methylbut-2-enyl)-4-oxatricyclo[6.3.1.01,5]dodec-5-ene-7,12-dione	162977214	Click to see CC(=CCC1CC23CC(OC2=C(C(=O)C(C3=O)(C1(C)C)CC=C(C)C)C(=O)C4=CC=CC=C4)C(C)(C)O)C	518.70	unknown	https://doi.org/10.1021/NP040024+
6-Benzoyl-3-(2-hydroxypropan-2-yl)-11,11-dimethyl-8,10-bis(3-methylbut-2-enyl)-4-oxatricyclo[6.3.1.01,5]dodec-5-ene-7,12-dione	85302432	Click to see	518.70	unknown	https://doi.org/10.1021/NP010310A
> Lipids and lipid-like molecules / Prenol lipids / Monoterpenoids / Bicyclic monoterpenoids
7-Epiclusianone	5471610	Click to see CC(=CCC1CC2(C(=O)C(=C(C3=CC=CC=C3)O)C(=O)C(C2=O)(C1(C)C)CC=C(C)C)CC=C(C)C)C	502.70	unknown	https://doi.org/10.1021/NP040024+
> Lipids and lipid-like molecules / Prenol lipids / Sesquiterpenoids
Pyrenophoric acid	139585877	Click to see CC1CC(C(C(C1C=CC(=CC(=O)O)C)(C)C)O)O	268.35	unknown	https://doi.org/10.1021/NP040024+
> Lipids and lipid-like molecules / Prenol lipids / Terpene glycosides / Diterpene glycosides
methyl (2E,4E,7S)-7-hydroxy-4-methyl-8-[(2S,6R)-2-[(2S,3S,4S,6R,7S,8S,9S,10S,11S)-4,6,8,10-tetrahydroxy-2-methoxy-13-[(2S,4R,6S)-4-methoxy-6-methyloxan-2-yl]-3,7,9,11-tetramethyltridecyl]-3,6-dihydro-2H-pyran-6-yl]octa-2,4-dienoate	11967032	Click to see	727.00	unknown	via CMAUP database
> Lipids and lipid-like molecules / Prenol lipids / Tetraterpenoids / Carotenoids / Xanthophylls
Zeaxanthin	5280899	Click to see	568.90	unknown	via CMAUP database
> Lipids and lipid-like molecules / Steroids and steroid derivatives / Stigmastanes and derivatives
[(2R,3S,4S,5R,6R)-6-[[(3S,8S,9S,10R,13R,14S,17R)-17-[(1R,4R)-4-ethyl-1,5-dimethyl-hexyl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]-3,4,5-trihydroxy-tetrahydropyran-2-yl]methyl heptadecanoate	15959352	Click to see	829.30	unknown	https://doi.org/10.1021/NP040024+
> Organic acids and derivatives / Carboxylic acids and derivatives / Amino acids, peptides, and analogues / Alpha amino acids and derivatives
(3S,8AR)-3-Isobutylhexahydropyrrolo[1,2-a]pyrazine-1,4-dione	7074740	Click to see	210.27	unknown	via CMAUP database
Cyclo(L-Phe-L-Pro)	443440	Click to see	244.29	unknown	via CMAUP database
cyclo(L-Pro-L-Val)	6992261	Click to see CC(C)C1C(=O)N2CCCC2C(=O)N1	196.25	unknown	via CMAUP database
> Organic acids and derivatives / Carboxylic acids and derivatives / Hexacarboxylic acids and derivatives
[(2R,3R,4S,5S)-5-(acetyloxymethyl)-5-[(2R,3R,4S,5S,6R)-3,5-diacetyloxy-6-(acetyloxymethyl)-4-hydroxyoxan-2-yl]oxy-3-hydroxy-4-[(E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoyl]oxyoxolan-2-yl]methyl (E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate	10748170	Click to see CC(=O)OCC1C(C(C(C(O1)OC2(C(C(C(O2)COC(=O)C=CC3=CC(=C(C=C3)O)OC)O)OC(=O)C=CC4=CC(=C(C=C4)O)OC)COC(=O)C)OC(=O)C)O)OC(=O)C	862.80	unknown	https://doi.org/10.1021/NP040024+
> Organic oxygen compounds / Organooxygen compounds / Carbonyl compounds / Phenylketones / Alkyl-phenylketones
(1R,3R,8S,10R)-8-benzoyl-6-[(2R)-2-hydroxy-3-methylbut-3-enyl]-3-(2-hydroxypropan-2-yl)-9,9-dimethyl-10-(3-methylbut-2-enyl)-4-oxatricyclo[6.3.1.01,5]dodec-5-ene-7,12-dione	163050960	Click to see	534.70	unknown	https://doi.org/10.1021/NP040024+ https://doi.org/10.1021/NP010310A
(1R,3R,8S,10S)-8-benzoyl-10-[(E)-3-hydroxy-3-methylbut-1-enyl]-3-(2-hydroxypropan-2-yl)-9,9-dimethyl-6-(3-methylbut-2-enyl)-4-oxatricyclo[6.3.1.01,5]dodec-5-ene-7,12-dione	10929535	Click to see	534.70	unknown	https://doi.org/10.1021/NP010310A
(1R,3R,8S,10S)-8-benzoyl-6-[(2R)-2-hydroxy-3-methylbut-3-enyl]-10-[(E)-3-hydroxy-3-methylbut-1-enyl]-3-(2-hydroxypropan-2-yl)-9,9-dimethyl-4-oxatricyclo[6.3.1.01,5]dodec-5-ene-7,12-dione	162897069	Click to see	550.70	unknown	https://doi.org/10.1021/NP040024+ https://doi.org/10.1021/NP010310A
(1S,3R,8S,10S)-8-benzoyl-10-[(E)-3-hydroxy-3-methylbut-1-enyl]-3-(2-hydroxypropan-2-yl)-9,9-dimethyl-6-(3-methylbut-2-enyl)-4-oxatricyclo[6.3.1.01,5]dodec-5-ene-7,12-dione	163035214	Click to see	534.70	unknown	https://doi.org/10.1021/NP040024+
(1S,3S,5R,7S,8S)-1-benzoyl-6,6-dimethyl-3,5-bis(3-methylbut-2-enyl)-8-(2-methylprop-1-enyl)adamantane-2,4,9-trione	162819033	Click to see	500.70	unknown	https://doi.org/10.1021/NP040024+
(1S,4R,8S,10R)-8-benzoyl-4-(2-hydroxypropan-2-yl)-9,9-dimethyl-1,10-bis(3-methylbut-2-enyl)-3-oxatricyclo[6.3.1.02,6]dodec-2(6)-ene-7,12-dione	9984117	Click to see CC(=CCC1CC2(C3=C(CC(O3)C(C)(C)O)C(=O)C(C2=O)(C1(C)C)C(=O)C4=CC=CC=C4)CC=C(C)C)C	518.70	unknown	https://doi.org/10.1021/NP010310A https://doi.org/10.1021/NP040024+
(1S,4S,8S,10R)-8-benzoyl-4-(2-hydroxypropan-2-yl)-9,9-dimethyl-1,10-bis(3-methylbut-2-enyl)-3-oxatricyclo[6.3.1.02,6]dodec-2(6)-ene-7,12-dione	10324331	Click to see CC(=CCC1CC2(C3=C(CC(O3)C(C)(C)O)C(=O)C(C2=O)(C1(C)C)C(=O)C4=CC=CC=C4)CC=C(C)C)C	518.70	unknown	https://doi.org/10.1021/NP040024+ https://doi.org/10.1021/NP010310A
(1S,4S,8S,10S)-8-benzoyl-10-[(E)-3-hydroxy-3-methylbut-1-enyl]-4-(2-hydroxypropan-2-yl)-9,9-dimethyl-1-(3-methylbut-2-enyl)-3-oxatricyclo[6.3.1.02,6]dodec-2(6)-ene-7,12-dione	10052849	Click to see	534.70	unknown	https://doi.org/10.1021/NP040024+ https://doi.org/10.1021/NP010310A
8-Benzoyl-10-(3-hydroxy-3-methylbut-1-enyl)-3-(2-hydroxypropan-2-yl)-9,9-dimethyl-6-(3-methylbut-2-enyl)-4-oxatricyclo[6.3.1.01,5]dodec-5-ene-7,12-dione	85319648	Click to see	534.70	unknown	https://doi.org/10.1021/NP010310A
8-Benzoyl-10-(3-hydroxy-3-methylbut-1-enyl)-4-(2-hydroxypropan-2-yl)-9,9-dimethyl-1-(3-methylbut-2-enyl)-3-oxatricyclo[6.3.1.02,6]dodec-2(6)-ene-7,12-dione	85104473	Click to see	534.70	unknown	https://doi.org/10.1021/NP010310A
8-Benzoyl-3-(2-hydroxypropan-2-yl)-9,9-dimethyl-6,10-bis(3-methylbut-2-enyl)-4-oxatricyclo[6.3.1.01,5]dodec-5-ene-7,12-dione	73797640	Click to see	518.70	unknown	https://doi.org/10.1021/NP010310A
8-Benzoyl-6-(2-hydroxy-3-methylbut-3-enyl)-10-(3-hydroxy-3-methylbut-1-enyl)-3-(2-hydroxypropan-2-yl)-9,9-dimethyl-4-oxatricyclo[6.3.1.01,5]dodec-5-ene-7,12-dione	85392256	Click to see CC(=C)C(CC1=C2C3(CC(C(C(C1=O)(C3=O)C(=O)C4=CC=CC=C4)(C)C)C=CC(C)(C)O)CC(O2)C(C)(C)O)O	550.70	unknown	https://doi.org/10.1021/NP010310A
8-Benzoyl-6-(2-hydroxy-3-methylbut-3-enyl)-3-(2-hydroxypropan-2-yl)-9,9-dimethyl-10-(3-methylbut-2-enyl)-4-oxatricyclo[6.3.1.01,5]dodec-5-ene-7,12-dione	85116970	Click to see CC(=CCC1CC23CC(OC2=C(C(=O)C(C3=O)(C1(C)C)C(=O)C4=CC=CC=C4)CC(C(=C)C)O)C(C)(C)O)C	534.70	unknown	https://doi.org/10.1021/NP010310A
hyperibone K	44575719	Click to see CC(=CCC12CC3C(C(C1=O)(C(=O)C(C2=O)(C3(C)C)CC=C(C)C)C(=O)C4=CC=CC=C4)C=C(C)C)C	500.70	unknown	https://doi.org/10.1021/NP040024+
Ochrocarpinone C	10256066	Click to see	518.70	unknown	https://doi.org/10.1021/NP010310A
Propolone D	11114020	Click to see	518.70	unknown	https://doi.org/10.1021/NP010310A https://doi.org/10.1021/NP040024+
> Organoheterocyclic compounds / Benzopyrans / 1-benzopyrans / Xanthones
(1R,2R)-1,4,8,10-tetrahydroxy-2-(2-hydroxypropan-2-yl)-1,2-dihydrofuro[3,2-a]xanthen-11-one	162980382	Click to see	360.30	unknown	https://doi.org/10.1021/NP040024+
(1S,2S)-1,4,8,10-tetrahydroxy-2-(2-hydroxypropan-2-yl)-1,2-dihydrofuro[3,2-a]xanthen-11-one	162980381	Click to see	360.30	unknown	https://doi.org/10.1021/NP040024+
(2R)-4,8,10-trihydroxy-2-(2-hydroxypropan-2-yl)-1,2-dihydrofuro[3,2-a]xanthen-11-one	162870165	Click to see CC(C)(C1CC2=C(O1)C(=CC3=C2C(=O)C4=C(C=C(C=C4O3)O)O)O)O	344.30	unknown	https://doi.org/10.1021/NP040024+
(2S)-4,8,10-trihydroxy-2-methoxy-1,2-dihydrofuro[3,2-a]xanthen-11-one	162870164	Click to see COC1CC2=C(O1)C(=CC3=C2C(=O)C4=C(C=C(C=C4O3)O)O)O	316.26	unknown	https://doi.org/10.1021/NP040024+
1,3,5,6-Tetrahydroxyxanthone	5479774	Click to see C1=CC(=C(C2=C1C(=O)C3=C(C=C(C=C3O2)O)O)O)O	260.20	unknown	https://doi.org/10.1021/NP040024+
1,3,7-Trihydroxyxanthone	5281635	Click to see	244.20	unknown	https://doi.org/10.1021/NP040024+
1,7-Dihydroxy-4-methoxyxanthone	5465785	Click to see	258.23	unknown	https://doi.org/10.1021/NP040024+
Euxanthone	5281631	Click to see	228.20	unknown	https://doi.org/10.1021/NP040024+
hyperxanthone A	11772291	Click to see CC(C)(C1CC2=C(O1)C(=CC3=C2C(=O)C4=C(C=C(C=C4O3)O)O)O)O	344.30	unknown	https://doi.org/10.1021/NP040024+
> Organoheterocyclic compounds / Benzopyrans / 1-benzopyrans / Xanthones / 8-prenylated xanthones
1,3,6,7-Tetrahydroxy-8-prenylxanthone	15307924	Click to see CC(=CCC1=C(C(=CC2=C1C(=O)C3=C(C=C(C=C3O2)O)O)O)O)C	328.30	unknown	https://doi.org/10.1021/NP040024+
2,3,6,8-tetrahydroxy-1-[(2R)-2-hydroxy-3-methylbut-3-enyl]xanthen-9-one	162914967	Click to see	344.30	unknown	https://doi.org/10.1021/NP040024+
2,6,8-trihydroxy-1-[(2R)-2-hydroxy-3-methylbut-3-enyl]xanthen-9-one	162936267	Click to see	328.30	unknown	https://doi.org/10.1021/NP040024+
2,6,8-trihydroxy-1-[(2S)-2-hydroxy-3-methylbut-3-enyl]xanthen-9-one	162936268	Click to see CC(=C)C(CC1=C(C=CC2=C1C(=O)C3=C(C=C(C=C3O2)O)O)O)O	328.30	unknown	https://doi.org/10.1021/NP040024+
hyperxanthone C	11302345	Click to see CC(=C)C(CC1=C(C(=CC2=C1C(=O)C3=C(C=C(C=C3O2)O)O)O)O)O	344.30	unknown	https://doi.org/10.1021/NP040024+
hyperxanthone D	11450273	Click to see CC(=C)C(CC1=C(C=CC2=C1C(=O)C3=C(C=C(C=C3O2)O)O)O)O	328.30	unknown	https://doi.org/10.1021/NP040024+
> Organoheterocyclic compounds / Benzopyrans / 1-benzopyrans / Xanthones / Pyranoxanthones
hyperxanthone E	11151593	Click to see CC1(CCC2=C(O1)C(=CC3=C2C(=O)C4=C(C=C(C=C4O3)O)O)O)C	328.30	unknown	https://doi.org/10.1021/NP040024+
Toxyloxanthone B	14886044	Click to see	326.30	unknown	https://doi.org/10.1021/NP040024+
> Organoheterocyclic compounds / Pyrans / Pyranones and derivatives
Pestalotiopyrone K	71733427	Click to see CC(=CC(=O)OCC(C(COC(=O)C)O)O)C1=CC(=CC(=O)O1)OC	356.32	unknown	https://doi.org/10.1021/NP040024+
> Phenylpropanoids and polyketides / Flavonoids / Biflavonoids and polyflavonoids
Biapigenin	10414856	Click to see	538.50	unknown	https://doi.org/10.1021/NP040024+
> Phenylpropanoids and polyketides / Flavonoids / Flavones
Luteolin	5280445	Click to see C1=CC(=C(C=C1C2=CC(=O)C3=C(C=C(C=C3O2)O)O)O)O	286.24	unknown	https://doi.org/10.1021/NP040024+
> Phenylpropanoids and polyketides / Flavonoids / Flavones / Flavonols
Myricetin	5281672	Click to see C1=C(C=C(C(=C1O)O)O)C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)O	318.23	unknown	https://doi.org/10.1021/NP040024+
Quercetin	5280343	Click to see	302.23	unknown	https://doi.org/10.1021/NP040024+
> Phenylpropanoids and polyketides / Flavonoids / Flavonoid glycosides / Flavonoid O-glycosides / Flavonoid-3-O-glycosides
2-(3,4-Dihydroxyphenyl)-5,7-Dihydroxy-3-(3,4,5-Trihydroxy-6-(Hydroxymethyl)Oxan-2-Yl)Oxychromen-4-One	5378597	Click to see	464.40	unknown	https://doi.org/10.1021/NP040024+
2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3-[(2R,3R,4S,5S)-3,4,5-trihydroxyoxan-2-yl]oxychromen-4-one	5317847	Click to see	434.30	unknown	https://doi.org/10.1021/NP040024+
2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3-[(2S,3S,4R,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-4-one	51521831	Click to see C1=CC(=C(C=C1C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)OC4C(C(C(C(O4)CO)O)O)O)O)O	464.40	unknown	https://doi.org/10.1021/NP040024+
2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3-[(2S,3S,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxychromen-4-one	26339717	Click to see CC1C(C(C(C(O1)OC2=C(OC3=CC(=CC(=C3C2=O)O)O)C4=CC(=C(C=C4)O)O)O)O)O	448.40	unknown	https://doi.org/10.1021/NP040024+
2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-1-benzopyran-3-yl 6-deoxyhexopyranoside	5353915	Click to see	448.40	unknown	https://doi.org/10.1021/NP040024+
3-(beta-D-Arabinopyranosyloxy)-5,7-dihydroxy-2-(3,4-dihydroxyphenyl)-4H-1-benzopyran-4-one	21722017	Click to see C1C(C(C(C(O1)OC2=C(OC3=CC(=CC(=C3C2=O)O)O)C4=CC(=C(C=C4)O)O)O)O)O	434.30	unknown	https://doi.org/10.1021/NP040024+
3-[(2S,3R,4S,5S)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-2-(3,4-dihydroxyphenyl)-5,7-dihydroxychromen-4-one	12308708	Click to see	434.30	unknown	https://doi.org/10.1021/NP040024+
5,7-Dihydroxy-3-(3,4,5-Trihydroxy-6-Methyloxan-2-Yl)Oxy-2-(3,4,5-Trihydroxyphenyl)Chromen-4-One	5352000	Click to see	464.40	unknown	https://doi.org/10.1021/NP040024+
5,7-dihydroxy-3-[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy-2-(3,4,5-trihydroxyphenyl)chromen-4-one	16103933	Click to see	464.40	unknown	https://doi.org/10.1021/NP040024+
5,7-dihydroxy-3-[(2S,3S,4S,5S,6R)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy-2-(3,4,5-trihydroxyphenyl)chromen-4-one	40491193	Click to see	464.40	unknown	https://doi.org/10.1021/NP040024+
acs.jmedchem.1c00409_ST.657	5878729	Click to see	434.30	unknown	https://doi.org/10.1021/NP040024+
Avicularin	5490064	Click to see C1=CC(=C(C=C1C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)OC4C(C(C(O4)CO)O)O)O)O	434.30	unknown	https://doi.org/10.1021/NP040024+
Avicularine	12308704	Click to see	434.30	unknown	https://doi.org/10.1016/S0378-8741(03)00112-0
Guaijaverin	5481224	Click to see	434.30	unknown	https://doi.org/10.1021/NP040024+
Hyperoside	5281643	Click to see C1=CC(=C(C=C1C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)OC4C(C(C(C(O4)CO)O)O)O)O)O	464.40	unknown	https://doi.org/10.1021/NP040024+
Myricitrin	5281673	Click to see	464.40	unknown	https://doi.org/10.1021/NP040024+
Quercitrin	5280459	Click to see CC1C(C(C(C(O1)OC2=C(OC3=CC(=CC(=C3C2=O)O)O)C4=CC(=C(C=C4)O)O)O)O)O	448.40	unknown	https://doi.org/10.1021/NP040024+
> Phenylpropanoids and polyketides / Isoflavonoids / Isoflav-2-enes / Isoflavones
Genistein	5280961	Click to see	270.24	unknown	https://doi.org/10.1021/NP040024+
> Phenylpropanoids and polyketides / Macrolides and analogues
Swinholide a	10964334	Click to see CC1CC(CC(O1)CCC(C)C(C(C)C2C(C(CC(C(C(CC3CC=CC(O3)CC(CC=C(C=CC(=O)OC(C(C(CC(C(C(CC4CC=CC(O4)CC(CC=C(C=CC(=O)O2)C)O)OC)C)O)O)C)C(C)C(C(C)CCC5CC(CC(O5)C)OC)O)C)O)OC)C)O)O)C)O)OC	1389.90	unknown	via CMAUP database

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Hypericum scabrum

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