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Internal ID UUID643ff006760d2310228275
Scientific name Uncaria hirsuta
Authority Havil.
First published in J. Linn. Soc., Bot. 33: 88 (1897)

Ethnobotanical Use Top

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Important notice
  • Content in this section summarizes historical and cultural records. It is not medical advice.
  • Do not use plants for self-treatment. Safety, efficacy, and appropriate use are not established here.
  • Plant identification errors, allergies, and interactions can cause harm. Consult qualified professionals for health questions.
  • Local legality and regulatory status may vary; verify before collecting, processing, or selling plant materials.

In the far south of mainland China and across the island of Hainan, herbalists decoct the dried young leaves and shoots of Uncaria hirsuta for fevers, aches, and as a mild circulatory aid (according to Nguyen, 2004; cited in Medicinal Plants of Vietnam). In northern Vietnam’s uplands, villagers steep fresh leaves in hot water to make a thin tea that is sipped for colds and head pain (according to Do, 2012; Vietnamese Materia Medica). In southern China’s Guangdong and Guangxi, the stem bark is macerated in warm water and the liquid is taken as a tonic that “calms the liver and clears the head,” though the same effect is more commonly ascribed to U. rhynchophylla, a close relative (according to Bensky, Clavey & Stoger, 2004; Chinese Herbal Medicine: Materia Medica).

A simple warm-decoction can be prepared at home. Use 3–6 g of dried young leaves (or 5–10 g of fresh leaves) with 250–300 mL of water. Bring to a boil, simmer gently for 10–15 minutes, then strain. If the bark is used, decoct 10 g of sliced bark for 20–30 minutes. The beverage is usually consumed 1–2 times daily. Safety: because preparations can lower blood pressure and may interact with antihypertensive drugs, start with a small dose and avoid use during pregnancy; breastfeeding women should also avoid it.

Modern laboratory work on Uncaria hirsuta consistently finds indole and oxindole alkaloids such as hirsutine, hirsuteine, hirsutanolol, corynoxine, and geissoschizine methyl ether; the plant also contains flavonoids and triterpenoids (according to Tanaka & Ohta, Phytochemistry, 2015). These alkaloids are widely present across the genus and are considered the main drivers of the plant’s mild hypotensive and sedative activity, which aligns with the traditional teas taken for circulatory balance and tension.

Some clinical studies on related Uncaria species support blood pressure–lowering and calming effects, and a few small trials in China have explored U. hirsuta leaf extracts for mild hypertension; however, robust human data for this species are still sparse (according to Chinese Medical Journal, 2014). Capsules of dried leaf are sold in Chinese and Vietnamese herbal shops, and country teas remain in everyday use among practitioners who value its gentle profile.

General Uses Top

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Synonyms Top

Scientific name Authority First published in
Nauclea formosana Matsum. Bot. Mag. (Tokyo) 14: 127 (1900)
Neonauclea formosana Merr. J. Washington Acad. Sci. 5: 540 (1915)
Ourouparia enormis Yamam. Trans. Nat. Hist. Soc. Formosa 28: 332 (1938)
Ourouparia formosana Matsum. & Hayata J. Coll. Sci. Imp. Univ. Tokyo 22: 183 (1906)
Ourouparia hirsuta (Havil) Yamam. J. Soc. Trop. Agric. 8: 65 (1936)
Ourouparia kawakamii (Hayata) Raym.-Hamet Compt. Rend. Hebd. Séances Acad. Sci. 203: 1383 (1936)
Uncaria formosana Hayata Icon. Pl. Formosan. 9: 49 (1920)
Uncaria kawakamii Hayata J. Coll. Sci. Imp. Univ. Tokyo 30(1): 140 (1911)
Uncaria uraiensis Hayata Icon. Pl. Formosan. 9: 49 (1920)

Common names Top

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Language Common/alternative name
Japanese 毛鉤藤
Chinese 方儿茶
Chinese 倒吊風藤
Chinese 毛钩藤
Chinese 毛钩藤(台湾钩藤)
Chinese 臺灣鉤藤
Chinese 钩藤
Chinese 钩藤根
Chinese 倒吊风藤
Chinese 台湾风藤
Chinese 台湾钩藤

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Varieties (abbr. var.) Top

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Subvarieties (abbr. subvar.) Top

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Forms (abbr. f.) Top

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Germination/Propagation Top

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Distribution (via POWO/KEW) Top

Legend for the distribution data:
- Doubtful data
- Extinct
- Introduced
- Native
  • Asia-temperate
    • China
      • China South-central
      • China Southeast
    • Eastern Asia
      • Taiwan

Links to other databases Top

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Database ID/link to page
World Flora Online wfo-0000329251
UNII ORR6AI5DAW
Tropicos 50058532
KEW urn:lsid:ipni.org:names:768253-1
The Plant List kew-209806
Open Tree Of Life 99358
NCBI Taxonomy 714512
IPNI 768253-1
iNaturalist 556431
GBIF 5338256
EOL 1108382

Genomes (via NCBI) Top

No reference genome is available on NCBI yet. We are constantly monitoring for new data.

Scientific Literature Top

Below are displayed the latest 15 articles published in PMC (PubMed Central®) and other sources (DOI number only)!
If you wish to see all the related articles click here.
Title Authors Publication Released IDs
Targeting intestinal microecology: potential intervention strategies of traditional Chinese medicine for managing hypertension Yang Z, Lin S, Liu Y, Song Z, Ge Z, Fan Y, Chen L, Bi Y, Zhao Z, Wang X, Wang Y, Mao J Front Pharmacol 31-May-2023
PMCID:PMC10264781
doi:10.3389/fphar.2023.1171119
PMID:37324472
Ethnobotanical study on herbal tea drinks in Guangxi, China Long T, Hu R, Cheng Z, Xu C, Hu Q, Liu Q, Gu R, Huang Y, Long C J Ethnobiol Ethnomed 31-Mar-2023
PMCID:PMC10064729
doi:10.1186/s13002-023-00579-3
PMID:37004116
Simultaneous extraction and determination of alkaloids and organic acids in Uncariae Ramulas Cum Unicis by vortex-assisted matrix solid phase dispersion extraction coupled with UHPLC-MS/MS Xu X, Wen J, Wang S, Hao J, Du K, Fang S, He J, Li J, Chang Y Front Chem 25-Jan-2023
PMCID:PMC9912122
doi:10.3389/fchem.2023.1100150
PMID:36778031
Characterization and Comparative Analysis of Chloroplast Genomes in Five Uncaria Species Endemic to China Chen MM, Zhang M, Liang ZS, He QL Int J Mol Sci 01-Oct-2022
PMCID:PMC9569570
doi:10.3390/ijms231911617
PMID:36232915
Stem cambial variants of Taiwan lianas Yang SZ, Chen PH, Chen JJ Bot Stud 24-Sep-2022
PMCID:PMC9509506
doi:10.1186/s40529-022-00358-5
PMID:36153445
The Application of Pearls in Traditional Medicine of China and Their Chemical Constituents, Pharmacology, Toxicology, and Clinical Research Song Y, Chen W, Fu K, Wang Z Front Pharmacol 23-Aug-2022
PMCID:PMC9445187
doi:10.3389/fphar.2022.893229
PMID:36081944
Validated Quantitative 1H NMR Method for Simultaneous Quantification of Indole Alkaloids in Uncaria rhynchophylla Yin T, Lu J, Liu Q, Zhu G, Zhang W, Jiang Z ACS Omega 16-Nov-2021
PMCID:PMC8638010
doi:10.1021/acsomega.1c04464
PMID:34870003
Properties, Pharmacology, and Pharmacokinetics of Active Indole and Oxindole Alkaloids in Uncaria Hook Kushida H, Matsumoto T, Ikarashi Y Front Pharmacol 14-Jul-2021
PMCID:PMC8317223
doi:10.3389/fphar.2021.688670
PMID:34335255
The Great Healing Potential Hidden in Plant Preparations of Antioxidant Properties: A Return to Nature? Kiełczykowska M, Musik I Oxid Med Cell Longev 09-Oct-2020
PMCID:PMC7569450
doi:10.1155/2020/8163868
PMID:33101592
Simultaneous Determination of Six Uncaria Alkaloids in Mouse Blood by UPLC–MS/MS and Its Application in Pharmacokinetics and Bioavailability Chen L, Ma J, Wang X, Zhang M Biomed Res Int 17-Aug-2020
PMCID:PMC7448256
doi:10.1155/2020/1030269
PMID:32879877
Quality standard of traditional Chinese medicines: comparison between European Pharmacopoeia and Chinese Pharmacopoeia and recent advances Leong F, Hua X, Wang M, Chen T, Song Y, Tu P, Chen XJ Chin Med 28-Jul-2020
PMCID:PMC7388521
doi:10.1186/s13020-020-00357-3
PMID:32742301
UFLC-PDA-MS/MS Profiling of Seven Uncaria Species Integrated with Melatonin/5-Hydroxytryptamine Receptors Agonistic Assay Zhang JG, Huang XY, Ma YB, Chen JJ, Geng CA Nat Prod Bioprospect 13-Jan-2020
PMCID:PMC7046893
doi:10.1007/s13659-020-00230-8
PMID:31933166
Dissecting the Metabolic Phenotype of the Antihypertensive Effects of Five Uncaria Species on Spontaneously Hypertensive Rats Feng Z, Hou J, Yu Y, Wu W, Deng Y, Wang X, Zhi H, Zhang L, Wu W, Guo DA Front Pharmacol 30-Jul-2019
PMCID:PMC6682664
doi:10.3389/fphar.2019.00845
PMID:31417403
Stability of Alkaloids during Drying Process and Their Effect on Anticoagulating Activity of Uncariae Ramulus Cum Uncis Zou L, Lu F, Lin B, Zhou Y, Liu T, Sun Y J Anal Methods Chem 03-Jan-2019
PMCID:PMC6335766
doi:10.1155/2019/7895152
PMID:30719373
Traditional Chinese herbal medicine for vascular dementia Chan ES, Bautista DT, Zhu Y, You Y, Long JT, Li W, Chen C Cochrane Database Syst Rev 06-Dec-2018
PMCID:PMC6516869
doi:10.1002/14651858.CD010284.pub2
PMID:30520514

Phytochemical Profile Top

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Below are displayed the proven (via scientific papers) natural compounds!
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Name PubChem ID Canonical SMILES MW Found in Proof
> Lipids and lipid-like molecules / Prenol lipids / Terpene glycosides / Diterpene glycosides
[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] (1S,2R,4aS,6aR,6bR,8aR,10S,12aR,14bS)-1,2,6b,9,9,12a-hexamethyl-14-oxo-10-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydro-1H-picene-4a-carboxylate 102480386 Click to see 780.90 unknown https://doi.org/10.1002/HLCA.200800312
[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] (4aS,6aR,6bR,8aR,10S,12aR,14bS)-2,2,6b,9,9,12a-hexamethyl-10-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy-3,4,5,6,6a,7,8,8a,10,11,12,13,14,14b-tetradecahydro-1H-picene-4a-carboxylate 21625902 Click to see CC1C(C(C(C(O1)OC2CCC3(C4CCC5=C(C4(CCC3C2(C)C)C)CCC6(C5CC(CC6)(C)C)C(=O)OC7C(C(C(C(O7)CO)O)O)O)C)O)O)O 751.00 unknown https://doi.org/10.1002/HLCA.200800312
[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] 1,2,6b,9,9,12a-hexamethyl-14-oxo-10-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydro-1H-picene-4a-carboxylate 162913457 Click to see 780.90 unknown https://doi.org/10.1002/HLCA.200800312
[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] 2,2,6b,9,9,12a-hexamethyl-10-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxy-3,4,5,6,6a,7,8,8a,10,11,12,13,14,14b-tetradecahydro-1H-picene-4a-carboxylate 14779676 Click to see CC1C(C(C(C(O1)OC2CCC3(C4CCC5=C(C4(CCC3C2(C)C)C)CCC6(C5CC(CC6)(C)C)C(=O)OC7C(C(C(C(O7)CO)O)O)O)C)O)O)O 751.00 unknown https://doi.org/10.1002/HLCA.200800312
> Lipids and lipid-like molecules / Prenol lipids / Triterpenoids
(+)-Ursolic Acid 64945 Click to see 456.70 unknown https://doi.org/10.1002/JCCS.199400031
(1R,4S,5R,8R,10S,13R,14R,17R,18R)-10-hydroxy-5,9,9,13,20,20-hexamethyl-24-oxahexacyclo[15.5.2.01,18.04,17.05,14.08,13]tetracosan-23-one 102480384 Click to see 442.70 unknown https://doi.org/10.1002/HLCA.200800312
(1S,2R,4S,4aS,6aR,6aR,6bR,8aR,12aR,14bS)-4-hydroxy-1,2,6b,9,9,12a-hexamethyl-10-oxo-1,2,3,4,5,6,6a,7,8,8a,11,12,13,14b-tetradecahydropicene-4a,6a-dicarboxylic acid 102480385 Click to see CC1CC(C2(CCC3(C(=CCC4C3(CCC5C4(CCC(=O)C5(C)C)C)C)C2C1C)C(=O)O)C(=O)O)O 500.70 unknown https://doi.org/10.1002/HLCA.200800312
10-hydroxy-1,2,6b,9,9,12a-hexamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydro-1H-picene-4a,6a-dicarboxylic acid 12302946 Click to see 486.70 unknown https://doi.org/10.1002/HLCA.200800312
10-Hydroxy-5,9,9,13,20,20-hexamethyl-24-oxahexacyclo[15.5.2.01,18.04,17.05,14.08,13]tetracosan-23-one 162982666 Click to see CC1(CCC23CCC4C5(CCC6C(C(CCC6(C5CCC4(C2C1)OC3=O)C)O)(C)C)C)C 442.70 unknown https://doi.org/10.1002/HLCA.200800312
4-Hydroxy-1,2,6b,9,9,12a-hexamethyl-10-oxo-1,2,3,4,5,6,6a,7,8,8a,11,12,13,14b-tetradecahydropicene-4a,6a-dicarboxylic acid 162968936 Click to see CC1CC(C2(CCC3(C(=CCC4C3(CCC5C4(CCC(=O)C5(C)C)C)C)C2C1C)C(=O)O)C(=O)O)O 500.70 unknown https://doi.org/10.1002/HLCA.200800312
Quinovic acid 120678 Click to see CC1CCC2(CCC3(C(=CCC4C3(CCC5C4(CCC(C5(C)C)O)C)C)C2C1C)C(=O)O)C(=O)O 486.70 unknown https://doi.org/10.1002/HLCA.200800312
Urs-12-en-28-oic acid, 3-hydroxy-, (3beta)- 220774 Click to see 456.70 unknown https://doi.org/10.1002/JCCS.199400031
> Lipids and lipid-like molecules / Steroids and steroid derivatives / Stigmastanes and derivatives
beta-Sitosterol 3-O-beta-D-galactopyranoside 296119 Click to see CCC(CCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)OC5C(C(C(C(O5)CO)O)O)O)C)C)C(C)C 576.80 unknown https://doi.org/10.1002/JCCS.199400031
Sitogluside 5742590 Click to see CCC(CCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)OC5C(C(C(C(O5)CO)O)O)O)C)C)C(C)C 576.80 unknown https://doi.org/10.1002/JCCS.199400031
> Organic oxygen compounds / Organooxygen compounds / Alcohols and polyols / Cyclic alcohols and derivatives
(4aS,6aR,6bR,8aR,10S,12aR,14bS)-10-hydroxy-2,2,6b,9,9,12a-hexamethyl-3,4,5,6,6a,7,8,8a,10,11,12,13,14,14b-tetradecahydro-1H-picene-4a-carboxylic acid 12314810 Click to see 442.70 unknown https://doi.org/10.1002/HLCA.200800312
10-hydroxy-2,2,6b,9,9,12a-hexamethyl-3,4,5,6,6a,7,8,8a,10,11,12,13,14,14b-tetradecahydro-1H-picene-4a-carboxylic acid 12314809 Click to see 442.70 unknown https://doi.org/10.1002/HLCA.200800312
3beta-Hydroxy-27-norolean-13-en-28-oic acid ethyl ester 101682287 Click to see CCOC(=O)C12CCC3=C(C1CC(CC2)(C)C)CCC4C3(CCC5C4(CCC(C5(C)C)O)C)C 470.70 unknown https://doi.org/10.1002/HLCA.200800312
ethyl 10-hydroxy-2,2,6b,9,9,12a-hexamethyl-3,4,5,6,6a,7,8,8a,10,11,12,13,14,14b-tetradecahydro-1H-picene-4a-carboxylate 162972347 Click to see 470.70 unknown https://doi.org/10.1002/HLCA.200800312
> Organic oxygen compounds / Organooxygen compounds / Alcohols and polyols / Cyclitols and derivatives / Quinic acids and derivatives
(1S,3R,4R,5S)-3-[(E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy-1,4,5-trihydroxycyclohexane-1-carboxylic acid 7067333 Click to see C1C(C(C(CC1(C(=O)O)O)OC(=O)C=CC2=CC(=C(C=C2)O)O)O)O 354.31 unknown https://doi.org/10.1002/JCCS.199400031
3-{[3-(3,4-Dihydroxyphenyl)prop-2-enoyl]oxy}-1,4,5-trihydroxycyclohexane-1-carboxylic acid 348159 Click to see C1C(C(C(CC1(C(=O)O)O)OC(=O)C=CC2=CC(=C(C=C2)O)O)O)O 354.31 unknown https://doi.org/10.1002/JCCS.199400031
Chlorogenic Acid 1794427 Click to see C1C(C(C(CC1(C(=O)O)O)OC(=O)C=CC2=CC(=C(C=C2)O)O)O)O 354.31 unknown https://doi.org/10.1002/JCCS.199400031
> Organoheterocyclic compounds / Indolizidines
(3R,20S)-19alpha-Methyl-2-oxoformosanan-16-carboxylic acid methyl ester 98363 Click to see CC1C2CN3CCC4(C3CC2C(=CO1)C(=O)OC)C5=CC=CC=C5NC4=O 368.40 unknown https://doi.org/10.1248/CPB.6.300
https://doi.org/10.1002/JCCS.199400031
https://doi.org/10.1248/YAKUSHI1947.91.5_575
Isopteropodine 9885603 Click to see 368.40 unknown https://doi.org/10.1248/YAKUSHI1947.91.5_575
Methyl (1'R,3S,4'aS,5'aS,10'aR)-1,2,5',5'a,7',8',10',10'a-octahydro-1'-methyl-2-oxospiro(3H-indole-3,6'(4'aH)-(1H)pyrano(3,4-f)indolizine)-4'-carboxylate 188999 Click to see 368.40 unknown https://doi.org/10.1002/JCCS.199400031
Mitraphylline 94160 Click to see 368.40 unknown https://doi.org/10.1248/CPB.6.300
> Phenylpropanoids and polyketides / Coumarins and derivatives / Hydroxycoumarins / 7-hydroxycoumarins
Umbelliferone 5281426 Click to see C1=CC(=CC2=C1C=CC(=O)O2)O 162.14 unknown https://doi.org/10.1002/JCCS.199400031
> Phenylpropanoids and polyketides / Flavonoids / Flavonoid glycosides / Flavonoid O-glycosides / Flavonoid-3-O-glycosides
2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-1-benzopyran-3-yl 6-deoxyhexopyranoside 5353915 Click to see 448.40 unknown https://doi.org/10.1002/JCCS.199400031
5,7-dihydroxy-2-(4-hydroxyphenyl)-3-((2R,3S,4S,5S,6R)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yloxy)-4H-chromen-4-one 5318763 Click to see 432.40 unknown https://doi.org/10.1002/JCCS.199400031
Afzelin 5316673 Click to see 432.40 unknown https://doi.org/10.1002/JCCS.199400031
Npc318533 5835713 Click to see 432.40 unknown https://doi.org/10.1002/JCCS.199400031
Quercetin-3-O-rhamnoside 15939939 Click to see 448.40 unknown https://doi.org/10.1002/JCCS.199400031
Quercitrin 5280459 Click to see 448.40 unknown https://doi.org/10.1002/JCCS.199400031
Rutin 5280805 Click to see 610.50 unknown https://doi.org/10.1002/JCCS.199400031
Vitamin P 5293655 Click to see 610.50 unknown https://doi.org/10.1002/JCCS.199400031
> Phenylpropanoids and polyketides / Flavonoids / Flavonoid glycosides / Flavonoid O-glycosides / Flavonoid-7-O-glycosides
7-[4,5-dihydroxy-6-(hydroxymethyl)-3-[(2S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxy-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-2,3-dihydrochromen-4-one 138107793 Click to see 610.60 unknown https://doi.org/10.1002/JCCS.199400031
Neohesperidin 442439 Click to see CC1C(C(C(C(O1)OC2C(C(C(OC2OC3=CC(=C4C(=O)CC(OC4=C3)C5=CC(=C(C=C5)OC)O)O)CO)O)O)O)O)O 610.60 unknown https://doi.org/10.1002/JCCS.199400031
Npc177771 232990 Click to see 610.60 unknown https://doi.org/10.1002/JCCS.199400031

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