(+)-Intermedine

Details

• Internal ID: 8b4795fd-ce2f-4726-b7e1-17a630595db3
• Taxonomy: Alkaloids and derivatives
• IUPAC Name: [(7R,8R)-7-hydroxy-5,6,7,8-tetrahydro-3H-pyrrolizin-1-yl]methyl (2S)-2-hydroxy-2-[(1R)-1-hydroxyethyl]-3-methylbutanoate
• InChI: InChI=1S/C15H25NO5/c1-9(2)15(20,10(3)17)14(19)21-8-11-4-6-16-7-5-12(18)13(11)16/h4,9-10,12-13,17-18,20H,5-8H2,1-3H3/t10-,12-,13-,15+/m1/s1
• InChI Key: SFVVQRJOGUKCEG-OPQSFPLASA-N
• Popularity: 893 references in papers

Physical and Chemical Properties

• Molecular Formula: C₁₅H₂₅NO₅
• Molecular Weight: 299.36 g/mol
• Exact Mass: 299.17327290 g/mol
• Topological Polar Surface Area (TPSA): 90.20 Ų
• XlogP: -0.40
• Atomic LogP (AlogP): -0.33
• H-Bond Acceptor: 6
• H-Bond Donor: 3
• Rotatable Bonds: 5

Synonyms

• 10285-06-0
• (+)-Intermedine
• Intermedinum
• Intermedina
• 9-(+)-Trachelanthylretronecine
• DLC9FEP81A
• INTERMEDINE, (+)-
• CHEBI:5941
• [(7R,8R)-7-hydroxy-5,6,7,8-tetrahydro-3H-pyrrolizin-1-yl]methyl (2S)-2-hydroxy-2-[(1R)-1-hydroxyethyl]-3-methylbutanoate
• Butanoic acid, 2,3-dihydroxy-2-(1-methylethyl)-, (2,3,5,7a-tetrahydro-1-hydroxy-1H-pyrrolizin-7-yl)methyl ester, (1R-(1alpha,7(2S*,3R*),7abeta))-
• [(1R,7aR)-1-hydroxy-2,3,5,7a-tetrahydro-1H-pyrrolo[1,2-a]pyrrol-7-yl]methyl (2S,3R)-2,3-dihydroxy-2-isopropylbutanoate
• DTXSID001020073
• ((1R,7aR)-1-hydroxy-2,3,5,7a-tetrahydro-1H-pyrrolo(1,2-a)pyrrol-7-yl)methyl (2S,3R)-2,3-dihydroxy-2-isopropylbutanoate
• ((7R,8R)-7-hydroxy-5,6,7,8-tetrahydro-3H-pyrrolizin-1-yl)methyl (2S)-2-hydroxy-2-((1R)-1-hydroxyethyl)-3-methylbutanoate
• RefChem:40105
• alpha-melanotropin (sheep)
• DTXCID101477916
• Active principle of the pars intermedia of the pituitary
• alpha-Melanotropin (human)
• alpha-Melanotropin (ox)
• Intermedin
• Melanotropin
• Melanotropin alpha
• Melantropin
• N-acetyl-acth(1-13)-amide
• OVF025LA77
• Valinamide, acetyl-l-seryl-l-tyrosyl-l-seryl-l-methionyl-l-glutamyl-l-histidyl-l-phenylalanyl-l-arginyl-l-tryptophyl-glycyl-l-lysyl-l-prolyl-, l-
• MFCD09970420
• 3'-EPI-LYCOPSAMINE
• C15H25NO5
• 1414-01-3
• UNII-DLC9FEP81A
• Butanoic acid, 2,3-dihydroxy-2-(1-methylethyl)-, [(1R,7aR)-2,3,5,7a-tetrahydro-1-hydroxy-1H-pyrrolizin-7-yl]methyl ester, (2S,3R)-; Butanoic acid, 2,3-dihydroxy-2-(1-methylethyl)-, (2,3,5,7a-tetrahydro-1-hydroxy-1H-pyrrolizin-7-yl)methyl ester, [1R-[1a,7(2S*,3R*),7ass]]-; Intermedine (7CI,8CI); (+)-Intermedine; 3'-epi-Lycopsamine
• Intermedine, HPLC Grade
• SCHEMBL23464
• (+)-Intermedine (Standard)
• orb1692015
• MSK14165
• Intermedine 100 microg/mL in Water
• AKOS040756430
• HY-113845R
• (2S,3R)-2,3-Dihydroxy-2-(1-methylethyl)butanoic Acid [(1R,7aR)-2,3,5,7a-Tetrahydro-1-hydroxy-1H-pyrrolizin-7-yl]methyl Ester
• Butanoic acid, 2,3-dihydroxy-2-(1-methylethyl)-, ((1R,7aR)-2,3,5,7a-tetrahydro-1-hydroxy-1H-pyrrolizin-7-yl)methyl ester, (2S,3R)-
• DA-54348
• MS-24309
• XI161638
• HY-113845
• CS-0062945
• NS00067002
• G13669
• Q27106936
• ((1R,7aR)-1-hydroxy-2,3,5,7a-tetrahydro-1H-pyrrolizin-7-yl)methyl (2S,3R)-2,3-dihydroxy-2-isopropylbutanoate
• [(7R,8R)-7-hydroxy-5,6,7,8-tetrahydro-3H-pyrrolizin-1-yl]methyl (2S)-2-hydroxy-2-[(1R)-1-hydroxyethyl]-3-methyl-butanoate
• BUTANOIC ACID, 2,3-DIHYDROXY-2-(1-METHYLETHYL)-, (2,3,5,7A-TETRAHYDRO-1-HYDROXY-1H-PYRROLIZIN-7-YL)METHYL ESTER, (1R-(1.ALPHA.,7(2S*,3R*),7A.BETA.))-

2D Structure

ADMET Properties (via admetSAR 2)

Target	Value	Probability (raw)	Probability (%)
Human Intestinal Absorption	+	0.8806	88.06%
Caco-2	+	0.5995	59.95%
Blood Brain Barrier	-	0.5000	50.00%
Human oral bioavailability	-	0.7571	75.71%
Subcellular localzation	Mitochondria	0.6994	69.94%
OATP2B1 inhibitior	-	0.8545	85.45%
OATP1B1 inhibitior	+	0.9088	90.88%
OATP1B3 inhibitior	+	0.9420	94.20%
MATE1 inhibitior	-	0.9200	92.00%
OCT2 inhibitior	-	0.9000	90.00%
BSEP inhibitior	-	0.6097	60.97%
P-glycoprotein inhibitior	-	0.9568	95.68%
P-glycoprotein substrate	-	0.5359	53.59%
CYP3A4 substrate	+	0.5630	56.30%
CYP2C9 substrate	-	0.8067	80.67%
CYP2D6 substrate	-	0.6570	65.70%
CYP3A4 inhibition	-	0.9801	98.01%
CYP2C9 inhibition	-	0.9020	90.20%
CYP2C19 inhibition	-	0.9040	90.40%
CYP2D6 inhibition	-	0.7063	70.63%
CYP1A2 inhibition	-	0.8746	87.46%
CYP2C8 inhibition	-	0.8620	86.20%
CYP inhibitory promiscuity	-	0.9646	96.46%
UGT catelyzed	+	0.6000	60.00%
Carcinogenicity (binary)	-	0.9800	98.00%
Carcinogenicity (trinary)	Danger	0.6767	67.67%
Eye corrosion	-	0.9817	98.17%
Eye irritation	-	0.9737	97.37%
Skin irritation	-	0.7514	75.14%
Skin corrosion	-	0.9160	91.60%
Ames mutagenesis	-	0.7500	75.00%
Human Ether-a-go-go-Related Gene inhibition	-	0.7496	74.96%
Micronuclear	+	0.8100	81.00%
Hepatotoxicity	+	1.0000	100.00%
skin sensitisation	-	0.8114	81.14%
Respiratory toxicity	+	0.6667	66.67%
Reproductive toxicity	+	0.7333	73.33%
Mitochondrial toxicity	+	0.8625	86.25%
Nephrotoxicity	-	0.6221	62.21%
Acute Oral Toxicity (c)	II	0.4619	46.19%
Estrogen receptor binding	-	0.6079	60.79%
Androgen receptor binding	-	0.5676	56.76%
Thyroid receptor binding	-	0.6094	60.94%
Glucocorticoid receptor binding	+	0.5955	59.55%
Aromatase binding	-	0.5690	56.90%
PPAR gamma	-	0.6117	61.17%
Honey bee toxicity	-	0.9047	90.47%
Biodegradation	-	0.5250	52.50%
Crustacea aquatic toxicity	-	0.6900	69.00%
Fish aquatic toxicity	-	0.6162	61.62%

Targets

Proven Targets:

No proven targets yet!

Predicted Targets (via Super-PRED):

CHEMBL ID	UniProt ID	Name	Probability	Model accuracy
CHEMBL3251	P19838	Nuclear factor NF-kappa-B p105 subunit	99.44%	96.09%
CHEMBL2581	P07339	Cathepsin D	97.19%	98.95%
CHEMBL4261	Q16665	Hypoxia-inducible factor 1 alpha	95.34%	85.14%
CHEMBL253	P34972	Cannabinoid CB2 receptor	93.20%	97.25%
CHEMBL4203	Q9HAZ1	Dual specificity protein kinase CLK4	89.12%	94.45%
CHEMBL1907603	Q05586	Glutamate NMDA receptor; GRIN1/GRIN2B	88.88%	95.89%
CHEMBL5619	P27695	DNA-(apurinic or apyrimidinic site) lyase	87.25%	91.11%
CHEMBL3137262	O60341	LSD1/CoREST complex	86.12%	97.09%
CHEMBL3060	Q9Y345	Glycine transporter 2	83.99%	99.17%
CHEMBL5608	Q16288	NT-3 growth factor receptor	81.67%	95.89%
CHEMBL2274	Q9H228	Sphingosine 1-phosphate receptor Edg-8	81.31%	100.00%
CHEMBL3108638	O15164	Transcription intermediary factor 1-alpha	80.31%	95.56%

Plants that contains it

• Ageratum houstonianum
• Amsinckia menziesii
• Anchusa officinalis
• Chromolaena odorata
• Cryptantha leiocarpa
• Eupatorium chinense
• Heliotropium keralense
• Lappula spinocarpos
• Lappula squarrosa
• Liatris punctata
• Lithospermum erythrorhizon
• Mertensia ciliata
• Mikania phaeoclados
• Oreocarya suffruticosa var. setosa
• Pulmonaria obscura
• Symphytum officinale
• Trichodesma africanum

Cross-Links

• PubChem: 114843
• NPASS: NPC221627
• LOTUS: LTS0204013
• wikiData: Q27106936