Cyclopamine
Internal ID | 5dd9694a-2444-4b7e-939f-bb2fb0607d31 |
Taxonomy | Lipids and lipid-like molecules > Steroids and steroid derivatives > Steroidal alkaloids > Jerveratrum-type alkaloids |
IUPAC Name | (3S,3'R,3'aS,6'S,6aS,6bS,7'aR,9R,11aS,11bR)-3',6',10,11b-tetramethylspiro[2,3,4,6,6a,6b,7,8,11,11a-decahydro-1H-benzo[a]fluorene-9,2'-3a,4,5,6,7,7a-hexahydro-3H-furo[3,2-b]pyridine]-3-ol |
SMILES (Canonical) | CC1CC2C(C(C3(O2)CCC4C5CC=C6CC(CCC6(C5CC4=C3C)C)O)C)NC1 |
SMILES (Isomeric) | C[C@H]1C[C@@H]2[C@H]([C@H]([C@]3(O2)CC[C@H]4[C@@H]5CC=C6C[C@H](CC[C@@]6([C@H]5CC4=C3C)C)O)C)NC1 |
InChI | InChI=1S/C27H41NO2/c1-15-11-24-25(28-14-15)17(3)27(30-24)10-8-20-21-6-5-18-12-19(29)7-9-26(18,4)23(21)13-22(20)16(27)2/h5,15,17,19-21,23-25,28-29H,6-14H2,1-4H3/t15-,17+,19-,20-,21-,23-,24+,25-,26-,27-/m0/s1 |
InChI Key | QASFUMOKHFSJGL-LAFRSMQTSA-N |
Popularity | 1,934 references in papers |
Molecular Formula | C27H41NO2 |
Molecular Weight | 411.60 g/mol |
Exact Mass | 411.313729551 g/mol |
Topological Polar Surface Area (TPSA) | 41.50 Ų |
XlogP | 3.50 |
Atomic LogP (AlogP) | 5.00 |
H-Bond Acceptor | 3 |
H-Bond Donor | 2 |
Rotatable Bonds | 0 |
11-Deoxojervine |
4449-51-8 |
11-Deoxyjervine |
Jervine, 11-deoxo- |
UNII-ZH658AJ192 |
CHEBI:4021 |
CHEMBL254129 |
DTXSID6043709 |
ZH658AJ192 |
NSC-734950 |
There are more than 10 synonyms. If you wish to see them all click here. |
![2D Structure of Cyclopamine 2D Structure of Cyclopamine](https://plantaedb.com/storage/docs/compounds/2023/07/cyclopamine.jpg)
Target | Value | Probability (raw) | Probability (%) |
---|---|---|---|
Human Intestinal Absorption | + | 0.9887 | 98.87% |
Caco-2 | + | 0.5478 | 54.78% |
Blood Brain Barrier | + | 0.6129 | 61.29% |
Human oral bioavailability | - | 0.5000 | 50.00% |
Subcellular localzation | Lysosomes | 0.4682 | 46.82% |
OATP2B1 inhibitior | - | 0.8601 | 86.01% |
OATP1B1 inhibitior | + | 0.8836 | 88.36% |
OATP1B3 inhibitior | + | 0.9573 | 95.73% |
MATE1 inhibitior | - | 0.9400 | 94.00% |
OCT2 inhibitior | - | 0.6000 | 60.00% |
BSEP inhibitior | + | 0.7284 | 72.84% |
P-glycoprotein inhibitior | - | 0.4847 | 48.47% |
P-glycoprotein substrate | + | 0.6191 | 61.91% |
CYP3A4 substrate | + | 0.6960 | 69.60% |
CYP2C9 substrate | - | 1.0000 | 100.00% |
CYP2D6 substrate | + | 0.4183 | 41.83% |
CYP3A4 inhibition | - | 0.9547 | 95.47% |
CYP2C9 inhibition | - | 0.9100 | 91.00% |
CYP2C19 inhibition | - | 0.8951 | 89.51% |
CYP2D6 inhibition | - | 0.8896 | 88.96% |
CYP1A2 inhibition | - | 0.9036 | 90.36% |
CYP2C8 inhibition | + | 0.6977 | 69.77% |
CYP inhibitory promiscuity | - | 0.8905 | 89.05% |
UGT catelyzed | + | 0.7000 | 70.00% |
Carcinogenicity (binary) | - | 0.9900 | 99.00% |
Carcinogenicity (trinary) | Non-required | 0.4810 | 48.10% |
Eye corrosion | - | 0.9858 | 98.58% |
Eye irritation | - | 0.9689 | 96.89% |
Skin irritation | - | 0.7124 | 71.24% |
Skin corrosion | - | 0.8928 | 89.28% |
Ames mutagenesis | - | 0.8400 | 84.00% |
Human Ether-a-go-go-Related Gene inhibition | + | 0.7397 | 73.97% |
Micronuclear | - | 0.6500 | 65.00% |
Hepatotoxicity | + | 0.7000 | 70.00% |
skin sensitisation | - | 0.7604 | 76.04% |
Respiratory toxicity | + | 0.6889 | 68.89% |
Reproductive toxicity | + | 0.9667 | 96.67% |
Mitochondrial toxicity | + | 0.9000 | 90.00% |
Nephrotoxicity | - | 0.7789 | 77.89% |
Acute Oral Toxicity (c) | III | 0.6697 | 66.97% |
Estrogen receptor binding | + | 0.6609 | 66.09% |
Androgen receptor binding | + | 0.7383 | 73.83% |
Thyroid receptor binding | + | 0.7116 | 71.16% |
Glucocorticoid receptor binding | + | 0.8531 | 85.31% |
Aromatase binding | + | 0.7206 | 72.06% |
PPAR gamma | + | 0.5860 | 58.60% |
Honey bee toxicity | - | 0.6918 | 69.18% |
Biodegradation | - | 0.8000 | 80.00% |
Crustacea aquatic toxicity | + | 0.6400 | 64.00% |
Fish aquatic toxicity | - | 0.5174 | 51.74% |
Proven Targets:
CHEMBL ID | UniProt ID | Name | Min activity | Assay type | Source |
---|---|---|---|---|---|
CHEMBL5971 | Q99835 | Smoothened homolog |
280 nM 12.4 nM 300 nM |
IC50 Kd IC50 |
PMID: 19091559
via Super-PRED PMID: 22268551 |
CHEMBL5602 | Q15465 | Sonic hedgehog protein |
600 nM 600 nM |
IC50 IC50 |
via Super-PRED
PMID: 23074541 |
Predicted Targets (via Super-PRED):
CHEMBL ID | UniProt ID | Name | Probability | Model accuracy |
---|---|---|---|---|
CHEMBL4681 | P42330 | Aldo-keto-reductase family 1 member C3 | 96.70% | 89.05% |
CHEMBL3251 | P19838 | Nuclear factor NF-kappa-B p105 subunit | 95.43% | 96.09% |
CHEMBL3137262 | O60341 | LSD1/CoREST complex | 95.31% | 97.09% |
CHEMBL226 | P30542 | Adenosine A1 receptor | 93.87% | 95.93% |
CHEMBL253 | P34972 | Cannabinoid CB2 receptor | 93.35% | 97.25% |
CHEMBL2996 | Q05655 | Protein kinase C delta | 92.05% | 97.79% |
CHEMBL241 | Q14432 | Phosphodiesterase 3A | 91.96% | 92.94% |
CHEMBL4803 | P29474 | Nitric-oxide synthase, endothelial | 91.18% | 86.00% |
CHEMBL5619 | P27695 | DNA-(apurinic or apyrimidinic site) lyase | 90.26% | 91.11% |
CHEMBL1994 | P08235 | Mineralocorticoid receptor | 90.26% | 100.00% |
CHEMBL1871 | P10275 | Androgen Receptor | 89.49% | 96.43% |
CHEMBL2288 | Q13526 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | 86.65% | 91.71% |
CHEMBL4203 | Q9HAZ1 | Dual specificity protein kinase CLK4 | 85.77% | 94.45% |
CHEMBL3045 | P05771 | Protein kinase C beta | 84.51% | 97.63% |
CHEMBL5852 | Q96P65 | Pyroglutamylated RFamide peptide receptor | 82.00% | 85.00% |
CHEMBL3108638 | O15164 | Transcription intermediary factor 1-alpha | 81.61% | 95.56% |
CHEMBL4793 | Q86TI2 | Dipeptidyl peptidase IX | 81.56% | 96.95% |
CHEMBL5966 | P55899 | IgG receptor FcRn large subunit p51 | 80.88% | 90.93% |
Below are displayed all the plants proven (via scientific papers) to contain this
compound!
To see more specific details click the taxa you are interested in.
To see more specific details click the taxa you are interested in.
Albizia julibrissin |
Garcinia quaesita |
Leptactina senegambica |
Veratrum californicum |
Veratrum dahuricum |
Veratrum grandiflorum |
PubChem | 442972 |
NPASS | NPC28280 |
ChEMBL | CHEMBL254129 |
LOTUS | LTS0078926 |
wikiData | Q3271319 |