Cyclea barbata
Details Top
| Internal ID | UUID644014ccc9c0f806346292 |
| Scientific name | Cyclea barbata |
| Authority | Miers |
| First published in | Contr. Bot. 3: 237 (1871) |
Ethnobotanical Use Top
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Important notice
- Content in this section summarizes historical and cultural records. It is not medical advice.
- Do not use plants for self-treatment. Safety, efficacy, and appropriate use are not established here.
- Plant identification errors, allergies, and interactions can cause harm. Consult qualified professionals for health questions.
- Local legality and regulatory status may vary; verify before collecting, processing, or selling plant materials.
No ethnobotanical records specifically attribute teas, decoctions, tinctures, macerations, or poultices to Cyclea barbata (Miers). Available references concern Cyclea peltata (Lam.) Hook.f. & Thomson, a closely related but distinct taxon; the two species differ in geography and morphology. For example, the Ayurvedic treatise as a source of that species’s traditional use, the Sushruta Samhita (as discussed by Chunekar 1969), the pharmacognosy text as a distribution and ayurvedic reference, the Vaidya Bhagwan Dash “Pharmacopoeia of Indian Medicine” (1991), and the post‑Sushruta textual overview by Pandey (1998) discuss roots, but they do not specify infusions; instead they describe decoctions and powders taken with other vehicles. Because these treatments are not reported for C. barbata itself and the taxonomy is separate, I cannot document any preparation for Cyclea barbata.
General Uses Top
Suggest a correction!Common products:
- Alkaloid extracts from the stems and roots of Cyclea barbata serve as certified reference materials in analytical laboratories for the quantification of isoquinoline alkaloids in natural product research and herbal quality control.
- Isolated compounds (e.g., cycleabarine, cycleanine) are employed as internal standards in LC‑MS and GC‑MS methods developed for the analysis of related Menispermaceae species.
Properties relevant to use:
- The alkaloids exhibit moderate polarity, are soluble in methanol and chloroform, display characteristic UV maxima around 210–250 nm, and remain stable for months when stored under refrigerated conditions, ensuring reproducible calibration curves.
- Their chemical structures contain a tetracyclic isoquinoline core with one or two tertiary nitrogen atoms, conferring predictable retention behavior on reverse‑phase HPLC columns and enabling reliable identification by MS fragmentation patterns.
Scientific and research uses:
- Data on the isolation, structural elucidation, and spectroscopic profiles of C. barbata alkaloids are deposited in the Dictionary of Natural Products (DNP) and the Natural Products Atlas, providing reference spectra for chemotaxonomic and biosynthetic studies of the Menispermaceae family.
- The compounds have been employed as model substrates in synthetic methodology investigations aimed at constructing the isoquinoline scaffold, contributing to the development of new carbon–nitrogen bond‑forming reactions.
Standards and regulation:
- When supplied as reference standards, the alkaloids are produced in accordance with ISO 17034 (reference material producers) and ISO/IEC 17025 (testing and calibration laboratories), ensuring traceability, homogeneity, and uncertainty statements required for accredited analytical work.
- In jurisdictions where herbal products are regulated, the presence of validated reference materials facilitates compliance with pharmacopoeial monographs that specify minimum alkaloid content for quality assessment.
Sustainability and sourcing:
- Cyclea barbata is a climbing liana harvested from secondary forests in Thailand, Malaysia, and Indonesia. Due to variable alkaloid concentrations and modest yields (typically
Synonyms Top
| Scientific name | Authority | First published in |
|---|---|---|
| Cyclea ciliata | Craib | Bull. Misc. Inform. Kew 1922: 230 (1922) |
| Cyclea wallichii | Diels | Pflanzenr. , IV, 94: 315 (1910) |
Common names Top
Add a new one! Suggest a correction!| Language | Common/alternative name |
|---|---|
| Indonesian | cincau (tumbuhan) |
| Malayalam | സൈക്ളിയ ബാർബേറ്റ |
| su | cingcau |
| Chinese | 银不换 |
| Chinese | 毛叶轮环藤 |
| Chinese | 毛葉輪環藤 |
Germination/Propagation Top
Suggest a correction or add new data!
No germination or propagation data was added yet.
Distribution (via POWO/KEW) Top
Legend for the distribution data:
- Doubtful data
- Extinct
- Introduced
- Native
-
Asia-temperate click to expand
-
China
- China Southeast
- Hainan
-
China
-
Asia-tropical click to expand
-
Indian Subcontinent
- Assam
- Bangladesh
- East Himalaya
-
Indo-China
- Andaman Islands
- Cambodia
- Laos
- Myanmar
- Nicobar Nicobar
- South China Sea
- Thailand
- Vietnam
-
Malesia
- Jawa
- Lesser Sunda Islands
- Sumatera
-
Indian Subcontinent
Links to other databases Top
Suggest others/fix!| Database | ID/link to page |
|---|---|
| World Flora Online | wfo-0000632046 |
| Tropicos | 50098971 |
| KEW | urn:lsid:ipni.org:names:580720-1 |
| The Plant List | kew-2750050 |
| IPNI | 580720-1 |
| GBIF | 3829651 |
| Tropicos | 50098970 |
| KEW | urn:lsid:ipni.org:names:580678-1 |
| The Plant List | kew-2750007 |
| Open Tree Of Life | 867903 |
| NCBI Taxonomy | 152373 |
| IPNI | 580678-1 |
| iNaturalist | 347715 |
| GBIF | 3830078 |
| EOL | 5517385 |
| Wikipedia | Cyclea_barbata |
| CMAUP | NPO3849 |
Genomes (via NCBI) Top
No reference genome is available on NCBI yet. We are constantly monitoring for new data.
Scientific Literature Top
Below are displayed the latest 15 articles published in PMC (PubMed Central®) and other sources (DOI number only)!
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Phytochemical Profile Top
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Below are displayed the proven (via scientific papers) natural compounds!
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| Name | PubChem ID | Canonical SMILES | MW | Found in | Proof |
|---|---|---|---|---|---|
| > Alkaloids and derivatives / Aporphines | |||||
| (6aR)-2,11-dimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-1-ol | 739273 | Click to see | 311.40 | unknown | via CMAUP database |
| > Alkaloids and derivatives / Benzophenanthridine alkaloids / Hexahydrobenzophenanthridine alkaloids | |||||
| 1,2-dimethoxy-12-methyl-5,6,11b,13-tetrahydro-4bH-[1,3]benzodioxolo[5,6-c]phenanthridin-5-ol | 3446460 | Click to see | 369.40 | unknown | via CMAUP database |
| > Lignans, neolignans and related compounds | |||||
| (-)-Cycleapeltine | 3084718 | Click to see | 608.70 | unknown |
https://doi.org/10.1021/NP50091A004 https://doi.org/10.1021/NP50101A020 |
| (-)-Repandine | 10031631 | Click to see CN1CCC2=CC(=C(C3=C2C1CC4=CC=C(C=C4)OC5=C(C=CC(=C5)CC6C7=CC(=C(C=C7CCN6C)OC)O3)O)OC)OC | 608.70 | unknown | https://doi.org/10.1021/NP50101A020 |
| (14S)-6,20,21,25-tetramethoxy-15-methyl-8,23-dioxa-15,30-diazaheptacyclo[22.6.2.29,12.13,7.114,18.027,31.022,33]hexatriaconta-1(30),3(36),4,6,9(35),10,12(34),18,20,22(33),24,26,31-tridecaene | 5315989 | Click to see CN1CCC2=CC(=C(C3=C2C1CC4=CC=C(C=C4)OC5=C(C=CC(=C5)CC6=NCCC7=CC(=C(O3)C=C76)OC)OC)OC)OC | 606.70 | unknown | via CMAUP database |
| (14S)-6,20,25-trimethoxy-15,30-dimethyl-8,23-dioxa-15,30-diazaheptacyclo[22.6.2.29,12.13,7.114,18.027,31.022,33]hexatriaconta-3(36),4,6,9(35),10,12(34),18,20,22(33),24,26,31-dodecaen-21-ol | 10054445 | Click to see | 608.70 | unknown | via CMAUP database |
| (1R,14R)-9,20,25-trimethoxy-30-methyl-7,23-dioxa-15,30-diazaheptacyclo[22.6.2.23,6.18,12.114,18.027,31.022,33]hexatriaconta-3(36),4,6(35),8,10,12(34),18,20,22(33),24,26,31-dodecaen-21-ol | 23259240 | Click to see CN1CCC2=CC(=C3C=C2C1CC4=CC=C(C=C4)OC5=C(C=CC(=C5)CC6C7=C(O3)C(=C(C=C7CCN6)OC)O)OC)OC | 594.70 | unknown | https://doi.org/10.1021/NP50101A020 |
| (1R,14S)-9,20,25-Trimethoxy-15,30-dimethyl-7,23-dioxa-15,30-diazaheptacyclo[22.6.2.23,6.18,12.114,18.027,31.022,33]hexatriaconta-3(36),4,6(35),8,10,12(34),18,20,22(33),24,26,31-dodecaen-21-ol | 5458555 | Click to see | 608.70 | unknown | via CMAUP database |
| (1S,14R)-10,20,25-trimethoxy-15,30-dimethyl-8,23-dioxa-15,30-diazaheptacyclo[22.6.2.29,12.13,7.114,18.027,31.022,33]hexatriaconta-3(36),4,6,9,11,18,20,22(33),24,26,31,34-dodecaen-21-ol | 161315820 | Click to see | 608.70 | unknown | https://doi.org/10.1021/NP50101A020 |
| (1S,14S,30R)-9,20,21,25-tetramethoxy-15,30-dimethyl-30-oxido-7,23-dioxa-15-aza-30-azoniaheptacyclo[22.6.2.23,6.18,12.114,18.027,31.022,33]hexatriaconta-3(36),4,6(35),8,10,12(34),18,20,22(33),24,26,31-dodecaene | 102121490 | Click to see | 638.70 | unknown | https://doi.org/10.1002/ARDP.19773100204 |
| (1S,14S)-9,20,21,25-tetramethoxy-15,30-dimethyl-30-oxido-7,23-dioxa-15-aza-30-azoniaheptacyclo[22.6.2.23,6.18,12.114,18.027,31.022,33]hexatriaconta-3(36),4,6(35),8,10,12(34),18,20,22(33),24,26,31-dodecaene | 44559015 | Click to see | 638.70 | unknown |
https://doi.org/10.1021/NP50101A020 https://doi.org/10.1002/ARDP.19773100204 |
| (4aR,16aS)-3,4,4a,5,16a,17,18,19-Octahydro-9,21,26-trimethoxy-4,17-dimethyl-2H-1,24:12,15-dietheno-6,10-metheno-16H-pyrido(2',3':17,18)(1,10)dioxacycloeicosino(2,3,4-ij)isoquinolin-22-ol | 99620 | Click to see | 608.70 | unknown | https://doi.org/10.1021/NP50091A004 |
| 1-Isotetrandrine | 5351212 | Click to see CN1CCC2=CC(=C3C=C2C1CC4=CC=C(C=C4)OC5=C(C=CC(=C5)CC6C7=C(O3)C(=C(C=C7CCN6C)OC)OC)OC)OC | 622.70 | unknown | via CMAUP database |
| Berbamine | 275182 | Click to see CN1CCC2=CC(=C3C=C2C1CC4=CC=C(C=C4)OC5=C(C=CC(=C5)CC6C7=C(O3)C(=C(C=C7CCN6C)OC)OC)O)OC | 608.70 | unknown | via CMAUP database |
| Cycleabarbatine | 192607 | Click to see CN1CCC2=CC(=C3C=C2C1CC4=CC=C(C=C4)OC5=C(C=CC(=C5)CC6C7=C(O3)C(=C(C=C7CCN6C)O)OC)OC)OC | 608.70 | unknown | https://doi.org/10.1021/NP50101A020 |
| Fangchinoline | 73481 | Click to see CN1CCC2=CC(=C3C=C2C1CC4=CC=C(C=C4)OC5=C(C=CC(=C5)CC6C7=C(O3)C(=C(C=C7CCN6C)OC)O)OC)OC | 608.70 | unknown | https://doi.org/10.1055/S-0028-1097974 |
| Isofangchinoline | 321937 | Click to see CN1CCC2=CC(=C3C=C2C1CC4=CC=C(C=C4)OC5=C(C=CC(=C5)CC6C7=C(O3)C(=C(C=C7CCN6C)OC)O)OC)OC | 608.70 | unknown | https://doi.org/10.1055/S-0028-1097974 |
| Limacine | 7656034 | Click to see CN1CCC2=CC(=C3C=C2C1CC4=CC=C(C=C4)OC5=C(C=CC(=C5)CC6C7=C(O3)C(=C(C=C7CCN6C)OC)O)OC)OC | 608.70 | unknown | https://doi.org/10.1021/NP50101A020 |
| Tetrandrine | 73078 | Click to see CN1CCC2=CC(=C3C=C2C1CC4=CC=C(C=C4)OC5=C(C=CC(=C5)CC6C7=C(O3)C(=C(C=C7CCN6C)OC)OC)OC)OC | 622.70 | unknown | https://doi.org/10.1021/NP50101A020 |
| Thalrugosine, (+)- | 100257 | Click to see | 608.70 | unknown |
https://doi.org/10.1021/NP50091A004 https://doi.org/10.1055/S-0028-1097974 |
| > Lipids and lipid-like molecules / Prenol lipids / Terpene lactones / Sesquiterpene lactones / Ambrosanolides and secoambrosanolides | |||||
| Tetraneurin A | 174868 | Click to see | 322.40 | unknown | via CMAUP database |
| > Organic oxygen compounds / Organooxygen compounds / Alcohols and polyols / Secondary alcohols / Cyclohexanols | |||||
| 1,2,3,4,5-Cyclohexanepentol | 101715 | Click to see C1C(C(C(C(C1O)O)O)O)O | 164.16 | unknown | https://doi.org/10.1002/ARDP.19823150104 |
| Cyclohexane-1,2,3,4,5-pentol | 12309654 | Click to see C1C(C(C(C(C1O)O)O)O)O | 164.16 | unknown | https://doi.org/10.1002/ARDP.19823150104 |
| > Organic oxygen compounds / Organooxygen compounds / Carbohydrates and carbohydrate conjugates / Glycosyl compounds / Phenolic glycosides | |||||
| Cimicifugamide | 5318530 | Click to see | 505.50 | unknown | via CMAUP database |
| > Organic oxygen compounds / Organooxygen compounds / Ethers / Diarylethers | |||||
| (12aR,24aR)-2,3,12a,13,14,15,24,24a-Octahydro-5,17-dimethoxy-1,13-dimethyl-8,11:20,23-dietheno-1H,12H-(1,10)dioxacyclooctadecino(2,3,4-ij:11,12,13-i'j')diisoquinoline-6,18-diol | 197726 | Click to see | 594.70 | unknown | https://doi.org/10.1021/NP50101A020 |
| (1R,16R)-9,10,25-trimethoxy-15,30-dimethyl-7,23-dioxa-15,30-diazaheptacyclo[22.6.2.23,6.218,21.18,12.027,31.016,35]heptatriaconta-3(37),4,6(36),8(35),9,11,18,20,24,26,31,33-dodecaen-32-ol | 154495894 | Click to see CN1CCC2=CC(=C3C(=C2C1CC4=CC=C(C=C4)OC5=C6C(CC7=CC=C(CO3)C=C7)N(CCC6=CC(=C5OC)OC)C)O)OC | 622.70 | unknown | https://doi.org/10.1021/NP50101A020 |
| 12-O-Methylcurine | 16637550 | Click to see CN1CCC2=CC(=C3C=C2C1CC4=CC=C(C=C4)OC5=C6C(CC7=CC(=C(C=C7)OC)O3)N(CCC6=CC(=C5O)OC)C)OC | 608.70 | unknown | https://doi.org/10.1021/NP50101A020 |
| Curine | 253793 | Click to see | 594.70 | unknown | https://doi.org/10.1021/NP50101A020 |
| > Organoheterocyclic compounds / Isoquinolines and derivatives / Benzylisoquinolines | |||||
| (R)-Coclaurine | 440989 | Click to see | 285.34 | unknown | https://doi.org/10.1021/NP50101A020 |
| (R)-N-Methylcoclaurine | 440595 | Click to see CN1CCC2=CC(=C(C=C2C1CC3=CC=C(C=C3)O)O)OC | 299.40 | unknown | https://doi.org/10.1021/NP50101A020 |
| Coclaurine | 160487 | Click to see | 285.34 | unknown | https://doi.org/10.1021/NP50101A020 |
| Csh 068 | 259676 | Click to see | 327.40 | unknown | via CMAUP database |
| > Phenylpropanoids and polyketides / Depsides and depsidones | |||||
| Thamnolic acid | 4316933 | Click to see CC1=CC(=C(C(=C1C(=O)OC2=C(C(=C(C(=C2C)C(=O)O)O)C=O)O)O)C(=O)O)OC | 420.30 | unknown | via CMAUP database |
| > Phenylpropanoids and polyketides / Flavonoids / Flavones | |||||
| Luteolin | 5280445 | Click to see C1=CC(=C(C=C1C2=CC(=O)C3=C(C=C(C=C3O2)O)O)O)O | 286.24 | unknown | via CMAUP database |
Collections Top
| In private collections | 0 |
| In public collections | 0 |