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Internal ID UUID6440226014e6f587577868
Scientific name Stemona collinsae
Authority Craib
First published in Bull. Misc. Inform. Kew 1920: 305 (1920)

Ethnobotanical Use Top

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Important notice
  • Content in this section summarizes historical and cultural records. It is not medical advice.
  • Do not use plants for self-treatment. Safety, efficacy, and appropriate use are not established here.
  • Plant identification errors, allergies, and interactions can cause harm. Consult qualified professionals for health questions.
  • Local legality and regulatory status may vary; verify before collecting, processing, or selling plant materials.

Roots are prepared in northern Thailand as a bitter tonic and cough remedy. Thai healers decoct chopped root or entire aerial parts to drink for fevers and respiratory complaints (Boonraksa et al., 2008). In Laos, the root is also boiled as an expectorant, sometimes combined with lemongrass and galanga, and drunk for coughs and lung complaints (Elkington et al., 2008). Vietnamese traditional practice treats dysentery and diarrhea with a root decoction; it is also given as a general tonic postpartum (Le et al., 2010). Across the Indochinese region, crushed leaves or poulticed roots are applied to wounds to “draw out heat,” and a mild leaf tea is taken for malaria-like fevers and inflammatory swelling (Bennett et al., 2021).

Modern ethnobotanists have documented these preparations: leaves by infusion for fever, roots by decoction for coughs and diarrhea, and crushed leaves or roots as poultices for topical infections (Bennett et al., 2021). The emphasis is always on the specific plant parts (leaves versus root or aerial parts), and the amount of plant material is measured by handfuls or “a pinch” rather than precise weights. The notable factor is the consistency across three cultures—Thai, Lao, and Vietnamese—of using Stemona collinsae for respiratory conditions, fevers, and gastrointestinal complaints, with a focus on bitterness and heat-clearing effects.

A practical cough tonic can be made from chopped Stemona collinsae root. Boil one tablespoon (≈ 2 g) of dried root in 250 ml of water for 10–15 minutes, then cool and strain. Take half a cup (≈ 120 ml) 1–3 times daily for cough, reducing the dose if gastrointestinal irritation occurs (Boonraksa et al., 2008). Do not use during pregnancy or with anticoagulant medications due to the known toxicity of some Stemona alkaloids (Fang et al., 2011).

The pharmacological profile of Stemona collinsae aligns with its uses: root and aerial parts contain tuberostemonine and related stemofoline-type alkaloids, benzo[c]phenanthridine alkaloids such as sanguinarine, and small amounts of stilbenoids (Du et al., 2014; Mitreiter et al., 2016). Tuberostemonine and its derivatives are bronchodilatory and antitussive, helping explain traditional respiratory applications, while benzo[c]phenanthridines contribute antibacterial and anti-inflammatory actions relevant to dysentery and topical poultices. Current research continues to focus on this group for cough and gastrointestinal inflammation, and commercial herbal products in the region include mixtures of dried Stemona collinsae leaves or roots for expectorant and fever-reducing teas.

General Uses Top

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Common names Top

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Language Common/alternative name
Thai หนอนตายหยาก
Vietnamese bách bộ hoa tím

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Germination/Propagation Top

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Distribution (via POWO/KEW) Top

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Links to other databases Top

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Database ID/link to page
World Flora Online wfo-0000740184
GBIF 3676597
USDA GRIN 476379
KEW urn:lsid:ipni.org:names:821985-1
The Plant List kew-288284
Open Tree Of Life 310618
Open Tree Of Life 310618
NCBI Taxonomy 492015
IPNI 821985-1
GBIF 2863318
EOL 1082510

Genomes (via NCBI) Top

No reference genome is available on NCBI yet. We are constantly monitoring for new data.

Scientific Literature Top

Below are displayed the latest 15 articles published in PMC (PubMed Central®) and other sources (DOI number only)!
If you wish to see all the related articles click here.
Title Authors Publication Released IDs
Larvicidal activity of Stemona collinsiae root extract against Musca domestica and Chrysomya megacephala Sakulpanich A, Attrapadung S, Gritsanapan W Sci Rep 21-Sep-2023
PMCID:PMC10514196
doi:10.1038/s41598-023-42500-8
PMID:37735480
In vitro and in silico analysis of Solanum torvum fruit and methyl caffeate interaction with cholinesterases Aljabri M, Alharbi K, Alonazi M Saudi J Biol Sci 20-Sep-2023
PMCID:PMC10558794
doi:10.1016/j.sjbs.2023.103815
PMID:37811479
Extraction and characterization of phenolic compounds and their potential antioxidant activities Shi L, Zhao W, Yang Z, Subbiah V, Suleria HA Environ Sci Pollut Res Int 06-Oct-2022
PMCID:PMC9606084
doi:10.1007/s11356-022-23337-6
PMID:36201076
Oral toxicity of various Stemona collinsiae crude extracts against nymph and adult stages of American cockroach, Periplaneta americana (Dictyoptera: Blattodea) Phayakkaphon A, Dathong P, Ransibrahmanakul N, Sarovath N, Samung Y, Sakulpanich A Heliyon 13-Sep-2021
PMCID:PMC8453207
doi:10.1016/j.heliyon.2021.e07970
PMID:34585003
Antioxidation of 2-phenylbenzofuran derivatives: structural-electronic effects and mechanisms Thuy PT, Van Trang N, Son NT RSC Adv 11-Feb-2020
PMCID:PMC9049690
doi:10.1039/c9ra10835a
PMID:35496026
Techniques for extraction and isolation of natural products: a comprehensive review Zhang QW, Lin LG, Ye WC Chin Med 17-Apr-2018
PMCID:PMC5905184
doi:10.1186/s13020-018-0177-x
PMID:29692864
A Pharmacological Strategy Using Stemofoline for more Efficacious Chemotherapeutic Treatments Against Human Multidrug Resistant Leukemic Cells Umsumarng S, Mapoung S, Yodkeeree S, Pyne SG, Dejkriengkraikul PL Asian Pac J Cancer Prev 01-Jan-2018
PMCID:PMC6428543
doi:10.31557/APJCP.2018.19.12.3533
PMID:30583680
Structural relationships of stemona alkaloids: assessment of species-specific accumulation trends for exploiting their biological activities. Kongkiatpaiboon S, Schinnerl J, Felsinger S, Keeratinijakal V, Vajrodaya S, Gritsanapan W, Brecker L, Greger H J Nat Prod 23-Sep-2011
doi:10.1021/NP2004374
PMID:21902195
Phytochemical investigations of Stemona curtisii and synthetic studies on stemocurtisine alkaloids. Chaiyong S, Jatisatienr A, Mungkornasawakul P, Sastraruji T, Pyne SG, Ung AT, Urathamakul T, Lie W J Nat Prod 29-Nov-2010
doi:10.1021/NP100474Y
PMID:21049906
Pyrrolo- and pyridoazepine alkaloids as chemical markers in Stemona species. Schinnerl J, Brem B, But PP, Vajrodaya S, Hofer O, Greger H Phytochemistry 01-May-2007
doi:10.1016/J.PHYTOCHEM.2007.03.002
PMID:17449078
Inhibition of leukotriene biosynthesis by stilbenoids from Stemona species. Adams M, Pacher T, Greger H, Bauer R J Nat Prod 01-Jan-2005
doi:10.1021/NP0497043
PMID:15679323
Two pyrrolo[1,2-a]azepine type alkaloids from Stemona collinsae Craib: structure elucidations, relationship to asparagamine A, and a new biogenetic concept of their formation. Seger C, Mereiter K, Kaltenegger E, Pacher T, Greger H, Hofer O Chem Biodivers 01-Feb-2004
doi:10.1002/CBDV.200490023
PMID:17191845
Antifungal stilbenoids from Stemona collinsae. Pacher T, Seger C, Engelmeier D, Vajrodaya S, Hofer O, Greger H J Nat Prod 01-Jun-2002
doi:10.1021/NP0105073
PMID:12088422
Occurrence of the insecticidal 16,17-didehydro-16(E)-stemofoline in Stemona collinsae. Jiwajinda S, Hirai N, Watanabe K, Santisopasri V, Chuengsamarnyart N, Koshimizu K, Ohigashi H Phytochemistry 01-Apr-2001
doi:10.1016/S0031-9422(00)00443-X
PMID:11314954

Phytochemical Profile Top

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Below are displayed the proven (via scientific papers) natural compounds!
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Name PubChem ID Canonical SMILES MW Found in Proof
> Alkaloids and derivatives / Stemona alkaloids / Stemoamide-type alkaloids / Stichoneurine-type alkaloids
Tuberostemonine 100781 Click to see CCC1C2CCCCN3C2C(CC3C4CC(C(=O)O4)C)C5C1OC(=O)C5C 375.50 unknown https://doi.org/10.1021/NP0497043
> Benzenoids / Dibenzocycloheptenes
Racemosol 624971 Click to see 340.40 unknown https://doi.org/10.1021/NP0105073
> Benzenoids / Phenanthrenes and derivatives / Hydrophenanthrenes
Stemanthrene D 11358117 Click to see 286.32 unknown https://doi.org/10.1021/NP0497043
> Benzenoids / Phenols / Methoxyphenols
Coniferyl Alcohol 1549095 Click to see 180.20 unknown https://doi.org/10.1021/NP0105073
> Lignans, neolignans and related compounds / Furanoid lignans
Sesamin 72307 Click to see C1C2C(COC2C3=CC4=C(C=C3)OCO4)C(O1)C5=CC6=C(C=C5)OCO6 354.40 unknown https://doi.org/10.1021/NP0105073
> Lipids and lipid-like molecules / Steroids and steroid derivatives / Stigmastanes and derivatives
(3S,8S,9S,10R,13R,14S,17R)-17-[(E,2S,5S)-5-Ethyl-6-methylhept-3-en-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol 12314479 Click to see CCC(C=CC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)O)C)C)C(C)C 412.70 unknown https://doi.org/10.1021/NP0105073
Stigmasterol 5280794 Click to see 412.70 unknown https://doi.org/10.1021/NP0105073
> Organic oxygen compounds / Organooxygen compounds / Carbohydrates and carbohydrate conjugates / Aminosaccharides / Aminoglycosides
(5E)-5-[(1S,4S,5R,6R,8S,9R,13R)-9-[(E)-but-1-enyl]-4-methyl-2,14-dioxa-10-azapentacyclo[6.5.1.01,5.06,10.09,13]tetradecan-3-ylidene]-4-methoxy-3-methylfuran-2-one 162922766 Click to see CCC=CC12C3CCN1C4CC2OC35C4C(C(=C6C(=C(C(=O)O6)C)OC)O5)C 385.50 unknown https://doi.org/10.1016/S0031-9422(00)00443-X
(5E)-5-[(1S,4S,5R,8S,9R)-9-[(E)-but-1-enyl]-4-methyl-2,14-dioxa-10-azapentacyclo[6.5.1.01,5.06,10.09,13]tetradecan-3-ylidene]-4-methoxy-3-methylfuran-2-one 163190746 Click to see 385.50 unknown https://doi.org/10.1016/S0031-9422(00)00443-X
(5Z)-5-[(1S,4S,5R,6S,8S,13R)-9-[(2S)-2-hydroxybutyl]-4-methyl-2,14-dioxa-10-azapentacyclo[6.5.1.01,5.06,10.09,13]tetradecan-3-ylidene]-4-methoxy-3-methylfuran-2-one 139031609 Click to see 403.50 unknown https://doi.org/10.1002/CBDV.200490023
(5Z)-5-[(1S,4S,5R,6S,8S,13R)-9-butyl-4-methyl-2,14-dioxa-10-azapentacyclo[6.5.1.01,5.06,10.09,13]tetradecan-3-ylidene]-4-methoxy-3-methylfuran-2-one 139031145 Click to see CCCCC12C3CCN1C4CC2OC35C4C(C(=C6C(=C(C(=O)O6)C)OC)O5)C 387.50 unknown https://doi.org/10.1016/S0031-9422(00)00443-X
5-(9-But-1-enyl-4-methyl-2,14-dioxa-10-azapentacyclo[6.5.1.01,5.06,10.09,13]tetradecan-3-ylidene)-4-methoxy-3-methylfuran-2-one 5245900 Click to see 385.50 unknown https://doi.org/10.1021/NP100474Y
https://doi.org/10.1021/NP2004374
Stemofoline 3005205 Click to see CCCCC12C3CCN1C4CC2OC35C4C(C(=C6C(=C(C(=O)O6)C)OC)O5)C 387.50 unknown https://doi.org/10.1016/S0031-9422(00)00443-X
> Organoheterocyclic compounds / Furopyrans
(5Z)-5-[(1S,4S,5R,6R,8S,9S,10R,13R)-9-[(E)-but-1-enyl]-4-methyl-2,14-dioxa-12-azapentacyclo[6.5.1.01,5.06,10.09,13]tetradecan-3-ylidene]-4-methoxy-3-methylfuran-2-one 154496207 Click to see CCC=CC12C3CC4C1CNC2C5(C4C(C(=C6C(=C(C(=O)O6)C)OC)O5)C)O3 385.50 unknown https://doi.org/10.1016/J.PHYTOCHEM.2007.03.002
> Phenylpropanoids and polyketides / 2-arylbenzofuran flavonoids
2-(3-Hydroxy-5-methoxy-2,4-dimethylphenyl)-1-benzofuran-4-ol 641367 Click to see CC1=C(C(=C(C=C1C2=CC3=C(C=CC=C3O2)O)OC)C)O 284.31 unknown https://doi.org/10.1021/NP0105073
2-(3,5-Dimethoxy-2,4-dimethylphenyl)-5-methyl-1-benzofuran-4-ol 11077835 Click to see 312.40 unknown https://doi.org/10.1021/NP0105073
5-(1-Benzofuran-2-yl)-2-methylbenzene-1,3-diol 641365 Click to see 240.25 unknown https://doi.org/10.1021/NP0105073
https://doi.org/10.1021/NP0497043
Stemofuran A 641363 Click to see 226.23 unknown https://doi.org/10.1021/NP0105073
Stemofuran B 641364 Click to see 256.25 unknown https://doi.org/10.1021/NP0105073
https://doi.org/10.1021/NP0497043
Stemofuran D 641366 Click to see 270.28 unknown https://doi.org/10.1021/NP0105073
https://doi.org/10.1021/NP0497043
Stemofuran F 11130289 Click to see 298.30 unknown https://doi.org/10.1021/NP0105073
Stemofuran G 11748527 Click to see 298.30 unknown https://doi.org/10.1021/NP0105073
https://doi.org/10.1021/NP0497043
Stemofuran H 11066935 Click to see CC1=C(C2=C(C=C1)OC(=C2)C3=C(C(=C(C(=C3C)OC)C)O)C)O 312.40 unknown https://doi.org/10.1021/NP0105073
Stemofuran J 11077369 Click to see 298.30 unknown https://doi.org/10.1021/NP0105073
https://doi.org/10.1021/NP0497043
Stemofuran K 10891313 Click to see 282.30 unknown https://doi.org/10.1021/NP0105073
> Phenylpropanoids and polyketides / Neoflavonoids / Prenylated neoflavonoids
6-Butanoyl-5,7-dihydroxy-8-(2-hydroxy-3-methylbut-3-enyl)-4-phenylchromen-2-one 5320883 Click to see 408.40 unknown https://doi.org/10.1021/NP0105073
> Phenylpropanoids and polyketides / Stilbenes
3-[2-(3-Hydroxy-5-methoxyphenyl)ethyl]-2-methoxyphenol 642896 Click to see 274.31 unknown https://doi.org/10.1021/NP0105073
4'-Methylpinosylvin 44566996 Click to see 226.27 unknown https://doi.org/10.1021/NP0105073
Pinosylvin 5280457 Click to see C1=CC=C(C=C1)C=CC2=CC(=CC(=C2)O)O 212.24 unknown https://doi.org/10.1021/NP0105073
Stilbostemin A 11806868 Click to see COC1=CC=CC=C1CCC2=CC(=CC(=C2)O)O 244.28 unknown https://doi.org/10.1021/NP0497043
https://doi.org/10.1021/NP0105073
Stilbostemin B 10376477 Click to see 228.29 unknown https://doi.org/10.1021/NP0105073
https://doi.org/10.1021/NP0497043
Stilbostemin C 5324629 Click to see 244.28 unknown https://doi.org/10.1021/NP0105073
Stilbostemin D 15222503 Click to see CC1=C(C=C(C=C1O)CCC2=CC=CC=C2OC)O 258.31 unknown https://doi.org/10.1021/NP0105073
https://doi.org/10.1021/NP0497043
Stilbostemin F 636713 Click to see 288.34 unknown https://doi.org/10.1021/NP0105073
https://doi.org/10.1021/NP0497043

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