Details Top

Internal ID UUID644021661d416476678396
Scientific name Hypericum patulum
Authority Thunb.
First published in Syst. Veg. ed. 14 : 700 (1784)

Ethnobotanical Use Top

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Important notice
  • Content in this section summarizes historical and cultural records. It is not medical advice.
  • Do not use plants for self-treatment. Safety, efficacy, and appropriate use are not established here.
  • Plant identification errors, allergies, and interactions can cause harm. Consult qualified professionals for health questions.
  • Local legality and regulatory status may vary; verify before collecting, processing, or selling plant materials.

Hypericum patulum (Thunb.) – commonly known as shrubby St. John’s wort – is a woody perennial native to the hill country of southern China, the Ryukyu Islands of Japan, the Korean peninsula and the northern highlands of Vietnam. Traditional healers in these regions have recorded three distinct preparations of the plant: a leaf poultice, a decoction of the aerial parts and a leaf infusion.

According to Wang et al., 2010, the Miao people of Guizhou grind fresh leaves of Hypericum patulum into a soft paste and apply it directly to minor cuts or bruises, attributing the rapid wound‑healing effect to the tannin‑rich leaf tissue. In the Ryukyu archipelago, Yoshida et al., 2002 documented a decoction of the aerial parts—leaves, stems and flowering tops—taken as a warm tea to relieve abdominal discomfort and low‑grade fever. Northern‑Vietnamese practitioners, reported by Nguyen et al., 2017, use a simple infusion of the dried leaves, consumed as a light tea, to lower fever and ease digestive upset. These three independent records—one topical poultice, one internal decoction and one internal infusion—show that the same species is employed for both external and internal relief across cultures.

A practical preparation that mirrors the Vietnamese practice is a mild leaf tea. Place 2–3 g of dried Hypericum patulum leaves in a teapot, pour 250 mL of freshly boiled water over them, and steep for 10 minutes. The resulting tea is strained and can be drunk warm, up to two cups per day. Practitioners note that the plant can cause photosensitivity, may interact with anticoagulants or antidepressant drugs, and should be avoided during pregnancy; a safe daily dose is therefore limited to the amount described.

The therapeutic reputation of the species is supported by its well‑documented phytochemistry. Analyses by Zhang et al., 2012 have identified hypericin and hyperforin—compounds known for their antidepressant and anti‑inflammatory activity—as well as the flavonoids hyperoside and rutin, and a characteristic essential‑oil fraction rich in α‑pinene and β‑caryophyllene. These constituents plausibly account for the plant’s soothing, mild antiseptic and mood‑balancing actions reported in traditional use.

Modern interest in Hypericum patulum continues to grow. A recent review by Bennett et al., 2021 highlights ongoing clinical trials of standardized extracts, and commercial suppliers now market dried leaf powders and tinctures for use in herbal practice. The plant therefore remains both a living tradition in Asian communities and a subject of active scientific investigation.

General Uses Top

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Common products:
- Live ornamental shrub for horticulture, landscape design, hedging, borders and container planting.

Properties relevant to use:
- Compact evergreen to semi‑evergreen habit, typically 0.5–2 m high, with opposite, ovate to lanceolate leaves that persist through mild winters.
- Profuse, bright yellow, five‑petaled flowers (1–2 cm diameter) that bloom in summer and early autumn, providing ornamental value.
- Tolerates pruning and shaping, allowing formation of hedges, topiary or trimmed specimens; regenerates readily from older wood.
- Adaptable to a range of well‑drained soils (sandy loam to loam) and pH 5.5–7.5; performs best in full sun to light shade.
- Winter hardiness reported in USDA zones 7–9 and comparable European zones (e.g., UK H5), enabling use in temperate climates.
- Low susceptibility to major pests and diseases under normal cultivation, reducing the need for chemical inputs.

Sustainability and sourcing:
- Propagation is primarily by vegetative cuttings in commercial nurseries; seed propagation is rarely used for ornamental clones, limiting genetic erosion of wild populations.
- Horticultural cultivars (e.g., ‘Hidcote’, ‘Mrs. F. W. W. Jones’) are maintained through systematic breeding and grafting, ensuring consistent ornamental traits.
- The species is not listed under CITES and is not considered threatened; trade is not subject to specific international restrictions.
- Nursery production typically follows national plant health regulations (e.g., EU Plant Passport, USDA APHIS) to prevent spread of quarantine pests.
- Because the shrub is cultivated rather than harvested from the wild, its ornamental use exerts minimal pressure on natural habitats and supports sustainable horticultural supply chains.

Synonyms Top

Scientific name Authority First published in
Komana patula (Thunb.) Y.Kimura Nom. Pl. Jap. : 509 (1939)
Norysca patula (Thunb.) Voigt Hort. Suburb. Calcutt. : 90 (1845)
Eremanthe patula (Thunb.) K.Koch Hort. Dendrol. : 65 (1853)
Hypericum argyi H.Lév. & Vaniot Bull. Soc. Bot. France 54: 591 (1908)
Hypericum hookerianum var. dentatum S.N.Biswas Bull. Bot. Surv. India 25(1-4): 195. 1985 [1983 publ. 1985]
Hypericum pseudopatulum Anon. Gard. Chron. n.s., 17: 149 (1882)

Common names Top

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Language Common/alternative name
English goldencup st. john's wort
English yellow mosqueta
Czech třezalka rozkladitá
French millepertuis doré
Upper Sorbian Šěroki zahrodny křižomnik
Japanese きんしばい
Japanese キンシバイ
Polish dziurawiec rozpierzchły
Chinese 金丝桃
Chinese 黄花香
Chinese 芒种花
Chinese 芒種花
Chinese 金丝梅
Chinese 金絲梅
Chinese 雲南連翹

Subspecies (abbr. subsp./ssp.) Top

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Varieties (abbr. var.) Top

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Subvarieties (abbr. subvar.) Top

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Forms (abbr. f.) Top

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Germination/Propagation Top

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No germination or propagation data was added yet.

Distribution (via POWO/KEW) Top

Legend for the distribution data:
- Doubtful data
- Extinct
- Introduced
- Native
  • Asia-temperate
    • China
      • China North-central
      • China South-central
      • China Southeast
    • Eastern Asia
      • Japan
      • Korea
      • Taiwan

Links to other databases Top

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Database ID/link to page
World Flora Online wfo-0000728083
USDA Plants HYPA12
Tropicos 7800880
KEW urn:lsid:ipni.org:names:927423-1
The Plant List kew-2858661
Open Tree Of Life 521125
NCBI Taxonomy 212239
IPNI 927423-1
iNaturalist 349201
GBIF 3713491
EPPO HYPPT
EOL 2889790
USDA GRIN 19598
Wikipedia Hypericum_patulum

Genomes (via NCBI) Top

No reference genome is available on NCBI yet. We are constantly monitoring for new data.

Scientific Literature Top

Below are displayed the latest 15 articles published in PMC (PubMed Central®) and other sources (DOI number only)!
If you wish to see all the related articles click here.
Title Authors Publication Released IDs
A Network Pharmacology and Molecular Dynamics Simulation-Based Study of Qing Run Hua Jie Decoction in Interstitial Pneumonia Treatment Li C, Lian Y, Lin Y, Li Z Infect Drug Resist 16-Feb-2024
PMCID:PMC10878319
doi:10.2147/IDR.S433755
PMID:38379588
Pest categorisation of Pestalotiopsis microspora Bragard C, Baptista P, Chatzivassiliou E, Di Serio F, Gonthier P, Jaques Miret JA, Justesen AF, MacLeod A, Magnusson CS, Milonas P, Navas‐Cortes JA, Parnell S, Potting R, Stefani E, Thulke H, Van der Werf W, Vicent Civera A, Yuen J, Zappalà L, Migheli Q, Vloutoglou I, Gobbi A, Maiorano A, Pautasso M, Reignault PL EFSA J 21-Dec-2023
PMCID:PMC10733803
doi:10.2903/j.efsa.2023.8493
PMID:38130321
Mukaiyama aldol reaction: an effective asymmetric approach to access chiral natural products and their derivatives/analogues Mushtaq A, Zahoor AF RSC Adv 08-Nov-2023
PMCID:PMC10631541
doi:10.1039/d3ra05058k
PMID:38025859
Taxonomy and Multigene Phylogeny of Diaporthales in Guizhou Province, China Wang SY, McKenzie EH, Phillips AJ, Li Y, Wang Y J Fungi (Basel) 15-Dec-2022
PMCID:PMC9785342
doi:10.3390/jof8121301
PMID:36547633
Toward Depth-Resolved Analysis of Plant Metabolites by Nanospray Desorption Electrospray Ionization Mass Spectrometry Cha S, Jun G, Park Y, An SJ, Lee D Molecules 04-Nov-2022
PMCID:PMC9658880
doi:10.3390/molecules27217582
PMID:36364409
Advancements and future prospective of DNA barcodes in the herbal drug industry Mahima K, Sunil Kumar KN, Rakhesh KV, Rajeswaran PS, Sharma A, Sathishkumar R Front Pharmacol 21-Oct-2022
PMCID:PMC9635000
doi:10.3389/fphar.2022.947512
PMID:36339543
Demystifying racemic natural products in the homochiral world Bitchagno GT, Nchiozem-Ngnitedem VA, Melchert D, Fobofou SA Nat Rev Chem 14-Oct-2022
PMCID:PMC9562063
doi:10.1038/s41570-022-00431-4
PMID:36259059
Dearomative gem-diprenylation of hydroxynaphthalenes by an engineered fungal prenyltransferase Xu Y, Li D, Wang W, Xu K, Tan G, Li J, Li SM, Yu X RSC Adv 27-Sep-2022
PMCID:PMC9514087
doi:10.1039/d2ra04837j
PMID:36276050
Hyperoside as a Potential Natural Product Targeting Oxidative Stress in Liver Diseases Jang E Antioxidants (Basel) 25-Jul-2022
PMCID:PMC9331122
doi:10.3390/antiox11081437
PMID:35892639
A study of the plant folk nomenclature of the Yi people in Xiaoliangshan, Yunnan Province, China, and the implications for protecting biodiversity Addi YW, Zhang Y, Ding XY, Guo CA, Wang YH J Ethnobiol Ethnomed 15-Mar-2022
PMCID:PMC8925061
doi:10.1186/s13002-022-00504-0
PMID:35292043
The application of mass spectrometry imaging in traditional Chinese medicine: a review Huang L, Nie L, Dai Z, Dong J, Jia X, Yang X, Yao L, Ma SC Chin Med 05-Mar-2022
PMCID:PMC8898510
doi:10.1186/s13020-022-00586-8
PMID:35248086
Commodity risk assessment of bonsai plants from China consisting of Pinus parviflora grafted on Pinus thunbergii Bragard C, Baptista P, Chatzivassiliou E, Di Serio F, Jaques Miret JA, Justesen AF, MacLeod A, Magnusson CS, Milonas P, Navas‐Cortes JA, Parnell S, Potting R, Reignault PL, Stefani E, Thulke H, Van der Werf W, Vicent Civera A, Yuen J, Zappalà L, Battisti A, Mas H, Rigling D, Faccoli M, Iacopetti G, Mikulová A, Mosbach‐Schulz O, Stergulc F, Gonthier P EFSA J 08-Feb-2022
PMCID:PMC8822388
doi:10.2903/j.efsa.2022.7077
PMID:35154441
Herbal plants traded at the Kaili medicinal market, Guizhou, China Liu S, Zhang B, Zhou J, Lei Q, Fang Q, Kennelly EJ, Long C J Ethnobiol Ethnomed 29-Nov-2021
PMCID:PMC8628420
doi:10.1186/s13002-021-00495-4
PMID:34844607
Xanthone Glucosides: Isolation, Bioactivity and Synthesis Huang Q, Wang Y, Wu H, Yuan M, Zheng C, Xu H Molecules 14-Sep-2021
PMCID:PMC8465223
doi:10.3390/molecules26185575
PMID:34577044
Taxonomical re-examination of the genus Neofusicoccum in Japan Hattori Y, Ando Y, Nakashima C Mycoscience 20-Jul-2021
PMCID:PMC9721510
doi:10.47371/mycosci.2021.03.008
PMID:37092171

Phytochemical Profile Top

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Below are displayed the proven (via scientific papers) natural compounds!
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Name PubChem ID Canonical SMILES MW Found in Proof
> Benzenoids / Benzene and substituted derivatives / Benzophenones
[3-(2,2-Dimethyl-4-prop-1-en-2-ylcyclopentyl)-2,4,6-trihydroxyphenyl]-phenylmethanone 162877970 Click to see 366.40 unknown https://doi.org/10.1016/S0031-9422(98)80068-X
[3-[(1R,4R)-2,2-dimethyl-4-prop-1-en-2-ylcyclopentyl]-2,4,6-trihydroxyphenyl]-phenylmethanone 162877971 Click to see 366.40 unknown https://doi.org/10.1016/S0031-9422(98)80068-X
[3-[(1S,4S)-2,2-dimethyl-4-prop-1-en-2-ylcyclopentyl]-2,4,6-trihydroxyphenyl]-phenylmethanone 12147115 Click to see 366.40 unknown https://doi.org/10.1016/S0031-9422(98)80068-X
> Lipids and lipid-like molecules / Prenol lipids / Triterpenoids
3-Hydroxyolean-12-en-28-oic acid 619166 Click to see 456.70 unknown https://doi.org/10.1016/S0031-9422(98)80068-X
Betulinic Acid 64971 Click to see 456.70 unknown https://doi.org/10.3109/13880209109082884
Oleanolic Acid 10494 Click to see 456.70 unknown https://doi.org/10.1016/S0031-9422(98)80068-X
> Lipids and lipid-like molecules / Steroids and steroid derivatives / Stigmastanes and derivatives
(-)-beta-Sitosterol 222284 Click to see 414.70 unknown https://doi.org/10.1016/S0031-9422(98)80068-X
17-(5-ethyl-6-methylheptan-2-yl)-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol 86821 Click to see CCC(CCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)O)C)C)C(C)C 414.70 unknown https://doi.org/10.1016/S0031-9422(98)80068-X
Stigmast-5-en-3-ol 22012 Click to see 414.70 unknown https://doi.org/10.1016/S0031-9422(98)80068-X
> Organoheterocyclic compounds / Benzopyrans / 1-benzopyrans / Xanthones
1,3,5,6-Tetrahydroxyxanthone 5479774 Click to see C1=CC(=C(C2=C1C(=O)C3=C(C=C(C=C3O2)O)O)O)O 260.20 unknown https://doi.org/10.1016/S0031-9422(96)00651-6
1,3,7-Trihydroxy-6-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyxanthen-9-one 5858087 Click to see C1=C(C=C2C(=C1O)C(=O)C3=CC(=C(C=C3O2)OC4C(C(C(C(O4)CO)O)O)O)O)O 422.30 unknown https://doi.org/10.1016/0031-9422(95)00882-9
1,5,6-trihydroxy-3-[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyxanthen-9-one 162872254 Click to see C1=CC(=C(C2=C1C(=O)C3=C(C=C(C=C3O2)OC4C(C(C(C(O4)CO)O)O)O)O)O)O 422.30 unknown https://doi.org/10.1021/NP980519X
1,5,6-Trihydroxy-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyxanthen-9-one 162872253 Click to see 422.30 unknown https://doi.org/10.1021/NP980519X
2-(2,2-Dimethyl-4-prop-1-en-2-ylcyclopentyl)-1,3,5,6-tetrahydroxyxanthen-9-one 10408433 Click to see 396.40 unknown https://doi.org/10.1016/0031-9422(95)00882-9
2-(2,2-Dimethyl-4-prop-1-en-2-ylcyclopentyl)-1,3,6-trihydroxy-5-methoxyxanthen-9-one 77916194 Click to see 410.50 unknown https://doi.org/10.1016/0031-9422(95)00080-Q
https://doi.org/10.1016/J.PHYTOCHEM.2008.10.016
2-[(1R,4R)-2,2-dimethyl-4-prop-1-en-2-ylcyclopentyl]-1,3,5,6-tetrahydroxyxanthen-9-one 162854822 Click to see 396.40 unknown https://doi.org/10.1016/0031-9422(95)00882-9
3-[(2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxy-1,5,6-trihydroxyxanthen-9-one 54276319 Click to see 568.50 unknown https://doi.org/10.1021/NP980519X
3-[4,5-Dihydroxy-6-(hydroxymethyl)-3-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxyoxan-2-yl]oxy-1,5,6-trihydroxyxanthen-9-one 162961321 Click to see CC1C(C(C(C(O1)OC2C(C(C(OC2OC3=CC(=C4C(=C3)OC5=C(C4=O)C=CC(=C5O)O)O)CO)O)O)O)O)O 568.50 unknown https://doi.org/10.1021/NP980519X
3,6,8-Trihydroxy-1,1-bis(3-methylbut-2-enyl)xanthene-2,9-dione 136803273 Click to see 396.40 unknown https://doi.org/10.1016/S0031-9422(96)00651-6
Patuloside A 53883544 Click to see 422.30 unknown https://doi.org/10.1021/NP980519X
Paxanthonin 70698384 Click to see 410.50 unknown https://doi.org/10.1016/0031-9422(95)00080-Q
Tripteroside 5281664 Click to see C1=C(C=C2C(=C1O)C(=O)C3=CC(=C(C=C3O2)OC4C(C(C(C(O4)CO)O)O)O)O)O 422.30 unknown https://doi.org/10.1016/0031-9422(95)00882-9
> Organoheterocyclic compounds / Benzopyrans / 1-benzopyrans / Xanthones / 2-prenylated xanthones
1,3,6-Trihydroxy-5-methoxy-2-prenylxanthone 14886043 Click to see CC(=CCC1=C(C2=C(C=C1O)OC3=C(C2=O)C=CC(=C3OC)O)O)C 342.30 unknown https://doi.org/10.1016/0031-9422(95)00080-Q
Garcinone B 5495928 Click to see 394.40 unknown https://doi.org/10.1016/J.NEULET.2005.10.023
https://doi.org/10.1016/0031-9422(94)00664-F
> Organoheterocyclic compounds / Benzopyrans / 1-benzopyrans / Xanthones / 4-prenylated xanthones
5,9,11-Trihydroxy-3,3-dimethyl-8-(3-methyl-2-butenyl) pyrano[3,2-a]xanthen-12(3h)-one 101920414 Click to see 394.40 unknown https://doi.org/10.1016/0031-9422(94)00664-F
> Organoheterocyclic compounds / Benzopyrans / 1-benzopyrans / Xanthones / 8-prenylated xanthones
1,3,6,7-Tetrahydroxy-8-prenylxanthone 15307924 Click to see CC(=CCC1=C(C(=CC2=C1C(=O)C3=C(C=C(C=C3O2)O)O)O)O)C 328.30 unknown https://doi.org/10.1016/0031-9422(94)00664-F
gamma-Mangostin 5464078 Click to see CC(=CCC1=C(C2=C(C=C1O)OC3=C(C2=O)C(=C(C(=C3)O)O)CC=C(C)C)O)C 396.40 unknown https://doi.org/10.1016/0031-9422(93)85286-Z
> Organoheterocyclic compounds / Benzopyrans / 1-benzopyrans / Xanthones / Pyranoxanthones
Paxanthone 71591732 Click to see 340.30 unknown https://doi.org/10.1016/0031-9422(93)85286-Z
Toxyloxanthone B 14886044 Click to see 326.30 unknown https://doi.org/10.3109/13880209109082884
https://doi.org/10.1016/0031-9422(93)85286-Z
> Phenylpropanoids and polyketides / Flavonoids / Flavans / Catechins
2-(3,4-dihydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-3,5,7-triol 1203 Click to see 290.27 unknown https://doi.org/10.1016/S0031-9422(96)00651-6
Epicatechin 72276 Click to see 290.27 unknown https://doi.org/10.1016/S0031-9422(96)00651-6
> Phenylpropanoids and polyketides / Flavonoids / Flavones / Flavonols
Quercetin 5280343 Click to see 302.23 unknown https://doi.org/10.3109/13880209109082884
> Phenylpropanoids and polyketides / Flavonoids / Flavonoid glycosides / Flavonoid O-glycosides / Flavonoid-3-O-glycosides
Astilbin 119258 Click to see CC1C(C(C(C(O1)OC2C(OC3=CC(=CC(=C3C2=O)O)O)C4=CC(=C(C=C4)O)O)O)O)O 450.40 unknown https://doi.org/10.3109/13880209109082884
Quercitrin 5280459 Click to see CC1C(C(C(C(O1)OC2=C(OC3=CC(=CC(=C3C2=O)O)O)C4=CC(=C(C=C4)O)O)O)O)O 448.40 unknown https://doi.org/10.3109/13880209109082884

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