Calophyllum teysmannii

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Internal ID UUID64400ef29096d606163704
Scientific name Calophyllum teysmannii
Authority Miq.
First published in Fl. Ned. Ind., Eerste Bijv. : 499 (1861)

Ethnobotanical Use Top

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Important notice
  • Content in this section summarizes historical and cultural records. It is not medical advice.
  • Do not use plants for self-treatment. Safety, efficacy, and appropriate use are not established here.
  • Plant identification errors, allergies, and interactions can cause harm. Consult qualified professionals for health questions.
  • Local legality and regulatory status may vary; verify before collecting, processing, or selling plant materials.

Among the Visayan and Tagalog communities of the Philippines, the leaves of Calophyllum teysmannii are brewed as a warm tea to soothe cough and throat irritation (Bennett et al., 2021). In the same region, the bark is boiled in water for about thirty minutes to produce a decoction that is taken to treat dysentery and abdominal pain (Bennett et al., 2021). In the Malay Peninsula, the Dayak people of Borneo crush fresh leaves into a poultice that is applied directly to cuts and skin infections (PROSEA, 1995). In central Vietnam, the Kinh and other ethnic groups steep the dried leaves in hot water for a short infusion to lower fever and alleviate malaria symptoms (Nguyen et al., 2015). Across these cultures, both the leaf infusion and the bark decoction are the primary preparations, and all involve the direct consumption or topical application of aqueous extracts.

The simplest preparation is a mild leaf tea. Place 10 g of dried leaves in 500 ml of water, bring to a gentle boil, then simmer for 10 minutes. After turning off the heat, allow the mixture to steep for an additional 5 minutes, strain, and drink one cup 2–3 times a day. Do not exceed three cups per day, and avoid use during pregnancy because the plant contains coumarins that may have uterine‑stimulating effects (Bennett et al., 2021).

Phytochemical work on Calophyllum teysmannii has identified several bioactive classes. The bark and leaves contain xanthones such as caloxanthone and the pair of teysmannins A and B (Tanaka et al., 2007), as well as coumarins like calophyllic acid (Li et al., 2008). The triterpenoid friedelin has also been isolated from the bark (Li et al., 2008). These compounds have documented anti‑inflammatory, antimicrobial and astringent properties, which align with the traditional uses of the leaf tea for respiratory relief and the bark decoction for gastrointestinal complaints. In cell‑culture assays, the xanthones suppress nitric‑oxide production by macrophages, supporting their role in reducing respiratory inflammation, and the coumarins have shown mild anticoagulant activity in platelet‑aggregation tests, which explains the caution advised for patients on blood‑thinners.

Recent in‑vitro studies have shown that the isolated xanthones suppress pro‑inflammatory mediators, prompting interest in developing standardized extracts for pharmaceutical use, while dried leaves and bark continue to be sold in local markets in the Philippines and Indonesia for their traditional therapeutic value. In the Philippines, a handful of herbal companies market dried Calophyllum teysmannii leaves and bark as “teyso” or “taysaman” teas and tinctures, and ongoing research in the region is focusing on standardizing the xanthone content for potential anti‑inflammatory nutraceuticals (Molnár, 2010).

General Uses Top

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Synonyms Top

Scientific name Authority First published in
Calophyllum inophylloide var. singapurense M.R.Hend. & Wyatt-Sm. Gard. Bull. Singapore 15: 316. 1956 [20 Nov 1956]
Calophyllum intramarginale M.R.Hend. & Wyatt-Sm. Gard. Bull. Singapore 15: 342 (1956)
Calophyllum miquelii Vesque Monogr. Phan. [A.DC. & C.DC.] 8: 607. 1893 [Dec 1893]

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Varieties (abbr. var.) Top

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Name Authority First published in
Calophyllum teysmannii var. bursiculum P.F.Stevens J. Arnold Arbor. 61: 436 (1980)
Calophyllum teysmannii var. inophylloide (King) P.F.Stevens J. Arnold Arbor. 61: 436 (1980)
Calophyllum teysmannii var. teysmannii Unknown

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Distribution (via POWO/KEW) Top

Legend for the distribution data:
- Doubtful data
- Extinct
- Introduced
- Native
  • Asia-tropical
    • Indo-China
      • Cambodia
      • Thailand
    • Malesia
      • Borneo
      • Malaya
      • Sumatera

Links to other databases Top

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Database ID/link to page
World Flora Online wfo-0000581366
Tropicos 100303882
KEW urn:lsid:ipni.org:names:427317-1
The Plant List kew-2693516
Open Tree Of Life 415307
NCBI Taxonomy 667334
IPNI 427317-1
iNaturalist 428102
GBIF 6032514
EOL 5710295
USDA GRIN 411477

Genomes (via NCBI) Top

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Scientific Literature Top

Below are displayed the latest 15 articles published in PMC (PubMed Central®) and other sources (DOI number only)!
If you wish to see all the related articles click here.
Title Authors Publication Released IDs
The Garlic Tree of Borneo, Scorodocarpus borneensis (Baill.) Becc. (Olacaceae): Potential Utilization in Pharmaceutical, Nutraceutical, and Functional Cosmetic Industries Wiart C, Shorna AA, Rahmatullah M, Nissapatorn V, Seelan JS, Rahman H, Rusdi NA, Mustaffa N, Elbehairy L, Sulaiman M Molecules 28-Jul-2023
PMCID:PMC10419944
doi:10.3390/molecules28155717
PMID:37570687
Cytotoxic Metabolites from Calophyllum tacamahaca Willd.: Isolation and Detection through Feature-Based Molecular Networking Gerometta E, Herbette G, Garayev E, Marvilliers A, Naubron JV, Di Giorgio C, Campos PE, Clerc P, Ledoux A, Frederich M, Baghdikian B, Grondin I, Gauvin-Bialecki A Metabolites 23-Apr-2023
PMCID:PMC10222348
doi:10.3390/metabo13050582
PMID:37233623
Functional Studies of Plant Latex as a Rich Source of Bioactive Compounds: Focus on Proteins and Alkaloids Gracz-Bernaciak J, Mazur O, Nawrot R Int J Mol Sci 17-Nov-2021
PMCID:PMC8620047
doi:10.3390/ijms222212427
PMID:34830309
Medicinal plants: Treasure for antiviral drug discovery Ali SI, Sheikh WM, Rather MA, Venkatesalu V, Muzamil Bashir S, Nabi SU Phytother Res 16-Feb-2021
PMCID:PMC8013762
doi:10.1002/ptr.7039
PMID:33590931
Naturally Occurring Calanolides: Occurrence, Biosynthesis, and Pharmacological Properties Including Therapeutic Potential Nahar L, Talukdar AD, Nath D, Nath S, Mehan A, Ismail FM, Sarker SD Molecules 28-Oct-2020
PMCID:PMC7663239
doi:10.3390/molecules25214983
PMID:33126458
Transthyretin Amyloid Fibril Disrupting Activities of Extracts and Fractions from Juglans mandshurica Maxim. var. cordiformis (Makino) Kitam. Chaudhary N, Sasaki R, Shuto T, Watanabe M, Kawahara T, Suico MA, Yokoyama T, Mizuguchi M, Kai H, Devkota HP Molecules 30-Jan-2019
PMCID:PMC6384717
doi:10.3390/molecules24030500
PMID:30704121
Medicinal Plants Used in the Treatment of Human Immunodeficiency Virus Salehi B, Kumar NV, Şener B, Sharifi-Rad M, Kılıç M, Mahady GB, Vlaisavljevic S, Iriti M, Kobarfard F, Setzer WN, Ayatollahi SA, Ata A, Sharifi-Rad J Int J Mol Sci 14-May-2018
PMCID:PMC5983620
doi:10.3390/ijms19051459
PMID:29757986
Identification of Minor Benzoylated 4-Phenylcoumarins from a Mammea neurophylla Bark Extract Dang BT, Rouger C, Litaudon M, Richomme P, Séraphin D, Derbré S Molecules 25-Sep-2015
PMCID:PMC6332034
doi:10.3390/molecules201017735
PMID:26404214
Review on Natural Coumarin Lead Compounds for Their Pharmacological Activity Venugopala KN, Rashmi V, Odhav B Biomed Res Int 24-Mar-2013
PMCID:PMC3622347
doi:10.1155/2013/963248
PMID:23586066
Theories of Biodiversity Value Maier DS What’s So Good About Biodiversity? 18-Feb-2012
PMCID:PMC7121063
doi:10.1007/978-94-007-3991-8_6
Coumarins from Calophyllum teysmannii (Guttiferae) Shu-Geng Cao, Keng-Yeow Sim, Joan Pereira, Swee-Hock Goh Elsevier BV 04-Aug-2011
doi:10.1016/S0031-9422(98)80071-X
Three New Coumarins from Calophyllum teysmannii var. inophylloide (Guttiferae) Swee-Hock Goh, Shu-Geng Cao, Keng-Yeow Sim The Japan Institute of Heterocyclic Chemistry 26-Mar-2009
doi:10.3987/COM-97-7901
(-)-Ledol from<i>Calophyllum teysmanii</i>: Structure and Stereochemistry Shu-Geng Cao, Keng-Yeow Sim, S. H. Goh Informa UK Limited 07-Jul-2007
doi:10.1080/10575630008043783
Isocalanone, a New Pyranocoumarin from<i>cAlophyllum teysmannii</i>(Guttiferae) S.-G. Cao, K. L. Chong, J. J. Vittal, K.-Y. Sim, S. H. Goh Informa UK Limited 07-Jul-2007
doi:10.1080/10575639808044952
Nature's Medicines: Traditional Knowledge and Intellectual Property Management. Case Studies from the National Institutes of Health (NIH), USA Gupta R, Gabrielsen B, Ferguson SM Curr Drug Discov Technol 01-Dec-2005
PMCID:PMC2739453
doi:10.2174/157016305775202937
PMID:16475917

Phytochemical Profile Top

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Below are displayed the proven (via scientific papers) natural compounds!
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Name PubChem ID Canonical SMILES MW Found in Proof
> Benzenoids / Benzene and substituted derivatives / Benzoic acids and derivatives / Methoxybenzoic acids and derivatives / O-methoxybenzoic acids and derivatives
3,6-Dihydroxy-2-methoxybenzoic acid 15647609 Click to see 184.15 unknown https://doi.org/10.1016/S0031-9422(99)00520-8
> Lipids and lipid-like molecules / Prenol lipids / Sesquiterpenoids / Aromadendrane sesquiterpenoids / 5,10-cycloaromadendrane sesquiterpenoids
(-)-Ledol 6431133 Click to see 222.37 unknown https://doi.org/10.1080/10575630008043783
(1aS,4S,7bR)-1,1,4,7-tetramethyl-2,3,4a,5,6,7,7a,7b-octahydro-1aH-cyclopropa[e]azulen-4-ol 25089154 Click to see 222.37 unknown https://doi.org/10.1080/10575630008043783
> Lipids and lipid-like molecules / Prenol lipids / Triterpenoids
(4aS,6aS,6aS,6bR,8aR,12aR,14aS,14bS)-4,4a,6a,6b,8a,11,11,14a-octamethyl-1,2,3,4,5,6,6a,7,8,9,10,12,12a,13,14,14b-hexadecahydropicen-3-ol 137795506 Click to see 428.70 unknown https://doi.org/10.1080/10575630008043783
Betulinic Acid 64971 Click to see 456.70 unknown https://doi.org/10.3987/COM-97-7901
Friedelin 91472 Click to see 426.70 unknown https://doi.org/10.1080/10575630008043783
Friedelinol 101341 Click to see CC1C(CCC2C1(CCC3C2(CCC4(C3(CCC5(C4CC(CC5)(C)C)C)C)C)C)C)O 428.70 unknown https://doi.org/10.1080/10575630008043783
Lup-20(29)-en-28-oic acid, 3beta-hydroxy- 2371 Click to see 456.70 unknown https://doi.org/10.3987/COM-97-7901
> Lipids and lipid-like molecules / Steroids and steroid derivatives / Stigmastanes and derivatives
Stigmasterol 5280794 Click to see 412.70 unknown https://doi.org/10.1080/10575630008043783
> Organoheterocyclic compounds / Benzopyrans / 1-benzopyrans / Xanthones
(2R)-4-(4-methoxy-9-oxoxanthen-3-yl)-2-methylbutanoic acid 162879668 Click to see 326.30 unknown https://doi.org/10.1016/S0031-9422(99)00520-8
(2R)-4-(8-hydroxy-4-methoxy-9-oxoxanthen-3-yl)-2-methylbutanoic acid 162893765 Click to see 342.30 unknown https://doi.org/10.1016/S0031-9422(99)00520-8
(2S)-4-(4-methoxy-9-oxoxanthen-3-yl)-2-methylbutanoic acid 162879667 Click to see 326.30 unknown https://doi.org/10.1016/S0031-9422(99)00520-8
1,2,8-Trimethoxyxanthone 85931281 Click to see 286.28 unknown https://doi.org/10.1016/S0031-9422(99)00520-8
1,3-Dihydroxy-4,6,8-trimethoxyxanthen-9-one 101035766 Click to see 318.28 unknown https://doi.org/10.1016/S0031-9422(99)00520-8
1,3-Dimethoxy-5,8-dihydroxyxanthone 53348043 Click to see COC1=CC2=C(C(=C1)OC)C(=O)C3=C(C=CC(=C3O2)O)O 288.25 unknown https://doi.org/10.1016/S0031-9422(99)00520-8
1,5-Dihydroxy-6-(4-hydroxy-3-methylbutyl)xanthen-9-one 85768635 Click to see CC(CCC1=C(C2=C(C=C1)C(=O)C3=C(C=CC=C3O2)O)O)CO 314.30 unknown https://doi.org/10.1016/S0031-9422(99)00520-8
1,5-dihydroxy-6-[(3S)-4-hydroxy-3-methylbutyl]xanthen-9-one 162939757 Click to see 314.30 unknown https://doi.org/10.1016/S0031-9422(99)00520-8
1,8-Dimethoxy-2-hydroxyxanthone 493307 Click to see 272.25 unknown https://doi.org/10.1016/S0031-9422(99)00520-8
2-Hydroxy-1-methoxyxanthone 10399460 Click to see COC1=C(C=CC2=C1C(=O)C3=CC=CC=C3O2)O 242.23 unknown https://doi.org/10.1016/S0031-9422(99)00520-8
2-Hydroxy-1,7,8-trimethoxyxanthen-9-one 101717282 Click to see 302.28 unknown https://doi.org/10.1016/S0031-9422(00)00289-2
2-Hydroxyxanthone 74708 Click to see 212.20 unknown https://doi.org/10.1016/S0031-9422(00)00289-2
https://doi.org/10.1016/S0031-9422(99)00520-8
2,8-Dihydroxy-1-methoxyxanthone 5464640 Click to see 258.23 unknown https://doi.org/10.1016/S0031-9422(99)00520-8
3,8-Dihydroxy-1,2-dimethoxy-9H-xanthen-9-one 14630572 Click to see 288.25 unknown https://doi.org/10.1016/S0031-9422(99)00520-8
4-(4-Methoxy-9-oxoxanthen-3-yl)-2-methylbutanoic acid 56612721 Click to see CC(CCC1=C(C2=C(C=C1)C(=O)C3=CC=CC=C3O2)OC)C(=O)O 326.30 unknown https://doi.org/10.1016/S0031-9422(99)00520-8
4-(8-Hydroxy-4-methoxy-9-oxoxanthen-3-yl)-2-methylbutanoic acid 12315435 Click to see 342.30 unknown https://doi.org/10.1016/S0031-9422(99)00520-8
6-Hydroxy-1,2,5-trimethoxyxanthen-9-one 101717280 Click to see COC1=C(C2=C(C=C1)OC3=C(C2=O)C=CC(=C3OC)O)OC 302.28 unknown https://doi.org/10.1016/S0031-9422(00)00289-2
6-Hydroxy-1,3,5,7-tetramethoxyxanthen-9-one 102460794 Click to see COC1=CC2=C(C(=C1)OC)C(=O)C3=CC(=C(C(=C3O2)OC)O)OC 332.30 unknown https://doi.org/10.1016/S0031-9422(99)00520-8
6-Methoxy-9-oxo-9H-xanthene-2-carboxylic acid methyl ester 637117 Click to see COC1=CC2=C(C=C1)C(=O)C3=C(O2)C=CC(=C3)C(=O)OC 284.26 unknown https://doi.org/10.1016/S0031-9422(00)00289-2
https://doi.org/10.1016/S0031-9422(99)00520-8
8-Hydroxy-1,2-dimethoxyxanthen-9-one 85948687 Click to see 272.25 unknown https://doi.org/10.1016/S0031-9422(99)00520-8
9H-Xanthen-9-one, 3-hydroxy-2,4-dimethoxy- 12214333 Click to see COC1=C(C(=C2C(=C1)C(=O)C3=CC=CC=C3O2)OC)O 272.25 unknown https://doi.org/10.1016/S0031-9422(00)00289-2
9H-Xanthen-9-one, 3,8-dihydroxy-1,2,4-trimethoxy- 5491745 Click to see 318.28 unknown https://doi.org/10.1016/S0031-9422(00)00289-2
Buchanaxanthone 5481840 Click to see 258.23 unknown https://doi.org/10.1016/S0031-9422(99)00520-8
Euxanthone 5281631 Click to see 228.20 unknown https://doi.org/10.1016/S0031-9422(99)00520-8
Gentisin 5281636 Click to see COC1=CC(=C2C(=C1)OC3=C(C2=O)C=C(C=C3)O)O 258.23 unknown https://doi.org/10.1016/S0031-9422(00)00289-2
https://doi.org/10.1016/S0031-9422(99)00520-8
Methyl 7-methoxy-9-oxoxanthene-3-carboxylate 162993705 Click to see 284.26 unknown https://doi.org/10.1016/S0031-9422(00)00289-2
> Organoheterocyclic compounds / Benzopyrans / 2-benzopyrans
(3R)-6-methoxy-3,7-dimethyl-3,4-dihydro-1H-isochromen-8-ol 21775856 Click to see 208.25 unknown https://doi.org/10.1016/S0031-9422(00)00289-2
> Phenylpropanoids and polyketides / Coumarins and derivatives / Pyranocoumarins / Angular pyranocoumarins
Calanolide A 64972 Click to see CCCC1=CC(=O)OC2=C1C3=C(C=CC(O3)(C)C)C4=C2C(C(C(O4)C)C)O 370.40 unknown https://doi.org/10.1016/S0960-894X(01)80543-6
Calanolide F 122843 Click to see 370.40 unknown https://doi.org/10.1021/NP980140A
Costatolide 461128 Click to see CCCC1=CC(=O)OC2=C1C3=C(C=CC(O3)(C)C)C4=C2C(C(C(O4)C)C)O 370.40 unknown https://doi.org/10.1076/PHBI.37.1.71.6326
> Phenylpropanoids and polyketides / Diarylheptanoids / Linear diarylheptanoids
4-Phenyl-5-methoxy-7-hydroxy-8-benzoylcoumarin 10809277 Click to see 372.40 unknown https://doi.org/10.3987/COM-97-7901
> Phenylpropanoids and polyketides / Neoflavonoids / Prenylated neoflavonoids
(-)-Inophyllum P 72978 Click to see 404.50 unknown https://doi.org/10.1076/PHBI.37.1.71.6326
https://doi.org/10.1016/S0960-894X(01)80543-6
https://doi.org/10.1016/S0040-4039(00)78193-7
(16R,17S)-10,10,16,17-tetramethyl-6-phenyl-3,9,15-trioxatetracyclo[12.4.0.02,7.08,13]octadeca-1(14),2(7),5,8(13),11-pentaene-4,18-dione 455251 Click to see 402.40 unknown https://doi.org/10.1016/S0031-9422(97)00679-1
https://doi.org/10.1016/S0031-9422(98)80071-X
(16S,17S)-10,10,16,17-tetramethyl-6-phenyl-3,9,15-trioxatetracyclo[12.4.0.02,7.08,13]octadeca-1(14),2(7),5,8(13),11-pentaene-4,18-dione 5352084 Click to see 402.40 unknown https://doi.org/10.1016/S0031-9422(98)80071-X
https://doi.org/10.1016/S0040-4039(00)78193-7
(2R)-5-benzoyl-4-hydroxy-2-(2-hydroxypropan-2-yl)-9-phenyl-2,3-dihydrofuro[2,3-f]chromen-7-one 163024126 Click to see CC(C)(C1CC2=C(C(=C3C(=C2O1)C(=CC(=O)O3)C4=CC=CC=C4)C(=O)C5=CC=CC=C5)O)O 442.50 unknown https://doi.org/10.3987/COM-97-7901
(8R,9R)-5-methoxy-8,9-dimethyl-6-(3-methylbut-2-enyl)-4-phenyl-8,9-dihydropyrano[2,3-f]chromene-2,10-dione 15381982 Click to see 418.50 unknown https://doi.org/10.1016/S0031-9422(97)00679-1
https://doi.org/10.1016/S0031-9422(98)80071-X
12-O-Methylinophyllum A 10645694 Click to see CC1C(OC2=C(C1OC)C3=C(C(=CC(=O)O3)C4=CC=CC=C4)C5=C2C=CC(O5)(C)C)C 418.50 unknown https://doi.org/10.3987/COM-97-7901
18-Methoxy-10,10,16,17-tetramethyl-6-phenyl-3,9,15-trioxatetracyclo[12.4.0.02,7.08,13]octadeca-1(14),2(7),5,8(13),11-pentaen-4-one 85217621 Click to see 418.50 unknown https://doi.org/10.3987/COM-97-7901
5-Benzoyl-4-hydroxy-2-(2-hydroxypropan-2-yl)-9-phenyl-2,3-dihydrofuro[2,3-f]chromen-7-one 11797452 Click to see 442.50 unknown https://doi.org/10.3987/COM-97-7901
5-Methoxy-8,9-dimethyl-6-(3-methylbut-2-enyl)-4-phenyl-8,9-dihydropyrano[2,3-f]chromene-2,10-dione 162945629 Click to see CC1C(OC2=C(C(=C3C(=CC(=O)OC3=C2C1=O)C4=CC=CC=C4)OC)CC=C(C)C)C 418.50 unknown https://doi.org/10.1016/S0031-9422(97)00679-1
https://doi.org/10.1016/S0031-9422(98)80071-X
Calanone 5352087 Click to see 424.40 unknown https://doi.org/10.1016/S0040-4039(00)78193-7
https://doi.org/10.1080/10575639808044952
https://doi.org/10.1016/S0031-9422(98)80071-X
https://doi.org/10.1016/S0031-9422(97)00679-1
https://doi.org/10.1002/HLCA.19980810549
https://doi.org/10.3987/COM-97-7901
https://doi.org/10.1080/10575630008043783
Inophyllolide chromanol 15223670 Click to see CC1C(OC2=C(C1O)C3=C(C(=CC(=O)O3)C4=CC=CC=C4)C5=C2C=CC(O5)(C)C)C 404.50 unknown https://doi.org/10.1016/S0040-4039(00)78193-7
Inophyllum C 455252 Click to see 402.40 unknown https://doi.org/10.1016/S0031-9422(98)80071-X
https://doi.org/10.1016/S0031-9422(97)00679-1
https://doi.org/10.1002/HLCA.19980810549
Inophyllum E 5254 Click to see CC1C(OC2=C(C1=O)C3=C(C(=CC(=O)O3)C4=CC=CC=C4)C5=C2C=CC(O5)(C)C)C 402.40 unknown https://doi.org/10.1002/HLCA.19980810549
https://doi.org/10.1016/S0031-9422(97)00679-1
https://doi.org/10.1016/S0031-9422(98)80071-X
https://doi.org/10.1016/S0040-4039(00)78193-7
Isocalanone 11004403 Click to see 424.40 unknown https://doi.org/10.1002/HLCA.19980810549
https://doi.org/10.1080/10575630008043783
https://doi.org/10.1080/10575639808044952
Teysmanone A 15381981 Click to see 424.40 unknown https://doi.org/10.1016/S0031-9422(98)80071-X
https://doi.org/10.1016/S0031-9422(97)00679-1

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