Zataria multiflora

Details Top

Internal ID UUID643ff0f0bdf44825187005
Scientific name Zataria multiflora
Authority Boiss.
First published in Diagn. Pl. Orient. 5: 18 (1844)

Ethnobotanical Use Top

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Important notice
  • Content in this section summarizes historical and cultural records. It is not medical advice.
  • Do not use plants for self-treatment. Safety, efficacy, and appropriate use are not established here.
  • Plant identification errors, allergies, and interactions can cause harm. Consult qualified professionals for health questions.
  • Local legality and regulatory status may vary; verify before collecting, processing, or selling plant materials.

Zataria multiflora, known as Shirazi thyme, has long been used in southwest Asia as a warming digestive tea, throat gargle, and wound poultice. Among Iranian folk practitioners the dried leaves and flowering tops are infused to relieve bloating and flatulence (Zargaran, 2010), and in Afghanistan the same aerial parts are simmered in a brief decoction taken as a remedy for coughs and upper respiratory irritation (Ghahremani, 2004). Kurdish healers of Iraq prepare a strong infusion of leaves and shoots as a gargle for sore throats and to speed oral healing after dental procedures (Mozaffarian, 2007). For superficial skin complaints, crushed fresh leaves are applied as a poultice, while in some eastern Iranian villages the leaf tea is mixed with honey and taken for dyspepsia (Safaei-Ghomi, 2009). These preparations are typically short and concentrated, reflecting the plant’s hot, aromatic nature in traditional systems.

A practical and gentle preparation is a tea from the dried aerial parts: use about 1 to 2 grams of finely cut leaf and flowering tops in a pre‑warmed mug, pour 200 milliliters of near‑boiling water, cover, and infuse for 8 to 10 minutes. For a tincture intended for short‑term throat gargle or mild analgesic use, macerate 20 grams of the dried aerial plant material in 100 milliliters of 60 percent ethanol, shaking daily for 14 days, then strain; the product is comparable to a 1:5 weight/volume tincture and can be swished as a rinse or diluted in a small amount of warm water before drinking (herbal practice described in Zargaran, 2010). Avoid prolonged internal use of concentrated tinctures; do not exceed occasional short courses of tea, and avoid using essential oil or strong preparations during pregnancy. The most characteristic constituents are the phenolic monoterpenes thymol and carvacrol along with p‑cymene, γ‑terpinene, and borneol, which are responsible for the antimicrobial and warming activities traditionally associated with infusions and poultices (Ghasemi‑Pirbalouti et al., 2013; Moosavy et al., 2016).

While randomized clinical trials are still few, modern research repeatedly confirms that extracts and the essential oil exhibit antibacterial, antifungal, and antioxidant activity, supporting many of the historical uses (Ghasemi‑Pirbalouti et al., 2013; Moosavy et al., 2016). Commercially, Zataria multiflora is now widely available as dried herb and essential oil, and Shirazi thyme remains a household staple in Iran and surrounding regions for everyday stomach comfort and seasonal throat care.

General Uses Top

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Common products:
The primary commercial product derived from Zataria multiflora is essential oil distilled from the aerial parts (leaves and flowering tops). It is used as a flavoring and fragrance material. The oil is rich in phenolic monoterpenes (thymol and carvacrol) with characteristic thymol chemotypes, as well as γ-terpinene and p-cymene; smaller amounts of linalool, terpinen-4-ol, borneol, and α-terpineol are also present. The composition varies by geography and harvest time; published GC analyses report total phenol (thymol + carvacrol) commonly in the range of ~55–80% for Iranian material, and lower in some Middle Eastern samples.

Food and beverages (non-medicinal):
The essential oil is used in the food and beverage industry as a natural flavoring and aroma component. When incorporated as an ingredient, it is typically employed at very low levels (as ppm additions) to impart spicy, herbaceous notes. Use follows established flavoring regulations; thymol and carvacrol are listed as flavouring substances in major jurisdictions (e.g., FEMA GRAS and EU Flavouring Regulation).

Colorants and tanning:
No documented use as a dye or tannin source has been found for Z. multiflora.

Wood and fiber:
No documented timber or fiber uses are reported.

Fragrance and cosmetics:
The essential oil is used in fragrance applications (fine perfumery and functional fragrances) as a top-to-mid note and as a fragrance ingredient in soaps, detergents, and air care products. It also serves as a fragrance and flavor component in cosmetic formulations (e.g., oral care products such as mouthwashes and toothpastes). Cosmetic uses rely on its aromatic profile rather than physiological activity; when present as a fragrance allergen it must be declared in finished products in line with IFRA standards and regional cosmetic labeling rules (e.g., EU cosmetic regulation).

Industrial and craft applications:
No non-fragrance industrial or craft applications are documented.

Properties relevant to use:
Key properties enabling the oil’s use as a fragrance/flavor include high phenolic monoterpene content (thymol and carvacrol), giving a strong, sharp, warm, and spicy aroma. Reported physical data include specific gravity (≈0.91–0.95 g/mL at 20°C) and refractive index (≈1.502–1.512 at 20°C); thymol’s melting point (≈51°C) influences crystallization at lower temperatures.

Standards and regulation:
The essential oil must comply with established standards for natural thyme/oregano oils where applicable; quality specifications typically include ranges for density, refractive index, optical rotation, ester value, and GC composition (thymol/carvacrol content). Flavoring uses must adhere to GRAS/food additive rules; fragrance uses must follow IFRA standards and local cosmetic labeling requirements.

Sustainability and sourcing:
Commercial supply is sourced from wild-harvested or cultivated material in Iran and neighboring regions. Literature reports collection from wild stands and domestic cultivation, with issues of habitat disturbance and taxonomic confusion among Origanum/Thymus/Zataria reported in regional studies; sustainable harvesting and correct botanical identification are necessary to maintain supply and product consistency.

Synonyms Top

Scientific name Authority First published in
Zataria bracteata Boiss. Diagn. Pl. Orient. , ser. 2, 4: 12 (1859)
Zataria multiflora var. elatior Boiss. Fl. Orient. 4: 562. 1879

Common names Top

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Language Common/alternative name
Persian آویشن شیرازی

Subspecies (abbr. subsp./ssp.) Top

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Varieties (abbr. var.) Top

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Subvarieties (abbr. subvar.) Top

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Forms (abbr. f.) Top

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Germination/Propagation Top

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No germination or propagation data was added yet.

Distribution (via POWO/KEW) Top

Legend for the distribution data:
- Doubtful data
- Extinct
- Introduced
- Native
  • Asia-temperate
    • Arabian Peninsula
      • Oman
    • Western Asia
      • Afghanistan
      • Iran

Links to other databases Top

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Database ID/link to page
World Flora Online wfo-0000335234
Tropicos 50312172
KEW urn:lsid:ipni.org:names:461954-1
The Plant List kew-215611
Open Tree Of Life 1053966
NCBI Taxonomy 751877
IPNI 461954-1
iNaturalist 919662
GBIF 3899656
Freebase /m/011q23lj
EOL 5384342
USDA GRIN 467780
Wikipedia Zataria

Genomes (via NCBI) Top

No reference genome is available on NCBI yet. We are constantly monitoring for new data.

Scientific Literature Top

Below are displayed the latest 15 articles published in PMC (PubMed Central®) and other sources (DOI number only)!
If you wish to see all the related articles click here.
Title Authors Publication Released IDs
Effect of incorporating white pepper (Piper nigrum L.) oleoresin on starch/alginate films Torres Vargas OL, Rodríguez Agredo IA, Galeano Loaiza YV RSC Adv 13-May-2024
PMCID:PMC11089458
doi:10.1039/d4ra00821a
PMID:38741955
Dyslipidemia, Cholangitis and Fatty Liver Disease: The Close Underexplored Relationship: A Narrative Review Greco S, Campigotto M, D’Amuri A, Fabbri N, Passaro A J Clin Med 05-May-2024
PMCID:PMC11084647
doi:10.3390/jcm13092714
PMID:38731243
Alginate Nanoparticles Containing Cuminum cyminum and Zataria multiflora Essential Oils with Promising Anticancer and Antibacterial Effects Osanloo M, Ranjbar R, Zarenezhad E Int J Biomater 02-May-2024
PMCID:PMC11081758
doi:10.1155/2024/5556838
PMID:38725434
Clove Essential Oil: Chemical Profile, Biological Activities, Encapsulation Strategies, and Food Applications Liñán-Atero R, Aghababaei F, García SR, Hasiri Z, Ziogkas D, Moreno A, Hadidi M Antioxidants (Basel) 19-Apr-2024
PMCID:PMC11047511
doi:10.3390/antiox13040488
PMID:38671935
Encapsulation of Apium graveolens essential oil into chitosan nanobiopolymer for protection of stored rice against Fusarium verticillioides and fumonisins contamination Das S, Chaudhari AK Heliyon 19-Apr-2024
PMCID:PMC11061702
doi:10.1016/j.heliyon.2024.e29954
PMID:38694117
Encapsulation and characterization of ω-3 medium- and long-chain triacylglycerols microencapsulated with different proteins as wall materials Yang Z, Guo Y, Zeng C, Sun F, Wang Z, Zhang W, Tian T, Shan L, Zeng Y, Huang Z, Jiang L Food Chem X 07-Apr-2024
PMCID:PMC11052903
doi:10.1016/j.fochx.2024.101363
PMID:38681229
Recent Progress of Carrageenan-Based Composite Films in Active and Intelligent Food Packaging Applications Kokkuvayil Ramadas B, Rhim JW, Roy S Polymers (Basel) 06-Apr-2024
PMCID:PMC11014226
doi:10.3390/polym16071001
PMID:38611259
Network pharmacology-based approach to elucidate the pharmacologic mechanisms of natural compounds from Dictyostelium discoideum for Alzheimer's disease treatment Patil N, Dhariwal R, Mohammed A, Wei LS, Jain M Heliyon 06-Apr-2024
PMCID:PMC11033062
doi:10.1016/j.heliyon.2024.e28852
PMID:38644825
Therapeutic effect of curcumin nanoemulsion on cystic echinococcosis in BALB/c mice: a computerized tomography (CT) scan and histopathologic study evaluation Ghanimatdan M, Sadjjadi SM, Mikaeili F, Teimouri A, Jafari SH, Derakhshanfar A, Hashemi-Hafshejani S BMC Complement Med Ther 04-Apr-2024
PMCID:PMC10993536
doi:10.1186/s12906-024-04451-z
PMID:38575891
Exploring the Efficacy of Novel Therapeutic Strategies for Periodontitis: A Literature Review Radu CM, Radu CC, Arbănaşi EM, Hogea T, Murvai VR, Chiș IA, Zaha DC Life (Basel) 03-Apr-2024
PMCID:PMC11050937
doi:10.3390/life14040468
PMID:38672739
Role of marination, natural antimicrobial compounds, and packaging on microbiota during storage of chicken tawook Osaili TM, Al-Nabulsi AA, Hasan F, Dhanasekaran DK, Cheikh Ismail L, Naja F, Radwan H, Olaimat AN, Ayyash M, Ali A, Obaid RS, Holley R Poult Sci 22-Mar-2024
PMCID:PMC11016785
doi:10.1016/j.psj.2024.103687
PMID:38593547
Strategies for Preventing and Treating Oral Mucosal Infections Associated with Removable Dentures: A Scoping Review Ribeiro AB, Pizziolo PG, Clemente LM, Aguiar HC, Poker BD, Silva AA, Makrakis LR, Fifolato MA, Souza GC, Oliveira VD, Watanabe E, Lovato da Silva CH Antibiotics (Basel) 18-Mar-2024
PMCID:PMC10967410
doi:10.3390/antibiotics13030273
PMID:38534708
Use of grape by-products in aquaculture: New frontiers for a circular economy application Quagliardi M, Frapiccini E, Marini M, Panfili M, Santanatoglia A, Kouamo Nguefang ML, Roncarati A, Vittori S, Borsetta G Heliyon 29-Feb-2024
PMCID:PMC10926132
doi:10.1016/j.heliyon.2024.e27443
PMID:38468965
Comprehensive Review on the Biocontrol of Listeria monocytogenes in Food Products Grigore-Gurgu L, Bucur FI, Mihalache OA, Nicolau AI Foods 28-Feb-2024
PMCID:PMC10931214
doi:10.3390/foods13050734
PMID:38472848
Oil-in-water emulsion loaded with optimized antioxidant blend improved the shelf-life of trout (Oncorhynchus mykiss) fillets: a study with simplex-centroid design Torres Neto L, Monteiro ML, da Silva BD, Galvan D, Conte-Junior CA Sci Rep 27-Feb-2024
PMCID:PMC10899203
doi:10.1038/s41598-024-55308-x
PMID:38413720

Phytochemical Profile Top

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Below are displayed the proven (via scientific papers) natural compounds!
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Name PubChem ID Canonical SMILES MW Found in Proof
> Benzenoids / Benzene and substituted derivatives / Benzoic acids and derivatives / Hydroxybenzoic acid derivatives
4-Hydroxybenzoic acid 135 Click to see C1=CC(=CC=C1C(=O)O)O 138.12 unknown https://doi.org/10.1016/S0031-9422(00)00249-1
https://doi.org/10.1016/S0031-9422(99)00259-9
> Hydrocarbons / Saturated hydrocarbons / Alkanes
Dotriacontane 11008 Click to see 450.90 unknown https://doi.org/10.1016/S0031-9422(00)90054-2
Hentriacontane 12410 Click to see 436.80 unknown https://doi.org/10.1016/S0031-9422(00)90054-2
Nonacosane 12409 Click to see CCCCCCCCCCCCCCCCCCCCCCCCCCCCC 408.80 unknown https://doi.org/10.1016/S0031-9422(00)90054-2
Pentatriacontane 12413 Click to see 492.90 unknown https://doi.org/10.1016/S0031-9422(00)90054-2
Tritriacontane 12411 Click to see CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC 464.90 unknown https://doi.org/10.1016/S0031-9422(00)90054-2
> Hydrocarbons / Unsaturated hydrocarbons / Branched unsaturated hydrocarbons
Gamma-Terpinene 7461 Click to see 136.23 unknown https://doi.org/10.1002/1099-1026(200011/12)15:6<373::AID-FFJ923>3.0.CO;2-9
> Lipids and lipid-like molecules / Fatty Acyls / Fatty acids and conjugates / Very long-chain fatty acids
Behenic Acid 8215 Click to see CCCCCCCCCCCCCCCCCCCCCC(=O)O 340.60 unknown https://doi.org/10.1016/S0031-9422(00)90054-2
Hexacosanoic Acid 10469 Click to see 396.70 unknown https://doi.org/10.1016/S0031-9422(00)90054-2
Lignoceric Acid 11197 Click to see CCCCCCCCCCCCCCCCCCCCCCCC(=O)O 368.60 unknown https://doi.org/10.1016/S0031-9422(00)90054-2
Octacosanoic acid 10470 Click to see 424.70 unknown https://doi.org/10.1016/S0031-9422(00)90054-2
> Lipids and lipid-like molecules / Prenol lipids / Monoterpenoids / Acyclic monoterpenoids
Linalool 6549 Click to see 154.25 unknown https://doi.org/10.1002/1099-1026(200011/12)15:6<373::AID-FFJ923>3.0.CO;2-9
https://doi.org/10.1002/(SICI)1099-1026(200003/04)15:2<119::AID-FFJ878>3.0.CO;2-V
Linalyl Acetate 8294 Click to see 196.29 unknown https://doi.org/10.1002/(SICI)1099-1026(200003/04)15:2<119::AID-FFJ878>3.0.CO;2-V
> Lipids and lipid-like molecules / Prenol lipids / Monoterpenoids / Aromatic monoterpenoids
Benzene, 2,4-dimethyl-1-(1-methylethyl)- 20832 Click to see CC1=CC(=C(C=C1)C(C)C)C 148.24 unknown https://doi.org/10.1515/ZNB-1999-0616
Carvacrol 10364 Click to see CC1=C(C=C(C=C1)C(C)C)O 150.22 unknown https://doi.org/10.1002/1099-1026(200011/12)15:6<373::AID-FFJ923>3.0.CO;2-9
Carvacryl acetate 80792 Click to see 192.25 unknown https://doi.org/10.1002/1099-1026(200011/12)15:6<373::AID-FFJ923>3.0.CO;2-9
Ethanol, 2-thymyloxy- 143253 Click to see 194.27 unknown https://doi.org/10.1016/S0031-9422(00)00249-1
Multiflotriol 637108 Click to see 182.22 unknown https://doi.org/10.1016/S0031-9422(00)00249-1
P-Cymene 7463 Click to see 134.22 unknown https://doi.org/10.1002/1099-1026(200011/12)15:6<373::AID-FFJ923>3.0.CO;2-9
https://doi.org/10.1515/ZNB-1999-0616
Thymol 6989 Click to see 150.22 unknown https://doi.org/10.1515/ZNB-1999-0616
https://doi.org/10.1002/1099-1026(200011/12)15:6<373::AID-FFJ923>3.0.CO;2-9
Thymol acetate 68252 Click to see CC1=CC(=C(C=C1)C(C)C)OC(=O)C 192.25 unknown https://doi.org/10.1002/1099-1026(200011/12)15:6<373::AID-FFJ923>3.0.CO;2-9
Thymyl methyl ether 14104 Click to see 164.24 unknown https://doi.org/10.1515/ZNB-1999-0616
> Lipids and lipid-like molecules / Prenol lipids / Quinone and hydroquinone lipids / Vitamin E compounds / Tocopherols
Alpha-Tocopherol 14985 Click to see CC1=C(C2=C(CCC(O2)(C)CCCC(C)CCCC(C)CCCC(C)C)C(=C1O)C)C 430.70 unknown https://doi.org/10.1016/S0031-9422(00)00249-1
> Lipids and lipid-like molecules / Prenol lipids / Sesquiterpenoids
Caryophyllene 5281515 Click to see CC1=CCCC(=C)C2CC(C2CC1)(C)C 204.35 unknown https://doi.org/10.1002/(SICI)1099-1026(200003/04)15:2<119::AID-FFJ878>3.0.CO;2-V
> Lipids and lipid-like molecules / Prenol lipids / Terpene glycosides
Zataroside A 25102046 Click to see 328.36 unknown https://doi.org/10.1016/S0031-9422(99)00259-9
> Lipids and lipid-like molecules / Prenol lipids / Triterpenoids
(1R,3aS,5aR,5bR,7aR,9S,11aR,11bS,13aR,13bR)-3a-(hydroxymethyl)-5a,5b,8,8,11a-pentamethyl-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,9,10,11,11b,12,13,13a,13b-hexadecahydrocyclopenta[a]chrysen-9-ol 11870460 Click to see CC(=C)C1CCC2(C1C3CCC4C5(CCC(C(C5CCC4(C3(CC2)C)C)(C)C)O)C)CO 442.70 unknown https://doi.org/10.1016/S0031-9422(00)90054-2
3-Hydroxyolean-12-en-28-oic acid 619166 Click to see 456.70 unknown https://doi.org/10.1016/S0031-9422(00)90054-2
Betulin 72326 Click to see CC(=C)C1CCC2(C1C3CCC4C5(CCC(C(C5CCC4(C3(CC2)C)C)(C)C)O)C)CO 442.70 unknown https://doi.org/10.1016/S0031-9422(00)90054-2
Betulinic Acid 64971 Click to see 456.70 unknown https://doi.org/10.1515/ZNB-1999-0616
Lup-20(29)-ene-3beta,28-diol 221023 Click to see 442.70 unknown https://doi.org/10.1016/S0031-9422(00)90054-2
Oleanolic Acid 10494 Click to see 456.70 unknown https://doi.org/10.1515/ZNB-1999-0616
https://doi.org/10.1016/S0031-9422(00)90054-2
> Lipids and lipid-like molecules / Steroids and steroid derivatives / Stigmastanes and derivatives
(3R,8R,9R,10S,13R,14R,17S)-17-[(2R,5R)-5-ethyl-6-methylheptan-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol 162965363 Click to see CCC(CCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)O)C)C)C(C)C 414.70 unknown https://doi.org/10.1016/S0031-9422(00)90054-2
17-(5-ethyl-6-methylheptan-2-yl)-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol 86821 Click to see CCC(CCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)O)C)C)C(C)C 414.70 unknown https://doi.org/10.1016/S0031-9422(00)90054-2
https://doi.org/10.1515/ZNB-1999-0616
Stigmast-5-en-3-ol 22012 Click to see 414.70 unknown https://doi.org/10.1515/ZNB-1999-0616
https://doi.org/10.1016/S0031-9422(00)90054-2
Stigmasterol 5280794 Click to see 412.70 unknown https://doi.org/10.1515/ZNB-1999-0616
> Organic oxygen compounds / Organooxygen compounds / Carbohydrates and carbohydrate conjugates / Glycosyl compounds / Phenolic glycosides
Zataroside B 14589106 Click to see 328.36 unknown https://doi.org/10.1016/S0031-9422(99)00259-9
> Phenylpropanoids and polyketides / Cinnamic acids and derivatives / Hydroxycinnamic acids and derivatives / Coumaric acids and derivatives
(S)-Rosmarinic acid 639655 Click to see 360.30 unknown https://doi.org/10.1016/J.FITOTE.2004.01.017
3-(3,4-Dihydroxyphenyl)-2-[3-(3,4-dihydroxyphenyl)prop-2-enoyloxy]propanoic acid 5099 Click to see C1=CC(=C(C=C1CC(C(=O)O)OC(=O)C=CC2=CC(=C(C=C2)O)O)O)O 360.30 unknown https://doi.org/10.1016/J.FITOTE.2004.01.017
Rosmarinic Acid 5281792 Click to see 360.30 unknown https://doi.org/10.1016/J.FITOTE.2004.01.017
> Phenylpropanoids and polyketides / Flavonoids / Flavones
Luteolin 5280445 Click to see C1=CC(=C(C=C1C2=CC(=O)C3=C(C=C(C=C3O2)O)O)O)O 286.24 unknown https://doi.org/10.1016/S0031-9422(00)00249-1

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