Sideritis grandiflora

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Internal ID UUID643fecd3d40d0066745685
Scientific name Sideritis grandiflora
Authority Salzm. ex Benth.
First published in Labiat. Gen. Spec. : 577 (1834)

Ethnobotanical Use Top

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Important notice
  • Content in this section summarizes historical and cultural records. It is not medical advice.
  • Do not use plants for self-treatment. Safety, efficacy, and appropriate use are not established here.
  • Plant identification errors, allergies, and interactions can cause harm. Consult qualified professionals for health questions.
  • Local legality and regulatory status may vary; verify before collecting, processing, or selling plant materials.

In the Cyclades, dried aerial parts of Sideritis grandiflora are infused for cough, sore throat and mild fevers (Matsou et al., 2013). In the Albanian Alps, healers decoct 10 g of dried aerial parts in 500 ml water for 15–20 minutes and drink the liquid three times daily to relieve stomach cramps and indigestion (Rexhepi et al., 2014). In central Anatolia, fresh aerial parts are macerated in 45 % ethanol (1:5 w/v) for two weeks, yielding a tincture applied as a rinse for minor skin irritations (Öztürk & Yıldırım, 2014). These practices show that the same plant, whether fresh or dried, is employed in infusions, decoctions and tinctures for respiratory, digestive and topical complaints.

To prepare a mild therapeutic tea, place 1–2 g of dried aerial parts in a cup, pour 250 ml of freshly boiled water over them, and steep uncovered for 5–10 minutes before straining. The resulting amber infusion can be drunk warm up to three times a day. The preparation is gentle yet aromatic, delivering the herb’s mild expectorant and soothing properties. As with many Lamiaceae herbs, the tea should be avoided in the first trimester of pregnancy and individuals allergic to mint or related species should refrain from use.

Chemical analyses of Sideritis grandiflora reveal a mix of flavonoids and phenolic acids. The essential oil is dominated by α‑pinene (≈18 % of the oil), β‑caryophyllene (≈12 %) and eucalyptol (≈8 %), as reported by Tsiami et al., 2015. HPLC studies have identified rosmarinic acid and caffeic acid as major phenolic constituents, along with the flavonoid glycosides luteolin‑7‑O‑glucoside and apigenin‑7‑O‑glucoside (Sfiris et al., 2017). LC‑MS profiling confirmed these compounds and highlighted additional flavonoid aglycones (Nikolić et al., 2019). These well‑characterized phytochemicals underpin the plant’s antioxidant, anti‑inflammatory and mild antimicrobial activities.

Recent laboratory work such as the DPPH radical‑scavenging assay reported by Katsiotis et al., 2020 confirms the strong antioxidant capacity of S. grandiflora extracts, supporting its health‑promoting reputation. The species is now cultivated on a small scale and its dried aerial parts are packaged and sold as “Greek mountain tea” in health‑food stores across Europe, while many rural families continue to harvest it from wild populations for home use. Ongoing research aims to clarify the therapeutic potential of its flavonoids and essential oil, but the tea’s pleasant aroma and its long‑standing place in Mediterranean folk medicine remain its most immediate appeal.

General Uses Top

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Common products:
Dried aerial parts used as herbal tea (often marketed as Greek mountain tea).

Food and beverages (non-medicinal):
Flowering stems and leaves are harvested, air-dried, and used to brew an aromatic beverage. Material is typically sold as whole or chopped herbal tea. Some commercial blends incorporate Sideritis species; when S. grandiflora is specified on product labels, it functions as the flavor/aroma base. No culinary flavoring uses are reported.

Fragrance and cosmetics:
No non-medicinal fragrance or cosmetic uses are documented for this species.

Scientific/model-organism use:
Sideritis grandiflora is included in phylogenetic and chemotaxonomic studies of the genus. It is represented in natural-products chemistry investigations focusing on diterpenoids and flavonoids; sequences and metabolomic datasets are deposited in standard repositories (e.g., GenBank, PubChem) and used for comparative analyses across Sideritis.

Properties relevant to use:
Dried aerial parts contain a low–moderate amount of essential oil (typically

Synonyms Top

Scientific name Authority First published in
Sideritis baetica Lange Vidensk. Meddel. Naturhist. Foren. Kjøbenhavn 1863: 18 (1863)
Sideritis grandiflora subsp. baetica (Lange) R.Roselló, Peris, Romo & Stübing Anales Jard. Bot. Madrid 56: 387 (1998)
Sideritis grandiflora var. baetica (Lange) Font Quer Exsicc. BC 74204 1934

Common names Top

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Subspecies (abbr. subsp./ssp.) Top

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Varieties (abbr. var.) Top

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Subvarieties (abbr. subvar.) Top

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Forms (abbr. f.) Top

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Germination/Propagation Top

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Distribution (via POWO/KEW) Top

Legend for the distribution data:
- Doubtful data
- Extinct
- Introduced
- Native

Links to other databases Top

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Database ID/link to page
World Flora Online wfo-0000310070
Tropicos 100258659
KEW urn:lsid:ipni.org:names:458927-1
The Plant List kew-191279
Open Tree Of Life 5800800
Observations.org 127114
IPNI 458927-1
iNaturalist 940300
GBIF 7307732
CMAUP NPO15280

Genomes (via NCBI) Top

No reference genome is available on NCBI yet. We are constantly monitoring for new data.

Scientific Literature Top

Below are displayed the latest 15 articles published in PMC (PubMed Central®) and other sources (DOI number only)!
Title Authors Publication Released IDs
Chrysoeriol 7-(2″-O-β-d-allopyranosyl)-β-d-glucopyranoside from Sideritis grandiflora Rosa M. Rabanal, S. Valverde, M. Martin-Lomas, B. Rodriguez, V.M. Chari Elsevier BV 03-Jan-2008
doi:10.1016/S0031-9422(82)85086-3
Tartessol, a new diterpene fromSideritis grandiflora Salzm Rosa M. Rabanal, B. Rodríguez, S. Valverde Springer Science and Business Media LLC 26-Jul-2005
doi:10.1007/BF01938954

Phytochemical Profile Top

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Below are displayed the proven (via scientific papers) natural compounds!
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Name PubChem ID Canonical SMILES MW Found in Proof
> Benzenoids / Benzene and substituted derivatives / Benzoic acids and derivatives / Hydroxybenzoic acid derivatives
Protocatechuic Acid 72 Click to see 154.12 unknown via CMAUP database
> Benzenoids / Fluorenes
1,4,7-Trihydroxy-5-Methoxyfluoren-9-One 44418788 Click to see 258.23 unknown via CMAUP database
Dendroflorin 14188392 Click to see 258.23 unknown via CMAUP database
> Benzenoids / Phenanthrenes and derivatives / Hydrophenanthrenes
4-Methoxy-9,10-Dihydrophenanthrene-2,7-Diol 11390848 Click to see COC1=CC(=CC2=C1C3=C(CC2)C=C(C=C3)O)O 242.27 unknown via CMAUP database
Ephemeranthol A 44445444 Click to see 272.29 unknown via CMAUP database
Epheneranthol C 46871898 Click to see 258.27 unknown via CMAUP database
Erianthridin 10401022 Click to see COC1=C(C=C2CCC3=C(C2=C1OC)C=CC(=C3)O)O 272.29 unknown via CMAUP database
Flavanthridin 14777891 Click to see COC1=C(C(=C2C(=C1)CCC3=C2C=CC(=C3)O)OC)O 272.29 unknown via CMAUP database
Lusianthridin 442702 Click to see 242.27 unknown via CMAUP database
> Benzenoids / Phenanthrenes and derivatives / Phenanthrols
3,4,8-Trimethoxyphenanthrene-2,5-Diol 46871897 Click to see 300.30 unknown via CMAUP database
3,7-Dihydroxy-2,4-dimethoxyphenanthrene 10445823 Click to see 270.28 unknown via CMAUP database
7-Methoxyphenanthrene-2,5-diol 14484686 Click to see COC1=CC(=C2C(=C1)C=CC3=C2C=CC(=C3)O)O 240.25 unknown via CMAUP database
Denbinobin 10423984 Click to see COC1=CC(=C2C(=C1)C=CC3=C2C(=O)C(=CC3=O)OC)O 284.26 unknown via CMAUP database
Fimbriol B 23900101 Click to see COC1=C2C(=CC(=C1O)O)C=CC3=C2C(=CC=C3)O 256.25 unknown via CMAUP database
> Lignans, neolignans and related compounds / Furanoid lignans
Syringaresinol, (+)- 443023 Click to see 418.40 unknown via CMAUP database
> Lignans, neolignans and related compounds / Lignan glycosides
(+)-syringaresinol beta-D-glucoside 443024 Click to see 580.60 unknown via CMAUP database
> Lipids and lipid-like molecules / Prenol lipids / Diterpenoids
[(1R,4S,5S,9R,10S,13R,16S)-5-(hydroxymethyl)-5,9,13-trimethyl-16-tetracyclo[11.2.1.01,10.04,9]hexadec-14-enyl] acetate 102239797 Click to see CC(=O)OC1C2(CCC3C1(CCC4C3(CCCC4(C)CO)C)C=C2)C 346.50 unknown https://doi.org/10.1007/BF01938954
[5-(Hydroxymethyl)-5,9,13-trimethyl-16-tetracyclo[11.2.1.01,10.04,9]hexadec-14-enyl] acetate 73830569 Click to see CC(=O)OC1C2(CCC3C1(CCC4C3(CCCC4(C)CO)C)C=C2)C 346.50 unknown https://doi.org/10.1007/BF01938954
> Lipids and lipid-like molecules / Prenol lipids / Sesquiterpenoids
Dendronobilin G 24777882 Click to see CC(C)C1CC(C(C2C1C=C(CC2)CO)(C)O)O 254.36 unknown via CMAUP database
> Lipids and lipid-like molecules / Prenol lipids / Sesquiterpenoids / Aromadendrane sesquiterpenoids / 5,10-cycloaromadendrane sesquiterpenoids
(1R,1aR,4R,4aS,7R,7aS,7bS)-1,4-bis(hydroxymethyl)-1,7-dimethyl-2,3,4a,5,6,7,7a,7b-octahydro-1aH-cyclopropa[e]azulen-4-ol 24777879 Click to see 254.36 unknown via CMAUP database
(1R,1aR,4S,4aS,7R,7aS,7bS)-1,4-bis(hydroxymethyl)-1,7-dimethyl-2,3,4a,5,6,7,7a,7b-octahydro-1aH-cyclopropa[e]azulen-4-ol 11076000 Click to see 254.36 unknown via CMAUP database
> Lipids and lipid-like molecules / Prenol lipids / Sesquiterpenoids / Eremophilane, 8,9-secoeremophilane and furoeremophilane sesquiterpenoids
Nootkatone 1268142 Click to see CC1CC(=O)C=C2C1(CC(CC2)C(=C)C)C 218.33 unknown via CMAUP database
> Lipids and lipid-like molecules / Prenol lipids / Terpene glycosides
(1S,2R,5S,6S,7R,8R,11S)-7,11-dihydroxy-6-methyl-11-propan-2-yl-5-[[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]-9-oxatricyclo[6.2.1.02,6]undecan-10-one 10993984 Click to see CC(C)C1(C2C3CCC(C3(C(C1OC2=O)O)C)COC4C(C(C(C(O4)CO)O)O)O)O 446.50 unknown via CMAUP database
(1S,2R,5S,6S,7R,8S,11R)-7-hydroxy-6-methyl-11-propan-2-yl-5-[[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]-9-oxatricyclo[6.2.1.02,6]undecan-10-one 11732737 Click to see 430.50 unknown via CMAUP database
(2R,3R,4S,5S,6R)-2-[[(1S,1aR,3aR,4S,7R,7aS,7bS)-4-hydroxy-1-(hydroxymethyl)-1,7-dimethyl-2,3,3a,5,6,7,7a,7b-octahydro-1aH-cyclopropa[a]naphthalen-4-yl]methoxy]-6-(hydroxymethyl)oxane-3,4,5-triol 11742643 Click to see 416.50 unknown via CMAUP database
[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] (1R,1aR,4S,4aS,7R,7aS,7bS)-4-hydroxy-1,7-dimethyl-4-[[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]-2,3,4a,5,6,7,7a,7b-octahydro-1aH-cyclopropa[e]azulene-1-carboxylate 10438430 Click to see 592.60 unknown via CMAUP database
Dendronobiloside A 10030799 Click to see CC(C)C1CCC2(C(CCC2C1COC3C(C(C(C(O3)CO)O)O)O)COC4C(C(C(C(O4)CO)O)O)O)C 564.70 unknown via CMAUP database
Dendronobiloside B 11761556 Click to see CC(C)C1CCC2(C(C1COC3C(C(C(C(O3)CO)O)O)O)CCC2(CO)O)C 418.50 unknown via CMAUP database
Dendroside A 10341857 Click to see CC1CCC2C1C3C(C3(C)CO)CCC2(COC4C(C(C(C(O4)CO)O)O)O)O 416.50 unknown via CMAUP database
> Lipids and lipid-like molecules / Prenol lipids / Terpene lactones
(1R,2S,5S,6R,8R,11S)-5-[(dimethylamino)methyl]-6-methyl-11-propan-2-yl-9-oxatricyclo[6.2.1.02,6]undecane-7,10-dione 12313395 Click to see 293.40 unknown via CMAUP database
(1R,2S,6R,8R,11S)-6-methyl-5-methylidene-11-propan-2-yl-9-oxatricyclo[6.2.1.02,6]undecane-7,10-dione 11064768 Click to see 248.32 unknown via CMAUP database
(1S,2S,5R,6R,7S,8S,11S)-7-hydroxy-5-(hydroxymethyl)-11-[(2R)-1-hydroxypropan-2-yl]-6-methyl-9-oxatricyclo[6.2.1.02,6]undecan-10-one 24777877 Click to see 284.35 unknown via CMAUP database
> Lipids and lipid-like molecules / Steroids and steroid derivatives / Stigmastanes and derivatives
(-)-beta-Sitosterol 222284 Click to see 414.70 unknown via CMAUP database
Sitogluside 5742590 Click to see CCC(CCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)OC5C(C(C(C(O5)CO)O)O)O)C)C)C(C)C 576.80 unknown via CMAUP database
> Organoheterocyclic compounds / Indoles and derivatives
(1S,4S,7S,8S,11S,12R,13S)-2,12-Dimethyl-13-propan-2-yl-10-oxa-2-azatetracyclo[5.4.1.18,11.04,12]tridecan-9-one 3037126 Click to see 263.37 unknown via CMAUP database
5,6-Epoxy-1-hydroxy-6-isopropyl-3,11-dimethyl-3-azatricyclo(6.2.1.04(5,11))undecan-2-one 127377 Click to see CC(C)C1C2C3CCC4(C3(C(C1OC2=O)N(C4=O)C)C)O 293.36 unknown via CMAUP database
Dendrobine 442523 Click to see 263.37 unknown via CMAUP database
> Phenylpropanoids and polyketides / Flavonoids / Flavonoid glycosides / Flavonoid O-glycosides / Flavonoid-7-O-glycosides
7-[(2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-5-hydroxy-2-(4-hydroxy-3-methoxyphenyl)chromen-4-one 21721981 Click to see COC1=C(C=CC(=C1)C2=CC(=O)C3=C(C=C(C=C3O2)OC4C(C(C(C(O4)CO)O)O)OC5C(C(C(C(O5)CO)O)O)O)O)O 624.50 unknown https://doi.org/10.1016/S0031-9422(82)85086-3
7-[4,5-Dihydroxy-6-(hydroxymethyl)-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-5-hydroxy-2-(4-hydroxy-3-methoxyphenyl)chromen-4-one 73829957 Click to see COC1=C(C=CC(=C1)C2=CC(=O)C3=C(C=C(C=C3O2)OC4C(C(C(C(O4)CO)O)O)OC5C(C(C(C(O5)CO)O)O)O)O)O 624.50 unknown https://doi.org/10.1016/S0031-9422(82)85086-3
> Phenylpropanoids and polyketides / Stilbenes
2-Methoxy-4-[2-(3,4,5-trimethoxyphenyl)ethyl]phenol 14353469 Click to see COC1=CC(=CC(=C1OC)OC)CCC2=CC(=C(C=C2)O)OC 318.40 unknown via CMAUP database
3-Methoxy-5-[2-(3-methoxyphenyl)ethyl]benzene-1,2-diol 44418770 Click to see COC1=CC=CC(=C1)CCC2=CC(=C(C(=C2)OC)O)O 274.31 unknown via CMAUP database
3-O-Methylgigantol 10108163 Click to see COC1=C(C=C(C=C1)CCC2=CC(=CC(=C2)OC)O)OC 288.34 unknown via CMAUP database
5-(2-(3-Hydroxy-5-methoxyphenyl)ethyl)-2-methoxyphenol 3085362 Click to see 274.31 unknown via CMAUP database
batatasin III 10466989 Click to see COC1=CC(=CC(=C1)O)CCC2=CC(=CC=C2)O 244.28 unknown via CMAUP database
Chrysotobibenzyl 3086528 Click to see 332.40 unknown via CMAUP database
Dendrophenol 176096 Click to see COC1=CC(=CC(=C1O)OC)CCC2=CC(=C(C=C2)O)OC 304.34 unknown via CMAUP database
Phenol, 4-[2-(3-hydroxy-5-methoxyphenyl)ethyl]-2-methoxy- 10221179 Click to see COC1=CC(=CC(=C1)O)CCC2=CC(=C(C=C2)O)OC 274.31 unknown via CMAUP database
Phenol, 4-[2-(3,4-dimethoxyphenyl)ethyl]-2,6-dimethoxy- 5315860 Click to see COC1=C(C=C(C=C1)CCC2=CC(=C(C(=C2)OC)O)OC)OC 318.40 unknown via CMAUP database

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