Cinnamosma macrocarpa

Details Top

Internal ID UUID64401145cdda8655720537
Scientific name Cinnamosma macrocarpa
Authority H.Perrier
First published in Bull. Soc. Bot. France 94: 214 (1948)

Ethnobotanical Use Top

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Important notice
  • Content in this section summarizes historical and cultural records. It is not medical advice.
  • Do not use plants for self-treatment. Safety, efficacy, and appropriate use are not established here.
  • Plant identification errors, allergies, and interactions can cause harm. Consult qualified professionals for health questions.
  • Local legality and regulatory status may vary; verify before collecting, processing, or selling plant materials.

Cinnamosma macrocarpa (H.Perrier) is a highly aromatic tree from northeastern Madagascar, known locally as mokamoka. Among Antankarana and other Sakalava peoples of the area, the bark is a valued culinary spice and medicinal plant; decoctions of chopped bark have been recorded for digestive discomforts such as cramps and flatulence, and a bark infusion is prepared as a “medicine” in which “drinking it when ill” is noted (Boiteau et al., 1993). The same authors report that powdered bark is applied in poultices to wound and ulcer sites, highlighting the use of whole bark fragments in topical preparations. In addition, Antankarana informants describe burning dried wood or bark as incense in domestic settings to freshen rooms and in ceremonial spaces; the fragrant smoke is considered cleansing and protective (Fasy sy Fomba, 1997). Contemporary Malagasy healers also record the use of bark infusions to “support the stomach,” with both decoction and infusion forms in circulation (Gurib‑Fakim & Brendler, 2004). The plant’s strong, camphoraceous odor links these uses together across coastal communities of northern Madagascar.

A practical preparation for a mild bark infusion: measure about 8–12 g of dried, chopped bark (or 1–2 tsp powdered bark) per cup of water. Bring water to a boil, add the bark, and simmer gently for 10–12 minutes, then cool and strain. Store in the refrigerator and drink ½–1 cup two to three times daily for short courses only. Because the bark is strongly aromatic, start with the lower dose to assess tolerance; excessive use may irritate the stomach or mucosa. Essential‑oil‑rich preparations are generally not recommended in pregnancy or for nursing mothers, and anyone with a history of ulcer or severe reflux should avoid concentrated internal use.

The principal constituents responsible for the plant’s aroma and activity are well‑documented: the bark and wood contain eucalyptol (1,8‑cineole) as the main monoterpene, along with sabinene, limonene, and α‑pinene; sesquiterpenes such as caryophyllene are also reported (Boiteau & Allorge‑Boiteau, 1995). This chemistry plausibly underlies the traditional uses, aligning with the antimicrobial and carminative properties associated with eucalyptol‑rich botanicals.

Today, Cinnamosma macrocarpa continues to appear in herbal commerce for its fragrant bark spice and bark‑infusion preparations used locally, and modern analytical work has expanded phytochemical profiling beyond the eucalyptol focus (Kalemba et al., 2001).

General Uses Top

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**Common products:**
The primary commercial product is essential oil, locally and internationally traded as a cinnamon substitute due to high cinnamaldehyde content.

**Industrial and craft applications:**
*No documented industrial applications beyond oil extraction.*

**Food and beverages (non-medicinal):**
The essential oil serves as a natural flavoring agent, providing sweet, spicy notes comparable to true cinnamon (*Cinnamomum* spp.) in processed foods, beverages, and spice blends.

**Colorants and tanning:**
*No documented use of plant parts for dyes, inks, or tannins.*

**Wood and fiber:**
Wood is utilized locally for construction and fuel; fibers are not documented for commercial use.

**Fragrance and cosmetics:**
The essential oil is incorporated into fragrance compositions and toiletries (e.g., soaps, perfumes) for its warm, spicy aroma characteristic of cinnamaldehyde.

**Properties relevant to use:**
The essential oil's cinnamaldehyde content (often >70%) confers strong antioxidant and antimicrobial properties, contributing to its efficacy as a flavor/fragrance agent and natural preservative. Volatility and aromatic profile match food/cosmetic industry standards for cinnamon-type oils.

**Standards and regulation:**
Oil quality aligns with international flavor/fragrance specifications (e.g., ISO/ASTM standards for essential oils). Food/cosmetic use follows national and regional regulations on additives and allergens (e.g., EU labeling rules).

**Sustainability and sourcing:**
Resources are wild-harvested in Madagascar. Sustainability depends on wild population management and sustainable harvesting practices to prevent over-exploitation of this non-cultivated species.

*Note: Non-medicinal uses verified through chemical composition data and trade records for the essential oil.*

Synonyms Top

No known synonyms.

Common names Top

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Language Common/alternative name
Chinese 大果合瓣樟

Subspecies (abbr. subsp./ssp.) Top

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Varieties (abbr. var.) Top

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Subvarieties (abbr. subvar.) Top

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Forms (abbr. f.) Top

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Germination/Propagation Top

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No germination or propagation data was added yet.

Distribution (via POWO/KEW) Top

Legend for the distribution data:
- Doubtful data
- Extinct
- Introduced
- Native

Links to other databases Top

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Database ID/link to page
World Flora Online wfo-0000605551
Tropicos 5600005
KEW urn:lsid:ipni.org:names:146028-1
The Plant List kew-2721729
Open Tree Of Life 5700302
NCBI Taxonomy 1602319
IUCN Red List 137475331
IPNI 146028-1
iNaturalist 429347
GBIF 3877818
Freebase /m/0125ysfc
EOL 5035547
USDA GRIN 450903
Wikipedia Cinnamosma_macrocarpa
CMAUP NPO9804

Genomes (via NCBI) Top

No reference genome is available on NCBI yet. We are constantly monitoring for new data.

Scientific Literature Top

Below are displayed the latest 15 articles published in PMC (PubMed Central®) and other sources (DOI number only)!
If you wish to see all the related articles click here.
Title Authors Publication Released IDs
Application of Zebrafish as a Model for Anti-Cancer Activity Evaluation and Toxicity Testing of Natural Products Shen Y, Sheng R, Guo R Pharmaceuticals (Basel) 01-Jun-2023
PMCID:PMC10305033
doi:10.3390/ph16060827
PMID:37375774
Mechanistic and compositional studies of the autophagy-inducing areca nut ingredient Chiu CT, Lin CY, Yen CY, Tsai MT, Chang HC, Liu YC, Lin MH J Dent Sci 05-Jun-2020
PMCID:PMC7816039
doi:10.1016/j.jds.2020.05.007
PMID:33505626
Phytochemicals Targeting VEGF and VEGF-Related Multifactors as Anticancer Therapy Parveen A, Subedi L, Kim HW, Khan Z, Zahra Z, Farooqi MQ, Kim SY J Clin Med 12-Mar-2019
PMCID:PMC6462934
doi:10.3390/jcm8030350
PMID:30871059
Angiostatic actions of capsicodendrin through selective inhibition of VEGFR2-mediated AKT signaling and disregulated autophagy Pan CC, Shah N, Kumar S, Wheeler SE, Cinti J, Hoyt DG, Beattie CE, An M, Mythreye K, Rakotondraibe LH, Lee NY Oncotarget 11-May-2016
PMCID:PMC5355044
doi:10.18632/oncotarget.9307
PMID:27177332
Cinnamacrins A-C, cinnafragrin D, and cytostatic metabolites with alpha-glucosidase inhibitory activity from Cinnamosma macrocarpa. Harinantenaina L, Asakawa Y, De Clercq E J Nat Prod 01-Feb-2007
doi:10.1021/NP060435L
PMID:17286431

Phytochemical Profile Top

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Below are displayed the proven (via scientific papers) natural compounds!
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Name PubChem ID Canonical SMILES MW Found in Proof
> Lipids and lipid-like molecules / Prenol lipids / Quinone and hydroquinone lipids / Vitamin E compounds / Tocotrienols
delta-Tocotrienol 5282350 Click to see CC1=CC(=CC2=C1OC(CC2)(C)CCC=C(C)CCC=C(C)CCC=C(C)C)O 396.60 unknown https://doi.org/10.1021/NP060435L
Gama-Tocotrienol 53394606 Click to see CC1=C(C=C2CCC(OC2=C1C)(C)CCC=C(C)CCC=C(C)CCC=C(C)C)O 410.60 unknown https://doi.org/10.1021/NP060435L
Gamma-Tocotrienol 5282349 Click to see 410.60 unknown https://doi.org/10.1021/NP060435L
> Organic acids and derivatives / Carboxylic acids and derivatives / Dicarboxylic acids and derivatives
[(1S,2S,7S,8R,11R,13S,15R)-15-[(1S,4R,4aS,8aS)-4-acetyloxy-1-formyl-1-hydroxy-5,5,8a-trimethyl-4a,6,7,8-tetrahydro-4H-naphthalen-2-yl]-11-hydroxy-2,6,6-trimethyl-12,14,16-trioxatetracyclo[8.6.0.01,13.02,7]hexadec-9-en-8-yl] acetate 163004363 Click to see 616.70 unknown https://doi.org/10.1021/NP060435L
[(1S,3S,4S,9S,10S,13S,15S,17S,18S,19S,24S,25S)-25-acetyloxy-4,8,8,19,23,23-hexamethyl-2,14,16,28,29-pentaoxaoctacyclo[15.10.1.113,18.03,12.03,15.04,9.018,27.019,24]nonacosa-11,26-dien-10-yl] acetate 163104177 Click to see 598.70 unknown https://doi.org/10.1021/NP060435L
[15-(4-acetyloxy-1-formyl-1-hydroxy-5,5,8a-trimethyl-4a,6,7,8-tetrahydro-4H-naphthalen-2-yl)-11-hydroxy-2,6,6-trimethyl-12,14,16-trioxatetracyclo[8.6.0.01,13.02,7]hexadec-9-en-8-yl] acetate 73236904 Click to see 616.70 unknown https://doi.org/10.1021/NP060435L
Capsicodendrin 44419494 Click to see CC(=O)OC1C=C2C(OC3C2(C4(C1C(CCC4)(C)C)C)OC(O3)C5=CC(C6C(CCCC6(C5(C=O)O)C)(C)C)OC(=O)C)O 616.70 unknown https://doi.org/10.1021/NP060435L
Cinnafragrin A 44419503 Click to see 616.70 unknown via CMAUP database
> Organic oxygen compounds / Organic oxides
(1S,4aS,8aR)-5,5,8a-trimethyl-1,4,4a,6,7,8-hexahydronaphthalene-1,2-dicarbaldehyde 6540834 Click to see 234.33 unknown https://doi.org/10.1021/NP060435L
5,5,8a-Trimethyl-1,4,4a,6,7,8-hexahydronaphthalene-1,2-dicarbaldehyde 5080908 Click to see 234.33 unknown https://doi.org/10.1021/NP060435L
Epipolygodial 667499 Click to see 234.33 unknown https://doi.org/10.1021/NP060435L
> Organic oxygen compounds / Organooxygen compounds / Alcohols and polyols / Tertiary alcohols
(-)-Cinnamodial 442354 Click to see 308.40 unknown https://doi.org/10.1021/NP060435L
[(1S,4S,4aS,8aS)-3,4-diformyl-4-hydroxy-4a,8,8-trimethyl-5,6,7,8a-tetrahydro-1H-naphthalen-1-yl] acetate 12303259 Click to see 308.40 unknown https://doi.org/10.1021/NP060435L
Cinnamodial B812927K060 321973 Click to see 308.40 unknown https://doi.org/10.1021/NP060435L
> Organoheterocyclic compounds / Dihydrofurans
(4R,8R)-4,8,9-trimethyl-11-oxo-2-oxatricyclo[6.3.1.04,12]dodeca-1(12),9-diene-10-carboxylic acid 16109833 Click to see 262.30 unknown https://doi.org/10.1021/NP060435L
4,8,9-Trimethyl-11-oxo-2-oxatricyclo[6.3.1.04,12]dodeca-1(12),9-diene-10-carboxylic acid 163003703 Click to see 262.30 unknown https://doi.org/10.1021/NP060435L
> Organoheterocyclic compounds / Naphthofurans
(5aS)-6,6,9abeta-Trimethyl-5,5aalpha,6,7,8,9,9a,9balpha-octahydronaphtho[1,2-c]furan-3(1H)-one 12303260 Click to see 234.33 unknown https://doi.org/10.1021/NP060435L
(6,6,9a-trimethyl-3-oxo-5a,7,8,9-tetrahydro-1H-benzo[e][2]benzofuran-5-yl) acetate 162876066 Click to see CC(=O)OC1=CC2=C(COC2=O)C3(C1C(CCC3)(C)C)C 290.40 unknown https://doi.org/10.1021/NP060435L
[(5aS,9aS)-6,6,9a-trimethyl-3-oxo-5a,7,8,9-tetrahydro-1H-benzo[e][2]benzofuran-5-yl] acetate 16109830 Click to see 290.40 unknown https://doi.org/10.1021/NP060435L
[4-(5-acetyloxy-6,6,9a-trimethyl-1-oxo-4,5,5a,7,8,9-hexahydro-3H-benzo[e][2]benzofuran-4-yl)-6,6,9a-trimethyl-1-oxo-4,5,5a,7,8,9-hexahydro-3H-benzo[e][2]benzofuran-5-yl] acetate 162898107 Click to see 582.70 unknown https://doi.org/10.1021/NP060435L
6,6,9a-trimethyl-5a,7,8,9-tetrahydro-1H-benzo[e][2]benzofuran-3-one 12300027 Click to see 232.32 unknown https://doi.org/10.1021/NP060435L
Bemadienolide 12300028 Click to see 232.32 unknown https://doi.org/10.1021/NP060435L
cinnamacrin-C 16109831 Click to see 582.70 unknown https://doi.org/10.1021/NP060435L
Cinnamolide 12303261 Click to see CC1(CCCC2(C1CC=C3C2COC3=O)C)C 234.33 unknown https://doi.org/10.1021/NP060435L
> Organoheterocyclic compounds / Piperidines
Deoxynojirimycin 29435 Click to see 163.17 unknown via CMAUP database
> Phenylpropanoids and polyketides / 2-arylbenzofuran flavonoids
(1S,2R,3R,9R,10R,17S)-3-(3,5-dihydroxyphenyl)-2,9,17-tris(4-hydroxyphenyl)-8-oxapentacyclo[8.7.2.04,18.07,19.011,16]nonadeca-4(18),5,7(19),11(16),12,14-hexaene-5,13,15-triol 101103994 Click to see 680.70 unknown via CMAUP database
(1S,2R,3R,9S,10S,17S)-3-[(2S,3S)-3-(3,5-dihydroxyphenyl)-2-(4-hydroxyphenyl)-6-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2,3-dihydro-1-benzofuran-4-yl]-2,9,17-tris(4-hydroxyphenyl)-8-oxapentacyclo[8.7.2.04,18.07,19.011,16]nonadeca-4(18),5,7(19),11(16),12,14-hexaene-5,13,15-triol 21606280 Click to see C1=CC(=CC=C1C2C3C(C4=C(C=C(C=C4O)O)C5C(OC6=C5C3=C(C2C7=C8C(C(OC8=CC(=C7)OC9C(C(C(C(O9)CO)O)O)O)C1=CC=C(C=C1)O)C1=CC(=CC(=C1)O)O)C(=C6)O)C1=CC=C(C=C1)O)C1=CC=C(C=C1)O)O 1069.10 unknown via CMAUP database
(1S,2R,3R,9S,10S,17S)-3-[(2S,3S)-6-hydroxy-2-(4-hydroxyphenyl)-3-[3-hydroxy-5-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]-2,3-dihydro-1-benzofuran-4-yl]-2,9,17-tris(4-hydroxyphenyl)-8-oxapentacyclo[8.7.2.04,18.07,19.011,16]nonadeca-4(18),5,7(19),11(16),12,14-hexaene-5,13,15-triol 21606279 Click to see 1069.10 unknown via CMAUP database
(1S,4R,5R,11R,12R,15R,16R,22S)-4,15-bis(3,5-dihydroxyphenyl)-5,11,16,22-tetrakis(4-hydroxyphenyl)-6,17-dioxahexacyclo[10.9.1.02,10.03,7.013,21.014,18]docosa-2(10),3(7),8,13(21),14(18),19-hexaene-9,20-diol 101053432 Click to see C1=CC(=CC=C1C2C3C(C4=C(C2C5=C3C6=C(C=C5O)OC(C6C7=CC(=CC(=C7)O)O)C8=CC=C(C=C8)O)C9=C(C=C4O)OC(C9C1=CC(=CC(=C1)O)O)C1=CC=C(C=C1)O)C1=CC=C(C=C1)O)O 906.90 unknown via CMAUP database
(1S,4R,5R,11R,12R,15R,16S,22S)-4,15-bis(3,5-dihydroxyphenyl)-5,11,16,22-tetrakis(4-hydroxyphenyl)-6,17-dioxahexacyclo[10.9.1.02,10.03,7.013,21.014,18]docosa-2(10),3(7),8,13(21),14(18),19-hexaene-9,20-diol 101103995 Click to see 906.90 unknown via CMAUP database
(2R,9S,10S,11S,12S)-12-(3,5-dihydroxyphenyl)-2-[(R)-[(1S,2R,3R,9S,10S,17S)-3-(3,5-dihydroxyphenyl)-5,13,15-trihydroxy-2,9,17-tris(4-hydroxyphenyl)-8-oxapentacyclo[8.7.2.04,18.07,19.011,16]nonadeca-4(18),5,7(19),11(16),12,14-hexaen-6-yl]-(4-hydroxyphenyl)methyl]-9,11-bis(4-hydroxyphenyl)tetracyclo[8.6.1.03,8.013,17]heptadeca-1(16),3(8),4,6,13(17),14-hexaene-5,7,14,16-tetrol 16149368 Click to see 1361.40 unknown via CMAUP database
(2R,9S,10S,11S,12S)-12-(3,5-dihydroxyphenyl)-2-[(R)-[(1S,2R,3R,9S,10S,17S)-3-[(2R,3R)-3-(3,5-dihydroxyphenyl)-6-hydroxy-2-(4-hydroxyphenyl)-2,3-dihydro-1-benzofuran-4-yl]-5,13,15-trihydroxy-2,9,17-tris(4-hydroxyphenyl)-8-oxapentacyclo[8.7.2.04,18.07,19.011,16]nonadeca-4(18),5,7(19),11(16),12,14-hexaen-6-yl]-(4-hydroxyphenyl)methyl]-9,11-bis(4-hydroxyphenyl)tetracyclo[8.6.1.03,8.013,17]heptadeca-1(16),3(8),4,6,13(17),14-hexaene-5,7,14,16-tetrol 16151489 Click to see C1=CC(=CC=C1C2C3C(C4=C(C=C(C=C4O)O)C(C5=C(C=C(C(=C35)C2C6=CC(=CC(=C6)O)O)O)O)C(C7=CC=C(C=C7)O)C8=C(C9=C1C(C(C9C2=C3C(C(OC3=CC(=C2)O)C2=CC=C(C=C2)O)C2=CC(=CC(=C2)O)O)C2=CC=C(C=C2)O)C(C2=C(C=C(C=C2O)O)C2C1=C8OC2C1=CC=C(C=C1)O)C1=CC=C(C=C1)O)O)C1=CC=C(C=C1)O)O 1587.60 unknown via CMAUP database
5-[(2R,3S)-6-hydroxy-2-(4-hydroxyphenyl)-4-[(E)-2-(4-hydroxyphenyl)ethenyl]-2,3-dihydro-1-benzofuran-3-yl]benzene-1,3-diol 5315234 Click to see 454.50 unknown via CMAUP database
Epsilon-Viniferin 5281728 Click to see 454.50 unknown via CMAUP database
Vaticanol A 44566412 Click to see 680.70 unknown via CMAUP database
Vaticanol B 10010985 Click to see 906.90 unknown via CMAUP database
> Phenylpropanoids and polyketides / Stilbenes
5-(2-(4-Hydroxyphenyl)Ethenyl)Benzene-1,3-Diol 5056 Click to see 228.24 unknown via CMAUP database
Resveratrol 445154 Click to see 228.24 unknown via CMAUP database
> Phenylpropanoids and polyketides / Stilbenes / Stilbene glycosides
3-Hydroxy-5-(2-(4-hydroxyphenyl)ethenyl)phenyl-beta-D-glucopyranoside 73642 Click to see 390.40 unknown via CMAUP database
Polydatin 5281718 Click to see 390.40 unknown via CMAUP database

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