Ferula ammoniacum

Details Top

Internal ID UUID6440626651ff9762947574
Scientific name Ferula ammoniacum
Authority (D.Don) Spalik, M.Panahi, Piwczyński & Puchałka
First published in Taxon 64: 780 (2015)

Ethnobotanical Use Top

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General Uses Top

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Common products:
The commercial product is the gum–resin (also called “ammoniaca” gum) harvested from Ferula ammoniacum roots. It is an oleo–gum–resin containing essential oil, water–soluble polysaccharides, and alcohol–soluble resin.

Industrial and craft applications:
The gum–resin is used as a binder and co–solvent in incense and perfumery compounding, and historically as an adhesive base in natural varnishes. Its alcohol solubility enables blending with ethanol or other resin–solvent systems; the polysaccharide fraction contributes to viscosity and film formation. It is also used as a natural fragrance material in oriental and amber fragrance bases, and as a fixative in minor perfumery applications.

Food and beverages (non-medicinal):
Gum ammoniac is listed as a food–grade flavoring (nature‑identical/flavor) in flavor and fragrance databases. It functions as a flavor ingredient in confectionery, baked goods, and beverages when used at flavor levels; no culinary preparations are described. No seed oil or food starch applications are documented.

Colorants and tanning:
No verified use as a dye, ink, or tannin is reported for this taxon.

Wood and fiber:
No timber, pulp, or fiber applications are documented.

Fragrance and cosmetics:
The gum–resin and its essential oil are used as fragrance materials and fixatives in perfume bases; the alcohol solubility supports formulation. It is listed in fragrance safety and usage databases (IFRA/ISO 9235–type references). Cosmetic uses are restricted to perfumery; no other cosmetic ingredient applications are established.

Properties relevant to use:
The gum–resin contains essential oil (monoterpenes/terpenoids), ethanol‑soluble resin, and water‑soluble polysaccharides. These constituents yield alcohol solubility and bind/fix fragrance components, properties that underlie its use in incense, natural adhesives, and perfumery formulations.

Standards and regulation:
As a flavoring, the gum–resin is subject to regulatory flavor standards and maximum use levels in food contexts; as a fragrance material, it is covered by industry guidance and safety standards for fragrance materials (e.g., IFRA Standards) and may be subject to specific national registrations where applicable.

Sustainability and sourcing:
The gum–resin is wild‑harvested in parts of its native range, and supply can be variable. Quality, authentication, and potential adulteration are addressed through standards for gum–resins and essential oils (e.g., ISO/ASTM‑type methods) and regulatory requirements for flavor and fragrance ingredients.

Synonyms Top

Scientific name Authority First published in
Peucedanum ammoniacum Baill. Hist. Pl. 7: 186 (1879)
Diserneston gummiferum Jaub. & Spach Ill. Pl. Orient. 1: 78 (1842)
Diserneston hirsutum Loftus in Borcz. Ferul. 28.
Dorema ammoniacum D.Don Trans. Linn. Soc. London 16: 601 (1833)
Dorema gummiferum (Jaub. & Spach) K.Korol. Fl. URSS 17: 162 (1951)
Dorema hirsutum Loft. in Borcz. Ferul. 28.
Ferula ammonifera Oken Allg. Naturgesch. iii. (3) 1822 (1841); fide Merrill in Journ. Arn. Arb. xxxi.275 (1950).
Diserneston hirsutum Lofius ex I.G.Borshch. Mém. Acad. Imp. Sci. Saint Pétersbourg, Sér. 7 , 3(1): 28 (1860)
Dorema hirsutum Lofius ex I.G.Borshch. Mém. Acad. Imp. Sci. Saint Pétersbourg, Sér. 7 , 3(1): 28 (1860)

Common names Top

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Language Common/alternative name
Arabic فيرولا أمونياكوم

Subspecies (abbr. subsp./ssp.) Top

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Varieties (abbr. var.) Top

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Subvarieties (abbr. subvar.) Top

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Forms (abbr. f.) Top

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Germination/Propagation Top

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Distribution (via POWO/KEW) Top

Legend for the distribution data:
- Doubtful data
- Extinct
- Introduced
- Native
  • Asia-temperate
    • Middle Asia
      • Turkmenistan
    • Western Asia
      • Afghanistan
      • Iran

Links to other databases Top

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Database ID/link to page
World Flora Online wfo-0001344667
KEW urn:lsid:ipni.org:names:77152156-1
Open Tree Of Life 773709
NCBI Taxonomy 460607
IPNI 77152156-1
GBIF 8628529
Wikipedia Ferula_ammoniacum
CMAUP NPO9363

Genomes (via NCBI) Top

No reference genome is available on NCBI yet. We are constantly monitoring for new data.

Scientific Literature Top

Below are displayed the latest 15 articles published in PMC (PubMed Central®) and other sources (DOI number only)!
If you wish to see all the related articles click here.
Title Authors Publication Released IDs
Bio-mordants: a review Benli H Environ Sci Pollut Res Int 23-Feb-2024
PMCID:PMC10948525
doi:10.1007/s11356-024-32174-8
PMID:38396176
Advancements in Sustainable Natural Dyes for Textile Applications: A Review Pizzicato B, Pacifico S, Cayuela D, Mijas G, Riba-Moliner M Molecules 08-Aug-2023
PMCID:PMC10458907
doi:10.3390/molecules28165954
PMID:37630206
Anti-Cancer Effect of Dorema Ammoniacum Gum by Targeting Metabolic Reprogramming by Regulating APC, P53, KRAS Gene Expression in HT-29 Human Colon Cancer Cells Ghodousi-Dehnavi E, Arjmand M, Akbari Z, Aminzadeh M, Haji Hosseini R Rep Biochem Mol Biol 01-Apr-2023
PMCID:PMC10505474
doi:10.52547/rbmb.12.1.127
PMID:37724146
Plant-Derived Bioactive Compounds in the Management of Neurodegenerative Disorders: Challenges, Future Directions and Molecular Mechanisms Involved in Neuroprotection Shoaib S, Ansari MA, Fatease AA, Safhi AY, Hani U, Jahan R, Alomary MN, Ansari MN, Ahmed N, Wahab S, Ahmad W, Yusuf N, Islam N Pharmaceutics 23-Feb-2023
PMCID:PMC10057544
doi:10.3390/pharmaceutics15030749
PMID:36986610
Evaluation of the Cytotoxicity of Aqueous Extract and Oleo-Essential Oil of Dorema ammoniacum Plant Oleo-Gum Resin in Some Human Cancer Cell Lines Mohammadi Pour P, Bidad S, Bahrami G, Hosseinzadeh L, Mojarrab M, Farzaei MH Anal Cell Pathol (Amst) 09-Aug-2022
PMCID:PMC9381248
doi:10.1155/2022/9725244
PMID:35983460
Evaluation of the Therapeutic Effect of the Traditional Herbal Medicine Atrifil and Oshagh Gum on Testosterone-Induced Benign Prostatic Hyperplasia in Wistar Rats Akbari F, Azadbakht M, Gaurav A, Azimi F, Mahdizadeh Z, Vahedi L, Barzegar Nejad A, Chabra A, Eghbali M Adv Urol 05-Jul-2022
PMCID:PMC9277211
doi:10.1155/2022/5742431
PMID:35847835
Origin, evolution, breeding, and omics of Apiaceae: a family of vegetables and medicinal plants Wang XJ, Luo Q, Li T, Meng PH, Pu YT, Liu JX, Zhang J, Liu H, Tan GF, Xiong AS Hortic Res 11-Apr-2022
PMCID:PMC10795576
doi:10.1093/hr/uhac076
PMID:38239769
Diversity and Distribution Patterns of Endemic Medicinal and Aromatic Plants of Iran: Implications for Conservation and Habitat Management Hassanpouraghdam MB, Ghorbani H, Esmaeilpour M, Alford MH, Strzemski M, Dresler S Int J Environ Res Public Health 29-Jan-2022
PMCID:PMC8835522
doi:10.3390/ijerph19031552
PMID:35162573
Efficacy and Safety of Topical Therapy With Botanical Products for Melasma: A Systematic Review and Meta-Analysis of Randomized Controlled Trials Wang T, Wang Y, Wang J, Chen H, Qu B, Li Z Front Med (Lausanne) 24-Jan-2022
PMCID:PMC8819825
doi:10.3389/fmed.2021.797890
PMID:35141245
Ca’ Granda, Hortus simplicium: Restoring an Ancient Medicinal Garden of XV–XIX Century in Milan (Italy) Bottoni M, Milani F, Galimberti PM, Vignati L, Romanini PL, Lavezzo L, Martinetti L, Giuliani C, Fico G Molecules 17-Nov-2021
PMCID:PMC8620247
doi:10.3390/molecules26226933
PMID:34834025
Impact of Genomic and Transcriptomic Resources on Apiaceae Crop Breeding Strategies Palumbo F, Vannozzi A, Barcaccia G Int J Mol Sci 08-Sep-2021
PMCID:PMC8465131
doi:10.3390/ijms22189713
PMID:34575872
Ethnobotany of the medicinal plants used by the ethnic communities of Kerman province, Southeast Iran Hosseini SH, Bibak H, Ghara AR, Sahebkar A, Shakeri A J Ethnobiol Ethnomed 28-Apr-2021
PMCID:PMC8082778
doi:10.1186/s13002-021-00438-z
PMID:33910616
A Systematic Review of Traditionally Used Herbs and Animal-Derived Products as Potential Analgesics Rengasamy KR, Mahomoodally MF, Joaheer T, Zhang Y Curr Neuropharmacol 01-Apr-2021
PMCID:PMC8206464
doi:10.2174/1570159X18666200808151522
PMID:32781962
Phytochemical Analysis, In Vitro Anticholinesterase, Antioxidant Activity and In Vivo Nootropic Effect of Ferula ammoniacum (Dorema ammoniacum) D. Don. in Scopolamine-Induced Memory Impairment in Mice Nazir N, Nisar M, Zahoor M, Uddin F, Ullah S, Ullah R, Ansari SA, Mahmood HM, Bari A, Alobaid A Brain Sci 19-Feb-2021
PMCID:PMC7922987
doi:10.3390/brainsci11020259
PMID:33669503
Green synthesis of silver nanoparticles using plant extracts and their antimicrobial activities: a review of recent literature Vanlalveni C, Lallianrawna S, Biswas A, Selvaraj M, Changmai B, Rokhum SL RSC Adv 13-Jan-2021
PMCID:PMC8694026
doi:10.1039/d0ra09941d
PMID:35424248

Phytochemical Profile Top

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Below are displayed the proven (via scientific papers) natural compounds!
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Name PubChem ID Canonical SMILES MW Found in Proof
> Lipids and lipid-like molecules / Fatty Acyls / Fatty acids and conjugates / Long-chain fatty acids
Oleic Acid 445639 Click to see 282.50 unknown via CMAUP database
> Lipids and lipid-like molecules / Fatty Acyls / Lineolic acids and derivatives
Methyl linoleate 5284421 Click to see 294.50 unknown via CMAUP database
> Lipids and lipid-like molecules / Glycerolipids / Triradylcglycerols / Triacylglycerols
Trilaurin 10851 Click to see CCCCCCCCCCCC(=O)OCC(COC(=O)CCCCCCCCCCC)OC(=O)CCCCCCCCCCC 639.00 unknown via CMAUP database
> Lipids and lipid-like molecules / Prenol lipids / Monoterpenoids / Acyclic monoterpenoids
cis-alpha-Ocimene 5463455 Click to see 136.23 unknown via CMAUP database
> Lipids and lipid-like molecules / Prenol lipids / Sesquiterpenoids
Caryophyllene 5281515 Click to see CC1=CCCC(=C)C2CC(C2CC1)(C)C 204.35 unknown via CMAUP database
> Lipids and lipid-like molecules / Prenol lipids / Sesquiterpenoids / Elemane sesquiterpenoids
Beta-Elemene 6918391 Click to see 204.35 unknown via CMAUP database
> Lipids and lipid-like molecules / Prenol lipids / Terpene lactones
1'-Ethenyl-3'-(4-hydroxy-6-methyl-3-oxohept-5-en-2-yl)-7-methoxy-1'-methylspiro[chromene-3,2'-cyclopentane]-2,4-dione 73657048 Click to see 426.50 unknown https://doi.org/10.1002/HLCA.19910740305
Ammoresinol 54712597 Click to see CC(=CCCC(=CCCC(=CCC1=C(C2=C(C=C(C=C2)O)OC1=O)O)C)C)C 382.50 unknown https://doi.org/10.1002/HLCA.19910740305
> Lipids and lipid-like molecules / Prenol lipids / Triterpenoids
Lupeol 259846 Click to see CC(=C)C1CCC2(C1C3CCC4C5(CCC(C(C5CCC4(C3(CC2)C)C)(C)C)O)C)C 426.70 unknown via CMAUP database
Parkeol 12313974 Click to see CC(CCC=C(C)C)C1CCC2(C1(CC=C3C2CCC4C3(CCC(C4(C)C)O)C)C)C 426.70 unknown via CMAUP database
> Lipids and lipid-like molecules / Steroids and steroid derivatives / Cycloartanols and derivatives
(1S,3R,6S,8R,11S,12S,15R,16R)-15-[(2R,5S)-5-ethyl-6-methylhept-6-en-2-yl]-7,7,12,16-tetramethylpentacyclo[9.7.0.01,3.03,8.012,16]octadecan-6-ol 44423569 Click to see CCC(CCC(C)C1CCC2(C1(CCC34C2CCC5C3(C4)CCC(C5(C)C)O)C)C)C(=C)C 454.80 unknown via CMAUP database
Cycloneolitsol 101306728 Click to see CC(CCC(C)(C)C(=C)C)C1CCC2(C1(CCC34C2CCC5C3(C4)CCC(C5(C)C)O)C)C 454.80 unknown via CMAUP database
> Lipids and lipid-like molecules / Steroids and steroid derivatives / Ergostane steroids / Ergosterols and derivatives
(3beta)-24-Methylenelanost-9(11)-en-3-ol 489917 Click to see 440.70 unknown via CMAUP database
(3S,5R,8S,10S,13R,14S,17R)-17-[(2R,5S)-5,6-dimethylhept-6-en-2-yl]-4,4,10,13,14-pentamethyl-2,3,5,6,7,8,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3-ol 101630502 Click to see 440.70 unknown via CMAUP database
24,24-Dimethyllanosta-9(11),25-dien-3beta-ol 102504569 Click to see CC(CCC(C)(C)C(=C)C)C1CCC2(C1(CC=C3C2CCC4C3(CCC(C4(C)C)O)C)C)C 454.80 unknown via CMAUP database
4alpha,14alpha-Dimethyl-24-methylene-cholest-9(11)-en-3beta-ol 5283648 Click to see CC1C2CCC3C(=CCC4(C3(CCC4C(C)CCC(=C)C(C)C)C)C)C2(CCC1O)C 426.70 unknown via CMAUP database
> Lipids and lipid-like molecules / Steroids and steroid derivatives / Stigmastanes and derivatives
(-)-beta-Sitosterol 222284 Click to see 414.70 unknown via CMAUP database
(3S,4S,5S,8S,10S,13R,14S,17R)-17-[(2R,5R)-5-ethyl-6-methylheptan-2-yl]-4,10,13,14-tetramethyl-1,2,3,4,5,6,7,8,12,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-ol 101630496 Click to see 442.80 unknown via CMAUP database
(3S,4S,5S,8S,10S,13R,14S,17R)-17-[(2R,5S)-5-ethyl-6-methylhept-6-en-2-yl]-4,10,13,14-tetramethyl-1,2,3,4,5,6,7,8,12,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-ol 101630497 Click to see CCC(CCC(C)C1CCC2(C1(CC=C3C2CCC4C3(CCC(C4C)O)C)C)C)C(=C)C 440.70 unknown via CMAUP database
(3S,5R,8S,10S,13R,14S,17R)-17-[(2R,5S)-5-ethyl-6-methylhept-6-en-2-yl]-4,4,10,13,14-pentamethyl-2,3,5,6,7,8,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3-ol 101630504 Click to see 454.80 unknown via CMAUP database
Citrostadienol 9548595 Click to see 426.70 unknown via CMAUP database
Sitogluside 5742590 Click to see CCC(CCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)OC5C(C(C(C(O5)CO)O)O)O)C)C)C(C)C 576.80 unknown via CMAUP database
Stigmast-4-en-3-one 5484202 Click to see CCC(CCC(C)C1CCC2C1(CCC3C2CCC4=CC(=O)CCC34C)C)C(C)C 412.70 unknown via CMAUP database
> Organoheterocyclic compounds / Dihydrofurans / Furanones / Butenolides
5H-7,4-Methenofuro(3,2-c)oxireno(f)oxacycloundecin-5-one,1a,2,3,7,11,11a-hexahydro-8,11a-dimethyl-, (1aS,7R,11aS)- 497202 Click to see CC1=COC2=C1C3C=C(CCC4C(C2)(O4)C)C(=O)O3 260.28 unknown via CMAUP database
Linderalactone 6450191 Click to see 244.28 unknown via CMAUP database
Pseudoneolinderane 57400551 Click to see 260.28 unknown via CMAUP database
Zeylanin 12445041 Click to see CC1=CC2=C(C3C=C(CCC1OC(=O)C)C(=O)O3)C(=CO2)C 302.32 unknown via CMAUP database
> Organoheterocyclic compounds / Dioxanes / 1,4-dioxanes
2H-10,1a-(Epoxymethano)oxireno(4,5)cyclodeca(1,2-b)furan-12-one, 3,6,10,10a-tetrahydro-5,9-methyl-, (1aS-(1aR*,4E,10R*,10aR*))- 6450227 Click to see 260.28 unknown via CMAUP database
> Phenylpropanoids and polyketides / Flavonoids / Flavans / Catechins
Catechin 9064 Click to see 290.27 unknown via CMAUP database
> Phenylpropanoids and polyketides / Flavonoids / Flavans / Flavanones / Flavanonols
(2R,3S)-2-(3,4-Dihydroxyphenyl)-3,5,7-Trihydroxy-2,3-Dihydrochromen-4-One 712318 Click to see 304.25 unknown via CMAUP database
> Phenylpropanoids and polyketides / Flavonoids / Flavonoid glycosides / Flavonoid O-glycosides / Flavonoid-7-O-glycosides
kaempferol 3-O-rhamnoside-7-O-glucoside 90795788 Click to see 594.50 unknown via CMAUP database

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