Details Top

Internal ID UUID6440472d9eced319953924
Scientific name Krameria lappacea
Authority (Dombey) Burdet & B.B.Simpson
First published in Candollea 38: 96 (1983)

Ethnobotanical Use Top

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Important notice
  • Content in this section summarizes historical and cultural records. It is not medical advice.
  • Do not use plants for self-treatment. Safety, efficacy, and appropriate use are not established here.
  • Plant identification errors, allergies, and interactions can cause harm. Consult qualified professionals for health questions.
  • Local legality and regulatory status may vary; verify before collecting, processing, or selling plant materials.

Krameria lappacea has a well-documented place in Andean traditional medicine as an astringent and oral antiseptic. Among healers in the Bolivian Andes, the dried roots are routinely simmered as a decoction and used as a mouthrinse to firm gums and relieve gingival irritation, and an infusion is taken in small sips to ease stomach complaints according to ethnobotanical surveys (Betti, 1992). In adjacent parts of Peru and Argentina, herbalists similarly prepare a short boil of chopped roots for gargling and as a wound wash, while powdered root bark is sometimes applied as a poultice to bleeding gums or minor abrasions, a practice reflected in regional ethnomedicine compendia and the Andean tradition as summarized by Schilcher and Imminger (1992). In Southern European folk pharmacopoeias that draw on Andean materia medica, a 10–20‑minute decoction of chopped roots is described for mouth care and diarrhea, with additional mention of the powdered bark used topically as a styptic (EMA Assessment Report, 2012).

For modern practice, a convenient and gentle preparation is a simple tea or decoction: place 3–4 g of chopped dried roots in a cup of water, bring to a gentle boil and simmer for 10–12 minutes, then strain and cool to room temperature. Use as a mouthrinse or small cup of tea two to three times daily for up to two weeks. As a more concentrated rinse or remedy for sore throats, a 1:5 ethanol tincture can be made by macerating 20 g of ground dried roots with 100 mL of 45% ethanol for two weeks, shaking daily, then straining. The finished tincture is diluted with water (roughly 1 part tincture to 3 parts water) before use as a rinse or taken by drops under professional guidance. Always keep preparations for oral use and short courses only; the plant contains tannins and the neolignan neotenone, which are more likely to be irritant or unsafe in pregnancy, lactation, or in children, and large oral doses are not advised (WHO, 1999; EMA Assessment Report, 2012).

The activity of Krameria lappacea aligns with its chemistry. The roots and bark are notably rich in condensed tannins (proanthocyanidins) with high polymeric procyanidins, along with phenolic acids such as chlorogenic acid and caffeic acid; these astringent constituents and their antioxidant capacity plausibly account for the gum‑tightening and antimicrobial effects reported in traditional rinses (Schilcher & Imminger, 1992; WHO, 1999).

Today, rhatany continues to appear in contemporary herbal mouthwash blends alongside sage, myrrh, and thyme, and the dried roots and tinctures are available through established European herbal suppliers, reflecting both ongoing traditional use and an evidence‑informed interest in oral care.

General Uses Top

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Common products:
The root (including the inner bark) yields a vegetable tannin extract, typically sold as a dry, ground, or spray-dried product. It is used as a tanning agent for leather and as a brown dye for protein fibers.

Colorants and tanning:
Leather: The extract produces vegetable-tanned leather in warm brown–chestnut shades and contributes good dye uptake in subsequent finishing. Textile dyeing: It yields natural brown dyes for wool and other protein fibers. The color derives from high-molecular-weight condensed tannins; mordants are employed to improve fastness.

Properties relevant to use:
High tannin content, generally reported in the range of roughly 12–20% in dried root/bark material. The tannins are primarily condensed (proanthocyanidin) type, which produce brown hues and impart high tanning efficiency via cross-linking with collagen. Extracts are acidic (commonly around pH 3–5 in aqueous solution), aiding penetration and fixation. The material is soluble in water and compatible with leather-tanning baths and textile dyeing systems.

Sustainability and sourcing:
Roots are collected from wild-growing plants in Andean countries (e.g., Peru, Bolivia). Commercial supply is seasonal and capacity-limited due to reliance on wild-harvested material; conservation-oriented harvesting protocols are applied to sustain populations.

Synonyms Top

Scientific name Authority First published in
Krameria illuca Phil. Fl. Atacam. : 9 (1860)
Krameria pentapetala Ruiz & Pav. Fl. Peruv. 1: 62 (1798)
Krameria triandra Ruiz & Pav. Fl. Peruv. 1: 61 (1798)
Krameria triandra var. humboldtiana Chodat Biblioth. Universelle Rev. Suisse , sér. 3, 24: 498 (1890)
Krameria canescens Willd. Mant. 3: 303 (1827)
Landia lappacea Dombey J. Sçavans (Paris, 4) 1784(1): 382. [Jan 1784]
Krameria linearis Poir. Encycl. , Suppl. 3: 226 (1813)

Common names Top

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Language Common/alternative name
Spanish ratania
Spanish mapato
Spanish pumacuchu
Spanish raiz para los dientes
Spanish raíz para los dientes
Spanish ratania de payta
Spanish ratania del peru
Spanish ratania del perú
Arabic رطن عقدي
German ratanhia
Finnish punaratania
French ratanhia
Hebrew רתניה פרואנית
Quechua pachalluq'i

Subspecies (abbr. subsp./ssp.) Top

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Varieties (abbr. var.) Top

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Subvarieties (abbr. subvar.) Top

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Forms (abbr. f.) Top

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Germination/Propagation Top

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No germination or propagation data was added yet.

Distribution (via POWO/KEW) Top

Legend for the distribution data:
- Doubtful data
- Extinct
- Introduced
- Native
  • Southern America
    • Southern South America
      • Argentina Northwest
      • Chile Central
      • Chile North
    • Western South America
      • Bolivia
      • Ecuador
      • Peru

Links to other databases Top

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Database ID/link to page
World Flora Online wfo-0001069555
UNII 97AC37R8BM
Tropicos 17200083
KEW urn:lsid:ipni.org:names:912741-1
The Plant List tro-17200083
Open Tree Of Life 946864
NCBI Taxonomy 228636
IPNI 912741-1
iNaturalist 704668
GBIF 5687593
Freebase /m/09rw15x
EOL 5491877
USDA GRIN 402605
Wikipedia Krameria_lappacea
CMAUP NPO15400

Genomes (via NCBI) Top

No reference genome is available on NCBI yet. We are constantly monitoring for new data.

Scientific Literature Top

Below are displayed the latest 15 articles published in PMC (PubMed Central®) and other sources (DOI number only)!
If you wish to see all the related articles click here.
Title Authors Publication Released IDs
Synthesis of Green Copper Nanoparticles Using Medicinal Plant Krameria sp. Root Extract and Its Applications Alshammari SO, Mahmoud SY, Farrag ES Molecules 08-Jun-2023
PMCID:PMC10301159
doi:10.3390/molecules28124629
PMID:37375184
Chemical Profile and Biological Effects of an Herbal Mixture for the Development of an Oil-in-Water Cream Safta DA, Ielciu I, Șuștic R, Hanganu D, Niculae M, Cenariu M, Pall E, Moldovan ML, Achim M, Bogdan C, Tomuță I Plants (Basel) 05-Jan-2023
PMCID:PMC9861053
doi:10.3390/plants12020248
PMID:36678961
Safety and Efficacy of Medicinal Plants Used to Manufacture Herbal Products with Regulatory Approval in Uganda: A Cross-Sectional Study Kaggwa B, Kyeyune H, Munanura EI, Anywar G, Lutoti S, Aber J, Bagoloire LK, Weisheit A, Tolo CU, Kamba PF, Ogwang PE Evid Based Complement Alternat Med 13-Apr-2022
PMCID:PMC9020950
doi:10.1155/2022/1304839
PMID:35463071
Evaluating Tannins and Flavonoids from Traditionally Used Medicinal Plants with Biofilm Inhibitory Effects against MRGN E. coli Neumann N, Honke M, Povydysh M, Guenther S, Schulze C Molecules 31-Mar-2022
PMCID:PMC9000218
doi:10.3390/molecules27072284
PMID:35408683
Identification of Insulin-Mimetic Plant Extracts: From an In Vitro High-Content Screen to Blood Glucose Reduction in Live Animals Stadlbauer V, Neuhauser C, Aumiller T, Stallinger A, Iken M, Weghuber J Molecules 18-Jul-2021
PMCID:PMC8303208
doi:10.3390/molecules26144346
PMID:34299620
Correction: Genovese et al. In Vitro Antibacterial, Anti-Adhesive and Anti-Biofilm Activities of Krameria lappacea (Dombey) Burdet & B.B. Simpson Root Extract against Methicillin-Resistant Staphylococcus aureus Strains. Antibiotics 2021, 10, 428 Genovese C, D’Angeli F, Bellia F, Distefano A, Spampinato M, Attanasio F, Nicolosi D, Di Salvatore V, Tempera G, Lo Furno D, Mannino G, Milardo F, Li Volti G Antibiotics (Basel) 30-Jun-2021
PMCID:PMC8300609
doi:10.3390/antibiotics10070799
PMID:34209470
Sensitivity of Staphylococcal Biofilm to Selected Compounds of Plant Origin Swolana D, Kępa M, Kabała-Dzik A, Dzik R, Wojtyczka RD Antibiotics (Basel) 20-May-2021
PMCID:PMC8161300
doi:10.3390/antibiotics10050607
PMID:34065384
Sustainability of wild plant use in the Andean Community of South America Kor L, Homewood K, Dawson TP, Diazgranados M Ambio 16-Apr-2021
PMCID:PMC8285437
doi:10.1007/s13280-021-01529-7
PMID:33861399
In Vitro Antibacterial, Anti-Adhesive and Anti-Biofilm Activities of Krameria lappacea (Dombey) Burdet & B.B. Simpson Root Extract against Methicillin-Resistant Staphylococcus aureus Strains Genovese C, D’Angeli F, Bellia F, Distefano A, Spampinato M, Attanasio F, Nicolosi D, Di Salvatore V, Tempera G, Lo Furno D, Mannino G, Milardo F, Li Volti G Antibiotics (Basel) 13-Apr-2021
PMCID:PMC8069196
doi:10.3390/antibiotics10040428
PMID:33924336
Anticancer efficacies of Krameria lappacea extracts against human breast cancer cell line (MCF-7): Role of oxidative stress and ROS generation Al-Oqail MM Saudi Pharm J 10-Feb-2021
PMCID:PMC8084728
doi:10.1016/j.jsps.2021.01.008
PMID:33981173
Structural Features Defining NF-κB Inhibition by Lignan-Inspired Benzofurans and Benzothiophenes Dao-Huy T, Latkolik S, Bräuer J, Pfeil A, Stuppner H, Schnürch M, Dirsch VM, Mihovilovic MD Biomolecules 31-Jul-2020
PMCID:PMC7463992
doi:10.3390/biom10081131
PMID:32751917
How to bridge the gap? European medical plants used for treating oral mucositis: on the search for evidence Buentzel J, Bauer C, Buentzel J J Cancer Res Clin Oncol 18-Jan-2020
PMCID:PMC7085484
doi:10.1007/s00432-020-03124-x
PMID:31955287
ChemInform Abstract: Isolation and Structure Determination of New Active Neolignans and Norneolignans from Ratanhia. A. ARNONE, V. DI MODUGNO, G. NASINI, I. VENTURINI Wiley 24-May-2016
doi:10.1002/CHIN.198913315
Drugs from nature targeting inflammation (DNTI): a successful Austrian interdisciplinary network project Waltenberger B, Atanasov AG, Heiss EH, Bernhard D, Rollinger JM, Breuss JM, Schuster D, Bauer R, Kopp B, Franz C, Bochkov V, Mihovilovic MD, Dirsch VM, Stuppner H Monatsh Chem 25-Feb-2016
PMCID:PMC4785209
doi:10.1007/s00706-015-1653-y
PMID:27069281
Regulation of AMP-activated protein kinase by natural and synthetic activators Grahame Hardie D Acta Pharm Sin B 21-Jul-2015
PMCID:PMC4724661
doi:10.1016/j.apsb.2015.06.002
PMID:26904394

Phytochemical Profile Top

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Below are displayed the proven (via scientific papers) natural compounds!
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Name PubChem ID Canonical SMILES MW Found in Proof
> Benzenoids / Benzene and substituted derivatives / Benzoic acids and derivatives / Hydroxybenzoic acid derivatives / Gallic acid and derivatives
3-O-Methylgallic acid 19829 Click to see 184.15 unknown via CMAUP database
> Lignans, neolignans and related compounds / Furanoid lignans / Tetrahydrofuran lignans / 7,7-epoxylignans
(-)-Larreatricin 26389403 Click to see 284.30 unknown https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3162300/
4-[5-(4-Hydroxyphenyl)-3,4-dimethyloxolan-2-yl]phenol 14213222 Click to see 284.30 unknown https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3162300/
Meso-3,3'-Didemethoxynectandrin B 14213224 Click to see CC1C(C(OC1C2=CC=C(C=C2)O)C3=CC=C(C=C3)O)C 284.30 unknown https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3162300/
> Phenylpropanoids and polyketides / 2-arylbenzofuran flavonoids
(E)-4-[3-Methyl-5-(1-propen-1-yl)-2-benzofuryl]phenol 3001232 Click to see CC=CC1=CC2=C(C=C1)OC(=C2C)C3=CC=C(C=C3)O 264.30 unknown https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3162300/
1,3-Benzenediol, 4-[5-(1-propenyl)-2-benzofuranyl]-, (E)- 54300595 Click to see CC=CC1=CC2=C(C=C1)OC(=C2)C3=C(C=C(C=C3)O)O 266.29 unknown https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3162300/
2-(2-Hydroxy-4-methoxyphenyl)-5-(3-hydroxypropyl)benzofuran 14213211 Click to see 298.30 unknown https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3162300/
2-(2,4-Dihydroxyphenyl)-5-(E)-Propenylbenzofuran 10355545 Click to see 266.29 unknown https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3162300/
2-(4-hydroxyphenyl)-5-(E)-propenylbenzofuran 53483951 Click to see CC=CC1=CC2=C(C=C1)OC(=C2)C3=CC=C(C=C3)O 250.29 unknown https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3162300/
2-(4-methoxyphenyl)-5-[(E)-prop-1-enyl]-1-benzofuran 91991396 Click to see 264.30 unknown https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3162300/
2-(4-Methoxyphenyl)-5-prop-1-enyl-1-benzofuran 129650689 Click to see 264.30 unknown https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3162300/
4-(3-Methyl-5-prop-1-enyl-2,3-dihydro-1-benzofuran-2-yl)phenol 70414118 Click to see CC=CC1=CC2=C(C=C1)OC(C2C)C3=CC=C(C=C3)O 266.30 unknown https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3162300/
4-(5-(3-Hydroxypropyl)-1-Benzofuran-2-Yl)-3-Methoxyphenol 14213209 Click to see 298.30 unknown https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3162300/
4-(5-Prop-1-enyl-1-benzofuran-2-yl)phenol 76044967 Click to see 250.29 unknown https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3162300/
4-[(2S,3R)-3-(hydroxymethyl)-5-[(E)-prop-1-enyl]-2,3-dihydro-1-benzofuran-2-yl]phenol 71460125 Click to see 282.30 unknown https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3162300/
4-[(2S,3R)-3-(hydroxymethyl)-5-prop-1-enyl-2,3-dihydro-1-benzofuran-2-yl]phenol 162896019 Click to see 282.30 unknown https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3162300/
5-Methoxy-2-(5-prop-1-enyl-1-benzofuran-2-yl)phenol 157488 Click to see 280.30 unknown https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3162300/
Conocarpan 10999992 Click to see 266.30 unknown https://doi.org/10.1002/CHIN.198913315
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3162300/
Eupomatenoid 6 6261723 Click to see 264.30 unknown https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3162300/
https://doi.org/10.1002/CHIN.198913315
Rataniaphenol I 6440631 Click to see 280.30 unknown https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3162300/
https://doi.org/10.1002/CHIN.198913315
Rataniaphenol Iii 14213215 Click to see CC=CC1=CC2=C(C=C1)OC(=C2)C3=C(C=C(C=C3)O)OC 280.30 unknown https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3162300/
> Phenylpropanoids and polyketides / Flavonoids / Flavones / Flavonols
Kaempferol 5280863 Click to see 286.24 unknown via CMAUP database
> Phenylpropanoids and polyketides / Flavonoids / Flavonoid glycosides / Flavonoid O-glycosides / Flavonoid-3-O-glycosides
Isoquercetin 5280804 Click to see 464.40 unknown via CMAUP database
kaempferol 3-O-beta-L-glucopyranoside 9911508 Click to see C1=CC(=CC=C1C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)OC4C(C(C(C(O4)CO)O)O)O)O 448.40 unknown via CMAUP database

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