Citrus aurantiifolia

Details Top

Internal ID UUID6440557d1d75b086434860
Scientific name Citrus aurantiifolia
Authority (Christm.) Swingle
First published in J. Washington Acad. Sci. 3: 465 (1913)

Ethnobotanical Use Top

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Important notice
  • Content in this section summarizes historical and cultural records. It is not medical advice.
  • Do not use plants for self-treatment. Safety, efficacy, and appropriate use are not established here.
  • Plant identification errors, allergies, and interactions can cause harm. Consult qualified professionals for health questions.
  • Local legality and regulatory status may vary; verify before collecting, processing, or selling plant materials.

Citrus aurantiifolia (Christm.) Swingle, commonly called lime, is pressed into service as a medicinal tea in several well‑documented folk traditions. In the Caribbean, especially among communities in Trinidad and Tobago, a mild infusion of the dried leaves is taken to calm infant colic and relieve indigestion (Heath, 2008). In the Caatinga region of northeastern Brazil, a decoction of fresh leaves is used to lower fever and act as a gentle diuretic (Silva et al., 2020). Indian Ayurvedic practitioners recommend a short steeping of dried lime leaves as a carminative to reduce flatulence and improve digestion (Sharma, 2015). Mexican Maya healers also prepare a decoction of the fruit peel for gastrointestinal upset, using the sour peel to settle stomach cramps (Márquez et al., 2003). In each of these cases the preparation is an infusion or decoction, and the plant part employed is either the leaf or the peel.

A practical recipe for a simple lime‑leaf tea is as follows: place one level teaspoon (≈2 g) of dried lime leaves into a cup, pour 250 ml of freshly boiled water over the leaves, cover and steep for five to ten minutes, then strain. The resulting beverage is mildly aromatic and can be sweetened with honey to taste. Safety notes advise limiting intake to no more than two or three cups per day; people with a known citrus allergy should avoid the infusion, and pregnant women are cautioned against consuming large quantities because of the plant’s potential uterine‑stimulating activity.

The therapeutic actions of the preparation are supported by well‑established phytochemicals present in C. aurantiifolia. The leaves contain appreciable amounts of ascorbic acid (vitamin C), a potent antioxidant that helps counteract oxidative stress associated with infections and inflammation (Duke, 1992). Flavonoids such as hesperidin and naringin have been isolated from both leaf and peel and are known for their anti‑inflammatory and spasmolytic effects (Silva et al., 2020). The essential‑oil fraction rich in limonene and citral contributes antimicrobial and carminative activity, which may explain the traditional use for digestive discomfort and fever (Márquez et al., 2003). These constituents together provide a plausible biochemical basis for the observed folk applications.

Modern relevance is evident in several directions. Research into the antimicrobial properties of lime‑leaf essential oil is expanding, with studies highlighting its activity against common pathogens (Heath, 2008). Commercial herbal‑tea blends that feature dried C. aurantiifolia leaves are now marketed in health‑food stores, echoing the age‑old Caribbean and Brazilian practices. At the same time, traditional healers in the Caatinga and Ayurvedic clinics continue to prescribe the leaf infusion for digestive ailments, underscoring the plant’s enduring role in both cultural heritage and contemporary herbal medicine.

General Uses Top

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Common products:
Cold‑pressed and distilled key lime oils (Citrus aurantiifolia) are produced from the peel; concentrated and clarified juice (singly or from mixed lime species) is produced from the fruit. Essential‑oil‑free (defatted) peel meal is obtained after oil extraction.

Food and beverages (non‑medicinal):
Cold‑pressed oil is used as a natural citrus flavor in confectionery, bakery fillings, ice cream, beverages (soft drinks, cocktail mixers), condiments, and sauces. Distilled (terpeneless) oil is preferred in many beverage and food applications where water‑soluble flavor is needed; juice concentrates and single‑strength juice are used in carbonated beverages, beverage bases, marinades, dairy formulations, and bakery fillings, as well as in the preparation of Key lime pie and similar desserts. Products are characterized by high citrus character due to major components such as citral (neral + geranial), limonene, and γ‑terpinene.

Fragrance and cosmetics:
Cold‑pressed key lime oil is used in fine fragrance compositions, toiletries (soaps, bath preparations), and cleaning products for its fresh citrus note. Distilled oil, with reduced monoterpene content, is often employed in household cleaners and laundry care where limited solubility and high impact are desired. IFRA provides standards and recommendations for safe use of these oils in fragrance applications. In the EU, key lime oil is listed as a natural flavoring substance in Regulation (EC) No 1334/2008, establishing purity criteria for use in food flavorings.

Properties relevant to use:
Key lime oil’s olfactory profile is dominated by citral (typically 3–7% in cold‑pressed oil), limonene (often >40%), and γ‑terpinene (typically 8–12%), with minor amounts of α‑ and β‑pinene, sabinene, myrcene, and linalool; distillation (terpeneless) oil increases the relative concentration of oxygenated terpenes while removing much of the monoterpene hydrocarbons, enhancing water solubility and stability for certain food and cleaning uses. Juice acidity derives primarily from citric acid; while this acidity contributes to preservation and sensory properties, it is not itself a documented non‑medicinal preservation method in commercial products.

Standards and regulation:
Food‑grade cold‑pressed key lime oil and juice are regulated as natural flavoring substances and food ingredients (e.g., EU Regulation (EC) No 1334/2008). Fragrance use is governed by IFRA standards, which include purity and usage‑level recommendations for key lime oils. No other well‑established standards are commonly applied to these products.

Synonyms Top

Scientific name Authority First published in
Limonia aurantiifolia Christm. Vollst. Pflanzensyst. 1: 618 (1777)
Limonia aurantiifolia Christm. Vollst. Pflanzensyst. 1: 618 (1777)
Citrus nipis Michel Traité Citronier : 44 (1816)
Citrus acida Pers. Syn. Pl. [Persoon] 2(1): 73. 1806 [Nov 1806]
Citrus amblycarpa Ochse Ind. Vrucht. : 217 (1917)
Citrus aurantiifolia subsp. murgetana García Lidón & al. Varied. Trad. Frut. Cuenca Río Segura Cat. Etnobot. 98 1998
Citrus davaoensis (Wester) Yu.Tanaka Syst. Pomol. 140 1951
Citrus excelsa Wester Philipp. Agric. Rev. 8: 26 (1915)
Citrus excelsa var. davaoensis Wester Philipp. Agric. Rev. 8: 25 1915
Citrus hystrix subsp. acida Engl. Nat. Pflanzenfam. 3(4): 200 1896
Citrus javanica Blume Catalogus : 95 (1823)
Citrus lima Macfad. Bot. Misc. 1: 300. 1830
Citrus limonellus Hassk. Flora 25(2, Beibl. 3): 43 (1842)
Citrus longispina Wester Philipp. Agric. Rev. 8: 15 (1915)
Citrus macrophylla Wester Philipp. Agric. Rev. 8: 16 (1915)
Citrus medica var. acida Brandis Forest Fl. N.W. India 52 1874
Citrus medica f. aurantifolia (Christm.) M.Hiroe Forest Pl. Hist. Jap. Islands 1: 219. 1974
Citrus montana (Wester) Yu.Tanaka Stud. Citrol. 9: 8 1939
Citrus notissima Blanco Fl. Filip. : 607 (1837)
Citrus ovata Hassk. Flora 25(2, Beibl. 1): 42 (1842)
Citrus papaya Hassk. Cat. Hort. Bot. Bogor. Alt. : 218 (1844)
Citrus pseudolimonum Wester Philipp. Agric. Rev. 8: 24 (1915)
Citrus spinosissima G.Mey. Prim. Fl. Esseq. : 247 (1818)
Citrus voangasay (Bory) Bojer Hortus Maurit. : 49 (1837)
Citrus webberi var. montana Wester Philipp. Agric. Rev. 8: 13 1915
Citrus depressa var. voangasay Bory Voy. îles Afrique 1: 296 1804
Citrus acida Roxb. Fl. Ind. ed. 1832 3: 390 1832
Citrus limonellus var. amblycarpa Hassk. Flora 25(2, Beibl. 3): 43 (1842)
Citrus limonellus var. oxycarpus Hassk. Flora 25(2, Beibl. 3): 43 (1842)
Citrus lima Lunan Hort. Jamaic. 1: 451 1814.
Citrus lima Raf. Sylva Tellur. 143 1838

Common names Top

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Subspecies (abbr. subsp./ssp.) Top

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Varieties (abbr. var.) Top

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Forms (abbr. f.) Top

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Germination/Propagation Top

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Distribution (via POWO/KEW) Top

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Links to other databases Top

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Database ID/link to page
World Flora Online wfo-0001242548
CMAUP NPO12807

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Scientific Literature Top

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Phytochemical Profile Top

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Below are displayed the proven (via scientific papers) natural compounds!
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Name PubChem ID Canonical SMILES MW Found in Proof
> Alkaloids and derivatives
7-Acetylrinderine 185847 Click to see 341.40 unknown via CMAUP database
Rinderine 442758 Click to see CC(C)C(C(C)O)(C(=O)OCC1=CCN2C1C(CC2)O)O 299.36 unknown via CMAUP database
Supinine 108053 Click to see CC(C)C(C(C)O)(C(=O)OCC1=CCN2C1CCC2)O 283.36 unknown via CMAUP database
> Alkaloids and derivatives / Morphinans
(1S,9S,10R)-3-hydroxy-4,13-dimethoxy-17-methyl-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5,13-tetraen-12-one 11667062 Click to see CN1CCC23C=C(C(=O)CC2C1CC4=C3C(=C(C=C4)OC)O)OC 329.40 unknown via CMAUP database
> Benzenoids / Benzene and substituted derivatives / Phenylpropanes
4-(2-Hydroxypropan-2-yl)benzoic acid 226122 Click to see CC(C)(C1=CC=C(C=C1)C(=O)O)O 180.20 unknown via CMAUP database
> Benzenoids / Phenol esters
(E)-2-Methyl-2-butenoic acid 2-isopropenyl-5-methylphenyl ester 10977290 Click to see CC=C(C)C(=O)OC1=C(C=CC(=C1)C)C(=C)C 230.30 unknown via CMAUP database
8,9-Dehydrothymol isobutyrate 11356419 Click to see CC1=CC(=C(C=C1)C(=C)C)OC(=O)C(C)C 218.29 unknown via CMAUP database
9-Acetoxy-8,10-Dehydrothymol 3-O-Tiglate 10869933 Click to see 288.34 unknown via CMAUP database
> Benzenoids / Phenols / Cresols / Meta cresols
9-Hydroxy-8,10-Dehydrothymol 20669228 Click to see 164.20 unknown via CMAUP database
9-O-Angeloyl-8,10-Dehydrothymol 53355237 Click to see 246.30 unknown via CMAUP database
> Lipids and lipid-like molecules / Fatty Acyls / Fatty alcohol esters
Neryl acetate 1549025 Click to see 196.29 unknown via CMAUP database
> Lipids and lipid-like molecules / Fatty Acyls / Fatty alcohols
1-Octacosanol 68406 Click to see CCCCCCCCCCCCCCCCCCCCCCCCCCCCO 410.80 unknown via CMAUP database
> Lipids and lipid-like molecules / Glycerophospholipids / Glycerophosphocholines / Monoalkylglycerophosphocholines
[(2R)-2-hydroxy-3-[(E)-octadec-11-enoxy]propyl] 2-(trimethylazaniumyl)ethyl phosphate 10097751 Click to see 507.70 unknown via CMAUP database
> Lipids and lipid-like molecules / Prenol lipids / Monoterpenoids / Aromatic monoterpenoids
(E)-2-Isopropyl-5-methylphenyl 2-methylbut-2-enoate 91698167 Click to see 232.32 unknown via CMAUP database
5-(Hydroxymethyl)-2-(propan-2-yl)phenol 14002478 Click to see 166.22 unknown via CMAUP database
P-Cymene 7463 Click to see 134.22 unknown via CMAUP database
Thymohydroquinone 95779 Click to see CC1=CC(=C(C=C1O)C(C)C)O 166.22 unknown via CMAUP database
Thymol 6989 Click to see 150.22 unknown via CMAUP database
Thymol isobutyrate 228738 Click to see CC1=CC(=C(C=C1)C(C)C)OC(=O)C(C)C 220.31 unknown via CMAUP database
Thymyl methyl ether 14104 Click to see 164.24 unknown via CMAUP database
> Lipids and lipid-like molecules / Prenol lipids / Monoterpenoids / Menthane monoterpenoids
Rel-(1r,2s,3r,4r,6s)p-menthane-1,2,3,6-tetrol 11542987 Click to see 204.26 unknown via CMAUP database
trans-5-Hydroxy-p-menth-1(6)-en-2-one 6429209 Click to see 168.23 unknown via CMAUP database
> Lipids and lipid-like molecules / Prenol lipids / Sesquiterpenoids
Clovanediol 15599878 Click to see 238.37 unknown via CMAUP database
> Lipids and lipid-like molecules / Prenol lipids / Sesquiterpenoids / Eudesmane, isoeudesmane or cycloeudesmane sesquiterpenoids
(1R,4aR,6R,8aS)-8a-methyl-4-methylidene-6-propan-2-yl-2,3,5,6,7,8-hexahydro-1H-naphthalene-1,4a-diol 636618 Click to see CC(C)C1CCC2(C(CCC(=C)C2(C1)O)O)C 238.37 unknown via CMAUP database
5-Epi-eudesm-4(15)-ene-1beta,6beta-diol 11746695 Click to see CC(C)C1CCC2(C(CCC(=C)C2C1O)O)C 238.37 unknown via CMAUP database
Voleneol 14137570 Click to see 238.37 unknown via CMAUP database
> Lipids and lipid-like molecules / Prenol lipids / Terpene lactones / Sesquiterpene lactones / Germacranolides and derivatives
[(3aR,4R,6Z,10E,11aR)-6-(acetyloxymethyl)-10-methyl-3-methylidene-2-oxo-3a,4,5,8,9,11a-hexahydrocyclodeca[b]furan-4-yl] (E)-4-hydroxy-2-(hydroxymethyl)but-2-enoate 23258872 Click to see 420.50 unknown via CMAUP database
> Lipids and lipid-like molecules / Prenol lipids / Triterpenoids
[(3S,4aR,6aR,6aR,6bR,8aR,12S,12aR,14aR,14bR)-4,4,6a,6b,8a,12,14b-heptamethyl-11-methylidene-1,2,3,4a,5,6,6a,7,8,9,10,12,12a,13,14,14a-hexadecahydropicen-3-yl] hexadecanoate 14055767 Click to see 665.10 unknown via CMAUP database
[(3S,5R,8R,9S,10R,13R,14S,17S)-17-[(2R)-2-hydroxy-6-methylhept-6-en-2-yl]-4,4,10,13,14-pentamethyl-2,3,5,6,7,8,9,11,12,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] hexadecanoate 11636139 Click to see 683.10 unknown via CMAUP database
Dammaradienyl acetate 14137680 Click to see 468.80 unknown via CMAUP database
> Lipids and lipid-like molecules / Steroids and steroid derivatives / Cycloartanols and derivatives
(1S,3R,6S,8R,11S,12S,15R,16R)-15-[(2R,5R)-5-hydroxy-6-methylhept-6-en-2-yl]-7,7,12,16-tetramethylpentacyclo[9.7.0.01,3.03,8.012,16]octadecan-6-ol 14313591 Click to see 442.70 unknown via CMAUP database
> Organic oxygen compounds / Organooxygen compounds / Alcohols and polyols / Tertiary alcohols
3,6-Caryolanediol 21726648 Click to see 238.37 unknown via CMAUP database
> Organic oxygen compounds / Organooxygen compounds / Carbohydrates and carbohydrate conjugates / Oligosaccharides / Oligosaccharide sulfates
[(3R,4R,5R,6S)-6-[[(3S,5R,8S,10S,13R,14S,17S)-17-acetyl-4,4,10,13,14-pentamethyl-2,3,5,6,7,8,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]-5-[(2S,3R,4S,5S,6R)-5-[(2S,3R,4S,5R,6R)-4-[(2S,3R,4S,5R,6R)-3,5-dihydroxy-4-methoxy-6-(sulfooxymethyl)oxan-2-yl]oxy-3,5-dihydroxy-6-(sulfooxymethyl)oxan-2-yl]oxy-4-hydroxy-6-methyl-3-[(2S,3R,4S,5R)-3,4,5-trihydroxyoxan-2-yl]oxyoxan-2-yl]oxy-4-hydroxyoxan-3-yl] hydrogen sulfate 10920380 Click to see 1347.40 unknown via CMAUP database
[(3R,4R,5R,6S)-6-[[(3S,5R,9S,10R,13R,14R,17S)-17-acetyl-4,4,10,13,14-pentamethyl-2,3,5,6,9,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]-5-[(2S,3R,4S,5S,6R)-5-[(2S,3R,4S,5R,6R)-4-[(2S,3R,4S,5R,6R)-3,5-dihydroxy-4-methoxy-6-(sulfooxymethyl)oxan-2-yl]oxy-3,5-dihydroxy-6-(sulfooxymethyl)oxan-2-yl]oxy-4-hydroxy-6-methyl-3-[(2S,3R,4S,5R)-3,4,5-trihydroxyoxan-2-yl]oxyoxan-2-yl]oxy-4-hydroxyoxan-3-yl] hydrogen sulfate 21672092 Click to see 1347.40 unknown via CMAUP database
> Organoheterocyclic compounds / Benzofurans
Euparin methyl ether 182181 Click to see 230.26 unknown via CMAUP database
> Organoheterocyclic compounds / Imidazopyrimidines / Purines and purine derivatives / Xanthines
1,3,9-Trimethyl-8-nitrosopurine-2,6-dione 23428337 Click to see CN1C2=C(C(=O)N(C(=O)N2C)C)N=C1N=O 223.19 unknown via CMAUP database
> Organoheterocyclic compounds / Piperidines
(3S,5S)-piperidine-3,4,5-triol 10080444 Click to see 133.15 unknown via CMAUP database
> Phenylpropanoids and polyketides / Cinnamic acids and derivatives / Hydroxycinnamic acids and derivatives / Hydroxycinnamic acids
O-Coumaric Acid 637540 Click to see 164.16 unknown via CMAUP database
> Phenylpropanoids and polyketides / Coumarins and derivatives / Pyranocoumarins / Linear pyranocoumarins
Xanthyletin 65188 Click to see 228.24 unknown via CMAUP database
> Phenylpropanoids and polyketides / Flavonoids / Flavonoid glycosides / Flavonoid O-glycosides / Flavonoid-3-O-glycosides
Eupatolin 5317290 Click to see 492.40 unknown via CMAUP database
> Phenylpropanoids and polyketides / Flavonoids / O-methylated flavonoids / 8-O-methylated flavonoids
Isosinensetin 632135 Click to see COC1=C(C=C(C=C1)C2=CC(=O)C3=C(O2)C(=C(C=C3OC)OC)OC)OC 372.40 unknown via CMAUP database
> Phenylpropanoids and polyketides / Linear 1,3-diarylpropanoids / Cinnamylphenols
Xenognosin 5281296 Click to see 256.30 unknown via CMAUP database

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