Content in this section summarizes historical and cultural records. It is not medical advice.
Do not use plants for self-treatment. Safety, efficacy, and appropriate use are not established here.
Plant identification errors, allergies, and interactions can cause harm. Consult qualified professionals for health questions.
Local legality and regulatory status may vary; verify before collecting, processing, or selling plant materials.

Ethnobotanical Uses

Across parts of Thailand, Laos, and Vietnam, Stephania venosa has long been used as a febrifuge and digestive aid. In Thailand, the sliced tuber (or the swollen stem called the “tuberous root” by Thai herbalists) is boiled to make a decoction for fever, stomachache, and dyspepsia, a practice recorded in Thai herbal pharmacopeias and clinical manuals (Thai Herbal Pharmacopoeia, 1995; Chaiyong et al., 2002; Picheansoonthon, 2008). Among the Akha and other hill-tribe groups in northern Thailand and in adjacent Lao areas, communities apply poultices made from the fresh root to sprains and muscular pain, while also drinking a weak decoction for intermittent fever (Picheansoonthon & Koonterm, 2009; Pothongsunun, 2011). In northern Vietnam, ethnic minorities use a short decoction of the tuber for digestive complaints and mild fevers, with topical applications of crushed root for trauma, noted in regional surveys (Do et al., 2012). Finally, some communities steam or lightly boil the tuber to make a medicated wash used externally on inflamed skin or insect bites (Chaiyong et al., 2002).

One practical recipe is a simple febrifuge/decoction: clean and thinly slice 10–20 g of the dried tuber, simmer in 500 ml water for 20–30 minutes, then strain and drink in divided doses (Thai Herbal Pharmacopoeia, 1995). A mild external wash can be made by cooling and diluting the decoction and applying to the skin as needed. Please note that the tuber is acrid and must be properly processed; untreated fresh root can irritate, and not all authors specify precise doses (Picheansoonthon & Koonterm, 2009). While these traditional uses are well documented, no reliable source reports its ingestion during pregnancy or lactation; consult a qualified practitioner before use.

Phytochemistry relevant to these indications includes alkaloids such as hasubanonine, stephanine, and related bisbenzylisoquinolines, along with flavonoids and sterols commonly found in Menispermaceae (Chaiyong et al., 2002; Do et al., 2012). These constituents have documented pharmacological activities—analgesic, antispasmodic, and anti-inflammatory—that plausibly underlie the documented fever, digestive, and topical uses.

Today, dried slices or powders are still sold in regional herbal stalls and featured in Thai monographs, while pharmacological research on the tuber’s alkaloids and essential oil continues (Picheansoonthon, 2008; Do et al., 2012).

General Uses Top

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Synonyms Top

Scientific name	Authority	First published in
Stephania prapatensis	Yamam.	J. Soc. Trop. Agric. 17: 143 (1944)
Clypea venosa	Blume	Bijdr. Fl. Ned. Ind. : 27 (1825)

Common names Top

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Filter by language:

Language	Common/alternative name
Thai	สบู่เลือด
Chinese	脉纹山乌龟

Subspecies (abbr. subsp./ssp.) Top

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Varieties (abbr. var.) Top

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Subvarieties (abbr. subvar.) Top

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Forms (abbr. f.) Top

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Germination/Propagation Top

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No germination or propagation data was added yet.

Distribution (via POWO/KEW) Top

Legend for the distribution data:

- Doubtful data

- Extinct

- Introduced

- Native

Asia-tropical click to expand
- Indian Subcontinent
  - Bangladesh
- Indo-China
  - Andaman Islands
  - Cambodia
  - Laos
  - Myanmar
  - Thailand
  - Vietnam
- Malesia
  - Borneo
  - Jawa
  - Malaya
  - Philippines
  - Sulawesi
  - Sumatera

Links to other databases Top

Suggest others/fix!

Database	ID/link to page
World Flora Online	wfo-0000505081
Tropicos	100384142
KEW	urn:lsid:ipni.org:names:581496-1
Open Tree Of Life	397063
NCBI Taxonomy	527508
IPNI	581496-1
GBIF	5592725

Genomes (via NCBI) Top

No reference genome is available on NCBI yet. We are constantly monitoring for new data.

Scientific Literature Top

Below are displayed the latest 15 articles published in PMC (PubMed Central®) and other sources (DOI number only)!
If you wish to see all the related articles click here.

Title

Authors

Publication

Released

IDs

Eco-friendly approaches to phytochemical production: elicitation and beyond

Jalota K, Sharma V, Agarwal C, Jindal S

Nat Prod Bioprospect

10-Jan-2024

PMCID:	PMC10776560
doi:	10.1007/s13659-023-00419-7
PMID:	38195902

A Critical Review of the Neuropharmacological Effects of Kratom: An Insight from the Functional Array of Identified Natural Compounds

Hossain R, Sultana A, Nuinoon M, Noonong K, Tangpong J, Hossain KH, Rahman MA

Molecules

31-Oct-2023

PMCID:	PMC10648626
doi:	10.3390/molecules28217372
PMID:	37959790

Mechanical investigations of the peltate leaf of Stephania japonica (Menispermaceae): Experiments and a continuum mechanical material model

Macek D, Holthusen H, Rjosk A, Ritzert S, Lautenschläger T, Neinhuis C, Simon JW, Reese S

Front Plant Sci

27-Jan-2023

PMCID:	PMC9911874
doi:	10.3389/fpls.2022.994320
PMID:	36777539

Antibacterial and Antifungal Alkaloids from Asian Angiosperms: Distribution, Mechanisms of Action, Structure-Activity, and Clinical Potentials

Sulaiman M, Jannat K, Nissapatorn V, Rahmatullah M, Paul AK, de Lourdes Pereira M, Rajagopal M, Suleiman M, Butler MS, Break MK, Weber JF, Wilairatana P, Wiart C

Antibiotics (Basel)

24-Aug-2022

PMCID:	PMC9495154
doi:	10.3390/antibiotics11091146
PMID:	36139926

Screening an In-House Isoquinoline Alkaloids Library for New Blockers of Voltage-Gated Na+ Channels Using Voltage Sensor Fluorescent Probes: Hits and Biases

Coquerel Q, Legendre C, Frangieh J, Waard SD, Montnach J, Cmarko L, Khoury J, Hassane CS, Bréard D, Siegler B, Fajloun Z, De Pomyers H, Mabrouk K, Weiss N, Henrion D, Richomme P, Mattei C, Waard MD, Le Ray AM, Legros C

Molecules

28-Jun-2022

PMCID:	PMC9268414
doi:	10.3390/molecules27134133
PMID:	35807390

A Comprehensive Review on the Chemical Properties, Plant Sources, Pharmacological Activities, Pharmacokinetic and Toxicological Characteristics of Tetrahydropalmatine

Du Q, Meng X, Wang S

Front Pharmacol

26-Apr-2022

PMCID:	PMC9086320
doi:	10.3389/fphar.2022.890078
PMID:	35559252

Spatial Distribution and Stability of Cholinesterase Inhibitory Protoberberine Alkaloids from Papaver setiferum

Safa N, Trobec T, Holland DC, Slazak B, Jacobsson E, Hawkes JA, Frangež R, Sepčić K, Göransson U, Moodie LW, Robertson LP

J Nat Prod

15-Dec-2021

PMCID:	PMC8805119
doi:	10.1021/acs.jnatprod.1c00980
PMID:	34910498

Natural Aporphine Alkaloids with Potential to Impact Metabolic Syndrome

Wang FX, Zhu N, Zhou F, Lin DX

Molecules

10-Oct-2021

PMCID:	PMC8540223
doi:	10.3390/molecules26206117
PMID:	34684698

Strengthening Structures in the Petiole–Lamina Junction of Peltate Leaves

Wunnenberg J, Rjosk A, Neinhuis C, Lautenschläger T

Biomimetics (Basel)

02-Apr-2021

PMCID:	PMC8167582
doi:	10.3390/biomimetics6020025
PMID:	33918405

Biologically Active Isoquinoline Alkaloids covering 2014-2018

Shang XF, Yang CJ, Morris-Natschke SL, Li JC, Yin XD, Liu YQ, Guo X, Peng JW, Goto M, Zhang JY, Lee KH

Med Res Rev

29-Jul-2020

PMCID:	PMC7554109
doi:	10.1002/med.21703
PMID:	32729169

Ovalbumin Hydrolysates Inhibit Nitric Oxide Production in LPS-induced RAW 264.7 Macrophages

Kim HS, Lee JH, Moon SH, Ahn DU, Paik HD

Food Sci Anim Resour

01-Mar-2020

PMCID:	PMC7057040
doi:	10.5851/kosfa.2020.e12
PMID:	32161922

Alkaloids from Plants with Antimalarial Activity: A Review of Recent Studies

Uzor PF

Evid Based Complement Alternat Med

12-Feb-2020

PMCID:	PMC7037883
doi:	10.1155/2020/8749083
PMID:	32104196

Antiplasmodial natural products: an update

Tajuddeen N, Van Heerden FR

Malar J

05-Dec-2019

PMCID:	PMC6896759
doi:	10.1186/s12936-019-3026-1
PMID:	31805944

Evaluation of Anti-HIV-1 Integrase and Anti-Inflammatory Activities of Compounds from Betula alnoides Buch-Ham

Chaniad P, Sudsai T, Septama AW, Chukaew A, Tewtrakul S

Adv Pharmacol Sci

02-Jun-2019

PMCID:	PMC6589325
doi:	10.1155/2019/2573965
PMID:	31275368

Diversity and Applications of Endophytic Actinobacteria of Plants in Special and Other Ecological Niches

Singh R, Dubey AK

Front Microbiol

08-Aug-2018

PMCID:	PMC6092505
doi:	10.3389/fmicb.2018.01767
PMID:	30135681

Phytochemical Profile Top

Add a new one!

Below are displayed the proven (via scientific papers) natural compounds!
You can also contribute to this by clicking here.

Name	PubChem ID	Canonical SMILES	MW	Found in	Proof
> Alkaloids and derivatives / Aporphines
(-)-Crebanine	139080500	Click to see	678.80	unknown	https://doi.org/10.3987/S-1981-02-1067 https://doi.org/10.1021/NP50054A017 https://doi.org/10.1021/NP50040A028
(-)-Nuciferoline	13996840	Click to see CN1CCC2=CC(=C(C3=C2C1CC4=C3C=C(C=C4)O)OC)OC	311.40	unknown	https://doi.org/10.1021/NP50054A017
(-)-Stephanine; (R)-(-)-Stephanine; 8-Methoxy-1,2-(methylenedioxy)-6abeta-aporphine; Stephanin; l-Stephanine	10335495	Click to see CN1CCC2=CC3=C(C4=C2C1CC5=C4C=CC=C5OC)OCO3	309.40	unknown	https://doi.org/10.1055/S-2006-960858
(+)-Mecambroline	442328	Click to see	295.30	unknown	https://doi.org/10.1021/NP50054A017
(12S)-15,16-dimethoxy-11-methyl-3,5-dioxa-11-azapentacyclo[10.7.1.02,6.08,20.014,19]icosa-1(20),2(6),7,14(19),15,17-hexaene	10042806	Click to see	339.40	unknown	https://doi.org/10.1055/S-2006-960858
[(12R,13S)-15,16-dimethoxy-11-methyl-3,5-dioxa-11-azapentacyclo[10.7.1.02,6.08,20.014,19]icosa-1(20),2(6),7,14(19),15,17-hexaen-13-yl] acetate	163106453	Click to see	397.40	unknown	https://doi.org/10.1021/NP50040A028
15-Hydroxy-3,5-dioxa-11-azapentacyclo[10.7.1.02,6.08,20.014,19]icosa-1(20),2(6),7,9,11,14(19),15,17-octaen-13-one	86137270	Click to see C1OC2=C(O1)C3=C4C(=C2)C=CN=C4C(=O)C5=C3C=CC=C5O	291.26	unknown	https://doi.org/10.1021/NP50040A028
5H-Benzo[g]-1,3-benzodioxolo[6,5,4-de]quinoline, 6,7,7a,8-tetrahydro-9,10-dimethoxy-7-methyl-, (7R)-	333544	Click to see	339.40	unknown	https://doi.org/10.1055/S-2006-960858 https://doi.org/10.1021/NP50040A028
Anonaine	160597	Click to see C1CNC2CC3=CC=CC=C3C4=C2C1=CC5=C4OCO5	265.31	unknown	https://doi.org/10.1021/NP50054A017
Crebanine	159999	Click to see	339.40	unknown	https://doi.org/10.1055/S-2006-960858
Dehydrocrebanine	149600	Click to see CN1CCC2=CC3=C(C4=C5C=CC(=C(C5=CC1=C24)OC)OC)OCO3	337.40	unknown	https://doi.org/10.1021/NP50040A028 https://doi.org/10.1021/NP50054A017 https://doi.org/10.1055/S-2006-960858
Dehydrostephanine	156870	Click to see	307.30	unknown	https://doi.org/10.1055/S-2006-960858
ethyl (6aR)-1-methoxy-2-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-6-carboxylate	101667575	Click to see	501.50	unknown	https://doi.org/10.1016/S0031-9422(00)90490-4
ethyl 1-methoxy-2-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-6-carboxylate	162903364	Click to see CCOC(=O)N1CCC2=CC(=C(C3=C2C1CC4=CC=CC=C43)OC)OC5C(C(C(C(O5)CO)O)O)O	501.50	unknown	https://doi.org/10.1016/S0031-9422(00)90490-4
Liriodenine	10144	Click to see C1OC2=C(O1)C3=C4C(=C2)C=CN=C4C(=O)C5=CC=CC=C53	275.26	unknown	https://doi.org/10.1021/NP50040A028
Mecambroline	5274588	Click to see	295.30	unknown	https://doi.org/10.1021/NP50054A017
Nuciferoline	821348	Click to see	311.40	unknown	https://doi.org/10.1021/NP50054A017
Oxocrebanine	3084713	Click to see	335.30	unknown	https://doi.org/10.1021/NP50040A028
Oxostephanine	343547	Click to see COC1=CC=CC2=C1C(=O)C3=NC=CC4=CC5=C(C2=C43)OCO5	305.30	unknown	https://doi.org/10.1021/NP50040A028
R-(-)-asimilobine	160875	Click to see	267.32	unknown	https://doi.org/10.1021/NP50054A017
Stephanine	160501	Click to see CN1CCC2=CC3=C(C4=C2C1CC5=C4C=CC=C5OC)OCO3	309.40	unknown	https://doi.org/10.1055/S-2006-960858
Stesakine	157110	Click to see	325.40	unknown	https://doi.org/10.1021/NP50054A017
Tsuduranine	363262	Click to see COC1=C(C2=C3C(CC4=C2C=C(C=C4)O)NCCC3=C1)OC	297.30	unknown	https://doi.org/10.1021/NP50054A017
> Alkaloids and derivatives / Aporphines / Hydroxy-7-aporphines
(-)-Stephadiolamine beta-N-oxide	163184422	Click to see	327.30	unknown	https://doi.org/10.1021/NP50054A017
(-)-Sukhodianine beta-N-oxide	163184421	Click to see C[N+]1(CCC2=CC3=C(C4=C2C1C(C5=C4C=CC(=C5OC)OC)O)OCO3)[O-]	371.40	unknown	https://doi.org/10.1021/NP50054A017
(+)-Norushinsunine N-oxide	13891870	Click to see	311.30	unknown	https://doi.org/10.1021/NP50054A017
(11R,12S,13R)-11-methyl-11-oxido-3,5-dioxa-11-azoniapentacyclo[10.7.1.02,6.08,20.014,19]icosa-1(20),2(6),7,14,16,18-hexaen-13-ol	13891872	Click to see C[N+]1(CCC2=CC3=C(C4=C2C1C(C5=CC=CC=C54)O)OCO3)[O-]	311.30	unknown	https://doi.org/10.1021/NP50054A017
(11S,12S,13S)-15,16-dimethoxy-11-methyl-11-oxido-3,5-dioxa-11-azoniapentacyclo[10.7.1.02,6.08,20.014,19]icosa-1(20),2(6),7,14(19),15,17-hexaen-13-ol	163188451	Click to see C[N+]1(CCC2=CC3=C(C4=C2C1C(C5=C4C=CC(=C5OC)OC)O)OCO3)[O-]	371.40	unknown	https://doi.org/10.1021/NP50054A017
(12R,13R)-15,16-dimethoxy-11-methyl-3,5-dioxa-11-azapentacyclo[10.7.1.02,6.08,20.014,19]icosa-1(20),2(6),7,14(19),15,17-hexaen-13-ol	101012862	Click to see	355.40	unknown	https://doi.org/10.1021/NP50021A019 https://doi.org/10.1055/S-2006-960858 https://doi.org/10.1021/NP50040A028 https://doi.org/10.1021/NP50054A017
(12S,13S)-15,16-dimethoxy-11-methyl-3,5-dioxa-11-azapentacyclo[10.7.1.02,6.08,20.014,19]icosa-1(20),2(6),7,14(19),15,17-hexaen-13-ol	154495920	Click to see	355.40	unknown	https://doi.org/10.1021/NP50054A017
(9R,11R,12R,13R)-11-methyl-11-oxido-3,5-dioxa-11-azoniapentacyclo[10.7.1.02,6.08,20.014,19]icosa-1(20),2(6),7,14,16,18-hexaene-9,13-diol	163188303	Click to see C[N+]1(CC(C2=CC3=C(C4=C2C1C(C5=CC=CC=C54)O)OCO3)O)[O-]	327.30	unknown	https://doi.org/10.1021/NP50054A017
15,16-Dimethoxy-11-methyl-3,5-dioxa-11-azapentacyclo[10.7.1.02,6.08,20.014,19]icosa-1(20),2(6),7,14(19),15,17-hexaen-13-ol	13996835	Click to see	355.40	unknown	https://doi.org/10.1055/S-2006-960858
5H-Benzo(g)-1,3-benzodioxolo(6,5,4-de)quinolin-8-ol, 6,7,7a,8-tetrahydro-9-methoxy-7-methyl-, (7aS,8R)-	158089	Click to see	325.40	unknown	https://doi.org/10.1021/NP50021A019
5H-Benzo(g)-1,3-benzodioxolo(6,5,4-de)quinolin-8-ol, 6,7,7a,8-tetrahydro-9,10-dimethoxy-7-methyl-, (7aS,8R)-	158088	Click to see	355.40	unknown	https://doi.org/10.1055/S-2006-960858 https://doi.org/10.1021/NP50021A019 https://doi.org/10.1021/NP50054A017
N-Oxyushinsunine	13891873	Click to see	311.30	unknown	https://doi.org/10.1021/NP50054A017
Ushinsunine	197018	Click to see CN1CCC2=CC3=C(C4=C2C1C(C5=CC=CC=C54)O)OCO3	295.30	unknown	https://doi.org/10.1021/NP50054A017
> Alkaloids and derivatives / Hasubanan alkaloids
Cepharamine	12302744	Click to see CN1CCC23C1(CCC4=C2C(=C(C=C4)OC)O)C=C(C(=O)C3)OC	329.40	unknown	https://doi.org/10.1021/NP50038A038
> Alkaloids and derivatives / Proaporphines
(2S,4R,5'S)-5',10,11-trimethoxyspiro[5-azatricyclo[6.3.1.04,12]dodeca-1(12),8,10-triene-2,4'-cyclohex-2-ene]-1'-one	13996826	Click to see	329.40	unknown	https://doi.org/10.1021/NP50054A017
(2S,4S,5'R)-5'-hydroxy-10,11-dimethoxyspiro[5-azatricyclo[6.3.1.04,12]dodeca-1(12),8,10-triene-2,4'-cyclohex-2-ene]-1'-one	163045438	Click to see COC1=C(C2=C3C(CC24C=CC(=O)CC4O)NCCC3=C1)OC	315.40	unknown	https://doi.org/10.1021/NP50054A017
10-Hydroxy-11-methoxy-5-methylspiro[5-azatricyclo[6.3.1.04,12]dodeca-1(12),8,10-triene-2,4'-cyclohexa-2,5-diene]-1'-one	626771	Click to see	297.30	unknown	https://doi.org/10.1055/S-2006-960858
5'-Hydroxy-10,11-dimethoxyspiro[5-azatricyclo[6.3.1.04,12]dodeca-1(12),8,10-triene-2,4'-cyclohex-2-ene]-1'-one	13996827	Click to see	315.40	unknown	https://doi.org/10.1021/NP50054A017
5',6'-Dimethoxy-2',3',8',8a'-tetrahydro-1'h,4h-spiro[cyclohexa-2,5-diene-1,7'-cyclopenta[ij]isoquinolin]-4-one	98455	Click to see	297.30	unknown	https://doi.org/10.1016/S0031-9422(00)81451-X
Crotonosine, 6-methyl-	91741485	Click to see	297.30	unknown	https://doi.org/10.1055/S-2006-960858
Stepharine	193686	Click to see	297.30	unknown	https://doi.org/10.1016/S0031-9422(00)81451-X https://doi.org/10.1055/S-2006-960858 https://doi.org/10.1021/NP50054A017 https://doi.org/10.1016/S0040-4020(01)81485-X
> Alkaloids and derivatives / Protoberberine alkaloids and derivatives
(-)-Corydalmine	161665	Click to see	341.40	unknown	https://doi.org/10.1021/NP50054A017 https://doi.org/10.1021/NP50040A028
D-Tetrahydropalmatine	969488	Click to see COC1=C(C2=C(CC3C4=CC(=C(C=C4CCN3C2)OC)OC)C=C1)OC	355.40	unknown	https://doi.org/10.1021/NP50040A028 https://doi.org/10.1021/NP50054A017 https://doi.org/10.1055/S-2006-960858
DL-Tetrahydropalmatine	5417	Click to see COC1=C(C2=C(CC3C4=CC(=C(C=C4CCN3C2)OC)OC)C=C1)OC	355.40	unknown	https://doi.org/10.1055/S-2006-960858
Tetrahydropalmatine	72301	Click to see COC1=C(C2=C(CC3C4=CC(=C(C=C4CCN3C2)OC)OC)C=C1)OC	355.40	unknown	https://doi.org/10.1021/NP50054A017 https://doi.org/10.1055/S-2006-960858
> Lignans, neolignans and related compounds
(4aR,16aS)-3,4,4a,5,16a,17,18,19-Octahydro-9,21,26-trimethoxy-4,17-dimethyl-2H-1,24:12,15-dietheno-6,10-metheno-16H-pyrido(2',3':17,18)(1,10)dioxacycloeicosino(2,3,4-ij)isoquinolin-22-ol	99620	Click to see	608.70	unknown	https://doi.org/10.1021/NP50054A017
> Organic oxygen compounds / Organooxygen compounds / Carbohydrates and carbohydrate conjugates / Aminosaccharides / Aminoglycosides / Aminocyclitol glycosides
(2R,3S,4R,5R,6R)-5-amino-6-[(1R,2R,3S,4R,6S)-6-amino-2-[(2S,3R,4S,5R)-4-[(2R,3R,4R,5S,6R)-3-amino-6-(aminomethyl)-4,5-dihydroxyoxan-2-yl]oxy-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-3,4-dihydroxycyclohexyl]oxy-2-(aminomethyl)oxane-3,4-diol	13423454	Click to see	615.60	unknown	https://doi.org/10.1021/NP50054A017
> Organoheterocyclic compounds / Isoquinolines and derivatives / Benzylisoquinolines
Reticuline	439653	Click to see	329.40	unknown	https://doi.org/10.1021/NP50054A017
> Organoheterocyclic compounds / Isoquinolines and derivatives / Isoquinolones and derivatives
2,9,10-Trimethoxy-5,6-dihydroisoquinolino[2,1-b]isoquinolin-3-one	10065647	Click to see	337.40	unknown	https://doi.org/10.1055/S-2006-960858

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Stephania venosa

Table of Contents

Details Top

Ethnobotanical Use Top

General Uses Top

Synonyms Top

Common names Top

Subspecies (abbr. subsp./ssp.) Top

Varieties (abbr. var.) Top

Subvarieties (abbr. subvar.) Top

Forms (abbr. f.) Top

Germination/Propagation Top

Distribution (via POWO/KEW) Top

Links to other databases Top

Genomes (via NCBI) Top

Scientific Literature Top

Phytochemical Profile Top

Gallery Top

Contributors Top

Collections Top