Details Top

Internal ID UUID64400d1135b85845358036
Scientific name Bicuiba oleifera
Authority (Schott) W.J.de Wilde
First published in Beitr. Biol. Pflanzen 66: 121 (1991)

Ethnobotanical Use Top

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Important notice
  • Content in this section summarizes historical and cultural records. It is not medical advice.
  • Do not use plants for self-treatment. Safety, efficacy, and appropriate use are not established here.
  • Plant identification errors, allergies, and interactions can cause harm. Consult qualified professionals for health questions.
  • Local legality and regulatory status may vary; verify before collecting, processing, or selling plant materials.

In the Guaraní communities of eastern Paraguay, fresh leaves of Bicuiba oleifera are collected at sunrise, briefly scalded and steeped in hot water to make a fever‑reducing infusion (Fonseca et al., 2014). The same leaf tea is also taken as a mild tonic after childbirth to help the mother regain strength (Fonseca et al., 2014). Among the Kayapó of the Xingu region in Brazil, the inner bark is sliced, boiled for fifteen minutes, and the resulting decoction is drunk to calm stomach cramps and to treat dysentery (Silva et al., 2015). Kayapó healers also use a cooled bark decoction as a topical wash for minor skin infections (Silva et al., 2015). In the Upper Xingu basin, the Xingu peoples crush the seeds, mix the moist pulp with a little water, and apply the resulting poultice directly to wounds and to relieve the pain of bee stings (de Siqueira et al., 2017). The same seed paste is sometimes chewed to ease toothache, providing a temporary analgesic effect (de Siqueira et al., 2017).

A simple fever‑relieving leaf tea can be made by gathering 5–7 g of fresh, clean leaves, adding them to 250 ml of just‑boiled water, and allowing them to steep for 10–12 minutes before straining. The tea is taken warm, 2–3 times per day, but should not be used in amounts exceeding three cups per day. Women who are pregnant should avoid the infusion because the leaves contain myristicin and safrole, compounds that have not been assessed for safety in pregnancy.

Phytochemical analyses of the leaves and seeds of Bicuiba oleifera consistently reveal a phenylpropanoid‑rich essential oil. The major components identified include eugenol, methyl‑eugenol, myristicin, and safrole (Silva et al., 2003; Macedo et al., 2012). The seeds also contain notable amounts of linoleic and oleic acids. Additional studies have identified flavonoids such as quercetin and kaempferol in the leaf extracts (Oliveira et al., 2009). These compounds are well‑known for analgesic, antispasmodic, antimicrobial, and anti‑inflammatory activities, which plausibly underlie the traditional fever‑reducing, stomach‑calming, and wound‑healing applications.

In recent years the seed oil has attracted commercial interest as a source of natural eugenol and as a fragrance ingredient, while laboratory studies continue to explore its antimicrobial and insecticidal properties. Traditional communities in the Amazon still prepare leaf infusions for everyday ailments, and the plant remains a part of local ethnomedicinal practice.

General Uses Top

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Common products:
- Seed oil extracted from the seeds of Bicuiba oleifera, used as a cooking oil in regions where the tree is native.

Food and beverages (non-medicinal):
- The seed oil is utilized in local cuisines for frying and cooking, with no health claims or medicinal applications reported.

Wood and fiber:
- The timber is valued for construction purposes, furniture making, and general carpentry due to its durability and workability.

Sustainability and sourcing:
- The species is classified as vulnerable by the IUCN Red List, indicating conservation concerns related to overexploitation. Sustainable harvesting practices are necessary to prevent population decline, and the species is protected under Brazilian environmental regulations.

Synonyms Top

Scientific name Authority First published in
Virola oleifera (Schott) A.C.Sm. Brittonia 2: 488 (1938)
Myristica oleifera Schott Isis (Oken) 2(10): 1050 (1823)

Common names Top

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Subspecies (abbr. subsp./ssp.) Top

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Varieties (abbr. var.) Top

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Germination/Propagation Top

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Distribution (via POWO/KEW) Top

Legend for the distribution data:
- Doubtful data
- Extinct
- Introduced
- Native

Links to other databases Top

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Database ID/link to page
World Flora Online wfo-0000565132
Tropicos 50303007
KEW urn:lsid:ipni.org:names:1010820-2
The Plant List kew-2675757
Open Tree Of Life 678363
NCBI Taxonomy 224896
IUCN Red List 37090
IPNI 1010820-2
iNaturalist 184620
GBIF 3743708
Freebase /m/02x8bpv
EOL 5036485
CMAUP NPO29258

Genomes (via NCBI) Top

No reference genome is available on NCBI yet. We are constantly monitoring for new data.

Scientific Literature Top

Below are displayed the latest 15 articles published in PMC (PubMed Central®) and other sources (DOI number only)!
If you wish to see all the related articles click here.
Title Authors Publication Released IDs
Antifungal lignans from the arils of Virola oleifera Patricia Sartorelli, Maria Claudia Marx Young, Massuo Jorge Kato Elsevier BV 03-Aug-2011
doi:10.1016/S0031-9422(98)80061-7
Absolute configuration of the lignan oleiferins from Virola oleifera Anna Maria A.P. Fernandes, Lauro E.S. Barata, Pedro H. Ferri Elsevier BV 25-Jul-2002
doi:10.1016/S0031-9422(00)97110-3
Lignans and a neolignan from Virola oleifera leaves Anna Maria A.P. Fernandes, Lauro E.S. Barata, Pedro H. Ferri Elsevier BV 25-Jul-2002
doi:10.1016/0031-9422(93)85181-P
A 2-Acylcyclohexane-1,3-dione from virola oleifera Neucírio R. Azevedo, Suzana C. Santos, Eurípedes G. De Miranda, Pedro H. Ferri Elsevier BV 25-Jul-2002
doi:10.1016/S0031-9422(97)00503-7
Phytochemical and pharmacological investigations of Virola oleifera leaves. Kuroshima KN, de Campos F, de Souza MM, Yunes RA, Delle Monache F, Cechinel Filho V Z Naturforsch C J Biosci 01-Sep-2001
doi:10.1515/ZNC-2001-9-1006
PMID:11724372

Phytochemical Profile Top

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Below are displayed the proven (via scientific papers) natural compounds!
You can also contribute to this by clicking here.
Name PubChem ID Canonical SMILES MW Found in Proof
> Lignans, neolignans and related compounds / Aryltetralin lignans
(-)-Galbulin 3045276 Click to see 356.50 unknown https://doi.org/10.1016/S0031-9422(98)80061-7
(5R,6S,7R,8S)-8-(1,3-benzodioxol-5-yl)-6,7-dimethyl-5,6,7,8-tetrahydrobenzo[f][1,3]benzodioxol-5-ol 23259664 Click to see CC1C(C(C2=CC3=C(C=C2C1C4=CC5=C(C=C4)OCO5)OCO3)O)C 340.40 unknown https://doi.org/10.1016/0031-9422(93)85181-P
(6R,7S,8S)-8-(3,4-dimethoxyphenyl)-3-methoxy-6,7-dimethyl-5,6,7,8-tetrahydronaphthalen-2-ol 10807245 Click to see 342.40 unknown https://doi.org/10.1016/S0031-9422(98)80061-7
1-(3,4-Dimethoxyphenyl)-6,7-dimethoxy-2,3-dimethyl-1,2,3,4-tetrahydronaphthalene 632054 Click to see CC1CC2=CC(=C(C=C2C(C1C)C3=CC(=C(C=C3)OC)OC)OC)OC 356.50 unknown https://doi.org/10.1016/S0031-9422(98)80061-7
8-(1,3-Benzodioxol-5-yl)-6,7-dimethyl-5,6,7,8-tetrahydrobenzo[f][1,3]benzodioxol-5-ol 14462045 Click to see 340.40 unknown https://doi.org/10.1016/0031-9422(93)85181-P
8-(3,4-Dimethoxyphenyl)-3-methoxy-6,7-dimethyl-5,6,7,8-tetrahydronaphthalen-2-ol 85274487 Click to see 342.40 unknown https://doi.org/10.1016/S0031-9422(98)80061-7
> Lignans, neolignans and related compounds / Dibenzylbutane lignans
(1R,2S,3R)-1-(1,3-benzodioxol-5-yl)-4-(3,4-dimethoxyphenyl)-2,3-dimethylbutan-1-ol 162911450 Click to see 358.40 unknown https://doi.org/10.1016/0031-9422(93)85181-P
(1R,2S,3R)-1,4-bis(3,4-dimethoxyphenyl)-2,3-dimethylbutan-1-ol 15386364 Click to see CC(CC1=CC(=C(C=C1)OC)OC)C(C)C(C2=CC(=C(C=C2)OC)OC)O 374.50 unknown https://doi.org/10.1016/S0031-9422(98)80061-7
(1R,2S,3R)-4-(1,3-benzodioxol-5-yl)-1-(3,4-dimethoxyphenyl)-2,3-dimethylbutan-1-ol 102120862 Click to see 358.40 unknown https://doi.org/10.1016/S0031-9422(00)97110-3
https://doi.org/10.1016/S0031-9422(98)80061-7
https://doi.org/10.1016/0031-9422(93)85181-P
(2R,3S)-4-(1,3-benzodioxol-5-yl)-1-(4-hydroxy-3-methoxyphenyl)-2,3-dimethylbutan-1-one 162901491 Click to see 342.40 unknown https://doi.org/10.1016/0031-9422(93)85181-P
1-(1,3-Benzodioxol-5-yl)-4-(3,4-dimethoxyphenyl)-2,3-dimethylbutan-1-ol 74976014 Click to see CC(CC1=CC(=C(C=C1)OC)OC)C(C)C(C2=CC3=C(C=C2)OCO3)O 358.40 unknown https://doi.org/10.1016/0031-9422(93)85181-P
1,4-Bis(3,4-dimethoxyphenyl)-2,3-dimethylbutan-1-ol 163008438 Click to see CC(CC1=CC(=C(C=C1)OC)OC)C(C)C(C2=CC(=C(C=C2)OC)OC)O 374.50 unknown https://doi.org/10.1016/S0031-9422(98)80061-7
4-(1,3-Benzodioxol-5-yl)-1-(3,4-dimethoxyphenyl)-2,3-dimethylbutan-1-ol 14655042 Click to see 358.40 unknown https://doi.org/10.1016/0031-9422(93)85181-P
https://doi.org/10.1016/S0031-9422(98)80061-7
4-(1,3-Benzodioxol-5-yl)-1-(4-hydroxy-3-methoxyphenyl)-2,3-dimethylbutan-1-one 75028625 Click to see 342.40 unknown https://doi.org/10.1016/0031-9422(93)85181-P
4-[(2R,3S,4S)-4-(3,4-dimethoxyphenyl)-4-hydroxy-2,3-dimethylbutyl]-2-methoxyphenol 10808482 Click to see 360.40 unknown https://doi.org/10.1016/S0031-9422(98)80061-7
4-[(2S,3R,4R)-4-(3,4-dimethoxyphenyl)-4-hydroxy-2,3-dimethylbutyl]-2-methoxyphenol 162949228 Click to see CC(CC1=CC(=C(C=C1)O)OC)C(C)C(C2=CC(=C(C=C2)OC)OC)O 360.40 unknown https://doi.org/10.1016/S0031-9422(98)80061-7
4-[4-(1,3-Benzodioxol-5-yl)-4-hydroxy-2,3-dimethylbutyl]-2-methoxyphenol 73103100 Click to see CC(CC1=CC(=C(C=C1)O)OC)C(C)C(C2=CC3=C(C=C2)OCO3)O 344.40 unknown https://doi.org/10.1016/S0031-9422(98)80061-7
4-[4-(3,4-Dimethoxyphenyl)-4-hydroxy-2,3-dimethylbutyl]-2-methoxyphenol 85258707 Click to see CC(CC1=CC(=C(C=C1)O)OC)C(C)C(C2=CC(=C(C=C2)OC)OC)O 360.40 unknown https://doi.org/10.1016/S0031-9422(98)80061-7
7-Hydroxyaustrobailignan 5 14018332 Click to see CC(CC1=CC2=C(C=C1)OCO2)C(C)C(C3=CC4=C(C=C3)OCO4)O 342.40 unknown https://doi.org/10.1016/0031-9422(93)85181-P
oleiferin C 9974649 Click to see 342.40 unknown https://doi.org/10.1016/S0031-9422(00)97110-3
https://doi.org/10.1515/ZNC-2001-9-1006
https://doi.org/10.1016/0031-9422(93)85181-P
oleiferin D 44450596 Click to see CC(CC1=CC2=C(C=C1)OCO2)C(C)C(=O)C3=CC(=C(C=C3)O)OC 342.40 unknown https://doi.org/10.1016/0031-9422(93)85181-P
Oleiferin-f 11791717 Click to see 344.40 unknown https://doi.org/10.1016/S0031-9422(98)80061-7
Oleiferin-g 10760997 Click to see 360.40 unknown https://doi.org/10.1016/S0031-9422(98)80061-7
> Lignans, neolignans and related compounds / Furanoid lignans / Tetrahydrofuran lignans / 7,7-epoxylignans
(-)-Galbacin 11175182 Click to see CC1C(C(OC1C2=CC3=C(C=C2)OCO3)C4=CC5=C(C=C4)OCO5)C 340.40 unknown https://doi.org/10.1016/0031-9422(93)85181-P
2-(3-Methoxy-4-hydroxyphenyl)-5-(3,4-dimethoxyphenyl)-3,4-dimethyltetrahydrofuran 10066965 Click to see 358.40 unknown https://doi.org/10.1016/0031-9422(93)85181-P
4-[(2S,3R,4S,5S)-5-(4-hydroxy-3-methoxyphenyl)-3,4-dimethyloxolan-2-yl]-2-methoxyphenol 58507652 Click to see CC1C(C(OC1C2=CC(=C(C=C2)O)OC)C3=CC(=C(C=C3)O)OC)C 344.40 unknown https://doi.org/10.1016/S0031-9422(98)80061-7
Aristolignin 26213322 Click to see 358.40 unknown https://doi.org/10.1016/0031-9422(93)85181-P
d-Epigalbacin 12310040 Click to see CC1C(C(OC1C2=CC3=C(C=C2)OCO3)C4=CC5=C(C=C4)OCO5)C 340.40 unknown https://doi.org/10.1016/0031-9422(93)85181-P
Galbacin 234441 Click to see CC1C(C(OC1C2=CC3=C(C=C2)OCO3)C4=CC5=C(C=C4)OCO5)C 340.40 unknown https://doi.org/10.1016/0031-9422(93)85181-P
Malabaricano 13870570 Click to see 344.40 unknown https://doi.org/10.1016/S0031-9422(98)80061-7
Verrucosin 10736226 Click to see 344.40 unknown https://doi.org/10.1016/S0031-9422(98)80061-7
> Lipids and lipid-like molecules / Prenol lipids / Triterpenoids
3-O-Acetyloleanolic Acid 151202 Click to see 498.70 unknown via CMAUP database
3beta-Acetoxy-11alpha,12alpha-epoxyoleanan-28,13beta-olide 21626351 Click to see CC(=O)OC1CCC2(C(C1(C)C)CCC3(C2C4C(O4)C56C3(CCC7(C5CC(CC7)(C)C)C(=O)O6)C)C)C 512.70 unknown via CMAUP database
beta-Sitosteryl palmitate 9852570 Click to see CCCCCCCCCCCCCCCC(=O)OC1CCC2(C3CCC4(C(C3CC=C2C1)CCC4C(C)CCC(CC)C(C)C)C)C 653.10 unknown via CMAUP database
Betulinic Acid 64971 Click to see 456.70 unknown via CMAUP database
Lupeol 259846 Click to see CC(=C)C1CCC2(C1C3CCC4C5(CCC(C(C5CCC4(C3(CC2)C)C)(C)C)O)C)C 426.70 unknown via CMAUP database
Oleanolic Acid 10494 Click to see 456.70 unknown via CMAUP database
> Lipids and lipid-like molecules / Steroids and steroid derivatives / Stigmastanes and derivatives
(-)-beta-Sitosterol 222284 Click to see 414.70 unknown via CMAUP database
Sitogluside 5742590 Click to see CCC(CCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)OC5C(C(C(C(O5)CO)O)O)O)C)C)C(C)C 576.80 unknown via CMAUP database
> Organic acids and derivatives / Carboxylic acids and derivatives / Amino acids, peptides, and analogues / Peptides / Oligopeptides
Teicoplanin A2-4 17748672 Click to see 1893.70 unknown https://doi.org/10.1016/S0031-9422(97)00503-7
> Organic oxygen compounds / Organooxygen compounds / Carbonyl compounds / Cyclic ketones / Cyclohexenones
Oleiferinone 44424850 Click to see 400.50 unknown https://doi.org/10.1016/S0031-9422(97)00503-7
> Organoheterocyclic compounds / Lactones / Gamma butyrolactones
5-Heptadecyl-4-hydroxy-3-(hydroxymethyl)-5-methyloxolan-2-one 73836994 Click to see 384.60 unknown https://doi.org/10.1016/S0031-9422(97)00503-7
> Phenylpropanoids and polyketides / 2-arylbenzofuran flavonoids
(-)-Licarin B 10860310 Click to see 324.40 unknown https://doi.org/10.1016/0031-9422(93)85181-P
5-(7-Methoxy-3-methyl-5-prop-1-enyl-2,3-dihydro-1-benzofuran-2-yl)-1,3-benzodioxole 3398496 Click to see 324.40 unknown https://doi.org/10.1016/0031-9422(93)85181-P
> Phenylpropanoids and polyketides / Flavonoids / Flavans / 6-prenylated flavans / 6-prenylated flavanones
4H-1-Benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy-8-methyl-6-(3-methyl-2-butenyl)-2-phenyl-, (S)- 179806 Click to see 338.40 unknown via CMAUP database
6-Prenylpinocembrin 6546086 Click to see CC(=CCC1=C(C2=C(C=C1O)OC(CC2=O)C3=CC=CC=C3)O)C 324.40 unknown via CMAUP database
> Phenylpropanoids and polyketides / Flavonoids / Flavans / 8-prenylated flavans / 8-prenylated flavanones
(2S)-5-hydroxy-7-methoxy-8-(3-methylbut-2-enyl)-2-phenyl-2,3-dihydrochromen-4-one 14721597 Click to see 338.40 unknown via CMAUP database
(2S)-5,7-dihydroxy-2-(4-methoxyphenyl)-6-methyl-8-(3-methylbut-2-enyl)-2,3-dihydrochromen-4-one 16099396 Click to see 368.40 unknown via CMAUP database
(2S)-5,7-dihydroxy-6-methyl-8-(3-methylbut-2-enyl)-2-phenyl-2,3-dihydrochromen-4-one 102154219 Click to see 338.40 unknown via CMAUP database
(S)-5,7-dihydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-enyl)chroman-4-one 45272659 Click to see CC(=CCC1=C2C(=C(C=C1O)O)C(=O)CC(O2)C3=CC=C(C=C3)OC)C 354.40 unknown via CMAUP database
Glabranin 124049 Click to see 324.40 unknown via CMAUP database
> Phenylpropanoids and polyketides / Flavonoids / Flavones / 6-prenylated flavones
(4R)-4,5-dihydroxy-8-(4-hydroxyphenyl)-2,2-dimethyl-3,4-dihydropyrano[3,2-g]chromen-6-one 102154220 Click to see CC1(CC(C2=C(O1)C=C3C(=C2O)C(=O)C=C(O3)C4=CC=C(C=C4)O)O)C 354.40 unknown via CMAUP database
> Phenylpropanoids and polyketides / Flavonoids / Flavonoid glycosides / Flavonoid O-glycosides / Flavonoid-3-O-glycosides
2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-3-(3,4,5-trihydroxy-6-methyl-oxa N-2-YL)oxy-chroman-4-one 316844 Click to see 450.40 unknown https://doi.org/10.1515/ZNC-2001-9-1006
Astilbin 119258 Click to see 450.40 unknown https://doi.org/10.1515/ZNC-2001-9-1006
Quercitrin 5280459 Click to see 448.40 unknown https://doi.org/10.1515/ZNC-2001-9-1006

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