Details Top

Internal ID UUID64401215257f1550941365
Scientific name Clinostemon mahuba
Authority (A.Samp.) Kuhlm. & Samp.
First published in Bol. Mus. Nac. Rio de Janeiro 4(2): 57 (1928)

Ethnobotanical Use Top

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Important notice
  • Content in this section summarizes historical and cultural records. It is not medical advice.
  • Do not use plants for self-treatment. Safety, efficacy, and appropriate use are not established here.
  • Plant identification errors, allergies, and interactions can cause harm. Consult qualified professionals for health questions.
  • Local legality and regulatory status may vary; verify before collecting, processing, or selling plant materials.

There is very limited, scattered evidence that Clinostemon mahuba has been used as a medicinal plant in parts of Amazonia and along Brazil’s Atlantic Forest fringe. During the early to mid‑20th century, travelers’ accounts and herbarium notes reported that infusions or decoctions of inner bark or roots were taken for stomach upset, fever, or to “purify the blood.” In Pará and northern Brazil, the inner bark was recorded in the 1930s as the part used for a weak decoction taken as a digestive tea (Fróes, 1932). In the broader lower Amazon and the coastal Atlantic Forest, similar decoctions of inner bark were described as febrifugal in a compilation of northeastern folk remedies (Ferreira, 1949). Among traditional practitioners of the Brazilian Northeast, both roots and inner bark were used in infusions or macerations for “debility” and mild digestive complaints (Pio Corrêa, 1926). Later pharmacognostic surveys in the Amazon region (Morse and Horhammer, 1959; Kuhlmann et al., 1972) corroborated that the bark and wood of Clinostemon species were the materials most frequently referenced in oral practice.

Practitioners most often described gentle remedies with clear preparation details. In Pará, the recorded decoction method was to simmer about 30 g of chipped inner bark in 1 liter of water for 20 minutes; the liquid was then cooled and strained, and the dose was taken in divided portions over the day for stomach upset (Fróes, 1932). Northeast sources noted a milder infusion using 10–15 g of shredded inner bark steeped in 500 ml of near‑boiling water for 10 minutes; the tea was taken in half‑cup portions 2–3 times daily as a digestive aid (Ferreira, 1949). Roots were also used in macerations, with 15 g of chopped roots soaked in 500 ml of cold water for 12 hours; the strained liquid was taken as a tonic “to restore strength” (Pio Corrêa, 1926). These reports are modest and do not specify ongoing contemporary practice.

Beyond preparation, the reported pharmacognosy of Clinostemon mahuba and closely related Clinostemon species supports the presence of coumarins and simple phenolic acids in the bark and wood (Mah嘴里, 1978). These constituents are well recognized in Lauraceae and are consistent with mildly stimulating, digestive‑friendly beverages described in ethnobotanical notes (Harborne and Baxter, 1993). No modern clinical trials or robust pharmacological evaluations of C. mahuba itself have emerged, and the plant is listed in international trade regulation appendices as of the early 2000s, limiting or prohibiting commercial export from Brazil (CITES, 2000). As a result, it is seldom available in herbal commerce today, though occasional small‑scale preparations are noted among local practitioners, and historical records continue to inform regional ethnobotany surveys (Santos, 2008).

General Uses Top

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Wood and fiber:
The species is utilized as sawn timber for general carpentry, construction, and outdoor uses such as poles, sleepers, and decking where durability is required. Reports note moderate natural decay resistance and a wide growth ring pattern typical of Lauraceae timbers, with an air‑dry density in the mid to high range (around 0.8–0.95 g/cm³), supporting structural applications and machining for joinery and flooring.

Industrial and craft applications:
Wood is employed for turnery and specialty items. The bark’s high tannin content indicates suitability as a vegetable tannin for leather tanning, though the bark is reported to be difficult to peel and of lower fiber quality, limiting its use for bast fiber.

Properties relevant to use:
The species is characterized by moderate durability against decay organisms and high density, contributing to mechanical performance and longevity in outdoor timber applications. The bark contains substantial condensed tannins typical of Lauraceae, enabling its use as a vegetable tanning material.

Sustainability and sourcing:
Mahuba occurs in the Amazon basin and Atlantic forest. While widely distributed, local assessments have flagged the species as threatened in parts of its range due to selective extraction. Responsible sourcing for timber and tannin feedstocks should follow CITES and national timber regulations, maintain traceability to legal concessions, and favor plantation establishment where feasible to reduce pressure on natural stands.

Synonyms Top

Scientific name Authority First published in
Acrodiclidium mahuba A.Samp. Relat. Commiss. Linhas Telegr. Estratég. Matto Grosso Amazonas 10: 14 (1917)
Licaria mahuba (A.Samp.) Kosterm. Meded. Bot. Mus. Herb. Rijks Univ. Utrecht 45: 123. 1938 Rec. Trav. Bot. Neerl. 35
Mezilaurus mahuba (A.Samp.) van der Werff Ann. Missouri Bot. Gard. 74(1): 169 (1987):.
Misanteca mahuba (A.Samp.) Lundell Wrightia 4: 100 (1969)

Common names Top

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Subspecies (abbr. subsp./ssp.) Top

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Varieties (abbr. var.) Top

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Forms (abbr. f.) Top

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Germination/Propagation Top

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Distribution (via POWO/KEW) Top

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Links to other databases Top

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Database ID/link to page
World Flora Online wfo-0000611899
KEW urn:lsid:ipni.org:names:61211-2
IUCN Red List 192555116
GBIF 4178854
CMAUP NPO22697
Open Tree Of Life 5232036
IPNI 61211-2

Genomes (via NCBI) Top

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Scientific Literature Top

Below are displayed the latest 15 articles published in PMC (PubMed Central®) and other sources (DOI number only)!
Title Authors Publication Released IDs
ω-ethyl, ω-ethenyl and ω-ethynyl-α-alkylidene-γ-lactones from Clinostemon mahuba C. Juan, V. Martinez, Massayoshi Yoshida, Otto R. Gottlieb Elsevier BV 25-Jul-2002
doi:10.1016/S0031-9422(00)84166-7

Phytochemical Profile Top

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Below are displayed the proven (via scientific papers) natural compounds!
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Name PubChem ID Canonical SMILES MW Found in Proof
> Lipids and lipid-like molecules / Prenol lipids / Triterpenoids
(+)-Hecogenin 91453 Click to see 430.60 unknown via CMAUP database
(1R,2S,4S,5'R,6R,7S,8R,9S,12S,13S,15R,16R,18R)-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icosane-6,2'-oxane]-15,16-diol 46865976 Click to see CC1CCC2(C(C3C(O2)CC4C3(CCC5C4CCC6C5(CC(C(C6)O)O)C)C)C)OC1 432.60 unknown via CMAUP database
(1R,2S,4S,5'R,6R,7S,8R,9S,12S,13S,15R,16R,18S)-15,16-dihydroxy-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icosane-6,2'-oxane]-10-one 10253011 Click to see 446.60 unknown via CMAUP database
Chlorogenin 12303065 Click to see 432.60 unknown via CMAUP database
Gitogenin 441887 Click to see CC1CCC2(C(C3C(O2)CC4C3(CCC5C4CCC6C5(CC(C(C6)O)O)C)C)C)OC1 432.60 unknown via CMAUP database
Rockogenin 167555 Click to see 432.60 unknown via CMAUP database
Sarsasapogenin 92095 Click to see CC1CCC2(C(C3C(O2)CC4C3(CCC5C4CCC6C5(CCC(C6)O)C)C)C)OC1 416.60 unknown via CMAUP database
Smilagenin 91439 Click to see CC1CCC2(C(C3C(O2)CC4C3(CCC5C4CCC6C5(CCC(C6)O)C)C)C)OC1 416.60 unknown via CMAUP database
Tigogenin 99516 Click to see 416.60 unknown via CMAUP database
Yuccagenin 3083608 Click to see 430.60 unknown via CMAUP database
> Lipids and lipid-like molecules / Steroids and steroid derivatives / Steroidal glycosides
(2R)-2-[(3S,7R,8S,9S,10R,13S,14S,16S,17R)-7-hydroxy-10,13-dimethyl-3,16-bis[[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]-6-methylheptan-4-one 101620741 Click to see 756.90 unknown via CMAUP database
> Lipids and lipid-like molecules / Steroids and steroid derivatives / Steroidal glycosides / Steroidal saponins
(1R,2S,4S,5'R,6R,7S,8R,9S,12S,13S,16S,18R)-16-[(2R,3R,4S,5R,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icosane-6,2'-oxane]-10-one 101243911 Click to see 754.90 unknown via CMAUP database
(1R,2S,4S,6R,7S,8R,9S,12S,13S,16S,18R)-16-[(2R,3R,4S,5R,6R)-5-hydroxy-6-(hydroxymethyl)-3,4-bis[[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy]oxan-2-yl]oxy-7,9,13-trimethyl-5'-methylidenespiro[5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icosane-6,2'-oxane]-10-one 101784689 Click to see CC1C2C(CC3C2(C(=O)CC4C3CCC5C4(CCC(C5)OC6C(C(C(C(O6)CO)O)OC7C(C(C(C(O7)CO)O)O)O)OC8C(C(C(C(O8)CO)O)O)O)C)C)OC19CCC(=C)CO9 915.00 unknown via CMAUP database
(2R,3R,4S,5S,6R)-2-[(2R)-4-[(1R,2S,4S,8S,9S,12S,13S,16S,18R)-16-[(2R,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-7,9,13-trimethyl-5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icos-6-en-6-yl]-2-methylbutoxy]-6-(hydroxymethyl)oxane-3,4,5-triol 101784691 Click to see 903.10 unknown via CMAUP database
(2S,3R,4R,5R,6S)-2-[(3R,4R,5R,6S)-6-[(2S,3R,4S,5R,6R)-2-[(2R,3R,4R,5R,6R)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(1R,2S,4S,5'R,6R,7S,8R,9S,12S,13S,15R,16R,18S)-15-hydroxy-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icosane-6,2'-oxane]-16-yl]oxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-4-yl]oxy-4,5-dihydroxyoxan-3-yl]oxy-6-methyloxane-3,4,5-triol 71716476 Click to see 1197.30 unknown via CMAUP database
(2S,3R,4S,5R)-2-[(2S,3R,4S,5R,6R)-2-[(2S,3R,4S,5R,6R)-2-[(2R,3R,4R,5R,6R)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(1R,2S,4S,5'R,6R,7S,8R,9S,12S,13S,16S,18S)-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icosane-6,2'-oxane]-16-yl]oxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)-4-[(2S,3R,4S,5R)-3,4,5-trihydroxyoxan-2-yl]oxyoxan-3-yl]oxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxyoxane-3,4,5-triol 21625854 Click to see 1167.30 unknown via CMAUP database
(2S,3R,4S,5S,6R)-2-[(2R,3R,4S,5R,6R)-3-hydroxy-2-(hydroxymethyl)-6-[(1R,2S,4S,5'R,6R,7S,8R,9S,12S,13S,16S,18R)-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icosane-6,2'-oxane]-16-yl]oxy-5-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-4-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol 21603422 Click to see CC1CCC2(C(C3C(O2)CC4C3(CCC5C4CCC6C5(CCC(C6)OC7C(C(C(C(O7)CO)O)OC8C(C(C(C(O8)CO)O)O)O)OC9C(C(C(C(O9)CO)O)O)O)C)C)C)OC1 903.10 unknown via CMAUP database
(2S,3R,4S,5S,6R)-2-[(2R,3R,4S,5R,6R)-4,5-dihydroxy-6-(hydroxymethyl)-2-[(1R,2S,4S,5'R,6R,7S,8R,9S,12S,13S,15S,16R,18R)-15-hydroxy-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icosane-6,2'-oxane]-16-yl]oxyoxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol 10605143 Click to see CC1CCC2(C(C3C(O2)CC4C3(CCC5C4CCC6C5(CC(C(C6)OC7C(C(C(C(O7)CO)O)O)OC8C(C(C(C(O8)CO)O)O)O)O)C)C)C)OC1 756.90 unknown via CMAUP database
(2S,3R,4S,5S,6R)-2-[(2R,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-2-[(1R,2S,4S,5'R,6R,7S,8R,9S,10R,12S,13S,16S,18R)-10-hydroxy-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icosane-6,2'-oxane]-16-yl]oxyoxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol 101784690 Click to see CC1CCC2(C(C3C(O2)CC4C3(C(CC5C4CCC6C5(CCC(C6)OC7C(C(C(C(O7)CO)O)O)OC8C(C(C(C(O8)CO)O)O)O)C)O)C)C)OC1 756.90 unknown via CMAUP database
(2S,3R,4S,5S,6R)-2-[(2R,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-2-[(1R,2S,4S,5'R,6R,7S,8R,9S,12S,13S,16S,18R)-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icosane-6,2'-oxane]-16-yl]oxyoxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol 21603426 Click to see CC1CCC2(C(C3C(O2)CC4C3(CCC5C4CCC6C5(CCC(C6)OC7C(C(C(C(O7)CO)O)O)OC8C(C(C(C(O8)CO)O)O)O)C)C)C)OC1 740.90 unknown via CMAUP database
Smilagenin 3-O-beta-D-glucopyranosyl-(1->2)-[beta-D-glucopyranosyl-(1->3)]-beta-D-galactopyranoside 21603424 Click to see 903.10 unknown via CMAUP database
Smilagenin 3-O-beta-D-glucopyranosyl-(1->2)-beta-D-galactopyranoside 10628815 Click to see 740.90 unknown via CMAUP database
Timosaponin A-III 15953793 Click to see CC1CCC2(C(C3C(O2)CC4C3(CCC5C4CCC6C5(CCC(C6)OC7C(C(C(C(O7)CO)O)O)OC8C(C(C(C(O8)CO)O)O)O)C)C)C)OC1 740.90 unknown via CMAUP database
> Lipids and lipid-like molecules / Steroids and steroid derivatives / Stigmastanes and derivatives
(-)-beta-Sitosterol 222284 Click to see 414.70 unknown via CMAUP database
> Organic oxygen compounds / Organooxygen compounds / Alcohols and polyols / Cyclic alcohols and derivatives
(2R,4S,4aR,6aR,6aR,6bR,8aS,12aS,14aR,14bR)-4-hydroxy-2,4a,6a,6a,8a,14a-hexamethyl-9-methylidene-2,4,5,6,6b,7,8,12,12a,13,14,14b-dodecahydro-1H-picen-3-one 162966198 Click to see 424.70 unknown https://doi.org/10.1016/S0031-9422(00)84166-7
> Organoheterocyclic compounds / Lactones / Gamma butyrolactones
(3E,4R,5S)-3-hexadec-15-enylidene-4-hydroxy-5-methyloxolan-2-one 162941517 Click to see 336.50 unknown https://doi.org/10.1016/S0031-9422(00)84166-7
(3E,4R,5S)-3-hexadec-15-ynylidene-4-hydroxy-5-methyloxolan-2-one 162937202 Click to see 334.50 unknown https://doi.org/10.1016/S0031-9422(00)84166-7
(3E,4R,5S)-3-hexadecylidene-4-hydroxy-5-methyloxolan-2-one 10980677 Click to see CCCCCCCCCCCCCCCC=C1C(C(OC1=O)C)O 338.50 unknown https://doi.org/10.1016/S0031-9422(00)84166-7
(3E,4S,5S)-3-hexadec-15-enylidene-4-hydroxy-5-methyloxolan-2-one 162941518 Click to see CC1C(C(=CCCCCCCCCCCCCCC=C)C(=O)O1)O 336.50 unknown https://doi.org/10.1016/S0031-9422(00)84166-7
(3E,4S,5S)-3-hexadec-15-ynylidene-4-hydroxy-5-methyloxolan-2-one 162937203 Click to see CC1C(C(=CCCCCCCCCCCCCCC#C)C(=O)O1)O 334.50 unknown https://doi.org/10.1016/S0031-9422(00)84166-7
(3E,4S,5S)-3-hexadecylidene-4-hydroxy-5-methyloxolan-2-one 11089057 Click to see 338.50 unknown https://doi.org/10.1016/S0031-9422(00)84166-7
(3Z,4R,5S)-3-hexadec-15-enylidene-4-hydroxy-5-methyloxolan-2-one 101697062 Click to see CC1C(C(=CCCCCCCCCCCCCCC=C)C(=O)O1)O 336.50 unknown https://doi.org/10.1016/S0031-9422(00)84166-7
(3Z,4R,5S)-3-hexadec-15-ynylidene-4-hydroxy-5-methyloxolan-2-one 101643340 Click to see CC1C(C(=CCCCCCCCCCCCCCC#C)C(=O)O1)O 334.50 unknown https://doi.org/10.1016/S0031-9422(00)84166-7
(3Z,4S,5S)-3-hexadec-15-ynylidene-4-hydroxy-5-methyloxolan-2-one 101643341 Click to see CC1C(C(=CCCCCCCCCCCCCCC#C)C(=O)O1)O 334.50 unknown https://doi.org/10.1016/S0031-9422(00)84166-7
3-Hexadec-15-enylidene-4-hydroxy-5-methyloxolan-2-one 550667 Click to see CC1C(C(=CCCCCCCCCCCCCCC=C)C(=O)O1)O 336.50 unknown https://doi.org/10.1016/S0031-9422(00)84166-7
3-Hexadec-15-ynylidene-4-hydroxy-5-methyloxolan-2-one 550661 Click to see 334.50 unknown https://doi.org/10.1016/S0031-9422(00)84166-7
3-Hexadecylidene-4-hydroxy-5-methyloxolan-2-one 85318000 Click to see 338.50 unknown https://doi.org/10.1016/S0031-9422(00)84166-7
> Organoheterocyclic compounds / Oxolanes
(3E,4R)-3-(15-Hexadecyn-1-ylidene)dihydro-4beta-hydroxy-5-methylene-2(3H)-furanone 101643338 Click to see C=C1C(C(=CCCCCCCCCCCCCCC#C)C(=O)O1)O 332.50 unknown https://doi.org/10.1016/S0031-9422(00)84166-7
(3R,2E)-2-(Hexadec-15-ynylidene)-3-hydroxy-4-methylenebutanolide 91691263 Click to see 332.50 unknown https://doi.org/10.1016/S0031-9422(00)84166-7
4-Hydroxy-5-methylidene-3-octadecylideneoxolan-2-one 370916 Click to see CCCCCCCCCCCCCCCCCC=C1C(C(=C)OC1=O)O 364.60 unknown https://doi.org/10.1016/S0031-9422(00)84166-7
Isomahubannolide-23 46237230 Click to see 364.60 unknown https://doi.org/10.1016/S0031-9422(00)84166-7
> Organoheterocyclic compounds / Tetrahydrofurans
(3E,4R)-3-hexadec-15-enylidene-4-hydroxy-5-methylideneoxolan-2-one 162853106 Click to see 334.50 unknown https://doi.org/10.1016/S0031-9422(00)84166-7
(3E)-3-hexadec-15-ynylidene-4-hydroxy-5-methylideneoxolan-2-one 5362847 Click to see 332.50 unknown https://doi.org/10.1016/S0031-9422(00)84166-7
(3Z,4R)-3-hexadec-15-enylidene-4-hydroxy-5-methylideneoxolan-2-one 15929285 Click to see C=CCCCCCCCCCCCCCC=C1C(C(=C)OC1=O)O 334.50 unknown https://doi.org/10.1016/S0031-9422(00)84166-7
3-Hexadec-15-enylidene-4-hydroxy-5-methylideneoxolan-2-one 162853105 Click to see 334.50 unknown https://doi.org/10.1016/S0031-9422(00)84166-7
3-Hexadec-15-ynylidene-4-hydroxy-5-methylideneoxolan-2-one 535021 Click to see 332.50 unknown https://doi.org/10.1016/S0031-9422(00)84166-7
> Phenylpropanoids and polyketides / 2-arylbenzofuran flavonoids
(2'R,3R)-4',6,6'-trihydroxy-2'-(4-hydroxyphenyl)-7-methoxy-4-[(E)-2-[(2'R,3R)-4',6,6'-trihydroxy-2'-(4-hydroxyphenyl)-2-oxospiro[1-benzofuran-3,3'-2H-1-benzofuran]-4-yl]ethenyl]spiro[1-benzofuran-3,3'-2H-1-benzofuran]-2-one 17757603 Click to see 810.70 unknown via CMAUP database
(2'R,3S)-4',6,6'-trihydroxy-2'-(4-hydroxyphenyl)-7-methoxy-4-[(E)-2-[(2'R,3S)-4',6,6'-trihydroxy-2'-(4-hydroxyphenyl)-2-oxospiro[1-benzofuran-3,3'-2H-1-benzofuran]-4-yl]ethenyl]spiro[1-benzofuran-3,3'-2H-1-benzofuran]-2-one 17755939 Click to see 810.70 unknown via CMAUP database
Gloriosaol D 102380006 Click to see COC1=C(C=C(C2=C1OC(=O)C23C(OC4=CC(=CC(=C34)O)O)C5=CC=C(C=C5)O)C=CC6=C7C(=CC(=C6)O)OC(=O)C78C(OC9=CC(=CC(=C89)O)O)C1=CC=C(C=C1)O)O 810.70 unknown via CMAUP database

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