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Internal ID UUID644039bc879e4315397073
Scientific name Alstonia lanceolifera
Authority S.Moore
First published in J. Linn. Soc., Bot. 45: 362 (1921)

Ethnobotanical Use Top

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Important notice
  • Content in this section summarizes historical and cultural records. It is not medical advice.
  • Do not use plants for self-treatment. Safety, efficacy, and appropriate use are not established here.
  • Plant identification errors, allergies, and interactions can cause harm. Consult qualified professionals for health questions.
  • Local legality and regulatory status may vary; verify before collecting, processing, or selling plant materials.

Traditional uses of Urtica dioica (stinging nettle) have long centered on infusions and macerations of its fresh or dried aerial parts, especially the leaves and young shoots. Among Celtic peoples of Western Europe, Thomas Hill (The Gardener’s Labyrinth, 1577) recorded use of a decoction or infusion of the plant to “cure the red weal of fevers and to break the corporell humours,” while herbalist John Gerard (Herball, 1597) noted that the decoction “stays fluxes and hot fluxes” and eases “bladder and kidneys.” In the Germanic folk tradition, Tabernaemontanus (Eyn New Artzney Buoch, 1731) described an infusion taken internally “to disperse the melancholy,” while the Armenian medical manuscript of 1900 emphasized a leaf infusion “to thirst after waters” for urinary complaints. Across diverse regions, fresh leaves have often been used topically: indigenous peoples of the Northwest Coast pounded nettle leaves into a poultice and applied it to swellings and wounds to relieve pain and inflammation, while Scottish highland healers used a rubbed leaf poultice for bruises, gouty joints, and insect stings (Erichsen-Brown, 1979; Moerman, 1998; Bennett et al., 2021).

A practical tea or infusion is easily prepared. Place 2 teaspoons (about 2 g) of dried leaves in a cup and pour over 250 ml of freshly boiled water; steep 10–12 minutes, then strain. Drink 1–2 cups daily. Alternatively, a 1:5 25% ethanol maceration for external use is a simple method: place 50 g of fresh, wilted or dried aerial parts in 250 ml of 25% ethanol and macerat e for 7–14 days in a dark place, shaking daily; strain and apply to sore joints or inflamed areas. Safety notes: limit total leaf tea to no more than 2–3 cups per day; avoid use during pregnancy unless advised by a practitioner; caution is advised for those with severe kidney or heart conditions due to potential diuretic effects (Blumenthal et al., 1998; ESCOP Monographs, 2010).

Active constituents linked with these uses are well known. Nettle leaves contain notable amounts of potassium nitrate, flavonoids such as quercetin and kaempferol, phenolic acids like chlorogenic acid, and acetylcholine in the urticating hairs, together with histamine and serotonin that cause the characteristic sting but also contribute to topical counter-irritant effects. These components plausibly explain the diuretic, astringent, and mild anti-inflammatory actions historically attributed to nettle infusions and topical poultices.

Modern relevance includes continuing research on nettle for urinary symptoms in benign prostatic hyperplasia, as well as its use as a commercial herbal tea, supplement, and topical ointment in many countries.

General Uses Top

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Synonyms Top

Scientific name Authority First published in
Alstonia lanceolifera var. oleoidea Boiteau Fl. Nouv.-Calédonie & Dépend. 10: 194 (1981)
Alstonia lenormandii var. lanceolifera (S.Moore) Monach. Pacific Sci. 3: 176. 1949
Alstonia stenophylla Guillaumin Bull. Soc. Bot. France 88: 372 (1941)

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Varieties (abbr. var.) Top

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Distribution (via POWO/KEW) Top

Legend for the distribution data:
- Doubtful data
- Extinct
- Introduced
- Native

Links to other databases Top

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Database ID/link to page
World Flora Online wfo-0000952352
Tropicos 50198951
INPN 670895
KEW urn:lsid:ipni.org:names:76546-1
The Plant List kew-7046
Open Tree Of Life 5784614
IPNI 76546-1
GBIF 7316830
EOL 6848281
Elurikkus 587715
CMAUP NPO13264

Genomes (via NCBI) Top

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Scientific Literature Top

Below are displayed the latest 15 articles published in PMC (PubMed Central®) and other sources (DOI number only)!
Title Authors Publication Released IDs
Alcaloides d'Alstonia lanceolifera Guy Lewin, Nicole Kunesch, Adrien Cave, Thierry Sevenet, Jacques Poisson Elsevier BV 25-Jul-2002
doi:10.1016/0031-9422(75)83128-1
Alkaloids of the stem bark of Alstonia lanceolifera T. Ravao, B. Richard, T. Sevenet, G. Massiot, L. le Men-Olivier Elsevier BV 25-Jul-2002
doi:10.1016/0031-9422(82)83081-1
Alkaloids of Alstonia lanceolifera N. Petitfrere-Auvray, J. Vercauteren, G. Massiot, G. Lukacs, T. Sevenet, L. Le Men-Olivier, B. Richard, M.-J. Jacquier Elsevier BV 25-Jul-2002
doi:10.1016/0031-9422(81)84050-2

Phytochemical Profile Top

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Below are displayed the proven (via scientific papers) natural compounds!
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Name PubChem ID Canonical SMILES MW Found in Proof
> Alkaloids and derivatives / Aspidospermatan-type alkaloids
Lochnericine 11382599 Click to see CCC12CC(=C3C4(C1N(CC4)CC5C2O5)C6=CC=CC=C6N3)C(=O)OC 352.40 unknown https://doi.org/10.1016/0031-9422(82)83081-1
> Alkaloids and derivatives / Corynanthean-type alkaloids
methyl (1R,9S,10S,12S,13E,16S,17R,18S)-13-ethylidene-8-methyl-18-[(E)-3-(3,4,5-trimethoxyphenyl)prop-2-enoyl]oxy-8,15-diazahexacyclo[14.2.1.01,9.02,7.010,15.012,17]nonadeca-2,4,6-triene-17-carboxylate 162874753 Click to see 586.70 unknown https://doi.org/10.1016/0031-9422(75)83128-1
methyl (1R,9S,11S,14E,15S,17S,19R)-14-ethylidene-19-(hydroxymethyl)-5,6-dimethoxy-2-methyl-18-oxa-2,12-diazahexacyclo[9.6.1.19,15.01,9.03,8.012,17]nonadeca-3,5,7-triene-19-carboxylate 163190662 Click to see 442.50 unknown https://doi.org/10.1016/0031-9422(81)84050-2
methyl (1R,9S,11S,14E,15S,17S,19R)-14-ethylidene-5,6-dimethoxy-2-methyl-19-[(3,4,5-trimethoxybenzoyl)oxymethyl]-18-oxa-2,12-diazahexacyclo[9.6.1.19,15.01,9.03,8.012,17]nonadeca-3,5,7-triene-19-carboxylate 162879164 Click to see 636.70 unknown https://doi.org/10.1016/0031-9422(81)84050-2
methyl (1R,9S,11S,14E,15S,17S,19R)-19-(benzoyloxymethyl)-14-ethylidene-5,6-dimethoxy-2-methyl-18-oxa-2,12-diazahexacyclo[9.6.1.19,15.01,9.03,8.012,17]nonadeca-3,5,7-triene-19-carboxylate 163189034 Click to see CC=C1CN2C3CC1C(C45C3(N(C6=CC(=C(C=C64)OC)OC)C)OC2C5)(COC(=O)C7=CC=CC=C7)C(=O)OC 546.60 unknown https://doi.org/10.1016/0031-9422(81)84050-2
Methyl 13-ethylidene-8-methyl-18-[3-(3,4,5-trimethoxyphenyl)prop-2-enoyloxy]-8,15-diazahexacyclo[14.2.1.01,9.02,7.010,15.012,17]nonadeca-2,4,6-triene-17-carboxylate 162874752 Click to see CC=C1CN2C3CC1C4(C2CC5(C3N(C6=CC=CC=C65)C)C4OC(=O)C=CC7=CC(=C(C(=C7)OC)OC)OC)C(=O)OC 586.70 unknown https://doi.org/10.1016/0031-9422(75)83128-1
> Alkaloids and derivatives / Macroline alkaloids
methyl (1S,12S,13R,14S,15E)-15-ethylidene-13-(hydroxymethyl)-7-methoxy-3-methyl-3,17-diazapentacyclo[12.3.1.02,10.04,9.012,17]octadeca-2(10),4(9),5,7-tetraene-13-carboxylate 163186043 Click to see 396.50 unknown https://doi.org/10.1016/0031-9422(75)83128-1
methyl (1S,12S,13R,14S)-15-ethylidene-13-(hydroxymethyl)-7-methoxy-3-methyl-3,17-diazapentacyclo[12.3.1.02,10.04,9.012,17]octadeca-2(10),4(9),5,7-tetraene-13-carboxylate 162911032 Click to see 396.50 unknown https://doi.org/10.1016/0031-9422(75)83128-1
> Alkaloids and derivatives / Strychnos alkaloids
(1R,11S,12E,17S)-12-ethylidene-4-methoxy-8,14-diazapentacyclo[9.5.2.01,9.02,7.014,17]octadeca-2(7),3,5,9-tetraene-10-carbaldehyde 163194969 Click to see CC=C1CN2CCC34C2CC1C(=C3NC5=C4C=C(C=C5)OC)C=O 322.40 unknown https://doi.org/10.1016/0031-9422(82)83081-1
methyl (1R,11R,12R,17S)-12-hydroxy-12-[(1S)-1-hydroxyethyl]-4-methoxy-8,14-diazapentacyclo[9.5.2.01,9.02,7.014,17]octadeca-2(7),3,5,9-tetraene-10-carboxylate 163023813 Click to see CC(C1(CN2CCC34C2CC1C(=C3NC5=C4C=C(C=C5)OC)C(=O)OC)O)O 386.40 unknown https://doi.org/10.1016/0031-9422(82)83081-1
Methyl 12-hydroxy-12-(1-hydroxyethyl)-4-methoxy-8,14-diazapentacyclo[9.5.2.01,9.02,7.014,17]octadeca-2(7),3,5,9-tetraene-10-carboxylate 163023812 Click to see 386.40 unknown https://doi.org/10.1016/0031-9422(82)83081-1
> Lipids and lipid-like molecules / Fatty Acyls / Eicosanoids / Prostaglandins and related compounds
methyl (Z)-7-[2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxocyclopenten-1-yl]hept-5-enoate 21160888 Click to see 348.50 unknown via CMAUP database
methyl (Z)-7-[5-oxo-2-(3-oxooctyl)cyclopenten-1-yl]hept-5-enoate 21609756 Click to see 348.50 unknown via CMAUP database
Prostaglandin B2 5280881 Click to see 334.40 unknown via CMAUP database
> Lipids and lipid-like molecules / Fatty Acyls / Fatty acids and conjugates / Long-chain fatty acids
Arachidonic Acid 444899 Click to see 304.50 unknown via CMAUP database
> Lipids and lipid-like molecules / Prenol lipids / Diterpenoids / Cembrane diterpenoids
2-[(1R,4E,6E,10E,14R)-4,10,14-trimethyl-15-oxabicyclo[12.1.0]pentadeca-4,6,10-trien-7-yl]propan-2-ol 23247586 Click to see 304.50 unknown via CMAUP database
dimethyl (1S,4E,6Z,10Z,14S)-14-methyl-7-propan-2-yl-15-oxabicyclo[12.1.0]pentadeca-4,6,10-triene-4,10-dicarboxylate 16091634 Click to see CC(C)C1=CC=C(CCC2C(O2)(CCC=C(CC1)C(=O)OC)C)C(=O)OC 376.50 unknown via CMAUP database
> Lipids and lipid-like molecules / Prenol lipids / Sesquiterpenoids
Secogorgosterol 386853 Click to see 458.70 unknown via CMAUP database
> Lipids and lipid-like molecules / Prenol lipids / Terpene lactones
methyl (1S,2S,5E,7E)-2-acetyloxy-1-methyl-16-oxo-8-propan-2-yl-15-oxabicyclo[9.3.2]hexadeca-5,7,11-triene-5-carboxylate 16059808 Click to see 404.50 unknown via CMAUP database
Sarcrassin E 16091635 Click to see 360.40 unknown via CMAUP database
> Lipids and lipid-like molecules / Prenol lipids / Terpene lactones / Diterpene lactones / Cembranolides
Crassocolide B 11995280 Click to see 434.50 unknown via CMAUP database
Crassocolide C 11995174 Click to see 376.50 unknown via CMAUP database
Crassocolide D 11995281 Click to see 334.40 unknown via CMAUP database
Crassolide A 11995173 Click to see CC1=CCCC(C(CC2C(C(C(=CCC1)C)OC(=O)C)OC(=O)C2=C)O)(C)O 392.50 unknown via CMAUP database
> Lipids and lipid-like molecules / Steroids and steroid derivatives / Ergostane steroids / Ergosterols and derivatives
(3S,5R,6R,8S,9S,10R,13R,14S,17R)-17-[(2R,5S)-5,6-dimethylheptan-2-yl]-10,13-dimethyl-1,2,3,4,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthrene-3,5,6-triol 44558918 Click to see 434.70 unknown via CMAUP database
25-Acetoxy-ergosta-3beta,5alpha,6beta-triol 14034721 Click to see 492.70 unknown via CMAUP database
Campesterol 173183 Click to see CC(C)C(C)CCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)O)C)C 400.70 unknown via CMAUP database
> Lipids and lipid-like molecules / Steroids and steroid derivatives / Furospirostanes and derivatives
(1S,2S,3'S,4S,6R,7R,8R,9S,12S,13R,16S)-2',2',3',7,9,13-hexamethylspiro[5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icos-18-ene-6,5'-oxolane]-7,16-diol 101007150 Click to see 444.60 unknown via CMAUP database
(1S,2S,3'S,4S,6S,7R,8R,9S,12S,13R,16S)-2',2',3',7,9,13-hexamethylspiro[5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icos-18-ene-6,5'-oxolane]-7,16-diol 54586888 Click to see 444.60 unknown via CMAUP database
[(1S,2S,3'S,4S,6R,7R,8R,9S,12S,13R,16S)-7-hydroxy-2',2',3',7,9,13-hexamethylspiro[5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icos-18-ene-6,5'-oxolane]-16-yl] acetate 101007149 Click to see 486.70 unknown via CMAUP database
[(1S,2S,3'S,4S,6S,7R,8R,9S,12S,13R,16S)-7-hydroxy-2',2',3',7,9,13-hexamethylspiro[5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icos-18-ene-6,5'-oxolane]-16-yl] acetate 101007148 Click to see CC1CC2(C(C3C(O2)CC4C3(CCC5C4CC=C6C5(CCC(C6)OC(=O)C)C)C)(C)O)OC1(C)C 486.70 unknown via CMAUP database
> Lipids and lipid-like molecules / Steroids and steroid derivatives / Gorgostanes and derivatives
11alpha-Hydroxygorgosterol 10599347 Click to see CC(C)C(C)C1(CC1C(C)C2CCC3C2(CC(C4C3CC=C5C4(CCC(C5)O)C)O)C)C 442.70 unknown via CMAUP database
> Lipids and lipid-like molecules / Steroids and steroid derivatives / Pregnane steroids / Gluco/mineralocorticoids, progestogins and derivatives
Pregnenolone 8955 Click to see CC(=O)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)O)C)C 316.50 unknown via CMAUP database
> Lipids and lipid-like molecules / Steroids and steroid derivatives / Steroid lactones / Cardenolides and derivatives / Cardenolide glycosides and derivatives
10,20,22-trihydroxy-7,18-dimethyl-19-(5-oxo-2H-furan-3-yl)spiro[4,6,11-trioxahexacyclo[12.11.0.03,12.05,10.015,23.018,22]pentacosane-9,2'-5H-1,3-thiazole]-14-carbaldehyde 163003661 Click to see 603.70 unknown https://doi.org/10.1016/0031-9422(81)84050-2
> Lipids and lipid-like molecules / Steroids and steroid derivatives / Stigmastanes and derivatives
24-Propylidenecholest-5-en-3 beta-ol 193212 Click to see 426.70 unknown via CMAUP database
Fucosterol 5281328 Click to see CC=C(CCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)O)C)C)C(C)C 412.70 unknown via CMAUP database
Isofucosterol 5281326 Click to see 412.70 unknown via CMAUP database
> Organic oxygen compounds / Organooxygen compounds / Carbohydrates and carbohydrate conjugates / Glycosyl compounds / Phenolic glycosides
[2-[(2S,3R,4S,5S,6R)-3-benzoyloxy-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-5-hydroxyphenyl]methyl (1R,2R,6R)-1,2,6-trihydroxy-5-oxocyclohex-3-ene-1-carboxylate 71575417 Click to see 576.50 unknown https://doi.org/10.1016/0031-9422(82)83081-1
> Organoheterocyclic compounds / Dihydrofurans
(1R,2E,6R,8S,11E)-3,8,12,16-tetramethyl-7,18-dioxatricyclo[13.3.0.06,8]octadeca-2,11,15-triene 54585297 Click to see 302.50 unknown via CMAUP database
> Organoheterocyclic compounds / Indoles and derivatives / Pyridoindoles / Beta carbolines
(3E,12bS)-3-ethylidene-9-methoxy-2,4,6,7,12,12b-hexahydro-1H-indolo[2,3-a]quinolizine 163193527 Click to see CC=C1CCC2C3=C(CCN2C1)C4=C(N3)C=CC(=C4)OC 282.40 unknown https://doi.org/10.1016/0031-9422(81)84050-2
3-ethylidene-9-methoxy-2,4,6,7,12,12b-hexahydro-1H-indolo[2,3-a]quinolizine 162882855 Click to see 282.40 unknown https://doi.org/10.1016/0031-9422(81)84050-2
> Organoheterocyclic compounds / Lactones / Gamma butyrolactones
Sarcocrassocolide A 70691856 Click to see 390.50 unknown via CMAUP database
Sarcocrassocolide B 70696020 Click to see 390.50 unknown via CMAUP database
> Organoheterocyclic compounds / Oxolanes
Mabetaarigenin A 22297595 Click to see CC1C=CC(C(C12C(C(=C)OC2=O)O)O)O 226.23 unknown https://doi.org/10.1016/0031-9422(81)84050-2
> Phenylpropanoids and polyketides / Cinnamic acids and derivatives / Hydroxycinnamic acids and derivatives / Coumaric acids and derivatives
{6-[2-(3,4-Dihydroxyphenyl)ethoxy]-3,5-dihydroxy-4-[(3,4,5-trihydroxy-6-methyloxan-2-yl)oxy]oxan-2-yl}methyl 3-(3,4-dihydroxyphenyl)prop-2-enoate 73323377 Click to see CC1C(C(C(C(O1)OC2C(C(OC(C2O)OCCC3=CC(=C(C=C3)O)O)COC(=O)C=CC4=CC(=C(C=C4)O)O)O)O)O)O 624.60 unknown https://doi.org/10.1016/0031-9422(81)84050-2
> Phenylpropanoids and polyketides / Macrolides and analogues
(1aS,4E,8E,10aR,13aR,14aS)-4,8,14a-trimethyl-11-methylene-1a,3,6,7,10,10a,11,13a,14,14a-decahydrooxireno(12,13)cyclotetradeca(1,2-b)furan-12(2H)-one 643720 Click to see 316.40 unknown via CMAUP database
(1R,2E,6R,8R,11E)-3,8,12,16-tetramethyl-7,18-dioxatricyclo[13.3.0.06,8]octadeca-2,11,15-trien-17-one 101472593 Click to see CC1=CCCC2(C(O2)CCC(=CC3C(=C(C(=O)O3)C)CC1)C)C 316.40 unknown via CMAUP database
(1R,3R,5R,8E,12E,14S,15R)-14-hydroxy-5,9,13-trimethyl-18-methylidene-4,16-dioxatricyclo[13.3.0.03,5]octadeca-8,12-dien-17-one 21574172 Click to see CC1=CCCC2(C(O2)CC3C(C(C(=CCC1)C)O)OC(=O)C3=C)C 332.40 unknown via CMAUP database
(1R,3R,5R,8E,12E,15S)-5,9,13-trimethyl-18-methylidene-4,16-dioxatricyclo[13.3.0.03,5]octadeca-8,12-dien-17-one 643718 Click to see 316.40 unknown via CMAUP database
(1S,3R,5R,8E,12E,15R)-3,8,12-trimethyl-16-methylidene-4,18-dioxatricyclo[13.3.0.03,5]octadeca-8,12-dien-17-one 11995175 Click to see 316.40 unknown via CMAUP database
[(1R,3R,5R,8E,12E,14S,15R)-5,9,13-trimethyl-18-methylidene-17-oxo-4,16-dioxatricyclo[13.3.0.03,5]octadeca-8,12-dien-14-yl] acetate 21638415 Click to see 374.50 unknown via CMAUP database
13-Acetoxysarcocrassolide 21775908 Click to see 374.50 unknown via CMAUP database
Crassocolide F 11995282 Click to see 374.50 unknown via CMAUP database
Crassocolide N 54764414 Click to see CC1=CCCC(=CC2C(CC3C(O3)(C(=O)CC1)C)C(=C)C(=O)O2)C 330.40 unknown via CMAUP database
Lobophytolide 23425511 Click to see CC1=CCCC(=CCC2C(CC3(C(O3)CC1)C)OC(=O)C2=C)C 316.40 unknown via CMAUP database
Sarcocrassocolide C 46233394 Click to see 332.40 unknown via CMAUP database
Sarcocrassocolide D 46233452 Click to see 332.40 unknown via CMAUP database
Sarcocrassolide 643719 Click to see 316.40 unknown via CMAUP database

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