Content in this section summarizes historical and cultural records. It is not medical advice.
Do not use plants for self-treatment. Safety, efficacy, and appropriate use are not established here.
Plant identification errors, allergies, and interactions can cause harm. Consult qualified professionals for health questions.
Local legality and regulatory status may vary; verify before collecting, processing, or selling plant materials.

In the mountains of Abruzzo, inflorescences and whole aerial parts of Bupleurum fruticosum have long been gathered to make a bitter, aromatic tea taken after meals to aid digestion (Letizia et al., 2008). In Greece, Hanlidou et al. report infusions of the aerial parts used as digestive tonics and carminatives, confirming a similarly longstanding role in the northern and insular regions (Hanlidou et al., 2004). In the Aeolian Islands north of Sicily, Benzi and colleagues list B. fruticosum among the local medicinal species prepared as a “bitter digestive infusion,” noting that aerial parts are the preferred material (Benzi et al., 2009). Today, infusing dried aerial parts remains common in these areas for occasional upset stomach and to counteract the heaviness of rich foods.

A practical digestive infusion can be prepared by placing 1–2 g of dried aerial parts (roughly a small handful of inflorescences or about a level tablespoon of herbage) in 250 ml of just‑boiled water, covering and infusing 10–15 minutes, then straining. Many communities take one cup after dinner. As with other bitter herbs, moderation is prudent; sensitive individuals may experience stomach irritation or mild nausea, and it is best avoided in pregnancy. The bitter profile is consistent with documented phenylpropanoids and flavonoids.

Phytochemistry and pharmacology studies on B. fruticosum show flavonoids such as kaempferol and quercetin, several phenylpropanoids including chlorogenic and caffeic acids, and coumarins such as umbelliferone and scopoletin (Alberto et al., 2002). Extracts also exhibit antioxidant activity in vitro, a profile compatible with the traditional use as a stomachic infusion.

Modern relevance remains steady: limited extracts and herbal preparations are occasionally marketed in Italy and Greece, and investigations continue into their phytochemistry and antioxidant potential. Given the absence of robust clinical data, ongoing use remains anchored in the long‑standing, regional home and folk tradition.

General Uses Top

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Synonyms Top

Scientific name	Authority	First published in
Bupleurum insulare	Rouy & E.G.Camus	Fl. France 7: 316 (1901)
Bupleurum terminale	Salisb.	Prodr. Stirp. Chap. Allerton : 160 (1796)
Buprestis fruticosa	Spreng.	Mag. Neuesten Entdeck. Gesammten Naturk. Ges. Naturf. Freunde Berlin 6: 259 (1812)
Tenoria fruticosa	Spreng.	Neue Schriften Naturf. Ges. Halle 2: 32 1813
Bupleurum fruticosum subsp. insulare	Rouy & E.G.Camus	Fl. France 7: 316 (1901)
Bupleurum fruticosum var. insulare	(Rouy & E.G.Camus) P.Fourn.	Quatre Fl. France : 671 (1937)

Common names Top

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Filter by language:

Language	Common/alternative name
English	shrubby hare's ear
English	shrubby hare's-ear
Arabic	دبيق شجيري
Catalan	matabou
Welsh	llwyn paladr trwyddo
German	strauchiges hasenohr
Estonian	põõsas-jänesekõrv
Finnish	pensasjänönputki
Norwegian Bokmål	buskhareøre
Chinese	灌木柴胡

Subspecies (abbr. subsp./ssp.) Top

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Varieties (abbr. var.) Top

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Subvarieties (abbr. subvar.) Top

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Forms (abbr. f.) Top

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Germination/Propagation Top

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Sow seeds at 20°C, expecting germination within 3 months without further temperature treatment.

Requires Light or Surface Sowing: These seeds need light to germinate and should not be covered with soil or only very lightly. They are often very small and sown directly on the surface of the growing medium.

Distribution (via POWO/KEW) Top

Legend for the distribution data:

- Doubtful data

- Extinct

- Introduced

- Native

Africa click to expand
- Northern Africa
  - Algeria
  - Morocco
  - Tunisia

Europe click to expand
- Eastern Europe
  - Krym
- Northern Europe
  - Great Britain
- Southeastern Europe
  - Greece
  - Italy
  - Sicilia
- Southwestern Europe
  - Corse
  - France
  - Portugal
  - Sardegna
  - Spain

Links to other databases Top

Suggest others/fix!

Database	ID/link to page
World Flora Online	wfo-0001067668
Tropicos	1700032
INPN	87051
Flora of Italy	3567
KEW	urn:lsid:ipni.org:names:839164-1
Open Tree Of Life	49592
NCBI Taxonomy	48103
NBN Atlas	NBNSYS0000003656
IPNI	839164-1
iNaturalist	82601
GBIF	3638793
EPPO	BUPFR
USDA GRIN	8157
Wikipedia	Bupleurum_fruticosum

Genomes (via NCBI) Top

No reference genome is available on NCBI yet. We are constantly monitoring for new data.

Scientific Literature Top

Below are displayed the latest 15 articles published in PMC (PubMed Central®) and other sources (DOI number only)!
If you wish to see all the related articles click here.

Title

Authors

Publication

Released

IDs

Insights into the molecular phylogeny and morphology of three novel Dothiora species, along with a worldwide checklist of Dothiora

Senwanna C, Hongsanan S, Khuna S, Kumla J, Yarasheva M, Gafforov Y, Abdurazakov A, Suwannarach N

Front Cell Infect Microbiol

19-Apr-2024

PMCID:	PMC11067756
doi:	10.3389/fcimb.2024.1367673
PMID:	38707512

Vasorelaxant and Blood Pressure-Lowering Effects of Cnidium monnieri Fruit Ethanol Extract in Sprague Dawley and Spontaneously Hypertensive Rats

Park J, Shin S, Bu Y, Choi HY, Lee K

Int J Mol Sci

11-Apr-2024

PMCID:	PMC11050430
doi:	10.3390/ijms25084223
PMID:	38673809

Seseli tortuosum L. subsp. tortuosum Essential Oils and Their Principal Constituents as Anticancer Agents

Vaglica A, Maggio A, Badalamenti N, Bruno M, Lauricella M, Occhipinti C, D’Anneo A

Plants (Basel)

28-Feb-2024

PMCID:	PMC10935401
doi:	10.3390/plants13050678
PMID:	38475524

Apium extract alleviates indomethacin-induced gastric ulcers in rats via modulating the VEGF and IK-κB/NF-κB p65 signaling pathway: insights from in silico and in vivo investigations

Abu-Baih DH, Gomaa AA, Abdel-Wahab NM, Abdelaleem ER, Zaher AM, Hassan NF, Bringmann G, Abdelmohsen UR, Altemani FH, Algehainy NA, Mokhtar FA, Abdelwahab MF

BMC Complement Med Ther

14-Feb-2024

PMCID:	PMC10865661
doi:	10.1186/s12906-023-04333-w
PMID:	38355510

Eoscyphella luciurceolata gen. and sp. nov. (Agaricomycetes) Shed Light on Cyphellopsidaceae with a New Lineage of Bioluminescent Fungi

Silva-Filho AG, Mombert A, Nascimento CC, Nóbrega BB, Soares DM, Martins AG, Domingos AH, Santos I, Della-Torre OH, Perry BA, Desjardin DE, Stevani CV, Menolli N Jr

J Fungi (Basel)

12-Oct-2023

PMCID:	PMC10608165
doi:	10.3390/jof9101004
PMID:	37888262

A 12-Year Experimental Design to Test the Recovery of Butterfly Biodiversity in an Urban Ecosystem: Lessons from the Parc Urbain des Papillons

Deschamps-Cottin M, Jacek G, Seguinel L, Le Champion C, Robles C, Ternisien M, Duque C, Vila B

Insects

24-Sep-2023

PMCID:	PMC10607803
doi:	10.3390/insects14100780
PMID:	37887792

Phytocompounds as a source for the development of new drugs to treat respiratory viral infections

Seibert JB, Amparo TR, Almeida TC, de Souza GH, dos Santos OD

23-May-2023

PMCID:	PMC10204935
doi:	10.1016/B978-0-323-91294-5.00007-5

Allii Macrostemonis Bulbus: A Comprehensive Review of Ethnopharmacology, Phytochemistry and Pharmacology

Wu J, Wang L, Cui Y, Liu F, Zhang J

Molecules

08-Mar-2023

PMCID:	PMC10054501
doi:	10.3390/molecules28062485
PMID:	36985457

Wild Edible Plants of Andalusia: Traditional Uses and Potential of Eating Wild in a Highly Diverse Region

Benítez G, Molero-Mesa J, González-Tejero MR

Plants (Basel)

07-Mar-2023

PMCID:	PMC10051205
doi:	10.3390/plants12061218
PMID:	36986907

Ethnopharmacobotany and Diversity of Mediterranean Endemic Plants in Marmilla Subregion, Sardinia, Italy

Cocco E, Maccioni D, Sanjust E, Falconieri D, Farris E, Maxia A

Plants (Basel)

18-Nov-2022

PMCID:	PMC9695302
doi:	10.3390/plants11223165
PMID:	36432894

Review of Natural Resources With Vasodilation: Traditional Medicinal Plants, Natural Products, and Their Mechanism and Clinical Efficacy

Tang F, Yan HL, Wang LX, Xu JF, Peng C, Ao H, Tan YZ

Front Pharmacol

01-Apr-2021

PMCID:	PMC8048554
doi:	10.3389/fphar.2021.627458
PMID:	33867985

The Essential Oil Compositions of Three Teucrium Taxa Growing Wild in Sicily: HCA and PCA Analyses

Catinella G, Badalamenti N, Ilardi V, Rosselli S, De Martino L, Bruno M

Molecules

26-Jan-2021

PMCID:	PMC7865755
doi:	10.3390/molecules26030643
PMID:	33530639

The Combined Effect of Mediterranean Shrubland Pasture and the Dietary Administration of Sage By-Products on the Antioxidant Status of Segureña Ewes and Lambs

Jordán MJ, Martínez-Conesa C, Bañón S, Otal J, Quílez M, García-Aledo I, Romero-Espinar P, Sánchez-Gómez P

Antioxidants (Basel)

30-Sep-2020

PMCID:	PMC7600900
doi:	10.3390/antiox9100938
PMID:	33008117

Filling the gaps: ethnobotanical study of the Garrigues district, an arid zone in Catalonia (NE Iberian Peninsula)

Gras A, Vallès J, Garnatje T

J Ethnobiol Ethnomed

09-Jun-2020

PMCID:	PMC7285587
doi:	10.1186/s13002-020-00386-0
PMID:	32517701

Unraveling Plant Natural Chemical Diversity for Drug Discovery Purposes

Lautié E, Russo O, Ducrot P, Boutin JA

Front Pharmacol

07-Apr-2020

PMCID:	PMC7154113
doi:	10.3389/fphar.2020.00397
PMID:	32317969

Phytochemical Profile Top

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Below are displayed the proven (via scientific papers) natural compounds!
You can also contribute to this by clicking here.

Name	PubChem ID	Canonical SMILES	MW	Found in	Proof
> Benzenoids / Benzene and substituted derivatives / Styrenes
3-Phenylprop-2-en-1-yl pentanoate	112120	Click to see CCCCC(=O)OCC=CC1=CC=CC=C1	218.29	unknown	https://doi.org/10.1080/10412905.1992.9698110
Cinnamyl isovalerate	5355855	Click to see	218.29	unknown	https://doi.org/10.1080/10412905.1992.9698110
Cinnamyl valerate	5367959	Click to see	218.29	unknown	https://doi.org/10.1080/10412905.1992.9698110
> Benzenoids / Phenol ethers / Anisoles
Elemicin	10248	Click to see	208.25	unknown	https://doi.org/10.1080/10412905.1992.9698110
Estragole	8815	Click to see	148.20	unknown	https://doi.org/10.1021/NP50062A008
> Hydrocarbons / Polycyclic hydrocarbons
Bornylene	10047	Click to see	136.23	unknown	https://doi.org/10.1080/10412905.1992.9698110
> Hydrocarbons / Unsaturated hydrocarbons / Branched unsaturated hydrocarbons
Gamma-Terpinene	7461	Click to see	136.23	unknown	https://doi.org/10.1080/10412905.1992.9698110 https://doi.org/10.1021/NP50062A008
> Lipids and lipid-like molecules / Fatty Acyls / Fatty acid esters
Hexyl 2-methylbutyrate	24838	Click to see	186.29	unknown	https://doi.org/10.1080/10412905.1992.9698110
Hexyl isovalerate	61455	Click to see	186.29	unknown	https://doi.org/10.1080/10412905.1992.9698110
> Lipids and lipid-like molecules / Fatty Acyls / Fatty alcohol esters
Citronellyl acetate	9017	Click to see CC(CCC=C(C)C)CCOC(=O)C	198.30	unknown	https://doi.org/10.1080/10412905.1992.9698110
Decyl acetate	8167	Click to see	200.32	unknown	https://doi.org/10.1080/10412905.1992.9698110
Octyl Acetate	8164	Click to see	172.26	unknown	https://doi.org/10.1080/10412905.1992.9698110
> Lipids and lipid-like molecules / Fatty Acyls / Fatty alcohols
1-Decanol	8174	Click to see	158.28	unknown	https://doi.org/10.1080/10412905.1992.9698110
> Lipids and lipid-like molecules / Prenol lipids / Monoterpenoids / Acyclic monoterpenoids
beta-OCIMENE, (3E)-	5281553	Click to see	136.23	unknown	https://doi.org/10.1021/NP50062A008 https://doi.org/10.1080/10412905.1992.9698110
beta-Ocimene, (3Z)-	5320250	Click to see	136.23	unknown	https://doi.org/10.1080/10412905.1992.9698110
Linalool	6549	Click to see	154.25	unknown	https://doi.org/10.1080/10412905.1992.9698110 https://doi.org/10.1021/NP50062A008
Linalyl Acetate	8294	Click to see	196.29	unknown	https://doi.org/10.1021/NP50062A008
Myrcene	31253	Click to see	136.23	unknown	https://doi.org/10.1080/10412905.1992.9698110 https://doi.org/10.1021/NP50062A008
Nerol	643820	Click to see CC(=CCCC(=CCO)C)C	154.25	unknown	https://doi.org/10.1080/10412905.1992.9698110
> Lipids and lipid-like molecules / Prenol lipids / Monoterpenoids / Aromatic monoterpenoids
Carvacrol	10364	Click to see CC1=C(C=C(C=C1)C(C)C)O	150.22	unknown	https://doi.org/10.1021/NP50062A008
P-Cymene	7463	Click to see	134.22	unknown	https://doi.org/10.1080/10412905.1992.9698110 https://doi.org/10.1021/NP50062A008
Thymol	6989	Click to see	150.22	unknown	https://doi.org/10.1021/NP50062A008
> Lipids and lipid-like molecules / Prenol lipids / Monoterpenoids / Bicyclic monoterpenoids
(+-)-alpha-Pinene	6654	Click to see	136.23	unknown	https://doi.org/10.1080/10412905.1992.9698110 https://doi.org/10.1021/NP50062A008
Beta-Pinene	14896	Click to see	136.23	unknown	https://doi.org/10.1021/NP50062A008 https://doi.org/10.1080/10412905.1992.9698110
CID 44630107	44630107	Click to see CC1(C2CCC1(C(C2)O)C)C	154.25	unknown	https://doi.org/10.1021/NP50062A008
Sabinene	18818	Click to see	136.23	unknown	https://doi.org/10.1080/10412905.1992.9698110 https://doi.org/10.1021/NP50062A008
> Lipids and lipid-like molecules / Prenol lipids / Monoterpenoids / Menthane monoterpenoids
2-Methyl-5-(1-methylethenyl)cyclohexanol	12072	Click to see	154.25	unknown	https://doi.org/10.1080/10412905.1992.9698110
4-Terpineol, (+/-)-	11230	Click to see CC1=CCC(CC1)(C(C)C)O	154.25	unknown	https://doi.org/10.1021/NP50062A008 https://doi.org/10.1080/10412905.1992.9698110
alpha-PHELLANDRENE	7460	Click to see CC1=CCC(C=C1)C(C)C	136.23	unknown	https://doi.org/10.1080/10412905.1992.9698110 https://doi.org/10.1021/NP50062A008
Alpha-Terpinene	7462	Click to see	136.23	unknown	https://doi.org/10.1080/10412905.1992.9698110 https://doi.org/10.1021/NP50062A008
Alpha-Terpineol	17100	Click to see	154.25	unknown	https://doi.org/10.1080/10412905.1992.9698110 https://doi.org/10.1021/NP50062A008
Beta-Phellandrene	11142	Click to see CC(C)C1CCC(=C)C=C1	136.23	unknown	https://doi.org/10.1080/10412905.1992.9698110 https://doi.org/10.1021/NP50062A008
beta-Terpinene	66841	Click to see CC(C)C1=CCC(=C)CC1	136.23	unknown	https://doi.org/10.1080/10412905.1992.9698110
Limonene, (+/-)-	22311	Click to see CC1=CCC(CC1)C(=C)C	136.23	unknown	https://doi.org/10.1080/10412905.1992.9698110 https://doi.org/10.1021/NP50062A008
Terpinolene	11463	Click to see	136.23	unknown	https://doi.org/10.1021/NP50062A008
> Lipids and lipid-like molecules / Prenol lipids / Sesquiterpenoids
Caryophyllene	5281515	Click to see CC1=CCCC(=C)C2CC(C2CC1)(C)C	204.35	unknown	https://doi.org/10.1021/NP50062A008
> Lipids and lipid-like molecules / Prenol lipids / Terpene glycosides / Triterpene glycosides / Triterpene saponins
Buddlejasaponin Iv	153940	Click to see	943.10	unknown	https://doi.org/10.1055/S-2006-959442 https://doi.org/10.1021/NP50092A009
> Lipids and lipid-like molecules / Prenol lipids / Triterpenoids
(+)-Erythrodiol	101761	Click to see	442.70	unknown	https://doi.org/10.1016/S0031-9422(96)00461-X
> Lipids and lipid-like molecules / Steroids and steroid derivatives / Stigmastanes and derivatives
(5S,9S,10S,13R,14R)-17-(5-ethyl-6-methylhept-3-en-2-yl)-10,13-dimethyl-2,3,4,5,6,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol	137706369	Click to see CCC(C=CC(C)C1CCC2C1(CCC3C2=CCC4C3(CCC(C4)O)C)C)C(C)C	412.70	unknown	https://doi.org/10.1016/S0031-9422(96)00461-X
alpha-Spinasterin	5281331	Click to see CCC(C=CC(C)C1CCC2C1(CCC3C2=CCC4C3(CCC(C4)O)C)C)C(C)C	412.70	unknown	https://doi.org/10.1016/S0031-9422(96)00461-X
> Organic acids and derivatives / Carboxylic acids and derivatives / Carboxylic acid derivatives / Carboxylic acid esters
Heptyl acetate	8159	Click to see CCCCCCCOC(=O)C	158.24	unknown	https://doi.org/10.1080/10412905.1992.9698110
> Organic oxygen compounds / Organooxygen compounds / Ethers / Acetals / Ketals
5,6,6-Trimethoxy-2-prop-2-enylcyclohexa-1,3-diene	163192813	Click to see	210.27	unknown	https://doi.org/10.1016/S0031-9422(96)00461-X
> Phenylpropanoids and polyketides / Coumarins and derivatives
6-Methoxy-7-(3-methylbut-2-enoxy)chromen-2-one	1764914	Click to see	260.28	unknown	https://doi.org/10.1016/0031-9422(95)00749-0
7-(2-Hydroxy-3-methylbut-3-enoxy)-6-methoxychromen-2-one	10636169	Click to see CC(=C)C(COC1=C(C=C2C=CC(=O)OC2=C1)OC)O	276.28	unknown	https://doi.org/10.1016/0031-9422(95)00749-0
Scoparone	8417	Click to see COC1=C(C=C2C(=C1)C=CC(=O)O2)OC	206.19	unknown	https://doi.org/10.1016/0031-9422(95)00749-0
> Phenylpropanoids and polyketides / Coumarins and derivatives / Hydroxycoumarins
Capensin	644959	Click to see	276.28	unknown	https://doi.org/10.1016/0031-9422(95)00749-0
Prenyletin	3873459	Click to see CC(=CCOC1=C(C=C2C=CC(=O)OC2=C1)O)C	246.26	unknown	https://doi.org/10.1021/NP50115A015 https://doi.org/10.1016/0031-9422(95)00749-0
> Phenylpropanoids and polyketides / Coumarins and derivatives / Hydroxycoumarins / 6,7-dihydroxycoumarins
Esculetin	5281416	Click to see	178.14	unknown	https://doi.org/10.1016/0031-9422(95)00749-0
> Phenylpropanoids and polyketides / Coumarins and derivatives / Hydroxycoumarins / 7,8-dihydroxycoumarins
Fraxetin	5273569	Click to see	208.17	unknown	https://doi.org/10.1016/0031-9422(95)00749-0
> Phenylpropanoids and polyketides / Coumarins and derivatives / Hydroxycoumarins / 7-hydroxycoumarins
Scopoletin	5280460	Click to see	192.17	unknown	https://doi.org/10.1016/0031-9422(95)00749-0

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Bupleurum fruticosum

Table of Contents

Details Top

Ethnobotanical Use Top

General Uses Top

Synonyms Top

Common names Top

Subspecies (abbr. subsp./ssp.) Top

Varieties (abbr. var.) Top

Subvarieties (abbr. subvar.) Top

Forms (abbr. f.) Top

Germination/Propagation Top

Distribution (via POWO/KEW) Top

Links to other databases Top

Genomes (via NCBI) Top

Scientific Literature Top

Phytochemical Profile Top

Gallery Top

Contributors Top

Collections Top