Bicuculline

Details

• Internal ID: 39021452-8211-4376-bda8-7fd634850976
• Taxonomy: Alkaloids and derivatives > Phthalide isoquinolines
• IUPAC Name: (6R)-6-[(5S)-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-yl]-6H-furo[3,4-g][1,3]benzodioxol-8-one
• SMILES (Canonical): CN1CCC2=CC3=C(C=C2C1C4C5=C(C6=C(C=C5)OCO6)C(=O)O4)OCO3
• SMILES (Isomeric): CN1CCC2=CC3=C(C=C2[C@H]1[C@H]4C5=C(C6=C(C=C5)OCO6)C(=O)O4)OCO3
• InChI: InChI=1S/C20H17NO6/c1-21-5-4-10-6-14-15(25-8-24-14)7-12(10)17(21)18-11-2-3-13-19(26-9-23-13)16(11)20(22)27-18/h2-3,6-7,17-18H,4-5,8-9H2,1H3/t17-,18+/m0/s1
• InChI Key: IYGYMKDQCDOMRE-ZWKOTPCHSA-N
• Popularity: 11,794 references in papers

Physical and Chemical Properties

• Molecular Formula: C₂₀H₁₇NO₆
• Molecular Weight: 367.40 g/mol
• Exact Mass: 367.10558726 g/mol
• Topological Polar Surface Area (TPSA): 66.50 Ų
• XlogP: 2.60
• Atomic LogP (AlogP): 2.58
• H-Bond Acceptor: 7
• H-Bond Donor: 0
• Rotatable Bonds: 1

Synonyms

• 485-49-4
• d-Bicuculline
• Bicculine
• Bicucullin
• CHEBI:3092
• Y37615DVKC
• (6R)-6-[(5S)-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-yl]-6H-furo[3,4-g][1,3]benzodioxol-8-one
• DTXSID3042687
• NSC-32192
• (6R)-6-[(5S)-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-5-yl]furo[3,4-e][1,3]benzodioxol-8(6H)-one
• Furo(3,4-e)-1,3-benzodioxol-8(6H)-one, 6-(5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo(4,5-g)isoquinolin-5-yl)-, (R-(R*,S*))-
• (6R)-6-((5S)-6-methyl-5,6,7,8-tetrahydro(1,3)dioxolo(4,5-g)isoquinolin-5-yl)furo(3,4-e)(1,3)benzodioxol-8(6H)-one
• (6R)-6-((5S)-6-methyl-7,8-dihydro-5H-(1,3)dioxolo(4,5-g)isoquinolin-5-yl)-6H-furo(3,4-g)(1,3)benzodioxol-8-one
• (6R)-6-((5S)-6-methyl-7,8-dihydro-5H-(1,3)dioxolo(4,5-g)isoquinolin-5-yl)-6H-furo(4,3-g)(1,3)benzodioxol-8-one
• (6R)-6-[(5S)-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-yl]-6H-furo[4,3-g][1,3]benzodioxol-8-one
• RefChem:119660
• 6-(5,6,7,8-Tetrahydro-6-methyl-1,3-dioxolo(4,5-g)isoquinolin-5-yl)furo(3,4-e)1,3-benzodioxol-8(6H)one
• DTXCID1022687
• (10R)-10-((5S)-6-methyl-2H,5H,6H,7H,8H-(1,3)dioxolo(4,5-g)isoquinolin-5-yl)-3,5,11-trioxatricyclo(7.3.0.02,6)dodeca-1(9),2(6),7-trien-12-one
• 207-619-7
• (+)-Bicuculline
• Bicuculline (+)
• MFCD00005006
• NSC32192
• CHEMBL417990
• (R)-6-((S)-6-methyl-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinolin-5-yl)-[1,3]dioxolo[4,5-e]isobenzofuran-8(6H)-one
• NSC 32192
• (6R)-6-((5S)-6-methyl(5,6,7,8-tetrahydro-2H-1,3-dioxolano[4,5-g]isoquinolin-5- yl))-6-hydro-2H-1,3-dioxoleno[4,5-e]isobenzofuran-8-one
• Furo[3,4-e]-1,3-benzodioxol-8(6H)-one, 6-[(5S)-5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-, (6R)-
• SR-01000075252
• EINECS 207-619-7
• BRN 0098786
• UNII-Y37615DVKC
• bicuculline-(+)
• IYGYMKDQCDOMRE-ZWKOTPCHSA-N
• Bicuculline,(+)
• Prestwick_96
• (6R)-6-[(5S)-5,6,7,8-Tetrahydro-6-methyl-1,3-dioxolo[4,5-g]lisoquinolin-5-yl]furo[3,4-e]-1,3-benzodioxol-8(6H)-one;Bicuculline;D-Bic uculline
• Furo(3,4-e)-1,3-benzodioxol-8(6H)-one, 6-((5S)-5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo(4,5-g)isoquinolin-5-yl)-, (6R)-
• (+)-Bicuculline?
• Bicuculline (Standard)
• BICUCULLINE [MI]
• Prestwick0_000589
• Prestwick1_000589
• Prestwick2_000589
• Prestwick3_000589
• Biomol-NT_000252
• (+)-Bicuculline, 98%
• SCHEMBL8222
• Lopac0_000234
• BSPBio_000438
• 4-27-00-06900 (Beilstein Handbook Reference)
• MLS002153892
• DivK1c_000609
• SPBio_002657
• BPBio1_000482
• BPBio1_000794
• GTPL2312
• orb1304933
• SCHEMBL29390611
• SCHEMBL29652597
• HMS501O11
• HY-N0219R
• KBio1_000609
• NINDS_000609
• GLXC-06284
• HMS1569F20
• HMS2096F20
• HMS2235H18
• HMS3266A07
• HMS3414D19
• HMS3652N20
• HMS3678D19
• HMS3886N09
• BCP04180
• HY-N0219
• BDBM50000693
• HB0896
• PDSP2_000138
• s7071
• (+)-Bicuculline - Bio-X trade mark
• AKOS024282673
• CCG-204329
• CS-5493
• DB11562
• FB18590
• IDI1_000609
• NCGC00017385-06
• (+)-Bicuculline, >=97.0% (TLC)
• AC-31293
• AS-17471
• BB164251
• SMR001233241
• ST057559
• ST057706
• B1890
• NS00031807
• SW196408-2
• B 9130
• C09364
• 485B494
• Q3639734
• SR-01000075252-1
• SR-01000075252-4
• SR-01000075252-5
• WLN: T C566 DO FO KN EH&&TJ K1 J- ET B565 CVO JO LO EH KHJ
• (6R)-6-((5S)-6-METHYL-5,6,7,8-TETRAHYDRO(1,3)DIOXOLO(4,5-G)ISOQUINOLIN-5-YL)FURO(3,4-E)(1,3BENZODIOXOL-8(6H)-ONE
• (bicuculline) 6-Methyl-5-(8-oxo-6,8-dihydro-furo[3'',4'':3,4]benzo[1,2-d][1,3]dioxol-6-yl)-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinolin-6-ium
• (R)-6-((S)-6-Methyl-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinolin-5-yl)-6H-furo[3'',4'':3,4]benzo[1,2-d][1,3]dioxol-8-one
• (R)-6-((S)-6-methyl-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinolin-5-yl)isobenzofuro[5,4-d][1,3]dioxol-8(6H)-one
• 6-((5S)-6-methyl-5,6,7,8-tetrahydro-2H-1,3-dioxoleno[4,5-g]isoquinolin-5-yl)-6 -hydro-2H-1,3-dioxoleno[4,5-e]isobenzofuran-8-one
• 6-(6-Methyl-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinolin-5-yl)-6H-furo[3'',4'':3,4]benzo[1,2-d][1,3]dioxol-8-one
• 6-(6-Methyl-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinolin-5-yl)-6H-furo[3'',4'':3,4]benzo[1,2-d][1,3]dioxol-8-one (Bicuculline)
• 6-(6-Methyl-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinolin-5-yl)-6H-furo[3'',4'':3,4]benzo[1,2-d][1,3]dioxol-8-one(bicuculline)
• Furo[3,3-benzodioxol-8(6H)-one, 6-(5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)-, [R-(R*,S*)]-
• H0Z

2D Structure

ADMET Properties (via admetSAR 2)

Target	Value	Probability (raw)	Probability (%)
Human Intestinal Absorption	+	0.9731	97.31%
Caco-2	+	0.7738	77.38%
Blood Brain Barrier	+	0.7000	70.00%
Human oral bioavailability	-	0.6143	61.43%
Subcellular localzation	Lysosomes	0.4400	44.00%
OATP2B1 inhibitior	-	1.0000	100.00%
OATP1B1 inhibitior	+	0.9247	92.47%
OATP1B3 inhibitior	+	0.9533	95.33%
MATE1 inhibitior	-	0.9409	94.09%
OCT2 inhibitior	-	0.8000	80.00%
BSEP inhibitior	+	0.8511	85.11%
P-glycoprotein inhibitior	-	0.6282	62.82%
P-glycoprotein substrate	-	0.8209	82.09%
CYP3A4 substrate	+	0.6019	60.19%
CYP2C9 substrate	+	0.8024	80.24%
CYP2D6 substrate	-	0.6799	67.99%
CYP3A4 inhibition	+	0.7959	79.59%
CYP2C9 inhibition	+	0.7664	76.64%
CYP2C19 inhibition	+	0.8993	89.93%
CYP2D6 inhibition	-	0.6229	62.29%
CYP1A2 inhibition	+	0.9107	91.07%
CYP2C8 inhibition	-	0.9319	93.19%
CYP inhibitory promiscuity	-	0.5366	53.66%
UGT catelyzed	-	0.0000	0.00%
Carcinogenicity (binary)	-	0.9800	98.00%
Carcinogenicity (trinary)	Non-required	0.5613	56.13%
Eye corrosion	-	0.9881	98.81%
Eye irritation	-	0.9577	95.77%
Skin irritation	-	0.7658	76.58%
Skin corrosion	-	0.9309	93.09%
Ames mutagenesis	+	0.5900	59.00%
Human Ether-a-go-go-Related Gene inhibition	-	0.4086	40.86%
Micronuclear	+	0.5474	54.74%
Hepatotoxicity	-	0.6250	62.50%
skin sensitisation	-	0.8574	85.74%
Respiratory toxicity	+	0.8333	83.33%
Reproductive toxicity	+	0.8000	80.00%
Mitochondrial toxicity	+	0.8625	86.25%
Nephrotoxicity	-	0.6036	60.36%
Acute Oral Toxicity (c)	III	0.7155	71.55%
Estrogen receptor binding	+	0.8442	84.42%
Androgen receptor binding	-	0.5329	53.29%
Thyroid receptor binding	-	0.7445	74.45%
Glucocorticoid receptor binding	+	0.8982	89.82%
Aromatase binding	+	0.5375	53.75%
PPAR gamma	+	0.7847	78.47%
Honey bee toxicity	-	0.8638	86.38%
Biodegradation	-	0.6500	65.00%
Crustacea aquatic toxicity	+	0.5700	57.00%
Fish aquatic toxicity	+	0.7800	78.00%

Targets

Proven Targets:

CHEMBL ID	UniProt ID	Name	Min activity	Assay type	Source
CHEMBL1293235	P02545	Prelamin-A/C	281.8 nM	Potency	via Super-PRED

Predicted Targets (via Super-PRED):

CHEMBL ID	UniProt ID	Name	Probability	Model accuracy
CHEMBL4303	P08238	Heat shock protein HSP 90-beta	98.56%	96.77%
CHEMBL5697	Q9GZT9	Egl nine homolog 1	98.00%	93.40%
CHEMBL3108638	O15164	Transcription intermediary factor 1-alpha	97.48%	95.56%
CHEMBL2581	P07339	Cathepsin D	95.51%	98.95%
CHEMBL3251	P19838	Nuclear factor NF-kappa-B p105 subunit	94.53%	96.09%
CHEMBL1293249	Q13887	Kruppel-like factor 5	89.21%	86.33%
CHEMBL4203	Q9HAZ1	Dual specificity protein kinase CLK4	88.39%	94.45%
CHEMBL1841	P06241	Tyrosine-protein kinase FYN	86.21%	81.29%
CHEMBL3192	Q9BY41	Histone deacetylase 8	86.00%	93.99%
CHEMBL5608	Q16288	NT-3 growth factor receptor	85.76%	95.89%
CHEMBL3038477	P67870	Casein kinase II alpha/beta	85.45%	99.23%
CHEMBL5311	P37023	Serine/threonine-protein kinase receptor R3	84.73%	82.67%
CHEMBL4261	Q16665	Hypoxia-inducible factor 1 alpha	84.33%	85.14%
CHEMBL2056	P21728	Dopamine D1 receptor	84.27%	91.00%
CHEMBL3384	Q16512	Protein kinase N1	83.70%	80.71%
CHEMBL1994	P08235	Mineralocorticoid receptor	83.54%	100.00%
CHEMBL2335	P42785	Lysosomal Pro-X carboxypeptidase	82.62%	100.00%
CHEMBL1806	P11388	DNA topoisomerase II alpha	82.30%	89.00%
CHEMBL2083	P15090	Fatty acid binding protein adipocyte	80.60%	95.71%
CHEMBL2146302	O94925	Glutaminase kidney isoform, mitochondrial	80.57%	100.00%
CHEMBL2373	P21730	C5a anaphylatoxin chemotactic receptor	80.50%	92.62%

Plants that contains it

• Adlumia fungosa
• Capnoides sempervirens
• Corydalis bungeana
• Corydalis caseana
• Corydalis caucasica
• Corydalis cava
• Corydalis chaerophylla
• Corydalis decumbens
• Corydalis gigantea
• Corydalis gortschakovii
• Corydalis govaniana
• Corydalis nobilis
• Corydalis paniculigera
• Corydalis pseudoadunca
• Corydalis racemosa
• Corydalis repens
• Corydalis rutifolia
• Corydalis scouleri
• Corydalis sibirica
• Corydalis solida
• Corydalis stricta
• Corydalis thyrsiflora
• Corydalis vaginans
• Corydalis yanhusuo
• Dicentra cucullaria
• Fumaria asepala
• Fumaria bracteosa
• Fumaria capreolata
• Fumaria densiflora
• Fumaria indica
• Fumaria macrocarpa
• Fumaria parviflora
• Fumaria vaillantii
• Pseudofumaria lutea

Cross-Links

• PubChem: 10237
• NPASS: NPC226652
• ChEMBL: CHEMBL417990
• LOTUS: LTS0267429
• wikiData: Q3639734