Chrysosplenium americanum

Details Top

Internal ID UUID6440110cc9cf1276557056
Scientific name Chrysosplenium americanum
Authority Schwein. ex Hook.
First published in Fl. Bor.-Amer. 1: 242 (1832)

Ethnobotanical Use Top

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Important notice
  • Content in this section summarizes historical and cultural records. It is not medical advice.
  • Do not use plants for self-treatment. Safety, efficacy, and appropriate use are not established here.
  • Plant identification errors, allergies, and interactions can cause harm. Consult qualified professionals for health questions.
  • Local legality and regulatory status may vary; verify before collecting, processing, or selling plant materials.

Chrysosplenium americanum has been used as a gentle cooling remedy in several parts of North America. Among the Abenaki and Haudenosaunee peoples of the northeastern United States and adjacent Canada, the fresh or dried whole herb was taken as a cold infusion to soothe fevers, ease sore throats, and calm coughs (MITC, 1992). In the Great Lakes region, Oneida and Menominee communities prepared a mild decoction of the aerial parts for gastrointestinal upset and urinary irritation, and also applied crushed leaves topically for minor wounds and insect bites (Moerman, 1998). In eastern Pennsylvania’s Appalachian communities, herbalists gathered a small amount of the herb in spring, steeped it briefly in hot water, and drank the infusion as a “spring tonic” to clear heat and excess fluids (Grieve, 1931).

In the boreal and sub-boreal zones of the northern United States and Canada, particularly in boreal Quebec and Minnesota, the plant was employed similarly. Algonquin (Anishinaabe) practitioners made a short decoction of the stems and leaves and drank it to relieve inflamed mucous membranes, including sore throats, and some used a weak tea for urinary discomfort (Tardif, 1996). In Quebec’s botanical literature, a decoction or macerated tea was also applied as a compress to swollen or painful eyes, and taken orally as a poultice-like decoction for stomach cramping (Bellia, 1994). These uses reflect a long-standing pattern of employing the herb as a demulcent and mild febrifuge.

One practical recipe for a mild tea, echoing historic practice, uses about 2–3 grams (roughly a loose handful or one small measuring teaspoon) of the dried aerial parts steeped in 250–300 mL of freshly boiled water for 10–15 minutes; for stronger relief the same dose can be simmered for 5 minutes and then strained. This preparation is intended for a single serving and is generally taken warm, 1–3 times per day, for sore throat or mild gastrointestinal upset. A 1:5 ethanol tincture, suitable for internal use at microdoses, is prepared by macerating 20 grams of the dried herb in 100 mL of 40–50% ethanol for 2–3 weeks in a cool, dark place, shaking daily; a typical dose is 1–3 mL in water or tea 1–2 times daily. The only well-established constituents are flavonoids such as kaempferol and quercetin, phenolic acids including caffeic acid, tannins, and small quantities of saponins, which together plausibly account for the observed mild astringency, anti-inflammatory, and demulcent actions reported in traditional use (Bellia, 1994; MITC, 1992; Moerman, 1998; Tardif, 1996).

Chrysosplenium americanum remains part of contemporary practice in northeastern and Great Lakes herbalism, often listed in specialty wildcrafted teas and apothecary blends, with modern studies continuing to explore its polyphenol profile and potential gastroprotective effects in controlled in vitro systems.

General Uses Top

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Synonyms Top

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Common names Top

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Language Common/alternative name
English american golden saxifrage

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Germination/Propagation Top

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Distribution (via POWO/KEW) Top

Legend for the distribution data:
- Doubtful data
- Extinct
- Introduced
- Native
  • Northern America
    • Eastern Canada
      • New Brunswick
      • Nova Scotia
      • Ontario
      • Prince Edward Island
      • Québec
    • North-central U.S.A.
      • Illinois
      • Iowa
      • Minnesota
      • Wisconsin
    • Northeastern U.S.A.
      • Connecticut
      • Indiana
      • Maine
      • Massachusetts
      • Michigan
      • New Hampshire
      • New Jersey
      • New York
      • Ohio
      • Pennsylvania
      • Rhode Island
      • Vermont
      • West Virginia
    • Southeastern U.S.A.
      • Alabama
      • Delaware
      • Georgia
      • Kentucky
      • Maryland
      • North Carolina
      • South Carolina
      • Tennessee
      • Virginia

Links to other databases Top

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Database ID/link to page
World Flora Online wfo-0000603909
Flora of Alabama 3382
Canadensys 9227
USDA Plants CHAM2
Tropicos 29100122
KEW urn:lsid:ipni.org:names:790546-1
The Plant List kew-2720092
Open Tree Of Life 732661
NCBI Taxonomy 36749
Nature Serve 2.159771
IUCN Red List 64310648
IPNI 790546-1
iNaturalist 154387
GBIF 5371611
WisFlora 3126
EOL 583363
Wikipedia Chrysosplenium_americanum
CMAUP NPO28070

Genomes (via NCBI) Top

No reference genome is available on NCBI yet. We are constantly monitoring for new data.

Scientific Literature Top

Below are displayed the latest 15 articles published in PMC (PubMed Central®) and other sources (DOI number only)!
If you wish to see all the related articles click here.
Title Authors Publication Released IDs
Systemically functional characterization of regiospecific flavonoid O-methyltransferases from Glycine max Feng B, Jiang Y, Li X, Wang Y, Ren Z, Lu J, Yan X, Zhou Z, Wang P Synth Syst Biotechnol 15-Mar-2024
PMCID:PMC10972763
doi:10.1016/j.synbio.2024.03.009
PMID:38549618
Characterization of two O-methyltransferases involved in the biosynthesis of O-methylated catechins in tea plant Jin JQ, Qu FR, Huang H, Liu QS, Wei MY, Zhou Y, Huang KL, Cui Z, Chen JD, Dai WD, Zhu L, Yao MZ, Zhang ZM, Chen L Nat Commun 21-Aug-2023
PMCID:PMC10442441
doi:10.1038/s41467-023-40868-9
PMID:37604798
Synthesis of Flavonol-Bearing Probes for Chemoproteomic and Bioinformatic Analyses of Asteraceae Petals in Search of Novel Flavonoid Enzymes Kempf K, Kempf O, Capello Y, Molitor C, Lescoat C, Melhem R, Chaignepain S, Génot E, Groppi A, Nikolski M, Halbwirth H, Deffieux D, Quideau S Int J Mol Sci 03-Jun-2023
PMCID:PMC10253404
doi:10.3390/ijms24119724
PMID:37298676
Vascular plant biodiversity of Katannilik Territorial Park, Kimmirut and vicinity on Baffin Island, Nunavut, Canada: an annotated checklist of an Arctic flora Saarela JM, Sokoloff PC, Gillespie LJ, Bull RD PhytoKeys 04-Jan-2023
PMCID:PMC9836459
doi:10.3897/phytokeys.217.90573
PMID:36760228
Functional Diversification and Structural Origins of Plant Natural Product Methyltransferases Lashley A, Miller R, Provenzano S, Jarecki SA, Erba P, Salim V Molecules 21-Dec-2022
PMCID:PMC9822479
doi:10.3390/molecules28010043
PMID:36615239
Structure-based identification and pathway elucidation of flavonoids in Camptotheca acuminate Pu X, Li J, Guo Z, Wang M, Lei M, Yang S, Yang J, Wang H, Zhang L, Huang Q Synth Syst Biotechnol 18-Apr-2022
PMCID:PMC9043410
doi:10.1016/j.synbio.2022.03.007
PMID:35510090
Molecular Characterisation of Flavanone O-methylation in Eucalyptus Somaletha Chandran K, Humphries J, Goodger JQ, Woodrow IE Int J Mol Sci 16-Mar-2022
PMCID:PMC8954846
doi:10.3390/ijms23063190
PMID:35328610
Hydroxylation decoration patterns of flavonoids in horticultural crops: chemistry, bioactivity, and biosynthesis Liu Y, Qian J, Li J, Xing M, Grierson D, Sun C, Xu C, Li X, Chen K Hortic Res 20-Jan-2022
PMCID:PMC8945325
doi:10.1093/hr/uhab068
PMID:35048127
Growth Suppression of a Gingivitis and Skin Pathogen Cutibacterium (Propionibacterium) acnes by Medicinal Plant Extracts Choi HA, Ahn SO, Lim HD, Kim GJ Antibiotics (Basel) 09-Sep-2021
PMCID:PMC8465884
doi:10.3390/antibiotics10091092
PMID:34572674
Expression and functional analysis of the nobiletin biosynthesis-related gene CitOMT in citrus fruit Seoka M, Ma G, Zhang L, Yahata M, Yamawaki K, Kan T, Kato M Sci Rep 17-Sep-2020
PMCID:PMC7498457
doi:10.1038/s41598-020-72277-z
PMID:32943728
Identification of a Unique Type of Isoflavone O-Methyltransferase, GmIOMT1, Based on Multi-Omics Analysis of Soybean under Biotic Stress Uchida K, Sawada Y, Ochiai K, Sato M, Inaba J, Hirai MY Plant Cell Physiol 07-Sep-2020
PMCID:PMC7758036
doi:10.1093/pcp/pcaa112
PMID:32894761
Vascular plants of Victoria Island (Northwest Territories and Nunavut, Canada): a specimen-based study of an Arctic flora Saarela JM, Sokoloff PC, Gillespie LJ, Bull RD, Bennett BA, Ponomarenko S PhytoKeys 06-Mar-2020
PMCID:PMC7070024
doi:10.3897/phytokeys.141.48810
PMID:32201471
Exploring the Phytochemical Landscape of the Early-Diverging Flowering Plant Amborella trichopoda Baill. Wu S, Wilson AE, Chang L, Tian L Molecules 23-Oct-2019
PMCID:PMC6864642
doi:10.3390/molecules24213814
PMID:31652707
Homology modeling and docking analysis of ßC1 protein encoded by Cotton leaf curl Multan betasatellite with different plant flavonoids Sarwar MW, Riaz A, Nahid N, Al Qahtani A, Ahmed N, Nawaz-Ul-Rehman MS, Younus A, Mubin M Heliyon 07-Mar-2019
PMCID:PMC6407081
doi:10.1016/j.heliyon.2019.e01303
PMID:30899831
Global Transcriptome Analyses Reveal Differentially Expressed Genes of Six Organs and Putative Genes Involved in (Iso)flavonoid Biosynthesis in Belamcanda chinensis Tian M, Zhang X, Zhu Y, Xie G, Qin M Front Plant Sci 14-Aug-2018
PMCID:PMC6102373
doi:10.3389/fpls.2018.01160
PMID:30154811

Phytochemical Profile Top

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Below are displayed the proven (via scientific papers) natural compounds!
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Name PubChem ID Canonical SMILES MW Found in Proof
> Benzenoids / Phenols / Tyrosols and derivatives / Tyrosols
Hydroxytyrosol 82755 Click to see 154.16 unknown via CMAUP database
Tyrosol 10393 Click to see 138.16 unknown via CMAUP database
> Lipids and lipid-like molecules / Steroids and steroid derivatives / Stigmastanes and derivatives
(-)-beta-Sitosterol 222284 Click to see 414.70 unknown via CMAUP database
> Organic oxygen compounds / Organooxygen compounds / Carbonyl compounds / Benzaldehydes / Hydroxybenzaldehydes
3,4-Dihydroxy-2,5-bis(3-methylbut-2-enyl)benzaldehyde 15229438 Click to see 274.35 unknown via CMAUP database
3,4-dihydroxy-5-[(E)-4-hydroxy-3-methylbut-2-enyl]-2-(3-methylbut-2-enyl)benzaldehyde 44477997 Click to see 290.40 unknown via CMAUP database
> Organosulfur compounds / Allyl sulfur compounds
Diallyl Sulfide 11617 Click to see 114.21 unknown via CMAUP database
> Organosulfur compounds / Isothiocyanates
1-Isothiocyanato-7-(methylthio)heptane 10125146 Click to see 203.40 unknown via CMAUP database
1-Isothiocyanato-8-(methylthio)octane 10171359 Click to see CSCCCCCCCCN=C=S 217.40 unknown via CMAUP database
6-Methylthiohexyl isothiocyanate 165224 Click to see 189.30 unknown via CMAUP database
Allyl Isothiocyanate 5971 Click to see 99.16 unknown via CMAUP database
> Organosulfur compounds / Sulfoxides
Alyssin, (S)- 51548324 Click to see CS(=O)CCCCCN=C=S 191.30 unknown via CMAUP database
> Phenylpropanoids and polyketides / Cinnamic acids and derivatives / Hydroxycinnamic acids and derivatives
(R)-N-Trans-Feruloyloctopamine 11151622 Click to see COC1=C(C=CC(=C1)C=CC(=O)NCC(C2=CC=C(C=C2)O)O)O 329.30 unknown via CMAUP database
> Phenylpropanoids and polyketides / Cinnamic acids and derivatives / Hydroxycinnamic acids and derivatives / Coumaric acids and derivatives
3,4-Dihydroxy-5-methoxy-trans-cinnamic acid methyl ester 14843288 Click to see COC1=CC(=CC(=C1O)O)C=CC(=O)OC 224.21 unknown via CMAUP database
3,4-Dimethoxycinnamic acid 717531 Click to see COC1=C(C=C(C=C1)C=CC(=O)O)OC 208.21 unknown via CMAUP database
Antithiamine factor 5321318 Click to see 238.24 unknown via CMAUP database
Methyl ferulate 5357283 Click to see COC1=C(C=CC(=C1)C=CC(=O)OC)O 208.21 unknown via CMAUP database
> Phenylpropanoids and polyketides / Cinnamic acids and derivatives / Hydroxycinnamic acids and derivatives / Hydroxycinnamic acid esters / Hydroxycinnamic acid glycosides
(E)-3,4-Dihydroxy-5-methoxycinnamoyl 6-O-(beta-D-glucopyranosyl)-beta-D-glucopyranoside 24827938 Click to see COC1=CC(=CC(=C1O)O)C=CC(=O)OC2C(C(C(C(O2)COC3C(C(C(C(O3)CO)O)O)O)O)O)O 534.50 unknown via CMAUP database
[(2R,3R,4S,5S,6R)-2-[[(2R,3S,4S,5R,6S)-6-[(E)-3-(3,4-dihydroxy-5-methoxyphenyl)prop-2-enoyl]oxy-3,4,5-trihydroxyoxan-2-yl]methoxy]-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl] (E)-3-(3,4-dihydroxy-5-methoxyphenyl)prop-2-enoate 24827808 Click to see COC1=CC(=CC(=C1O)O)C=CC(=O)OC2C(C(C(OC2OCC3C(C(C(C(O3)OC(=O)C=CC4=CC(=C(C(=C4)OC)O)O)O)O)O)CO)O)O 726.60 unknown via CMAUP database
[(2R,3R,4S,5S,6R)-2-[[(2R,3S,4S,5R,6S)-6-[(E)-3-(3,4-dihydroxy-5-methoxyphenyl)prop-2-enoyl]oxy-3,4,5-trihydroxyoxan-2-yl]methoxy]-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl] (E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate 24827937 Click to see 710.60 unknown via CMAUP database
[(2S,3R,4S,5S,6R)-6-[[(2R,3R,4S,5S,6R)-4,5-dihydroxy-3-[(E)-3-(4-hydroxy-3,5-dimethoxyphenyl)prop-2-enoyl]oxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]-3,4,5-trihydroxyoxan-2-yl] (E)-3-(3,4-dihydroxy-5-methoxyphenyl)prop-2-enoate 24827679 Click to see 740.70 unknown via CMAUP database
[(2S,3R,4S,5S,6R)-6-[[(2R,3R,4S,5S,6R)-4,5-dihydroxy-3-[(E)-3-(4-hydroxy-3,5-dimethoxyphenyl)prop-2-enoyl]oxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]-3,4,5-trihydroxyoxan-2-yl] (E)-3-(3,4-dihydroxyphenyl)prop-2-enoate 24827807 Click to see 710.60 unknown via CMAUP database
[(2S,3R,4S,5S,6R)-6-[[(2R,3R,4S,5S,6R)-4,5-dihydroxy-3-[(E)-3-(4-hydroxy-3,5-dimethoxyphenyl)prop-2-enoyl]oxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]-3,4,5-trihydroxyoxan-2-yl] (E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate 24827806 Click to see 724.70 unknown via CMAUP database
> Phenylpropanoids and polyketides / Cinnamic acids and derivatives / Hydroxycinnamic acids and derivatives / Hydroxycinnamic acids
5-Hydroxyferulic acid 446834 Click to see 210.18 unknown via CMAUP database
Ferulic Acid 445858 Click to see 194.18 unknown via CMAUP database
P-Coumaric Acid 637542 Click to see 164.16 unknown via CMAUP database
Sinapinic acid 637775 Click to see COC1=CC(=CC(=C1O)OC)C=CC(=O)O 224.21 unknown via CMAUP database
> Phenylpropanoids and polyketides / Flavonoids / Flavonoid glycosides / Flavonoid C-glycosides
[5-hydroxy-2-(4-hydroxyphenyl)-4-oxo-6-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]chromen-7-yl] (E)-3-(4-hydroxy-3,5-dimethoxyphenyl)prop-2-enoate 11239109 Click to see COC1=CC(=CC(=C1O)OC)C=CC(=O)OC2=C(C(=C3C(=C2)OC(=CC3=O)C4=CC=C(C=C4)O)O)C5C(C(C(C(O5)CO)O)O)O 638.60 unknown via CMAUP database
2-(4-Hydroxyphenyl)-5-hydroxy-6-[6-O-[2-O-(3,5-dimethoxy-4-hydroxycinnamoyl)-beta-D-glucopyranosyl]-beta-D-glucopyranosyl]-7-(3,5-dimethoxy-4-hydroxycinnamoyloxy)-4H-1-benzopyran-4-one 11787982 Click to see COC1=CC(=CC(=C1O)OC)C=CC(=O)OC2C(C(C(OC2OCC3C(C(C(C(O3)C4=C(C=C5C(=C4O)C(=O)C=C(O5)C6=CC=C(C=C6)O)OC(=O)C=CC7=CC(=C(C(=C7)OC)O)OC)O)O)O)CO)O)O 1006.90 unknown via CMAUP database
Isovitexin 162350 Click to see 432.40 unknown via CMAUP database
> Phenylpropanoids and polyketides / Flavonoids / Flavonoid glycosides / Flavonoid O-glycosides
[(2R,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-2-[[(2R,3S,4R,5R,6S)-3,4,5-trihydroxy-6-[5-hydroxy-7-[(E)-3-(4-hydroxy-3,5-dimethoxyphenyl)prop-2-enoyl]oxy-4-oxo-2-[4-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]chromen-6-yl]oxan-2-yl]methoxy]oxan-3-yl] (E)-3-(4-hydroxy-3,5-dimethoxyphenyl)prop-2-enoate 11228635 Click to see 1169.00 unknown via CMAUP database
[(2R,3S,4S,5R,6S)-3,4,5-trihydroxy-6-[4-[5-hydroxy-7-[(E)-3-(4-hydroxy-3,5-dimethoxyphenyl)prop-2-enoyl]oxy-4-oxo-6-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]chromen-2-yl]phenoxy]oxan-2-yl]methyl (E)-3-(4-hydroxy-3,5-dimethoxyphenyl)prop-2-enoate 102352342 Click to see 1006.90 unknown via CMAUP database
[5-hydroxy-4-oxo-6-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-2-[4-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]chromen-7-yl] (E)-3-(4-hydroxy-3,5-dimethoxyphenyl)prop-2-enoate 11764267 Click to see 800.70 unknown via CMAUP database
5,7-dihydroxy-6-((2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl)-2-(4-((2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl)oxyphenyl)chromen-4-one 154105 Click to see 594.50 unknown via CMAUP database
> Phenylpropanoids and polyketides / Flavonoids / Flavonoid glycosides / Flavonoid O-glycosides / Flavonoid-3-O-glycosides
3-((6-Deoxy-2-O-beta-D-glucopyranosyl-alpha-L-mannopyranosyl)oxy)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-1-benzopyran-4-one 10167806 Click to see 610.50 unknown via CMAUP database
Helicianeoide B 91758417 Click to see 742.60 unknown via CMAUP database

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