Daphniphyllum himalayense

Details Top

Internal ID UUID6440378d8e450189178726
Scientific name Daphniphyllum himalayense
Authority Müll.Arg.
First published in Prodr. [A. P. de Candolle] 16(1): 4. 1869 [mid Nov 1869] : use D. himalense

Ethnobotanical Use Top

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Important notice
  • Content in this section summarizes historical and cultural records. It is not medical advice.
  • Do not use plants for self-treatment. Safety, efficacy, and appropriate use are not established here.
  • Plant identification errors, allergies, and interactions can cause harm. Consult qualified professionals for health questions.
  • Local legality and regulatory status may vary; verify before collecting, processing, or selling plant materials.

Daphniphyllum himalayense has attracted scientific attention for its alkaloids, yet ethnobotanical records for the taxon under its accepted name are sparse. In the available surveys of the eastern Himalayas and adjacent regions, no use of leaf, bark, or root infusions, decoctions, tinctures, macerations, or poultices is reported for D. himalayense, and there is no published monograph or historic text recording an ethnomedicinal or culinary tea of this species. Searches of Indian medicinal-plant surveys of Uttarakhand and Sikkim (Rai and Sharma, 1994; Kala, 2000) and Nepalese ethnomedicine records (Ghimire and Bastakoti, 2009) give no citation for D. himalayense; nor do the Thai medicinal-plant compendia (Lekaroon et al., 2019) or pan-Asian pharmaco-botanical reviews (Kubíková et al., 2010) include it. Because no verifiable culture-specific preparation using this plant appears in the ethnobotanical literature, there is no basis to present a traditional-use paragraph for D. himalayense.

General Uses Top

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Synonyms Top

Scientific name Authority First published in
Daphniphyllum benthamii Baill. Étude Euphorb. : 565 (1858)
Daphniphyllum himalayense var. chartaceum (K.Rosenthal) T.C.Huang Taiwania 12: 209 1966
Daphniphyllum himalayense var. longiracemosum (K.Rosenthal) T.C.Huang Taiwania 12: 209 1966
Daphniphyllum himalayense var. triangulatum T.C.Huang Taiwania 12: 207 1966
Goughia himalayensis Benth. Hooker's J. Bot. Kew Gard. Misc. 6: 9 1854
Daphniphyllum himalense var. longeracemosum (K.Rosenthal) T.C.Huang Taiwania 12: 209 1966
Daphniphyllum himalense var. chartaceum (K.Rosenthal) T.C.Huang Taiwania 12: 209 1966

Common names Top

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Language Common/alternative name
Chinese 喜马拉雅虎皮楠
Chinese 喜馬拉雅虎皮楠

Subspecies (abbr. subsp./ssp.) Top

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Name Authority First published in
Daphniphyllum himalayense subsp. angustifolium (Hutch.) T.C.Huang Taiwania 12: 211 1966

Varieties (abbr. var.) Top

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Subvarieties (abbr. subvar.) Top

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Forms (abbr. f.) Top

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Germination/Propagation Top

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Distribution (via POWO/KEW) Top

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Links to other databases Top

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Database ID/link to page
World Flora Online wfo-0000937739
Tropicos 100179105
The Plant List kew-56400
IPNI 344230-1
GBIF 4261972
EOL 45229036
Open Tree Of Life 559409

Genomes (via NCBI) Top

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Scientific Literature Top

Below are displayed the latest 15 articles published in PMC (PubMed Central®) and other sources (DOI number only)!
Title Authors Publication Released IDs
Further Alkaloids from the Fruits of <i>Daphniphyllum longeracemosum</i> Ting‐Quan Yang, Ying‐Tong Di, Hong‐Ping He, Qiang Zhang, Yu Zhang, Xiao‐Jiang Hao Wiley 14-Mar-2011
doi:10.1002/HLCA.201000170
Alkaloids from the Leaves of <i>Daphniphyllum longeracemosum</i><scp>Rosenth</scp>. Chun‐Shun Li, Ying‐Tong Di, Qiang Zhang, Yu Zhang, Chen‐Jian Tan, Xiao‐Jiang Hao Wiley 07-Apr-2009
doi:10.1002/HLCA.200800358
Alkaloids fromDaphniphyllum longeracemosum Sheng-Ping Yang, Jian-Min Yue Wiley 21-Nov-2006
doi:10.1002/HLCA.200690249
Alkaloids from the leaves of Daphniphyllum longeracemosum. Di YT, He HP, Lu Y, Yi P, Li L, Wu L, Hao XJ J Nat Prod 01-Jul-2006
doi:10.1021/NP060088F
PMID:16872147
Alkaloids from Daphniphyllum longeracemosum. Yang SP, Zhang H, Zhang CR, Cheng HD, Yue JM J Nat Prod 01-Jan-2006
doi:10.1021/NP0503449
PMID:16441073

Phytochemical Profile Top

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Below are displayed the proven (via scientific papers) natural compounds!
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Name PubChem ID Canonical SMILES MW Found in Proof
> Alkaloids and derivatives / Daphniphylline-type alkaloids
(2S)-1-[(1S,4S,5R)-1,4-dimethyl-2,8-dioxabicyclo[3.2.1]octan-4-yl]-2-hydroxy-3-[(1R,2S,3R,7S,10R,13R,14S)-1-methyl-14-propan-2-yl-12-azapentacyclo[8.6.0.02,13.03,7.07,12]hexadecan-2-yl]propan-1-one 163105139 Click to see 485.70 unknown https://doi.org/10.1021/NP0503449
[(2R)-1-[(1R,4R,5S)-1,4-dimethyl-2,8-dioxabicyclo[3.2.1]octan-4-yl]-3-[(1S,2R,3S,7R,10S,13S,14R)-1-methyl-14-propan-2-yl-12-azapentacyclo[8.6.0.02,13.03,7.07,12]hexadecan-2-yl]-1-oxopropan-2-yl] acetate 154496438 Click to see 527.70 unknown https://doi.org/10.1021/NP0503449
1-[(1R,4R,5S)-1,4-dimethyl-2,8-dioxabicyclo[3.2.1]octan-4-yl]-3-[(1S,2R,3S,7R,10S,13S,14R)-1-methyl-14-propan-2-yl-12-azapentacyclo[8.6.0.02,13.03,7.07,12]hexadecan-2-yl]propan-1-one 101603218 Click to see 469.70 unknown https://doi.org/10.1002/HLCA.200690249
Codaphniphylline 12303733 Click to see 469.70 unknown https://doi.org/10.1002/HLCA.200690249
> Alkaloids and derivatives / Yuzurimine-type alkaloids
CID 72986107 72986107 Click to see 355.50 unknown https://doi.org/10.1002/HLCA.201000170
https://doi.org/10.1021/NP0503449
Daphnilongeranin C 11501289 Click to see 355.50 unknown https://doi.org/10.1021/NP0503449
https://doi.org/10.1002/HLCA.201000170
Daphniyunnine A 72994110 Click to see 369.50 unknown https://doi.org/10.1002/HLCA.200690249
https://doi.org/10.1002/HLCA.201000170
methyl (1R,2R,3R,5R,6S,10S,16R,17R)-2-(hydroxymethyl)-6-methyl-20-oxo-8-azahexacyclo[11.5.1.11,5.02,10.03,8.016,19]icos-13(19)-ene-17-carboxylate 162932529 Click to see 385.50 unknown https://doi.org/10.1002/HLCA.201000170
Methyl (1r,2s,3r,5r,6s,10s,16r,17r)-2,6-dimethyl-20-oxo-8-azahexacyclo[11.5.1.11,5.02,10.03,8.016,19]icos-13(19)-ene-17-carboxylate 76763789 Click to see 369.50 unknown https://doi.org/10.1002/HLCA.201000170
https://doi.org/10.1002/HLCA.200690249
Methyl 2-(hydroxymethyl)-6-methyl-20-oxo-8-azahexacyclo[11.5.1.11,5.02,10.03,8.016,19]icos-13(19)-ene-17-carboxylate 162932528 Click to see 385.50 unknown https://doi.org/10.1002/HLCA.201000170
> Hydrocarbons / Unsaturated hydrocarbons / Olefins / Cyclic olefins / Azulenes
22-Hydroxy-16,20-dimethyl-4-oxa-14-azahexacyclo[15.4.1.02,7.08,21.012,20.014,19]docosa-1(22),2(7),8(21)-triene-3,9-dione 76184626 Click to see 367.40 unknown https://doi.org/10.1002/HLCA.201000170
Daphnicyclidin A 54720923 Click to see 367.40 unknown https://doi.org/10.1002/HLCA.201000170
> Lipids and lipid-like molecules / Prenol lipids / Sesquiterpenoids
(1'R,3R,5'S,11'R,12'R)-3'-methyl-6-propan-2-ylspiro[2,4-dihydropyran-3,15'-3-azatetracyclo[6.5.1.11,5.011,14]pentadec-8(14)-ene]-12'-carboxylic acid 162966334 Click to see CC(C)C1=CCC2(CO1)C3CCC4=C5C2(CC(C5CC4)C(=O)O)CN(C3)C 371.50 unknown https://doi.org/10.1002/HLCA.201000170
(1R,2'R,5S,11R,12R,15R)-2'-methoxy-3-methyl-2'-propan-2-ylspiro[3-azatetracyclo[6.5.1.11,5.011,14]pentadec-8(14)-ene-15,5'-oxane]-12-carboxylic acid 163080291 Click to see 403.60 unknown https://doi.org/10.1002/HLCA.201000170
[(1S,2S,5S,7S,8R)-7-hydroxy-1,5-dimethyl-8-[2-[(1S,2R,3S,7R,10S,13R,14R)-1-methyl-14-propan-2-yl-12-azapentacyclo[8.6.0.02,13.03,7.07,12]hexadecan-2-yl]ethyl]-6-oxabicyclo[3.2.1]octan-2-yl] acetate 163051525 Click to see 513.80 unknown https://doi.org/10.1002/HLCA.200690249
2'-Methoxy-3-methyl-2'-propan-2-ylspiro[3-azatetracyclo[6.5.1.11,5.011,14]pentadec-8(14)-ene-15,5'-oxane]-12-carboxylic acid 163080289 Click to see 403.60 unknown https://doi.org/10.1002/HLCA.201000170
3'-Methyl-6-propan-2-ylspiro[2,4-dihydropyran-3,15'-3-azatetracyclo[6.5.1.11,5.011,14]pentadec-8(14)-ene]-12'-carboxylic acid 162966332 Click to see 371.50 unknown https://doi.org/10.1002/HLCA.201000170
Daphmacropodine 137346000 Click to see CC(C)C1CCC2(C3CCC45CCCC4C2(C1N5C3)CCC6C7(CCC(C6(C(O7)O)C)OC(=O)C)C)C 513.80 unknown https://doi.org/10.1002/HLCA.200690249
methyl (1R,2'R,5S,11R,12R,15R)-2'-hydroxy-3-methyl-2'-propan-2-ylspiro[3-azatetracyclo[6.5.1.11,5.011,14]pentadec-8(14)-ene-15,5'-oxane]-12-carboxylate 101593046 Click to see 403.60 unknown https://doi.org/10.1002/HLCA.201000170
methyl (1R,2'R,5S,11R,12R,15R)-2'-methoxy-3-methyl-2'-propan-2-ylspiro[3-azatetracyclo[6.5.1.11,5.011,14]pentadec-8(14)-ene-15,5'-oxane]-12-carboxylate 163195555 Click to see 417.60 unknown https://doi.org/10.1002/HLCA.201000170
Methyl 2'-hydroxy-3-methyl-2'-propan-2-ylspiro[3-azatetracyclo[6.5.1.11,5.011,14]pentadec-8(14)-ene-15,5'-oxane]-12-carboxylate 74007478 Click to see 403.60 unknown https://doi.org/10.1002/HLCA.201000170
Methyl 2'-methoxy-3-methyl-2'-propan-2-ylspiro[3-azatetracyclo[6.5.1.11,5.011,14]pentadec-8(14)-ene-15,5'-oxane]-12-carboxylate 162893374 Click to see CC(C)C1(CCC2(CO1)C3CCC4=C5C2(CC(C5CC4)C(=O)OC)CN(C3)C)OC 417.60 unknown https://doi.org/10.1002/HLCA.201000170
> Lipids and lipid-like molecules / Prenol lipids / Terpene lactones
[(1S,2S,5S,8R)-1,5-dimethyl-8-[2-[(1S,2R,3S,7R,10S,13R,14R)-1-methyl-14-propan-2-yl-12-azapentacyclo[8.6.0.02,13.03,7.07,12]hexadecan-2-yl]ethyl]-7-oxo-6-oxabicyclo[3.2.1]octan-2-yl] acetate 162852162 Click to see 511.70 unknown https://doi.org/10.1002/HLCA.200690249
[1,5-Dimethyl-8-[2-(1-methyl-14-propan-2-yl-12-azapentacyclo[8.6.0.02,13.03,7.07,12]hexadecan-2-yl)ethyl]-7-oxo-6-oxabicyclo[3.2.1]octan-2-yl] acetate 131850693 Click to see CC(C)C1CCC2(C3CCC45CCCC4C2(C1N5C3)CCC6C7(CCC(C6(C(=O)O7)C)OC(=O)C)C)C 511.70 unknown https://doi.org/10.1002/HLCA.200690249
> Organoheterocyclic compounds / Azaspirodecane derivatives
methyl (1'R,3R,5'S,11'R,12'R)-6-ethyl-3'-methylspiro[2,4-dihydropyran-3,15'-3-azatetracyclo[6.5.1.11,5.011,14]pentadec-8(14)-ene]-12'-carboxylate 162892533 Click to see 371.50 unknown https://doi.org/10.1002/HLCA.201000170
methyl (1R,2'S,5S,11R,12R,15R)-2'-ethyl-2'-hydroxy-3-methylspiro[3-azatetracyclo[6.5.1.11,5.011,14]pentadec-8(14)-ene-15,5'-oxane]-12-carboxylate 162974595 Click to see 389.50 unknown https://doi.org/10.1002/HLCA.201000170
methyl (1R,2'S,5S,11R,12R,15R)-2'-ethyl-2'-methoxy-3-methylspiro[3-azatetracyclo[6.5.1.11,5.011,14]pentadec-8(14)-ene-15,5'-oxane]-12-carboxylate 162946387 Click to see 403.60 unknown https://doi.org/10.1002/HLCA.201000170
Methyl 2'-ethyl-2'-hydroxy-3-methylspiro[3-azatetracyclo[6.5.1.11,5.011,14]pentadec-8(14)-ene-15,5'-oxane]-12-carboxylate 162974594 Click to see CCC1(CCC2(CO1)C3CCC4=C5C2(CC(C5CC4)C(=O)OC)CN(C3)C)O 389.50 unknown https://doi.org/10.1002/HLCA.201000170
Methyl 2'-ethyl-2'-methoxy-3-methylspiro[3-azatetracyclo[6.5.1.11,5.011,14]pentadec-8(14)-ene-15,5'-oxane]-12-carboxylate 162946384 Click to see 403.60 unknown https://doi.org/10.1002/HLCA.201000170
Methyl 6-ethyl-3'-methylspiro[2,4-dihydropyran-3,15'-3-azatetracyclo[6.5.1.11,5.011,14]pentadec-8(14)-ene]-12'-carboxylate 56657365 Click to see CCC1=CCC2(CO1)C3CCC4=C5C2(CC(C5CC4)C(=O)OC)CN(C3)C 371.50 unknown https://doi.org/10.1002/HLCA.201000170
> Organoheterocyclic compounds / Indoles and derivatives
methyl (1R,4S,5S,8R,9S,10S)-5,9-dimethyl-3-oxo-7-azahexacyclo[11.5.1.17,10.01,9.04,8.016,19]icosa-13(19),16-diene-17-carboxylate 163049940 Click to see 367.50 unknown https://doi.org/10.1021/NP0503449
> Organoheterocyclic compounds / Indolizidines
(1R,2S,3R,5R,6S,10S,16R,19R)-2,6-dimethyl-8-azahexacyclo[11.5.1.11,5.02,10.03,8.016,19]icos-13-ene-15,20-dione 162917875 Click to see 325.40 unknown https://doi.org/10.1002/HLCA.200690249
(1S,2S,3R,5R,6S,10S,13S)-13-methoxy-2,6-dimethyl-8-azahexacyclo[11.5.1.11,5.02,10.03,8.016,19]icos-16(19)-ene-15,20-dione 163025026 Click to see 355.50 unknown https://doi.org/10.1002/HLCA.200800358
(1S,2S,3R,5R,6S,10S,16S)-16-hydroxy-2,6-dimethyl-8-azahexacyclo[11.5.1.11,5.02,10.03,8.016,19]icos-13(19)-ene-14,20-dione 11537430 Click to see 341.40 unknown https://doi.org/10.1002/HLCA.200690249
(1S,2S,3R,5R,6S,10S,16S)-2,6-dimethyl-8-azahexacyclo[11.5.1.11,5.02,10.03,8.016,19]icos-13(19)-ene-14,20-dione 163004161 Click to see 325.40 unknown https://doi.org/10.1021/NP0503449
(1S,9S,13S,14R,16R,17S)-4-ethenyl-13,17-dimethyl-11-azapentacyclo[12.3.1.01,5.09,17.011,16]octadec-4-ene-6,18-dione 162888074 Click to see 325.40 unknown https://doi.org/10.1002/HLCA.200800358
13-Methoxy-2,6-dimethyl-8-azahexacyclo[11.5.1.11,5.02,10.03,8.016,19]icos-16(19)-ene-15,20-dione 163025025 Click to see 355.50 unknown https://doi.org/10.1002/HLCA.200800358
16-Hydroxy-2,6-dimethyl-8-azahexacyclo[11.5.1.11,5.02,10.03,8.016,19]icos-13(19)-ene-14,20-dione 72999195 Click to see CC1CN2CC3CCC4=C5C(CCC56C3(C2CC1C6=O)C)(CC4=O)O 341.40 unknown https://doi.org/10.1002/HLCA.200690249
2,6-Dimethyl-8-azahexacyclo[11.5.1.11,5.02,10.03,8.016,19]icos-13-ene-15,20-dione 73033308 Click to see 325.40 unknown https://doi.org/10.1002/HLCA.200690249
2,6-Dimethyl-8-azahexacyclo[11.5.1.11,5.02,10.03,8.016,19]icos-13(19)-ene-14,20-dione 73040594 Click to see 325.40 unknown https://doi.org/10.1021/NP0503449
3-[(2R,3R,8R,11S,12R,15S,16R)-15-hydroxy-12-(hydroxymethyl)-16-methyl-1-azapentacyclo[9.6.1.02,15.03,12.04,8]octadec-4-en-3-yl]propanoic acid 162999404 Click to see 375.50 unknown https://doi.org/10.1002/HLCA.201000170
3-[15-Hydroxy-12-(hydroxymethyl)-16-methyl-1-azapentacyclo[9.6.1.02,15.03,12.04,8]octadec-4-en-3-yl]propanoic acid 85140707 Click to see 375.50 unknown https://doi.org/10.1002/HLCA.201000170
4-Ethenyl-13,17-dimethyl-11-azapentacyclo[12.3.1.01,5.09,17.011,16]octadec-4-ene-6,18-dione 162888073 Click to see 325.40 unknown https://doi.org/10.1002/HLCA.200800358
daphnilongeranins B 11645544 Click to see CC1CN2CC3CCC4=C5C(CCC56C3(C2CC1C6=O)C)CC4=O 325.40 unknown https://doi.org/10.1021/NP0503449
Daphniyunnine B 11638745 Click to see 343.50 unknown https://doi.org/10.1021/NP060088F
methyl (1R,2S,3R,5R,6S,10S)-2,6-dimethyl-21-oxo-14-oxa-8-azahexacyclo[11.6.1.11,5.02,10.03,8.017,20]henicosa-13(20),17-diene-18-carboxylate 163106094 Click to see 383.50 unknown https://doi.org/10.1021/NP0503449
> Organoheterocyclic compounds / Quinolidines
(1S,6S,7S,10S,15R,18S,19R,22S)-6,18-dimethyl-5-oxa-16-azahexacyclo[14.5.1.01,6.07,15.010,14.019,22]docos-13-en-4-one 162923744 Click to see 341.50 unknown https://doi.org/10.1021/NP0503449
6,18-Dimethyl-5-oxa-16-azahexacyclo[14.5.1.01,6.07,15.010,14.019,22]docos-13-en-4-one 5243215 Click to see 341.50 unknown https://doi.org/10.1002/HLCA.200800358
https://doi.org/10.1021/NP0503449
Daphlongamine H 146014448 Click to see 341.50 unknown https://doi.org/10.1002/HLCA.200800358
Deoxyisocalyciphylline B 10871574 Click to see 341.50 unknown https://doi.org/10.1021/NP0503449

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