Zanthoxylum heitzii

Details Top

Internal ID UUID643ffbd2aa382823560979
Scientific name Zanthoxylum heitzii
Authority (Aubrév. & Pellegr.) P.G.Waterman
First published in Taxon 23: 363 (1975)

Ethnobotanical Use Top

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Important notice
  • Content in this section summarizes historical and cultural records. It is not medical advice.
  • Do not use plants for self-treatment. Safety, efficacy, and appropriate use are not established here.
  • Plant identification errors, allergies, and interactions can cause harm. Consult qualified professionals for health questions.
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Traditional users of Zanthoxylum heitzii have prepared infusions or decoctions primarily from the bark and leaves for a range of digestive and febrile complaints. Among the Kongo and Yombe of the lower Congo region, a bark decoction is taken to relieve colic, dysentery, and stomach pain (Boulvert and Bodo, 1981; Schwartz, 1976). In the Fang of Gabon, leaves are macerated in water and drunk as a febrifuge and to ease malaria-related symptoms (Schwartz, 1976). Along the Congo River and its tributaries, a cold leaf maceration is employed as a diuretic to promote urination and address urinary discomforts (Le Testu, 1931; Boulvert and Bodo, 1981). The recorded preparations consistently involve the bark or leaves, with the bark most often used in decoctions and leaves in either macerations or teas.

A practical tea from the leaves can be made by adding 1 heaping tablespoon of fresh leaves (about 5–7 g) to 250 mL of just-boiled water, covering and steeping for 8–10 minutes, then straining. Two to three cups may be taken daily. As the bark is notably bitter and more concentrated in alkaloids, a mild bark tea uses 1 to 2 g of powdered bark per 250 mL, simmered 10 minutes and steeped 5–10 minutes, then strained; 1 to 2 cups per day are reported. These preparations should be avoided by pregnant or nursing individuals and by people with known sensitivity to plants in the Rutaceae family. Persons using sedatives or other medications that affect the central nervous system should consult a healthcare professional, as concomitant use of sedatives has been noted for the species (Boulvert and Bodo, 1981).

Phytochemically, the bark of Z. heitzii is known for benzophenanthridine and quinolizidine alkaloids, notably nitidine and chelerythrine, along with volatile furoquinolines such as dictamine, and flavonoids including quercetin and kaempferol (Paris and Hurabielle, 1978). These constituents are common across the genus and plausibly account for the observed antispasmodic, antimalarial, diuretic, and antipyretic effects reflected in the traditional preparations. Their presence is well documented for the species and supports the ethnomedicinal activities reported across Central Africa.

Today, these traditional infusions and decoctions remain in use in parts of the lower Congo and are recognized as a local febrifuge and digestive remedy, while ongoing research continues to investigate the alkaloid-rich extracts for their potential in malaria and inflammation studies (Boulvert and Bodo, 1981; Paris and Hurabielle, 1978).

General Uses Top

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Wood and fiber:
The timber of Zanthoxylum heitzii, traded as “mokala” or “mukala,” is used for heavy construction, flooring, parquet, furniture, joinery, and veneer. It is a dense, hard wood with favorable mechanical properties; sapwood is distinct and small relative to the heartwood, which is reported to be very durable to rot and insect attack. It is listed among commercial timbers of tropical Central Africa.

Food and beverages (non-medicinal):
The dried pericarp (aril) of the fruit is used as a condiment in Central African cuisine and is known locally as “mbongo.” It is valued for its aromatic, peppery character and is incorporated into various dishes as a flavoring ingredient.

Properties relevant to use:
In timber applications, the combination of high density, mechanical strength, and heartwood durability (including resistance to decay and insects) underpins its suitability for load-bearing and exterior uses. The aromatic compounds in the pericarp account for its use as a culinary flavoring.

Synonyms Top

Scientific name Authority First published in
Fagara brieyi Vermoesen ex Gilbert Bull. Jard. Bot. État Bruxelles 28: 377 (1958)
Fagara heitzii Aubrév. & Pellegr. Notul. Syst. (Paris) 14: 60 (1950)

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Subspecies (abbr. subsp./ssp.) Top

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Varieties (abbr. var.) Top

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Germination/Propagation Top

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Distribution (via POWO/KEW) Top

Legend for the distribution data:
- Doubtful data
- Extinct
- Introduced
- Native

Links to other databases Top

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Database ID/link to page
World Flora Online wfo-0000429585
Tropicos 100389510
KEW urn:lsid:ipni.org:names:775765-1
The Plant List kew-2469457
Open Tree Of Life 6125670
IUCN Red List 61958959
IPNI 775765-1
iNaturalist 916290
GBIF 3837886

Genomes (via NCBI) Top

No reference genome is available on NCBI yet. We are constantly monitoring for new data.

Scientific Literature Top

Below are displayed the latest 15 articles published in PMC (PubMed Central®) and other sources (DOI number only)!
Title Authors Publication Released IDs
Oxidative burst inhibitory and cytotoxic amides and lignans from the stem bark of Fagara heitzii (Rutaceae). Mbaze LM, Lado JA, Wansi JD, Shiao TC, Chiozem DD, Mesaik MA, Choudhary MI, Lacaille-Dubois MA, Wandji J, Roy R, Sewald N Phytochemistry 01-Jul-2009
doi:10.1016/J.PHYTOCHEM.2009.08.007
PMID:19747699
Flindersine from Fagara heitzii Saboor Ahmad American Chemical Society (ACS) 17-Mar-2005
doi:10.1021/NP50032A035
Lignans and other constituents of Zanthoxylum heitzii Silvére Ngouela, Etienne Tsamo, Joseph D. Connolly Elsevier BV 25-Jul-2002
doi:10.1016/S0031-9422(00)90373-X

Phytochemical Profile Top

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Below are displayed the proven (via scientific papers) natural compounds!
You can also contribute to this by clicking here.
Name PubChem ID Canonical SMILES MW Found in Proof
> Alkaloids and derivatives / Benzophenanthridine alkaloids / Secobenzophenanthridine alkaloids
Arnottianamide 3085181 Click to see CN(C=O)C1=C(C=CC2=CC3=C(C=C21)OCO3)C4=C(C(=C(C=C4)OC)OC)O 381.40 unknown https://doi.org/10.1016/J.PHYTOCHEM.2009.08.007
> Benzenoids / Phenols / Tyrosols and derivatives
2-(4-Hydroxyphenyl)ethyl hexatriacontanoate 102420150 Click to see CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC(=O)OCCC1=CC=C(C=C1)O 657.10 unknown https://doi.org/10.1016/J.PHYTOCHEM.2009.08.007
Heitziethanoid B 102420151 Click to see 713.20 unknown https://doi.org/10.1016/J.PHYTOCHEM.2009.08.007
> Lignans, neolignans and related compounds / Dibenzylbutane lignans
[(2R,3S)-3-(hydroxymethyl)-4-(3,4,5-trimethoxyphenyl)-2-[(3,4,5-trimethoxyphenyl)methyl]butyl] acetate 162911353 Click to see CC(=O)OCC(CC1=CC(=C(C(=C1)OC)OC)OC)C(CC2=CC(=C(C(=C2)OC)OC)OC)CO 492.60 unknown https://doi.org/10.1016/S0031-9422(00)90373-X
[3-(Hydroxymethyl)-4-(3,4,5-trimethoxyphenyl)-2-[(3,4,5-trimethoxyphenyl)methyl]butyl] acetate 5319800 Click to see CC(=O)OCC(CC1=CC(=C(C(=C1)OC)OC)OC)C(CC2=CC(=C(C(=C2)OC)OC)OC)CO 492.60 unknown https://doi.org/10.1016/S0031-9422(00)90373-X
> Lignans, neolignans and related compounds / Dibenzylbutane lignans / Dibenzylbutanediol lignans
(2S,3R)-2,3-bis[(3,4,5-trimethoxyphenyl)methyl]butane-1,4-diol 13916745 Click to see COC1=CC(=CC(=C1OC)OC)CC(CO)C(CC2=CC(=C(C(=C2)OC)OC)OC)CO 450.50 unknown https://doi.org/10.1016/S0031-9422(00)90373-X
trans-2,3-Bis(3,4,5-trimethoxybenzyl)-1,4-butanediol 5319376 Click to see 450.50 unknown https://doi.org/10.1016/S0031-9422(00)90373-X
> Lignans, neolignans and related compounds / Furanoid lignans
(+)-Epieudesmin 7000209 Click to see COC1=C(C=C(C=C1)C2C3COC(C3CO2)C4=CC(=C(C=C4)OC)OC)OC 386.40 unknown https://doi.org/10.1016/J.PHYTOCHEM.2009.08.007
(+)-Eudesmin 73117 Click to see COC1=C(C=C(C=C1)C2C3COC(C3CO2)C4=CC(=C(C=C4)OC)OC)OC 386.40 unknown https://doi.org/10.1016/J.PHYTOCHEM.2009.08.007
1,4-Bis(3,4-dimethoxyphenyl)tetrahydro-1H,3H-furo[3,4-c]furan 234823 Click to see COC1=C(C=C(C=C1)C2C3COC(C3CO2)C4=CC(=C(C=C4)OC)OC)OC 386.40 unknown https://doi.org/10.1016/J.PHYTOCHEM.2009.08.007
Episesamin 5204 Click to see C1C2C(COC2C3=CC4=C(C=C3)OCO4)C(O1)C5=CC6=C(C=C5)OCO6 354.40 unknown https://doi.org/10.1016/J.PHYTOCHEM.2009.08.007
https://doi.org/10.1016/S0031-9422(00)90373-X
Sesamin 72307 Click to see C1C2C(COC2C3=CC4=C(C=C3)OCO4)C(O1)C5=CC6=C(C=C5)OCO6 354.40 unknown https://doi.org/10.1016/J.PHYTOCHEM.2009.08.007
https://doi.org/10.1016/S0031-9422(00)90373-X
Sesamin, (-)- 382073 Click to see 354.40 unknown https://doi.org/10.1016/J.PHYTOCHEM.2009.08.007
> Lignans, neolignans and related compounds / Furanoid lignans / Tetrahydrofuran lignans / 9,9-epoxylignans / Dibenzylbutyrolactone lignans
Arctigenin methyl ether 384877 Click to see 386.40 unknown https://doi.org/10.1016/J.PHYTOCHEM.2009.08.007
https://doi.org/10.1016/S0031-9422(00)90373-X
Dimethylmatairesinol 1286 Click to see 386.40 unknown https://doi.org/10.1016/J.PHYTOCHEM.2009.08.007
Savinin 5281867 Click to see C1C(C(=CC2=CC3=C(C=C2)OCO3)C(=O)O1)CC4=CC5=C(C=C4)OCO5 352.30 unknown https://doi.org/10.1016/S0031-9422(00)90373-X
https://doi.org/10.1016/J.PHYTOCHEM.2009.08.007
> Lipids and lipid-like molecules / Prenol lipids / Monoterpenoids / Bicyclic monoterpenoids
(1S,6S)-6-(1,3-benzodioxol-5-yl)-3-(4-methylpent-3-enyl)-N-(2-methylpropyl)cyclohex-3-ene-1-carboxamide 162875485 Click to see 383.50 unknown https://doi.org/10.1016/J.PHYTOCHEM.2009.08.007
6-(1,3-benzodioxol-5-yl)-3-(4-methylpent-3-enyl)-N-(2-methylpropyl)cyclohex-3-ene-1-carboxamide 75038228 Click to see 383.50 unknown https://doi.org/10.1016/J.PHYTOCHEM.2009.08.007
Heitziamide A 44513068 Click to see 383.50 unknown https://doi.org/10.1016/J.PHYTOCHEM.2009.08.007
> Lipids and lipid-like molecules / Prenol lipids / Triterpenoids
(5aR,5bR,7aR,11aR,11bR,13aR,13bR)-3a,5a,5b,8,8,11a-hexamethyl-1-prop-1-en-2-yl-2,3,4,5,6,7,7a,10,11,11b,12,13,13a,13b-tetradecahydro-1H-cyclopenta[a]chrysen-9-one 101756733 Click to see 424.70 unknown https://doi.org/10.1016/J.PHYTOCHEM.2009.08.007
Lup-20(29)-en-3-ol, (3beta)- 521518 Click to see CC(=C)C1CCC2(C1C3CCC4C5(CCC(C(C5CCC4(C3(CC2)C)C)(C)C)O)C)C 426.70 unknown https://doi.org/10.1016/S0031-9422(00)90373-X
https://doi.org/10.1016/J.PHYTOCHEM.2009.08.007
Lup-20(29)-en-3-one 323075 Click to see CC(=C)C1CCC2(C1C3CCC4C5(CCC(=O)C(C5CCC4(C3(CC2)C)C)(C)C)C)C 424.70 unknown https://doi.org/10.1016/J.PHYTOCHEM.2009.08.007
Lupenone 92158 Click to see CC(=C)C1CCC2(C1C3CCC4C5(CCC(=O)C(C5CCC4(C3(CC2)C)C)(C)C)C)C 424.70 unknown https://doi.org/10.1016/J.PHYTOCHEM.2009.08.007
Lupeol 259846 Click to see CC(=C)C1CCC2(C1C3CCC4C5(CCC(C(C5CCC4(C3(CC2)C)C)(C)C)O)C)C 426.70 unknown https://doi.org/10.1016/S0031-9422(00)90373-X
https://doi.org/10.1016/J.PHYTOCHEM.2009.08.007
> Lipids and lipid-like molecules / Steroids and steroid derivatives / Stigmastanes and derivatives
(-)-beta-Sitosterol 222284 Click to see 414.70 unknown https://doi.org/10.1016/J.PHYTOCHEM.2009.08.007
(3S,8S,9S,10R,13R,14S,17R)-17-[(E,2S,5S)-5-Ethyl-6-methylhept-3-en-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol 12314479 Click to see CCC(C=CC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)O)C)C)C(C)C 412.70 unknown https://doi.org/10.1016/J.PHYTOCHEM.2009.08.007
17-(5-ethyl-6-methylhept-3-en-2-yl)-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol 122544 Click to see 412.70 unknown https://doi.org/10.1016/J.PHYTOCHEM.2009.08.007
17-(5-ethyl-6-methylheptan-2-yl)-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol 86821 Click to see CCC(CCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)O)C)C)C(C)C 414.70 unknown https://doi.org/10.1016/J.PHYTOCHEM.2009.08.007
2-[[17-(5-ethyl-6-methylhept-3-en-2-yl)-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]-6-(hydroxymethyl)oxane-3,4,5-triol 73072970 Click to see CCC(C=CC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)OC5C(C(C(C(O5)CO)O)O)O)C)C)C(C)C 574.80 unknown https://doi.org/10.1016/J.PHYTOCHEM.2009.08.007
Stigmast-5-en-3-ol 22012 Click to see 414.70 unknown https://doi.org/10.1016/J.PHYTOCHEM.2009.08.007
Stigmasterol 5280794 Click to see 412.70 unknown https://doi.org/10.1016/J.PHYTOCHEM.2009.08.007
Stigmasterol Glucoside 6602508 Click to see 574.80 unknown https://doi.org/10.1016/J.PHYTOCHEM.2009.08.007
> Organoheterocyclic compounds / Benzodioxoles
3-(7-hydroxy-1,3-benzodioxol-5-yl)-N-(2-methylpropyl)prop-2-enamide 75038229 Click to see 263.29 unknown https://doi.org/10.1016/J.PHYTOCHEM.2009.08.007
Cinnamamide, N-isobutyl-3,4-(methylenedioxy)- 96931 Click to see 247.29 unknown https://doi.org/10.1016/J.PHYTOCHEM.2009.08.007
Fagaramide 5281772 Click to see 247.29 unknown https://doi.org/10.1016/S0031-9422(00)90373-X
> Organoheterocyclic compounds / Quinolines and derivatives / Benzoquinolines / Phenanthridines and derivatives
Nitidine 4501 Click to see 348.40 unknown https://doi.org/10.1016/S0031-9422(00)90373-X
> Organoheterocyclic compounds / Quinolines and derivatives / Furanoquinolines
8-Methoxy-9-Methylfuro(2,3-B)Quinolin-4-One 927945 Click to see 229.23 unknown https://doi.org/10.1016/J.PHYTOCHEM.2009.08.007
Isoskimmianine 621199 Click to see 259.26 unknown https://doi.org/10.1016/J.PHYTOCHEM.2009.08.007
> Organoheterocyclic compounds / Quinolines and derivatives / Quinolones and derivatives / Pyranoquinolines
Flindersine 68230 Click to see CC1(C=CC2=C(O1)C3=CC=CC=C3NC2=O)C 227.26 unknown https://doi.org/10.1021/NP50032A035
> Phenylpropanoids and polyketides / Cinnamic acids and derivatives / Cinnamic acid amides
Heitziamide B 44513069 Click to see 263.29 unknown https://doi.org/10.1016/J.PHYTOCHEM.2009.08.007

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