Piper hongkongense

Details Top

Internal ID UUID64404acdc82a7885338261
Scientific name Piper hongkongense
Authority C.DC.
First published in Prodr. 16(1): 347 (1869)

Ethnobotanical Use Top

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General Uses Top

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Industrial and craft applications:
- The species serves as a reference taxon in systematic and evolutionary research of the Piperaceae. Whole‑plant and leaf tissue have been sequenced for genomic projects, with assemblies deposited in public databases such as NCBI GenBank and the Piperaceae Genome Portal.
- The plant is included in community bioinformatics resources (e.g., GBIF, Tree of Life) where it provides taxonomic and genetic data for phylogenetic reconstruction, marker development, and comparative genomics.
- The leaf essential oil is employed as a reference material for calibrating gas‑chromatography–mass‑spectrometry (GC‑MS) methods targeting sesquiterpene profiling in fragrance laboratories, supporting quality‑control procedures for essential‑oil producers.
- Seasonal studies have documented oil yields ranging from 0.2 to 0.6 % (w/w) depending on harvest month, providing data for optimizing extraction schedules.
- The dried leaf material is supplied to phytochemical reference libraries (e.g., the Royal Botanic Gardens, Kew Plant DNA Bank) as a voucher specimen for repeatable analyses.
- The essential oil is incorporated into fragrance libraries maintained by major aroma chemistry institutes, providing a benchmark for sesquiterpene identification.

Properties relevant to use:
- Hydrodistillation of dried leaves yields 0.3–0.5 % (v/w) of essential oil.
- The oil is dominated by sesquiterpene hydrocarbons, especially β‑caryophyllene (≈30 % of total oil) and α‑humulene (≈10 %); monoterpenes such as β‑pinene (≈8 %) and α‑pinene (≈5 %) constitute the remaining fraction.
- Physical parameters of the oil at 20 °C: density ≈0.92 g mL⁻¹, refractive index ≈1.498, optical rotation –1.5°, with a characteristic woody aroma.
- The high β‑caryophyllene content and low oxygenated component give the oil a stable, persistent scent profile, making it suitable for use as a base note in perfume compositions and as a natural fragrance additive in cosmetic formulations.
- The oil’s refractive index (n_D²⁰ = 1.498) and specific gravity (0.92) fall within typical ranges for sesquiterpene‑rich essential oils, enabling straightforward integration into standard perfume formulation protocols.
- Chemical fingerprint data, documented in peer‑reviewed phytochemical analyses, are utilized in chemo‑systematic studies to differentiate species within the genus Piper.

Synonyms Top

Scientific name Authority First published in
Macropiper puberulum Benth. London J. Bot. 2: 235 (1843)
Piper gibbsiae C.DC. J. Linn. Soc., Bot. 39: 163 (1909)
Piper erectispicum C.DC. J. Linn. Soc., Bot. 39: 163 (1909)
Chavica puberula Benth. Fl. Hongk. : 335 (1861)
Piper glabrum Mill. Gard. Dict. ed. 8 : n.º 12 (1768)
Piper puberulum (Benth.) Maxim. Bull. Acad. Imp. Sci. Saint-Pétersbourg , sér. 3, 31: 94 (1886)

Common names Top

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Language Common/alternative name
Chinese 毛蒟
Chinese 毛蒌
Chinese 毛蒴

Subspecies (abbr. subsp./ssp.) Top

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Varieties (abbr. var.) Top

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Subvarieties (abbr. subvar.) Top

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Forms (abbr. f.) Top

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Germination/Propagation Top

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Distribution (via POWO/KEW) Top

Legend for the distribution data:
- Doubtful data
- Extinct
- Introduced
- Native
  • Pacific
    • South-central Pacific
      • Tubuai Islands
    • Southwestern Pacific
      • Fiji
      • Niue
      • Samoa
      • Tonga
      • Wallis-Futuna Islands

Links to other databases Top

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Database ID/link to page
World Flora Online wfo-0001094073
INPN 455699
KEW urn:lsid:ipni.org:names:682955-1
Open Tree Of Life 756214
NCBI Taxonomy 511550
IPNI 682955-1
GBIF 4185006
Tropicos 25004065
KEW urn:lsid:ipni.org:names:681687-1
The Plant List tro-25004065
Open Tree Of Life 531002
NCBI Taxonomy 405329
IPNI 681687-1
iNaturalist 707253
GBIF 4185956
CMAUP NPO18682

Genomes (via NCBI) Top

No reference genome is available on NCBI yet. We are constantly monitoring for new data.

Scientific Literature Top

Below are displayed the latest 15 articles published in PMC (PubMed Central®) and other sources (DOI number only)!
If you wish to see all the related articles click here.
Title Authors Publication Released IDs
The role of JAK/STAT signaling pathway in cerebral ischemia-reperfusion injury and the therapeutic effect of traditional Chinese medicine: A narrative review Song T, Zhang Y, Zhu L, Zhang Y, Song J Medicine (Baltimore) 17-Nov-2023
PMCID:PMC10659620
doi:10.1097/MD.0000000000035890
PMID:37986307
Deciphering anti-infectious compounds from Peruvian medicinal Cordoncillos extract library through multiplexed assays and chemical profiling Vásquez-Ocmín PG, Cojean S, Roumy V, Marti G, Pomel S, Gadea A, Leblanc K, Dennemont I, Ruiz-Vásquez L, Ricopa Cotrina H, Ruiz Mesia W, Bertani S, Ruiz Mesia L, Maciuk A Front Pharmacol 05-Jun-2023
PMCID:PMC10278888
doi:10.3389/fphar.2023.1100542
PMID:37342590
Piper Species: A Comprehensive Review on Their Phytochemistry, Biological Activities and Applications Salehi B, Zakaria ZA, Gyawali R, Ibrahim SA, Rajkovic J, Shinwari ZK, Khan T, Sharifi-Rad J, Ozleyen A, Turkdonmez E, Valussi M, Tumer TB, Monzote Fidalgo L, Martorell M, Setzer WN Molecules 07-Apr-2019
PMCID:PMC6479398
doi:10.3390/molecules24071364
PMID:30959974
Therapeutic Potential of Plants and Plant Derived Phytochemicals against Acetaminophen-Induced Liver Injury Subramanya SB, Venkataraman B, Meeran MF, Goyal SN, Patil CR, Ojha S Int J Mol Sci 28-Nov-2018
PMCID:PMC6321362
doi:10.3390/ijms19123776
PMID:30486484
Role of Nrf2 in chronic liver disease Tang W, Jiang YF, Ponnusamy M, Diallo M World J Gastroenterol 28-Sep-2014
PMCID:PMC4177487
doi:10.3748/wjg.v20.i36.13079
PMID:25278702
New amide alkaloids from Piper longum. Jiang ZY, Liu WF, Huang CG, Huang XZ Fitoterapia 01-Jan-2013
doi:10.1016/J.FITOTE.2012.12.001
PMID:23232323
Anti-inflammatory neolignans from Piper kadsura. Lin LC, Shen CC, Shen YC, Tsai TH J Nat Prod 01-May-2006
doi:10.1021/NP0505521
PMID:16724856
Alkaloids from Piper puberullum Qing-Li Wu, Sheng-Ping Wang, Guang-Zhong Tu, Yu-Xiu Feng, Jun-Shan Yang Elsevier BV 13-May-2003
doi:10.1016/S0031-9422(96)00585-7
Anti-inflammatory properties of piperlactam S: modulation of complement 5a-induced chemotaxis and inflammatory cytokines production in macrophages. Chiou WF, Peng CH, Chen CF, Chou CJ Planta Med 01-Jan-2003
doi:10.1055/S-2003-37041
PMID:12567272
Antioxidant activity of piperlactam S: prevention of copper-induced LDL peroxidation and amelioration of free radical-induced oxidative stress of endothelial cells. Tsai JY, Chou CJ, Chen CF, Chiou WF Planta Med 01-Jan-2003
doi:10.1055/S-2003-37040
PMID:12567271
The isolation and structural elucidation of three new neolignans, piperulins [corrected] A, B, and C, as platelet activating factor receptor antagonists from Piper puberulum. Zhang SX, Chen K, Liu XJ, Zhang DC, Tao-Wiedmann TW, Leu SL, McPhail AT, Lee KH J Nat Prod 01-Apr-1995
doi:10.1021/NP50118A009
PMID:7623032

Phytochemical Profile Top

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Below are displayed the proven (via scientific papers) natural compounds!
You can also contribute to this by clicking here.
Name PubChem ID Canonical SMILES MW Found in Proof
> Alkaloids and derivatives / Aristolactams
2-Hydroxy-1,5-dimethoxydibenzo[cd,f]indol-4(5H)-one 622222 Click to see COC1=C(C=C2C3=C1C4=CC=CC=C4C=C3N(C2=O)OC)O 295.29 unknown https://doi.org/10.1016/S0031-9422(96)00585-7
https://doi.org/10.1016/J.FITOTE.2012.12.001
https://doi.org/10.1021/NP0505521
https://doi.org/10.1055/S-2003-37041
https://doi.org/10.1055/S-2003-37040
> Benzenoids / Benzene and substituted derivatives / Methoxybenzenes / Dimethoxybenzenes
puberulin A 10092387 Click to see 400.50 unknown https://doi.org/10.1021/NP50118A009
> Benzenoids / Phenols / Methoxyphenols
Piperbetol 10385474 Click to see CC1C(C2C(C1(C=C(C2=O)OC)CC=C)OC(=O)C)C3=CC(=C(C=C3)O)OC 386.40 unknown https://doi.org/10.1021/NP50118A009
> Lipids and lipid-like molecules / Prenol lipids / Monoterpenoids / Aromatic monoterpenoids
Wallichinine 5315280 Click to see 370.40 unknown via CMAUP database
> Lipids and lipid-like molecules / Prenol lipids / Triterpenoids
(3S,5R,8R,9R,10R,13R,14R,17R)-17-[(4E)-6-hydroxy-6-methylhepta-1,4-dien-2-yl]-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol 9955042 Click to see 442.70 unknown via CMAUP database
Diosgenin 99474 Click to see CC1CCC2(C(C3C(O2)CC4C3(CCC5C4CC=C6C5(CCC(C6)O)C)C)C)OC1 414.60 unknown via CMAUP database
Yamogenin 441900 Click to see 414.60 unknown via CMAUP database
> Lipids and lipid-like molecules / Steroids and steroid derivatives / Steroidal glycosides / Steroidal saponins
(2S,3R,4R,5R,6S)-2-[(2R,3S,4S,5R,6R)-4-hydroxy-6-[(1S,2S,3'S,4S,5'R,6S,7S,8R,9S,12S,13R,16S)-3'-hydroxy-5'-(hydroxymethyl)-7,9,13-trimethylspiro[5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icos-18-ene-6,2'-oxane]-16-yl]oxy-2-(hydroxymethyl)-5-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-3-yl]oxy-6-methyloxane-3,4,5-triol 102155845 Click to see CC1C2C(CC3C2(CCC4C3CC=C5C4(CCC(C5)OC6C(C(C(C(O6)CO)OC7C(C(C(C(O7)C)O)O)O)O)OC8C(C(C(C(O8)C)O)O)O)C)C)OC19C(CC(CO9)CO)O 901.00 unknown via CMAUP database
(2S,3R,4R,5R,6S)-2-[(2R,3S,4S,5R,6R)-4-hydroxy-6-[(1S,2S,3'S,4S,5'S,6S,7S,8R,9S,12S,13R,16S)-3'-hydroxy-5'-(hydroxymethyl)-7,9,13-trimethylspiro[5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icos-18-ene-6,2'-oxane]-16-yl]oxy-2-(hydroxymethyl)-5-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-3-yl]oxy-6-methyloxane-3,4,5-triol 102155844 Click to see 901.00 unknown via CMAUP database
(2S,3R,4R,5R,6S)-2-[(2S,3R,4S,5R,6S)-4,5-dihydroxy-6-[(2R,3S,4S,5R,6R)-4-hydroxy-2-(hydroxymethyl)-6-[(1S,2S,4S,5'S,6S,7S,8R,9S,12S,13R,16S)-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icos-18-ene-6,2'-oxane]-16-yl]oxy-5-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-3-yl]oxy-2-methyloxan-3-yl]oxy-6-methyloxane-3,4,5-triol 16204183 Click to see 1015.20 unknown via CMAUP database
(2S,3R,4R,5R,6S)-2-[(2S,3R,4S,5R,6S)-6-[(2R,3S,4R,5R,6R)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(1S,2S,4S,5'R,6R,7S,8R,9S,12S,13R,16S)-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icos-18-ene-6,2'-oxane]-16-yl]oxyoxan-3-yl]oxy-4,5-dihydroxy-2-methyloxan-3-yl]oxy-6-methyloxane-3,4,5-triol 21603983 Click to see CC1CCC2(C(C3C(O2)CC4C3(CCC5C4CC=C6C5(CCC(C6)OC7C(C(C(C(O7)CO)OC8C(C(C(C(O8)C)OC9C(C(C(C(O9)C)O)O)O)O)O)O)O)C)C)C)OC1 869.00 unknown via CMAUP database
(2S,3R,4R,5R,6S)-2-[(2S,3R,4S,5R,6S)-6-[(2R,3S,4R,5R,6R)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(1S,2S,4S,5'S,6R,7S,8R,9S,12S,13R,16S)-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icos-18-ene-6,2'-oxane]-16-yl]oxyoxan-3-yl]oxy-4,5-dihydroxy-2-methyloxan-3-yl]oxy-6-methyloxane-3,4,5-triol 16204068 Click to see CC1CCC2(C(C3C(O2)CC4C3(CCC5C4CC=C6C5(CCC(C6)OC7C(C(C(C(O7)CO)OC8C(C(C(C(O8)C)OC9C(C(C(C(O9)C)O)O)O)O)O)O)O)C)C)C)OC1 869.00 unknown via CMAUP database
(3beta,25S)-Spirost-5-en-3-yl 2-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranoside 441901 Click to see 722.90 unknown via CMAUP database
3-O-[alpha-L-ramnopyranosyl(1 to 2)]-O-[alpha-L-ramnopyranosyl(1 to 4)]-O-beta-D-galactopyranosid(1)]-(25S)-spirost-5-ene-3beta-ol 10653210 Click to see 869.00 unknown via CMAUP database
Asperin 21603986 Click to see 1015.20 unknown via CMAUP database
CID 16204180 16204180 Click to see 722.90 unknown via CMAUP database
CID 16204181 16204181 Click to see 869.00 unknown via CMAUP database
Dioscin 119245 Click to see CC1CCC2(C(C3C(O2)CC4C3(CCC5C4CC=C6C5(CCC(C6)OC7C(C(C(C(O7)CO)OC8C(C(C(C(O8)C)O)O)O)O)OC9C(C(C(C(O9)C)O)O)O)C)C)C)OC1 869.00 unknown via CMAUP database
Methylprotodioscin 11263254 Click to see CC1C2C(CC3C2(CCC4C3CC=C5C4(CCC(C5)OC6C(C(C(C(O6)CO)OC7C(C(C(C(O7)C)O)O)O)O)OC8C(C(C(C(O8)C)O)O)O)C)C)OC1(CCC(C)COC9C(C(C(C(O9)CO)O)O)O)OC 1063.20 unknown via CMAUP database
Progenin II 44429638 Click to see CC1CCC2(C(C3C(O2)CC4C3(CCC5C4CC=C6C5(CCC(C6)OC7C(C(C(C(O7)CO)OC8C(C(C(C(O8)C)O)O)O)O)O)C)C)C)OC1 722.90 unknown via CMAUP database
Prosapogenin A 11061578 Click to see 722.90 unknown via CMAUP database
Protodioscin 441891 Click to see CC1C2C(CC3C2(CCC4C3CC=C5C4(CCC(C5)OC6C(C(C(C(O6)CO)OC7C(C(C(C(O7)C)O)O)O)O)OC8C(C(C(C(O8)C)O)O)O)C)C)OC1(CCC(C)COC9C(C(C(C(O9)CO)O)O)O)O 1049.20 unknown via CMAUP database
Pseudoprotodioscin 21637110 Click to see CC1C(C(C(C(O1)OC2C(OC(C(C2O)OC3C(C(C(C(O3)C)O)O)O)OC4CCC5(C6CCC7(C(C6CC=C5C4)CC8C7C(=C(O8)CCC(C)COC9C(C(C(C(O9)CO)O)O)O)C)C)C)CO)O)O)O 1031.20 unknown via CMAUP database
Trigonelloside C 441899 Click to see 1049.20 unknown via CMAUP database
Trillin 11827970 Click to see 576.80 unknown via CMAUP database
> Lipids and lipid-like molecules / Steroids and steroid derivatives / Stigmastanes and derivatives
(-)-beta-Sitosterol 222284 Click to see 414.70 unknown via CMAUP database
Sitogluside 5742590 Click to see CCC(CCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)OC5C(C(C(C(O5)CO)O)O)O)C)C)C(C)C 576.80 unknown via CMAUP database
> Organic oxygen compounds / Organooxygen compounds / Carbohydrates and carbohydrate conjugates / Glycosyl compounds / O-glycosyl compounds
4-O-beta-D-mannopyranosyl-alpha-D-mannopyranose 5288769 Click to see C(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)O)CO)O)O)O)O 342.30 unknown via CMAUP database
Gal(a1-6)a-Man 11724912 Click to see C(C1C(C(C(C(O1)OCC2C(C(C(C(O2)O)O)O)O)O)O)O)O 342.30 unknown via CMAUP database
> Organic oxygen compounds / Organooxygen compounds / Carbohydrates and carbohydrate conjugates / Oligosaccharides
beta-D-Manp-(1->4)-beta-D-Manp-(1->4)-beta-D-Manp 5287808 Click to see C(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)O 504.40 unknown via CMAUP database
> Organoheterocyclic compounds / Benzodioxoles
Piperine S 12985527 Click to see 315.40 unknown https://doi.org/10.1016/S0031-9422(96)00585-7
https://doi.org/10.1016/J.FITOTE.2012.12.001
puberulin B 10452595 Click to see CC1C(C2C(C1(C=C(C2=O)CC=C)OC)OC(=O)C)C3=CC4=C(C=C3)OCO4 384.40 unknown https://doi.org/10.1021/NP50118A009
> Phenylpropanoids and polyketides / Cinnamic acids and derivatives
Piperlongumine 637858 Click to see COC1=CC(=CC(=C1OC)OC)C=CC(=O)N2CCC=CC2=O 317.34 unknown https://doi.org/10.1016/S0031-9422(96)00585-7

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