Aristolochia triangularis

Details Top

Internal ID UUID64400ab391d78761928820
Scientific name Aristolochia triangularis
Authority Cham.
First published in Linnaea 7: 209 (1832)

Ethnobotanical Use Top

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General Uses Top

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Common products:
No commercial products derived from Aristolochia triangularis have been documented. The species is not cultivated for timber, fiber, food, or any other material use. It remains primarily a wild plant with no established market.

Industrial and craft applications:
There are no known industrial or craft uses. The plant serves solely as a source of raw material for scientific research; dried aerial parts are extracted to obtain aristolochic acids (AA I and AA II). These compounds are employed as reference standards for toxicology studies, DNA adduct formation assays, and for the authenticity testing of herbal products containing aristolochic acids.

Food and beverages (non-medicinal):
No food or beverage applications are reported. The presence of toxic aristolochic acids precludes any edible use of the plant or its parts.

Properties relevant to use:
Aristolochia triangularis contains aristolochic acids AA I and AA II, which can be quantified by HPLC with UV detection at 254 nm. The presence of these lipophilic, stable compounds enables their use as analytical reference standards, given their defined chemical identity. Concentrations vary with plant part (leaves, stems, roots) and geographic origin, but the compounds remain the primary chemical markers used in toxicology research and authenticity testing of herbal products.

Standards and regulation:
Aristolochic acids are subject to regulatory limits in many jurisdictions as contaminants in dietary supplements and herbal products (e.g., United States FDA, European Union EFSA). The European Pharmacopoeia includes monographs for aristolochic acids, specifying purity requirements for reference materials. Although no product‑specific standard exists for A. triangularis, research‑grade extracts must comply with general chemical reference‑material standards (e.g., ISO 17025 for analytical purity).

Sustainability and sourcing:
The species occurs in wild populations across its native Andean range. No large‑scale cultivation exists, and research collections are generally small. Field surveys suggest that populations are not currently considered threatened; however, sustainable harvesting practices—such as limiting collection to non‑protected areas, avoiding over‑harvesting, and monitoring population status—are recommended to ensure continued availability.

Synonyms Top

Scientific name Authority First published in
Aristolochia antihysterica Mart. ex Duch. Prodr. 15(1): 477 (1864)
Aristolochia paraguariensis D.Parodi Anales Soc. Ci. Argent. 5: 156 (1878)
Aristolochia salpinx Mast. Gard. Chron. , n.s., 26: 456 (1886)
Aristolochia sellowiana Duch. Prodr. 15(1): 458 (1864)
Aristolochia triangularis f. minor Chodat & Hassl. Bull. Herb. Boissier , sér. 2, 3: 788 (1903)
Aristolochia triangularis var. salpinx Hauman Anales Mus. Nac. Hist. Nat. Buenos Aires 32: 332 (1923)
Howardia sellowiana Klotzsch Monatsber. Königl. Preuss. Akad. Wiss. Berlin 1859: 616 (1859)
Howardia triangularis Klotzsch Monatsber. Königl. Preuss. Akad. Wiss. Berlin 1859: 620 (1859)

Common names Top

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Language Common/alternative name
Portuguese mil-homens-do-rio-grande

Subspecies (abbr. subsp./ssp.) Top

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Varieties (abbr. var.) Top

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Subvarieties (abbr. subvar.) Top

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Forms (abbr. f.) Top

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Germination/Propagation Top

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Distribution (via POWO/KEW) Top

Legend for the distribution data:
- Doubtful data
- Extinct
- Introduced
- Native
  • Southern America
    • Brazil
      • Brazil North
      • Brazil South
      • Brazil Southeast
      • Brazil West-central
    • Southern South America
      • Argentina Northeast
      • Paraguay
      • Uruguay
    • Western South America
      • Bolivia

Links to other databases Top

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Database ID/link to page
World Flora Online wfo-0000548415
Tropicos 2500138
KEW urn:lsid:ipni.org:names:93402-1
The Plant List kew-2651973
Open Tree Of Life 603714
NCBI Taxonomy 158574
IPNI 93402-1
GBIF 7313743
CMAUP NPO20173

Genomes (via NCBI) Top

No reference genome is available on NCBI yet. We are constantly monitoring for new data.

Scientific Literature Top

Below are displayed the latest 15 articles published in PMC (PubMed Central®) and other sources (DOI number only)!
If you wish to see all the related articles click here.
Title Authors Publication Released IDs
The Meaning of Plants' Names: A New Discovering Approach to Its Medicinal and/or Toxic Properties dos Santos Dantas Lima L, Felipe Domingues Passero L, Indriunas A, de Souza Santos I, Francisco Uchôa Coqueiro L, Alexandre Souza da Cruz K, Batista de Almeida A, Carlos Fernandes Galduróz J, Rodrigues E Evid Based Complement Alternat Med 19-Feb-2024
PMCID:PMC10896657
doi:10.1155/2024/6678557
PMID:38410808
Germacrene B – a central intermediate in sesquiterpene biosynthesis Xu H, Dickschat JS Beilstein J Org Chem 20-Feb-2023
PMCID:PMC9972886
doi:10.3762/bjoc.19.18
PMID:36865023
Systematic Overview of Aristolochic Acids: Nephrotoxicity, Carcinogenicity, and Underlying Mechanisms Han J, Xian Z, Zhang Y, Liu J, Liang A Front Pharmacol 11-Jun-2019
PMCID:PMC6580798
doi:10.3389/fphar.2019.00648
PMID:31244661
Astonishing diversity—the medicinal plant markets of Bogotá, Colombia Bussmann RW, Paniagua Zambrana NY, Romero C, Hart RE J Ethnobiol Ethnomed 20-Jun-2018
PMCID:PMC6011411
doi:10.1186/s13002-018-0241-8
PMID:29925407
The Colletotrichum dracaenophilum, C. magnum and C. orchidearum species complexes Damm U, Sato T, Alizadeh A, Groenewald JZ, Crous PW Stud Mycol 07-Apr-2018
PMCID:PMC6030544
doi:10.1016/j.simyco.2018.04.001
PMID:29997400
Yerba Mate (Ilex paraguariensis) Beverage: Nutraceutical Ingredient or Conveyor for the Intake of Medicinal Plants? Evidence from Paraguayan Folk Medicine Kujawska M Evid Based Complement Alternat Med 14-Mar-2018
PMCID:PMC5872613
doi:10.1155/2018/6849317
PMID:29725356
Cognition, culture and utility: plant classification by Paraguayan immigrant farmers in Misiones, Argentina Kujawska M, Jiménez-Escobar ND, Nolan JM, Arias-Mutis D J Ethnobiol Ethnomed 25-Jul-2017
PMCID:PMC5526315
doi:10.1186/s13002-017-0169-4
PMID:28743302
Medicinal Plant Diversity and Inter-Cultural Interactions between Indigenous Guarani, Criollos and Polish Migrants in the Subtropics of Argentina Kujawska M, Hilgert NI, Keller HA, Gil G PLoS One 11-Jan-2017
PMCID:PMC5226798
doi:10.1371/journal.pone.0169373
PMID:28076407
Anticancer activity of Aristolochia ringens Vahl. (Aristolochiaceae) Akindele AJ, Wani Z, Mahajan G, Sharma S, Aigbe FR, Satti N, Adeyemi OO, Mondhe DM J Tradit Complement Med 18-Dec-2014
PMCID:PMC4488040
doi:10.1016/j.jtcme.2014.05.001
PMID:26151007
Traditional botanical knowledge of artisanal fishers in southern Brazil Baptista MM, Ramos MA, de Albuquerque UP, Coelho-de-Souza G, Ritter MR J Ethnobiol Ethnomed 30-Jul-2013
PMCID:PMC3737040
doi:10.1186/1746-4269-9-54
PMID:23898973
Transformation of traditional knowledge of medicinal plants: the case of Tyroleans (Austria) who migrated to Australia, Brazil and Peru Pirker H, Haselmair R, Kuhn E, Schunko C, Vogl CR J Ethnobiol Ethnomed 16-Nov-2012
PMCID:PMC3539874
doi:10.1186/1746-4269-8-44
PMID:23157876
Exploring the Links between Ethnobotany, Local Therapeutic Practices, and Protected Areas in Santa Catarina Coastline, Brazil Zank S, Hanazaki N Evid Based Complement Alternat Med 17-Nov-2011
PMCID:PMC3235720
doi:10.1155/2012/563570
PMID:22203874
Database Survey of Anti-Inflammatory Plants in South America: A Review de Morais Lima GR, de Albuquerque Montenegro C, de Almeida CL, de Athayde-Filho PF, Barbosa-Filho JM, Batista LM Int J Mol Sci 21-Apr-2011
PMCID:PMC3127143
doi:10.3390/ijms12042692
PMID:21731467
Terpenes from Aristolochia triangularis Lucia M.X. Lopes, Vanderlan Da S. Bolzani, Lígia M.V. Trevisan, Tania M. Grigolli Elsevier BV 25-Jul-2002
doi:10.1016/0031-9422(90)85139-7

Phytochemical Profile Top

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Below are displayed the proven (via scientific papers) natural compounds!
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Name PubChem ID Canonical SMILES MW Found in Proof
> Alkaloids and derivatives / Camptothecins
9-Methoxycamptothecin 123617 Click to see 378.40 unknown via CMAUP database
Camptothecin 24360 Click to see 348.40 unknown via CMAUP database
> Benzenoids / Phenol ethers / Anisoles
(6R,7aS)-7a-(2-methoxy-4-prop-2-enylphenoxy)-6-prop-2-enyl-6,7-dihydro-1,3-benzodioxol-5-one 11501047 Click to see COC1=C(C=CC(=C1)CC=C)OC23CC(C(=O)C=C2OCO3)CC=C 342.40 unknown via CMAUP database
> Lignans, neolignans and related compounds / Furanoid lignans / Tetrahydrofuran lignans / 7,7-epoxylignans
(+)-Galbacin 442873 Click to see 340.40 unknown via CMAUP database
> Lignans, neolignans and related compounds / Furanoid lignans / Tetrahydrofuran lignans / 9,9-epoxylignans / Dibenzylbutyrolactols
(2S,3R,4R)-3,4-Bis(1,3-benzodioxol-5-ylmethyl)tetrahydro-2-furanol 117443 Click to see 356.40 unknown https://doi.org/10.1016/0031-9422(90)85139-7
rac-Cubebin 14137603 Click to see 356.40 unknown via CMAUP database
> Lignans, neolignans and related compounds / Furanoid lignans / Tetrahydrofuran lignans / 9,9-epoxylignans / Dibenzylbutyrolactone lignans
2(3H)-Furanone, 3,4-bis(1,3-benzodioxol-5-ylmethyl)dihydro-, (3S,4S)- 11002708 Click to see 354.40 unknown via CMAUP database
3,4-Bis(1,3-benzodioxol-5-ylmethyl)tetrahydrofuran-2-one 327062 Click to see 354.40 unknown https://doi.org/10.1016/0031-9422(90)85139-7
Hinokinin 442879 Click to see C1C(C(C(=O)O1)CC2=CC3=C(C=C2)OCO3)CC4=CC5=C(C=C4)OCO5 354.40 unknown https://doi.org/10.1016/0031-9422(90)85139-7
Nortrachelogenin 394846 Click to see COC1=C(C=CC(=C1)CC2COC(=O)C2(CC3=CC(=C(C=C3)O)OC)O)O 374.40 unknown via CMAUP database
> Lipids and lipid-like molecules / Prenol lipids / Diterpenoids / Kaurane diterpenoids
(1S,4R,9R,10R,13R,14S)-5,5,9-trimethyltetracyclo[11.2.1.01,10.04,9]hexadecane-14-carboxylic acid 101879007 Click to see 304.50 unknown https://doi.org/10.1016/0031-9422(90)85139-7
(1S,4S,9S,10S,13S,14R)-5,5,9,14-tetramethyltetracyclo[11.2.1.01,10.04,9]hexadecane 9548699 Click to see CC1CC23CCC4C(CCCC4(C2CCC1C3)C)(C)C 274.50 unknown via CMAUP database
[(1R,4R,9R,10S,13R,14R,16R)-5,5,9-trimethyl-15-oxapentacyclo[11.3.1.01,10.04,9.014,16]heptadecan-14-yl]methanol 163043375 Click to see 304.50 unknown https://doi.org/10.1016/0031-9422(90)85139-7
5,5,9-Trimethyltetracyclo[11.2.1.01,10.04,9]hexadecane-14-carboxylic acid 14335951 Click to see 304.50 unknown https://doi.org/10.1016/0031-9422(90)85139-7
5,5,9,14-Tetramethyltetracyclo[11.2.1.01,10.04,9]hexadecane 5232068 Click to see 274.50 unknown https://doi.org/10.1016/0031-9422(90)85139-7
Ent-Kaurane 65390 Click to see 274.50 unknown https://doi.org/10.1016/0031-9422(90)85139-7
Ent-Kaurene 11966109 Click to see 272.50 unknown https://doi.org/10.1016/0031-9422(90)85139-7
Kaur-15-en-17-ol 3082069 Click to see CC1(CCCC2(C1CCC34C2CCC(C3)C(=C4)CO)C)C 288.50 unknown https://doi.org/10.1016/0031-9422(90)85139-7
Kauran-16,17-diol 13816761 Click to see CC1(CCCC2(C1CCC34C2CCC(C3)C(C4)(CO)O)C)C 306.50 unknown https://doi.org/10.1016/0031-9422(90)85139-7
Kaurane-16,17-diol 13816758 Click to see 306.50 unknown https://doi.org/10.1016/0031-9422(90)85139-7
> Lipids and lipid-like molecules / Prenol lipids / Sesquiterpenoids
(3R,6E)-Nerolidol 11241545 Click to see 222.37 unknown https://doi.org/10.1016/0031-9422(90)85139-7
1,6,10-Dodecatrien-3-ol, 3,7,11-trimethyl- 8888 Click to see 222.37 unknown https://doi.org/10.1016/0031-9422(90)85139-7
3-[(3S,3aS,5aR,6S,7R,9R,9aR)-9-[(Z,2R)-2-hydroxy-3-methylpent-3-enoyl]oxy-7-(2-hydroxypropan-2-yl)-3a,6,9a-trimethyl-3-[(3S,5S)-5-(2-methylprop-1-enyl)oxolan-3-yl]-2,3,4,5,5a,7,8,9-octahydrocyclopenta[a]naphthalen-6-yl]propanoic acid 163106434 Click to see CC=C(C)C(C(=O)OC1CC(C(C2C1(C3=CCC(C3(CC2)C)C4CC(OC4)C=C(C)C)C)(C)CCC(=O)O)C(C)(C)O)O 600.80 unknown https://doi.org/10.1016/0031-9422(90)85139-7
> Lipids and lipid-like molecules / Steroids and steroid derivatives / Stigmastanes and derivatives
17-(5-ethyl-6-methylheptan-2-yl)-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol 86821 Click to see CCC(CCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)O)C)C)C(C)C 414.70 unknown https://doi.org/10.1016/0031-9422(90)85139-7
Lawsaritol 14890646 Click to see 414.70 unknown via CMAUP database
Stigmast-4-en-3-one 5484202 Click to see CCC(CCC(C)C1CCC2C1(CCC3C2CCC4=CC(=O)CCC34C)C)C(C)C 412.70 unknown via CMAUP database
Stigmast-5-en-3-ol 22012 Click to see 414.70 unknown https://doi.org/10.1016/0031-9422(90)85139-7
> Organic acids and derivatives / Organic sulfuric acids and derivatives / Organic sulfuric acids
hydrogen sulfate;[N'-(3-methylbut-2-enyl)carbamimidoyl]azanium 71669596 Click to see 225.27 unknown via CMAUP database
> Organic nitrogen compounds / Organonitrogen compounds / Guanidines
N-(3-Methyl-2-buten-1-yl)guanidine 10983 Click to see 127.19 unknown via CMAUP database
> Organoheterocyclic compounds / Azoles / Imidazoles
Allantoin 204 Click to see C1(C(=O)NC(=O)N1)NC(=O)N 158.12 unknown https://doi.org/10.1016/0031-9422(90)85139-7
> Organoheterocyclic compounds / Azolidines / Imidazolidines / Hydantoins / Allantoins
(S)-(+)-allantoin 439714 Click to see 158.12 unknown https://doi.org/10.1016/0031-9422(90)85139-7
> Organoheterocyclic compounds / Benzodioxoles
Didymochlaenone B 11617367 Click to see C=CCC1CC2(C(=CC1=O)OCO2)OC3=CC4=C(C=C3CC=C)OCO4 356.40 unknown via CMAUP database
> Phenylpropanoids and polyketides / Stilbenes
Pinosylvin methyl ether 5281719 Click to see COC1=CC(=CC(=C1)O)C=CC2=CC=CC=C2 226.27 unknown via CMAUP database

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