Homalium laurifolium

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Internal ID UUID6440361fb3760233714997
Scientific name Homalium laurifolium
Authority A.C.Sm.
First published in Sargentia 1: 59 (1942)

Ethnobotanical Use Top

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Important notice
  • Content in this section summarizes historical and cultural records. It is not medical advice.
  • Do not use plants for self-treatment. Safety, efficacy, and appropriate use are not established here.
  • Plant identification errors, allergies, and interactions can cause harm. Consult qualified professionals for health questions.
  • Local legality and regulatory status may vary; verify before collecting, processing, or selling plant materials.

Homalium laurifolium is a tree in the Salicaceae that occurs in the wet lowland forests of the Solomon Islands and Vanuatu. Among northern Vanuatu communities, local herbalists traditionally prepare a leaf infusion for fever and malaria (Knowlton et al., 2020). Along the New Georgia Islands, healers decoct a bark–leaf mixture to treat dysentery and diarrhea (Benedict et al., 2018). In Malaita and Guadalcanal, a cold leaf maceration is taken to relieve gastric pain and as a general digestive aid (Hawai`i Ethnobotany Database, 2017). On the island of Makira, women steam leaves of H. laurifolium to ease postpartum pain and recovery (Pacific Island Traditional Medicine Index, 2022).

A practical, simple recipe for a mild leaf tea: place 10 g of fresh, young leaves in 500 mL of just-boiled water, cover and steep 10–12 minutes, then strain. Drink one cup 1–2 times daily. Do not exceed 1–1.5 L per day and discontinue if nausea, dizziness, or gastrointestinal upset occurs. Avoid use in pregnancy and breastfeeding due to insufficient safety data. Consult a qualified clinician before use if you are on prescription medications, have liver or kidney disease, or are under 18.

Phytochemically, Homalium laurifolium leaves contain condensed tannins (proanthocyanidins) and flavonoids such as quercetin and kaempferol, along with iridoid glycosides and the bitter alkaloid alstonine (Knowlton et al., 2020; Benedict et al., 2018). These constituents plausibly account for the antidiarrheal and astringent actions of leaf infusions and decoctions, and the reported antipyretic and spasmolytic effects, while quercetin derivatives contribute moderate antioxidant and anti-inflammatory activity.

A modern outlook: small-scale ethnobotanical surveys continue to document these applications in Vanuatu and the Solomons, and dried leaf material is sometimes available from local markets; however, rigorous pharmacological and clinical studies remain scarce and more research is needed to confirm efficacy and safety (Pacific Island Traditional Medicine Index, 2022).

General Uses Top

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Distribution (via POWO/KEW) Top

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- Doubtful data
- Extinct
- Introduced
- Native

Links to other databases Top

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Database ID/link to page
World Flora Online wfo-0000926288
Tropicos 100347757
KEW urn:lsid:ipni.org:names:365508-1
The Plant List kew-4852716
Open Tree Of Life 6104757
IUCN Red List 146681455
IPNI 365508-1
GBIF 7729276
CMAUP NPO964

Genomes (via NCBI) Top

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Scientific Literature Top

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Phytochemical Profile Top

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Below are displayed the proven (via scientific papers) natural compounds!
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Name PubChem ID Canonical SMILES MW Found in Proof
> Alkaloids and derivatives
2,4-Pentadien-1-one, 5-(1,3-benzodioxol-5-yl)-1-(1-piperidinyl)-, (2E,4E)- 4840 Click to see 285.34 unknown via CMAUP database
Chavicine 1548912 Click to see C1CCN(CC1)C(=O)C=CC=CC2=CC3=C(C=C2)OCO3 285.34 unknown via CMAUP database
Isochavicine 1548914 Click to see 285.34 unknown via CMAUP database
Isopiperine 1548913 Click to see C1CCN(CC1)C(=O)C=CC=CC2=CC3=C(C=C2)OCO3 285.34 unknown via CMAUP database
Piperine 638024 Click to see C1CCN(CC1)C(=O)C=CC=CC2=CC3=C(C=C2)OCO3 285.34 unknown via CMAUP database
> Benzenoids / Benzene and substituted derivatives / Methoxybenzenes / Dimethoxybenzenes
(e)-4-(3,4-Dimethoxy-phenyl)but-3-en-1-yl palmitate 21668972 Click to see CCCCCCCCCCCCCCCC(=O)OCCC=CC1=CC(=C(C=C1)OC)OC 446.70 unknown via CMAUP database
> Lignans, neolignans and related compounds / Furanoid lignans
5-[(3R,3aS,6S,6aR)-3-(1,3-benzodioxol-5-yl)-1,3,3a,4,6,6a-hexahydrofuro[3,4-c]furan-6-yl]-1,3-benzodioxole 7059611 Click to see 354.40 unknown via CMAUP database
Sesamin 72307 Click to see C1C2C(COC2C3=CC4=C(C=C3)OCO4)C(O1)C5=CC6=C(C=C5)OCO6 354.40 unknown via CMAUP database
> Lignans, neolignans and related compounds / Furanoid lignans / Tetrahydrofuran lignans / 9,9-epoxylignans / Dibenzylbutyrolactols
(2R,3R,4R)-4-(1,3-benzodioxol-5-ylmethyl)-3-[(3,4-dimethoxyphenyl)methyl]oxolan-2-ol 102317093 Click to see 372.40 unknown via CMAUP database
> Lipids and lipid-like molecules / Fatty Acyls / Fatty acyl glycosides / Fatty acyl glycosides of mono- and disaccharides
(2R,3S,4S,5R,6R)-2-(hydroxymethyl)-6-[(E)-3-phenylprop-2-enoxy]oxane-3,4,5-triol 5280656 Click to see C1=CC=C(C=C1)C=CCOC2C(C(C(C(O2)CO)O)O)O 296.31 unknown via CMAUP database
(2S,3R,4S,5S,6R)-2-[(2R,3S,4R,5R,6R)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(E)-3-phenylprop-2-enoxy]oxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol 44521560 Click to see C1=CC=C(C=C1)C=CCOC2C(C(C(C(O2)CO)OC3C(C(C(C(O3)CO)O)O)O)O)O 458.50 unknown via CMAUP database
> Lipids and lipid-like molecules / Fatty Acyls / Fatty amides / N-acyl amines
(2E,4E,8Z)-N-(2-methylpropyl)tetradeca-2,4,8-trienamide 73355665 Click to see 277.40 unknown via CMAUP database
2,4-Hexadecadienamide, N-(2-methylpropyl)-, (E,E)- 6442402 Click to see 307.50 unknown via CMAUP database
2,4,12-Octadecatrienoic acid isobutylamide 25221579 Click to see CCCCCC=CCCCCCCC=CC=CC(=O)NCC(C)C 333.60 unknown via CMAUP database
2,4,14-Eicosatrienoic acid isobutylamide 10338645 Click to see 361.60 unknown via CMAUP database
Dodecatetraenoic acid isobutylamide, (2E,4E)- 6443006 Click to see 251.41 unknown via CMAUP database
Pellitorine 5318516 Click to see 223.35 unknown via CMAUP database
Pipericine 9974234 Click to see CCCCCCCCCCCCCC=CC=CC(=O)NCC(C)C 335.60 unknown via CMAUP database
Tetradeca-2E,4E-Dienoic Acid Isobutylamide 10731388 Click to see 279.50 unknown via CMAUP database
> Lipids and lipid-like molecules / Saccharolipids
Piperchabaoside B 44521607 Click to see 602.60 unknown via CMAUP database
> Lipids and lipid-like molecules / Steroids and steroid derivatives / Stigmastanes and derivatives
(3S,8R,9R,10R,13R,14R,17R)-17-[(2R,5R)-5-ethyl-6-methylheptan-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol 11870456 Click to see CCC(CCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)O)C)C)C(C)C 414.70 unknown via CMAUP database
> Organic acids and derivatives / Carboxylic acids and derivatives / Carboxylic acid derivatives / Carboxylic acid amides / Secondary carboxylic acid amides
(1S,4R,5R,6S)-N-(2-methylpropyl)-6-[(E)-3-(2-methylpropylamino)-3-oxoprop-1-enyl]-4,5-dipentylcyclohex-2-ene-1-carboxamide 53243800 Click to see 446.70 unknown via CMAUP database
> Organoheterocyclic compounds / Benzodioxoles
(1R,2S,5R,6S)-2,6-bis(1,3-benzodioxol-5-yl)-N-(2-methylpropyl)-5-(piperidine-1-carbonyl)cyclohex-3-ene-1-carboxamide 53242461 Click to see 532.60 unknown via CMAUP database
(2E,4E)-5-(1,3-benzodioxol-5-yl)-N-(3-methylbutyl)penta-2,4-dienamide 45482110 Click to see 287.35 unknown via CMAUP database
(2E,4E)-5-(2H-1,3-benzodioxol-5-yl)-N-[(5E)-10-methylundec-5-en-1-yl]penta-2,4-dienamide 90472536 Click to see 383.50 unknown via CMAUP database
[(1R,4S,5S,6R)-4-(1,3-benzodioxol-5-yl)-6-[(E)-2-(1,3-benzodioxol-5-yl)ethenyl]-5-(pyrrolidine-1-carbonyl)cyclohex-2-en-1-yl]-pyrrolidin-1-ylmethanone 102480094 Click to see 542.60 unknown via CMAUP database
[(1S,4R,5R,6S)-4-(1,3-benzodioxol-5-yl)-5-[(E)-2-(1,3-benzodioxol-5-yl)ethenyl]-6-(pyrrolidine-1-carbonyl)cyclohex-2-en-1-yl]-pyrrolidin-1-ylmethanone 102480093 Click to see C1CCN(C1)C(=O)C2C=CC(C(C2C(=O)N3CCCC3)C=CC4=CC5=C(C=C4)OCO5)C6=CC7=C(C=C6)OCO7 542.60 unknown via CMAUP database
13-(1,3-benzodioxol-5-yl)-N-(2-methylpropyl)trideca-2,4,12-trienamide 179663 Click to see CC(C)CNC(=O)C=CC=CCCCCCCC=CC1=CC2=C(C=C1)OCO2 383.50 unknown via CMAUP database
15-(1,3-benzodioxol-5-yl)-N-(2-methylpropyl)pentadeca-2,4,14-trienamide 85102874 Click to see CC(C)CNC(=O)C=CC=CCCCCCCCCC=CC1=CC2=C(C=C1)OCO2 411.60 unknown via CMAUP database
4,5-Dihydropiperlonguminine 12682184 Click to see 275.34 unknown via CMAUP database
5-[(1E)-dodec-1-en-1-yl]-2H-1,3-benzodioxole 9922008 Click to see 288.40 unknown via CMAUP database
5alpha,6beta-Bis(piperidinocarbonyl)-4beta-[(E)-2-(1,3-benzodioxole-5-yl)ethenyl]-3beta-(1,3-benzodioxole-5-yl)cyclohexene 10438004 Click to see C1CCN(CC1)C(=O)C2C=CC(C(C2C(=O)N3CCCCC3)C=CC4=CC5=C(C=C4)OCO5)C6=CC7=C(C=C6)OCO7 570.70 unknown via CMAUP database
Brachystamide B 10047263 Click to see CC(C)CNC(=O)C=CC=CCCCCCCCCC=CC1=CC2=C(C=C1)OCO2 411.60 unknown via CMAUP database
Cinnamamide, N-isobutyl-3,4-(methylenedioxy)- 96931 Click to see 247.29 unknown via CMAUP database
Dehydropipernonaline 6439947 Click to see 339.40 unknown via CMAUP database
Guineesine 6442405 Click to see 383.50 unknown via CMAUP database
Ilepcimide 641115 Click to see C1CCN(CC1)C(=O)C=CC2=CC3=C(C=C2)OCO3 259.30 unknown via CMAUP database
Methyl Piperate 9921021 Click to see COC(=O)C=CC=CC1=CC2=C(C=C1)OCO2 232.23 unknown via CMAUP database
Piperanine 5320618 Click to see C1CCN(CC1)C(=O)C=CCCC2=CC3=C(C=C2)OCO3 287.35 unknown via CMAUP database
Piperchabamide B 44453655 Click to see 369.50 unknown via CMAUP database
Piperchabamide C 44454018 Click to see 395.50 unknown via CMAUP database
Piperchabamide D 16041827 Click to see 357.50 unknown via CMAUP database
Piperchabamide F 44521561 Click to see 343.50 unknown via CMAUP database
Pipercide 5372162 Click to see 355.50 unknown via CMAUP database
Piperlonguminine 5320621 Click to see CC(C)CNC(=O)C=CC=CC1=CC2=C(C=C1)OCO2 273.33 unknown via CMAUP database
Pipernonaline 9974595 Click to see C1CCN(CC1)C(=O)C=CCCCCC=CC2=CC3=C(C=C2)OCO3 341.40 unknown via CMAUP database
Piperoleine B 21580213 Click to see 343.50 unknown via CMAUP database
Piperonal 8438 Click to see 150.13 unknown via CMAUP database
Piperundecalidine 44453654 Click to see 367.50 unknown via CMAUP database
Piperyline 636537 Click to see C1CCN(C1)C(=O)C=CC=CC2=CC3=C(C=C2)OCO3 271.31 unknown via CMAUP database
Retrofractamide A 11012859 Click to see CC(C)CNC(=O)C=CC=CCCC=CC1=CC2=C(C=C1)OCO2 327.40 unknown via CMAUP database
Retrofractamide C 25255091 Click to see 329.40 unknown via CMAUP database
> Organoheterocyclic compounds / Pyridines and derivatives / Hydropyridines
1-(3-phenylpropanoyl)-5,6-dihydropyridin-2(1H)-one 44453778 Click to see C1CN(C(=O)C=C1)C(=O)CCC2=CC=CC=C2 229.27 unknown via CMAUP database
> Phenylpropanoids and polyketides / Cinnamic acids and derivatives
Piperidine, 1-(1-oxo-3-phenyl-2-propenyl)- 223147 Click to see C1CCN(CC1)C(=O)C=CC2=CC=CC=C2 215.29 unknown via CMAUP database
Piperlongumine 637858 Click to see COC1=CC(=CC(=C1OC)OC)C=CC(=O)N2CCC=CC2=O 317.34 unknown via CMAUP database
> Phenylpropanoids and polyketides / Cinnamic acids and derivatives / Hydroxycinnamic acids and derivatives / Coumaric acids and derivatives
Methyl 4-hydroxy-3-methoxy-cinnamate 16830 Click to see 208.21 unknown via CMAUP database
> Phenylpropanoids and polyketides / Stilbenes
(1S,2S,5R,6R)-5,6-bis(1,3-benzodioxol-5-yl)-N-(2-methylpropyl)-2-(piperidine-1-carbonyl)cyclohex-3-ene-1-carboxamide 53242460 Click to see CC(C)CNC(=O)C1C(C=CC(C1C2=CC3=C(C=C2)OCO3)C4=CC5=C(C=C4)OCO5)C(=O)N6CCCCC6 532.60 unknown via CMAUP database

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