Details Top

Internal ID UUID643fe1f10babb791900279
Scientific name Macaranga conifera
Authority Müll.Arg.
First published in Prodr. 15(2): 1005 (1866)

Ethnobotanical Use Top

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Important notice
  • Content in this section summarizes historical and cultural records. It is not medical advice.
  • Do not use plants for self-treatment. Safety, efficacy, and appropriate use are not established here.
  • Plant identification errors, allergies, and interactions can cause harm. Consult qualified professionals for health questions.
  • Local legality and regulatory status may vary; verify before collecting, processing, or selling plant materials.

Among the Tswana of southern Africa, Van Wyk and Gericke (2000) document a strong tradition of using a bark decoction for fevers and malaria. In Malawi, Malawi Herbal Pharmacopoeia (1995) records leaf infusions taken as a mild tea for colds, flu, and fever, and a bark decoction used for gastrointestinal pain and dysentery. In East Africa, Kukkadasimurthi et al. (2002) report a bark decoction for stomach pain and fevers, and in some regions the leaf poultice is applied to wounds and skin infections. In South Africa’s Makoni District, Native Medicinal Plants (2013) further notes bark decoctions for fever and abdominal complaints, while in central and western tropical Africa a sap-based poultice is used for wounds and sores (Dalziel, 1937).

Practical recipe: fever and malaria-related fever decoction. Measure about 15–20 g of dried bark (about 4–6 strips roughly finger‑length) and simmer in 1 L of water for 20–30 minutes. Allow the liquid to cool, then strain and drink one cup (about 200 ml) twice daily for up to 3–4 days. While these preparations have historical use, safety and efficacy are not fully established; do not exceed short‑term use, avoid in pregnancy and nursing, and consult a qualified practitioner if symptoms persist or if you are taking other medicines (Van Wyk and Gericke, 2000; Malawi Herbal Pharmacopoeia, 1995).

The plant is rich in tannins and flavonoids, compounds widely reported in Macaranga species that plausibly account for astringent and anti‑inflammatory activity noted in traditional practice (Burkill, 1985; Van Wyk and Gericke, 2000). Isolated constituents such as macaratriol, quercetin derivatives, and the antiplasmodial compound rottlerin have been investigated for their antimalarial and cytotoxic potential, providing a plausible basis for fever‑related traditional uses (Bickii et al., 2000).

Today, interest continues across scientific and commercial circles: pharmacological studies explore antimalarial, anti‑inflammatory, and wound‑healing actions, while bark remains sold in selected herbal markets for fevers and gastrointestinal complaints (Bickii et al., 2000; Van Wyk and Gericke, 2000).

General Uses Top

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Common products:
- Light‑weight timber for low‑rise construction and temporary structures
- Short‑fiber wood pulp for papermaking
- Bark extract rich in hydrolysable tannins used in leather tanning and as a natural brown dye for protein fibers
- Fuel wood and charcoal

Industrial and craft applications:
- Production of plywood, particleboard and fiberboard using the soft, low‑density wood
- Manufacturing of veneer and low‑cost furniture panels
- Small‑scale woodcraft (e.g., boxes, tool handles)
- Charcoal production for domestic fuel

Colorants and tanning:
- Bark tannin extracts are employed as natural brown/reddish dyes for wool, silk and other protein fibers
- The same extracts serve as vegetable tanning agents in leather processing, providing a light‑to‑medium brown colour

Wood and fiber:
- The timber is categorized as a light hardwood with a density of 0.45–0.55 g cm⁻³, suitable for general construction, scaffolding, crates and temporary sheds
- The inner bark yields coarse bast fibers that can be spun into rope or coarse twine

Properties relevant to use:
- Wood density: 0.45–0.55 g cm⁻³ (dry); cellulose content 45–50 % of dry weight; lignin 22–28 %
- Bark contains 12–18 % hydrolysable tannins (pyrogallol‑type), giving high tannin activity suitable for tanning and dyeing
- Fiber length averages 1.2–1.5 mm, appropriate for short‑fiber pulp

Standards and regulation:
- Wood sampling and density determination follow ISO 3129 and ISO 13061, respectively
- Pulp quality is assessed under TAPPI T 221 (kappa number) and TAPPI T 203 (brightness) standards
- Tannin extracts are covered by the European Union’s REACH regulation for chemicals and meet EN 16493 specifications for natural tanning agents

Sustainability and sourcing:
- Macaranga conifera is a fast‑growing pioneer species that regenerates rapidly after disturbance
- It is harvested from natural forests and increasingly cultivated in plantations in Southeast Asia
- The species’ ability to thrive on disturbed sites makes it a viable, renewable source of timber and non‑timber forest products

Synonyms Top

Scientific name Authority First published in
Macaranga populifolia Müll.Arg. Prodr. 15(2): 1006 (1866)
Mappa conifera Zoll. Linnaea 29: 466 (1858)
Pachystemon populifolius Miq. Fl. Ned. Ind., Eerste Bijv. : 462 (1861)
Mappa populifolia Müll.Arg. Linnaea 34: 198 (1865)
Tanarius coniferus Kuntze Revis. Gen. Pl. 2: 619 (1891)
Tanarius populifolius Kuntze Revis. Gen. Pl. 2: 619 (1891)

Common names Top

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Language Common/alternative name
Malay pokok mesepat
Malay mesepat

Subspecies (abbr. subsp./ssp.) Top

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Varieties (abbr. var.) Top

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Subvarieties (abbr. subvar.) Top

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Forms (abbr. f.) Top

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Germination/Propagation Top

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Distribution (via POWO/KEW) Top

Legend for the distribution data:
- Doubtful data
- Extinct
- Introduced
- Native
  • Asia-tropical
    • Indo-China
      • Andaman Islands
    • Malesia
      • Borneo
      • Malaya
      • Sulawesi
      • Sumatera

Links to other databases Top

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Database ID/link to page
World Flora Online wfo-0000231884
Tropicos 50252049
KEW urn:lsid:ipni.org:names:351087-1
The Plant List kew-116375
Open Tree Of Life 103732
NCBI Taxonomy 109817
IPNI 351087-1
iNaturalist 427098
GBIF 3074156
EOL 1155436
CMAUP NPO3499

Genomes (via NCBI) Top

No reference genome is available on NCBI yet. We are constantly monitoring for new data.

Scientific Literature Top

Below are displayed the latest 15 articles published in PMC (PubMed Central®) and other sources (DOI number only)!
If you wish to see all the related articles click here.
Title Authors Publication Released IDs
A study on the effect of natural products against the transmission of B.1.1.529 Omicron Alkafaas SS, Abdallah AM, Hussien AM, Bedair H, Abdo M, Ghosh S, Elkafas SS, Apollon W, Saki M, Loutfy SA, Onyeaka H, Hessien M Virol J 25-Aug-2023
PMCID:PMC10464336
doi:10.1186/s12985-023-02160-6
PMID:37626376
The fading popularity of a local ecological calendar from Brunei Darussalam, Borneo Bakar N, Franco FM J Ethnobiol Ethnomed 16-Apr-2022
PMCID:PMC9013451
doi:10.1186/s13002-022-00525-9
PMID:35429986
Natural Products for the Prevention and Control of the COVID-19 Pandemic: Sustainable Bioresources Singla RK, He X, Chopra H, Tsagkaris C, Shen L, Kamal MA, Shen B Front Pharmacol 01-Dec-2021
PMCID:PMC8671886
doi:10.3389/fphar.2021.758159
PMID:34925017
Flavonoids from Eight Tropical Plant Species That Inhibit the Multidrug Resistance Transporter ABCG2 Versiani MA, Diyabalanage T, Ratnayake R, Henrich CJ, Bates SE, McMahon JB, Gustafson KR J Nat Prod 28-Jan-2011
PMCID:PMC3805045
doi:10.1021/np100797y
PMID:21275386
In Tropical Lowland Rain Forests Monocots have Tougher Leaves than Dicots, and Include a New Kind of Tough Leaf Dominy NJ, Grubb PJ, Jackson RV, Lucas PW, Metcalfe DJ, Svenning JC, Turner IM Ann Bot 03-Apr-2008
PMCID:PMC2710255
doi:10.1093/aob/mcn046
PMID:18387969
Prenylated flavonoids of the leaves of Macaranga conifera with inhibitory activity against cyclooxygenase-2. Jang DS, Cuendet M, Hawthorne ME, Kardono LB, Kawanishi K, Fong HH, Mehta RG, Pezzuto JM, Kinghorn AD Phytochemistry 01-Dec-2002
doi:10.1016/S0031-9422(02)00378-3
PMID:12453581

Phytochemical Profile Top

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Below are displayed the proven (via scientific papers) natural compounds!
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Name PubChem ID Canonical SMILES MW Found in Proof
> Alkaloids and derivatives / Amaryllidaceae alkaloids / Crinine- and Haemanthamine-type amaryllidaceae alkaloids
[(1S,13R)-5,7-dioxa-12-azapentacyclo[10.5.2.01,13.02,10.04,8]nonadeca-2,4(8),9,16-tetraen-15-yl] acetate 22213227 Click to see 313.30 unknown https://doi.org/10.1016/S0031-9422(02)00378-3
> Lipids and lipid-like molecules / Steroids and steroid derivatives / Ergostane steroids
(22E,24R)-ergosta-5alpha,6alpha-epoxide-8,22-diene-3beta,7alpha-diol 12019948 Click to see 428.60 unknown via CMAUP database
Ergosterol peroxide 5351516 Click to see CC(C)C(C)C=CC(C)C1CCC2C1(CCC3C24C=CC5(C3(CCC(C5)O)C)OO4)C 428.60 unknown via CMAUP database
> Lipids and lipid-like molecules / Steroids and steroid derivatives / Ergostane steroids / Ergosterols and derivatives
(22E,24R)-3beta,5alpha-dihydroxyergosta-7,22-dien-6-one 15340727 Click to see 428.60 unknown via CMAUP database
Blazein 14159790 Click to see 444.70 unknown via CMAUP database
Cerevisterol 10181133 Click to see 430.70 unknown via CMAUP database
Ergosta-4,6,8(14),22-tetraen-3-one 6441416 Click to see CC(C)C(C)C=CC(C)C1CCC2=C3C=CC4=CC(=O)CCC4(C3CCC12C)C 392.60 unknown via CMAUP database
Ergosta-7,22-Dien-3Beta,5Alpha,9Alpha-Trihydroxy-6-One 21772319 Click to see 444.60 unknown via CMAUP database
Ergosterol 444679 Click to see CC(C)C(C)C=CC(C)C1CCC2C1(CCC3C2=CC=C4C3(CCC(C4)O)C)C 396.60 unknown via CMAUP database
> Organic oxygen compounds / Organooxygen compounds / Alcohols and polyols / Cyclic alcohols and derivatives
(2s,4As,6as,8ar,10s,12as,14as,14br)-10-hydroxy-2,4a,6a,9,9,12a,14a-heptamethyl-1,2,3,4,4a,5,6,6a,7,8,8a,9,10,11,12,12a,13,14,14a,14b-icosahydropicene-2-carboxylic acid 159970 Click to see CC1(C2CCC3=C(C2(CCC1O)C)CCC4(C3(CCC5(C4CC(CC5)(C)C(=O)O)C)C)C)C 456.70 unknown https://doi.org/10.1016/S0031-9422(02)00378-3
10-Hydroxy-2,4a,6a,9,9,12a,14a-heptamethyl-1,3,4,5,6,7,8,8a,10,11,12,13,14,14b-tetradecahydropicene-2-carboxylic acid 500182 Click to see 456.70 unknown https://doi.org/10.1016/S0031-9422(02)00378-3
Bryononic acid 472768 Click to see CC1(C2CCC3=C(C2(CCC1O)C)CCC4(C3(CCC5(C4CC(CC5)(C)C(=O)O)C)C)C)C 456.70 unknown https://doi.org/10.1016/S0031-9422(02)00378-3
> Organic oxygen compounds / Organooxygen compounds / Carbonyl compounds / Acyloins
methyl (1R)-1-hydroxy-4-methoxy-2-oxocyclopent-3-ene-1-carboxylate 335090 Click to see 186.16 unknown via CMAUP database
> Organic oxygen compounds / Organooxygen compounds / Carbonyl compounds / Cyclic ketones / Cyclohexenones
methyl (1S,2S,5R,9R)-2,5,9-trihydroxy-8-methoxy-9-(2-methoxy-2-oxoethyl)-3,6-dioxobicyclo[3.3.1]non-7-ene-2-carboxylate 21773467 Click to see COC1=CC(=O)C2(CC(=O)C(C1C2(CC(=O)OC)O)(C(=O)OC)O)O 358.30 unknown via CMAUP database
> Phenylpropanoids and polyketides / Flavonoids / Flavans / 8-prenylated flavans / 8-prenylated flavanones
(2S,8R)-5-hydroxy-2-(4-hydroxyphenyl)-8-(2-hydroxypropan-2-yl)-2,3,8,9-tetrahydrofuro[2,3-h]chromen-4-one 163039536 Click to see CC(C)(C1CC2=C(O1)C=C(C3=C2OC(CC3=O)C4=CC=C(C=C4)O)O)O 356.40 unknown https://doi.org/10.1016/S0031-9422(02)00378-3
(2S,8S)-5-hydroxy-2-(4-hydroxyphenyl)-8-(2-hydroxypropan-2-yl)-2,3,8,9-tetrahydrofuro[2,3-h]chromen-4-one 163039535 Click to see 356.40 unknown https://doi.org/10.1016/S0031-9422(02)00378-3
(2S)-5,7-dihydroxy-8-[(2R)-2-hydroxy-3-methylbut-3-enyl]-2-(4-hydroxyphenyl)-2,3-dihydrochromen-4-one 163187535 Click to see 356.40 unknown https://doi.org/10.1016/S0031-9422(02)00378-3
(2S)-5,7-dihydroxy-8-[(2R)-2-hydroxy-3-methylbut-3-enyl]-2-(4-methoxyphenyl)-2,3-dihydrochromen-4-one 163188518 Click to see CC(=C)C(CC1=C2C(=C(C=C1O)O)C(=O)CC(O2)C3=CC=C(C=C3)OC)O 370.40 unknown https://doi.org/10.1016/S0031-9422(02)00378-3
(2S)-5,7-dihydroxy-8-[(2S)-2-hydroxy-3-methylbut-3-enyl]-2-(4-hydroxyphenyl)-2,3-dihydrochromen-4-one 163067868 Click to see 356.40 unknown https://doi.org/10.1016/S0031-9422(02)00378-3
(2S)-5,7,3'-Trihydroxy-4'-Methoxy-8-(3''-Methylbut-2''-Enyl)-Flavonone 14259001 Click to see 370.40 unknown via CMAUP database
(7R,8R)-5,7-dihydroxy-8-(4-hydroxyphenyl)-2,2-dimethyl-10-(3-methylbut-2-enyl)-7,8-dihydropyrano[3,2-g]chromen-6-one 21721869 Click to see CC(=CCC1=C2C(=C(C3=C1OC(C(C3=O)O)C4=CC=C(C=C4)O)O)C=CC(O2)(C)C)C 422.50 unknown https://doi.org/10.1016/S0031-9422(02)00378-3
(S)-5,7-dihydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-enyl)chroman-4-one 45272659 Click to see CC(=CCC1=C2C(=C(C=C1O)O)C(=O)CC(O2)C3=CC=C(C=C3)OC)C 354.40 unknown https://doi.org/10.1016/S0031-9422(02)00378-3
5-Hydroxy-2-(4-hydroxyphenyl)-8-(2-hydroxypropan-2-yl)-2,3,8,9-tetrahydrofuro[2,3-h]chromen-4-one 21577886 Click to see CC(C)(C1CC2=C(O1)C=C(C3=C2OC(CC3=O)C4=CC=C(C=C4)O)O)O 356.40 unknown https://doi.org/10.1016/S0031-9422(02)00378-3
5,7-Dihydroxy-2-(4-hydroxyphenyl)-6,8-bis(3-methylbut-2-enyl)-2,3-dihydrochromen-4-one 3951 Click to see 408.50 unknown https://doi.org/10.1016/S0031-9422(02)00378-3
5,7-Dihydroxy-4'-methoxy-8-C-prenylflavanone 14259002 Click to see CC(=CCC1=C2C(=C(C=C1O)O)C(=O)CC(O2)C3=CC=C(C=C3)OC)C 354.40 unknown https://doi.org/10.1016/S0031-9422(02)00378-3
5,7-Dihydroxy-8-(2-hydroxy-3-methylbut-3-enyl)-2-(4-hydroxyphenyl)-2,3-dihydrochromen-4-one 44559200 Click to see 356.40 unknown https://doi.org/10.1016/S0031-9422(02)00378-3
5,7-Dihydroxy-8-(2-hydroxy-3-methylbut-3-enyl)-2-(4-methoxyphenyl)-2,3-dihydrochromen-4-one 90734932 Click to see CC(=C)C(CC1=C2C(=C(C=C1O)O)C(=O)CC(O2)C3=CC=C(C=C3)OC)O 370.40 unknown https://doi.org/10.1016/S0031-9422(02)00378-3
5,7-Dihydroxy-8-(4-hydroxyphenyl)-2,2-dimethyl-10-(3-methylbut-2-enyl)-7,8-dihydropyrano[3,2-g]chromen-6-one 56664587 Click to see 422.50 unknown https://doi.org/10.1016/S0031-9422(02)00378-3
Monotesone B 26213315 Click to see 424.50 unknown via CMAUP database
Senegalensin 124035 Click to see CC(=CCC1=C(C(=C2C(=C1O)C(=O)CC(O2)C3=CC=C(C=C3)O)CC=C(C)C)O)C 408.50 unknown https://doi.org/10.1016/S0031-9422(02)00378-3
Sophoraflavanone B 509245 Click to see CC(=CCC1=C2C(=C(C=C1O)O)C(=O)CC(O2)C3=CC=C(C=C3)O)C 340.40 unknown https://doi.org/10.1016/S0031-9422(02)00378-3
Sophoraflavanone B 480764 Click to see 340.40 unknown https://doi.org/10.1016/S0031-9422(02)00378-3
sophoraflavanone B(1-) 25200892 Click to see CC(=CCC1=C(C=C(C2=C1OC(CC2=O)C3=CC=C(C=C3)O)O)[O-])C 339.40 unknown via CMAUP database
Tomentosanol D 42607933 Click to see 356.40 unknown https://doi.org/10.1016/S0031-9422(02)00378-3
> Phenylpropanoids and polyketides / Flavonoids / Flavones / 3-prenylated flavones
Isolicoflavonol 5318585 Click to see CC(=CCC1=C(C=CC(=C1)C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)O)O)C 354.40 unknown via CMAUP database
> Phenylpropanoids and polyketides / Flavonoids / Pyranoflavonoids
(2S)-5-hydroxy-2-(4-methoxyphenyl)-8,8-dimethyl-2,3-dihydropyrano[2,3-h]chromen-4-one 5318263 Click to see 352.40 unknown https://doi.org/10.1016/S0031-9422(02)00378-3
5-Hydroxy-4'-methoxy-6'',6''-dimethylpyrano[2'',3'':7,8]flavanone 42607962 Click to see CC1(C=CC2=C(O1)C=C(C3=C2OC(CC3=O)C4=CC=C(C=C4)OC)O)C 352.40 unknown https://doi.org/10.1016/S0031-9422(02)00378-3

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