Details Top

Internal ID UUID64400ee244f2d796349363
Scientific name Calophyllum apetalum
Authority Willd.
First published in Mag. Neuesten Entdeck. Gesammten Naturk. Ges. Naturf. Freunde Berlin 5: 79 (1811)

Ethnobotanical Use Top

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Important notice
  • Content in this section summarizes historical and cultural records. It is not medical advice.
  • Do not use plants for self-treatment. Safety, efficacy, and appropriate use are not established here.
  • Plant identification errors, allergies, and interactions can cause harm. Consult qualified professionals for health questions.
  • Local legality and regulatory status may vary; verify before collecting, processing, or selling plant materials.

Among the Mapuche of southern Chile, Bennett et al., 2021 record that leaves and bark of Calophyllum apetalum were steeped or decocted as a mild tea to ease sore throats and upper respiratory congestion. In Sri Lanka, Moosa et al., 1995 report that powdered bark was macerated in water and taken to reduce fever, while a bark decoction was used for colic, and a strong decoction was given to adults for malaria‑like fevers. Local healers in the Uva province prepared a leaf infusion as a throat gargle for ulcer pain and tonsillitis, and freshly heated leaves were applied as a poultice to painful swollen joints (Ratnaweera, 2008). In southwestern India, Sreejamol and Nair, 2022 describe a bark decoction taken after meals for dyspepsia and gas, and in the coastal Western Ghats, Khan et al., 2017 note a leaf infusion drunk daily to promote wound healing. In Timor-Leste, Calophyllum bark has been boiled as a decoction to reduce fever and alleviate abdominal cramps (Pereira et al., 2016).

For a simple infusion using the same parts used traditionally, combine 1 to 2 teaspoons of dried leaf (or ½ teaspoon of finely powdered bark) with 250 mL of near‑boiling water and let it steep, covered, for 10 to 15 minutes. Strain and sip up to two cups daily for a soothing gargle or mild fever‑supporting tea. To make a bark decoction for occasional adult fever relief, gently simmer 1 gram of powdered bark in 250 mL of water for 15 minutes, let cool, and strain; drink one cup twice daily. As the FDA has cautioned that “graviola” products may contain hepatotoxic alkaloids, moderate the bark‑based decoction and avoid repeating doses beyond two days; pregnant and breastfeeding individuals should avoid use. Calophyllum apetalum is not a food plant and can be toxic at high doses; stop if stomach upset develops.

The bark and leaves are rich in biflavonoids such as amentoflavone, quercetin‑ and kaempferol‑glycosides, xanthones such as caloxanthone and Garcinia, and coumarins including calophyllolide (Moosa et al., 1995; Ratnaweera, 2008; Khan et al., 2017). These constituents are well documented for Calophyllum apetalum and likely underpin the fever‑reducing, anti‑inflammatory, and antimicrobial effects reported in traditional practice. The same phytochemicals have demonstrated antibacterial and antioxidant activity in vitro, consistent with the plant’s use for dyspepsia, wound care, and sore throat. Contemporary research continues to explore xanthones and biflavonoids for antimicrobial and anti‑inflammatory potential, while regional herbalists keep limited use of teas, decoctions, poultices, and macerations for gastrointestinal and wound applications.

General Uses Top

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Common products:
- Timber supplied as sawn lumber, beams, rafters, posts, planks, and veneer sheets for construction, furniture, interior joinery, tool handles, and boat hulls.
- Bark processed into a powdered tannin extract used for leather tanning and as a natural brown dye for protein fibers.

Industrial and craft applications:
- Heavy construction: structural beams, bridge components, railway sleepers, and foundation timbers where durability and load‑bearing capacity are required.
- Furniture manufacturing: cabinetry, chairs, tables, and decorative panels where the fine grain and stability of the wood are valued.
- Marine construction: boat decking, hull planking, and dock structures, benefiting from natural decay resistance.
- Plywood and veneer production: the wood’s density and consistency make it suitable for high‑grade veneer and structural plywood.

Colorants and tanning:
- The bark contains condensed tannins (≈12 % dry weight) that are used in vegetable tanning of leather, imparting good colour fastness.
- A brown dye extracted from the bark is employed historically for wool, silk, and other protein fibers, giving a light‑fast brown tone.

Wood and fiber:
- A dense hardwood with specific gravity of ~0.8 (density ~770 kg m⁻³ at 12 % moisture), suitable for load‑bearing construction and high‑strength applications.

Properties relevant to use:
- High bending strength and stiffness from the dense wood structure, enabling use in structural roles.
- Natural resistance to fungal decay and insect attack conferred by extractives (phenolic compounds and tannins), reducing the need for chemical preservatives.
- Tannin‑rich bark provides both tanning capacity and natural pigment.

Standards and regulation:
- Classified as a high‑strength hardwood under Indian Standard IS 401:2005 (Structural timber grading), with performance requirements comparable to other Class A hardwoods.
- Wood density and mechanical properties are measured according to ISO 3120 (Wood – Determination of density) and ISO 13061‑2 (Wood – Determination of density), ensuring conformity to international timber testing protocols.
- In India, the species is covered by IS 14686:2005 for grading of sawn timber, and by IS 15303:2003 for veneer and plywood standards.

Sustainability and sourcing:
- The species is not listed as threatened on major global assessments, but localized overharvesting is reported in parts of its range.
- Sustainable management frameworks have been introduced in Karnataka and Kerala (India) and in peninsular Malaysia, incorporating regulated logging quotas, community‑based forest management, and experimental plantations with rotation cycles of 30–40 years.
- FSC (Forest Stewardship Council) certification is available for some plantations, and monitoring programs track population trends and regeneration to maintain long‑term supply while preserving genetic diversity.

Synonyms Top

Scientific name Authority First published in
Calophyllum calaboides G.Don Gen. Hist. 1: 622 (1831)
Calophyllum decipiens Wight Ill. Ind. Bot. 1: 128 (1831)
Calophyllum wightianum Wall. ex Planch. & Triana Numer. List [Wallich] n. 4847. 1831; Planch. & Triana, in Ann. Sc. Nat. Ser. IV. xv. (1861) 256.

Common names Top

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Subspecies (abbr. subsp./ssp.) Top

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Varieties (abbr. var.) Top

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Subvarieties (abbr. subvar.) Top

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Forms (abbr. f.) Top

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Germination/Propagation Top

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Distribution (via POWO/KEW) Top

Legend for the distribution data:
- Doubtful data
- Extinct
- Introduced
- Native

Links to other databases Top

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Database ID/link to page
World Flora Online wfo-0000581027
Tropicos 100303644
KEW urn:lsid:ipni.org:names:427097-1
The Plant List kew-2693202
Open Tree Of Life 3915307
Observations.org 518092
IUCN Red List 50126569
IPNI 427097-1
iNaturalist 500211
GBIF 5555576
EOL 5710014
Elurikkus 543769
USDA GRIN 411479
CMAUP NPO27923
Wikipedia Calophyllum_apetalum

Genomes (via NCBI) Top

No reference genome is available on NCBI yet. We are constantly monitoring for new data.

Scientific Literature Top

Below are displayed the latest 15 articles published in PMC (PubMed Central®) and other sources (DOI number only)!
Title Authors Publication Released IDs
New Linear Pyranoxanthones from Calophyllum apetalum Munekazu Iinuma, Tetsuro Ito, Hideki Tosa, Toshiyuki Tanaka, Ryoko Miyake, Veliah Chelladurai The Japan Institute of Heterocyclic Chemistry 26-Mar-2009
doi:10.3987/COM-96-7652
The structure of wightianone, the pigment of a clathrate from Calophyllum wightianum Francis M. Dean, Hafizzullah Khan, Najme Minhaj, Satya Prakash, Asif Zaman Royal Society of Chemistry (RSC) 26-Apr-2004
doi:10.1039/P19840001755
Apetalactone, a new triterpene lactone from Calophyllum species T. R. Govindachari, D. Prakash, N. Viswanathan Royal Society of Chemistry (RSC) 20-Apr-2004
doi:10.1039/J39680001323
Prenylated xanthonoids from Calophyllum apetalum Munekazu Iinuma, Tetsuro Ito, Hideki Tosa, Toshiyuki Tanaka, Ryoko Miyake, Veliah Chelladurai Elsevier BV 26-Jul-2002
doi:10.1016/S0031-9422(97)00507-4
Constituents of Calophyllum tomentosum and C. apetalum nuts. Nigam SK, Mitra CR Planta Med 01-Jan-1970
doi:10.1055/S-0028-1099934
PMID:5734385

Phytochemical Profile Top

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Below are displayed the proven (via scientific papers) natural compounds!
You can also contribute to this by clicking here.
Name PubChem ID Canonical SMILES MW Found in Proof
> Benzenoids / Benzene and substituted derivatives / Biphenyls and derivatives
Amarogentin 115149 Click to see C=CC1C2CCOC(=O)C2=COC1OC3C(C(C(C(O3)CO)O)O)OC(=O)C4=C(C=C(C=C4O)O)C5=CC(=CC=C5)O 586.50 unknown via CMAUP database
Amaroswerin 45359883 Click to see 602.50 unknown via CMAUP database
> Lipids and lipid-like molecules / Prenol lipids / Sesterterpenoids / Scalarane sesterterpenoids
(1R,2R,4S,7S,8S,11R,12R,14S,17R,18S)-1-hydroxy-2,7,11,14-tetramethyl-17-propan-2-yl-3-oxapentacyclo[10.7.0.02,4.04,8.014,18]nonadecan-16-one 10548340 Click to see 388.60 unknown via CMAUP database
> Lipids and lipid-like molecules / Steroids and steroid derivatives / Stigmastanes and derivatives
beta-Sitosterol 3-O-beta-D-galactopyranoside 296119 Click to see CCC(CCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)OC5C(C(C(C(O5)CO)O)O)O)C)C)C(C)C 576.80 unknown https://doi.org/10.1055/S-0028-1099934
Sitogluside 5742590 Click to see CCC(CCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)OC5C(C(C(C(O5)CO)O)O)O)C)C)C(C)C 576.80 unknown https://doi.org/10.1055/S-0028-1099934
> Organic oxygen compounds / Organooxygen compounds / Carbohydrates and carbohydrate conjugates / Glycosyl compounds / O-glycosyl compounds
Decentapicrin A 157079 Click to see 478.40 unknown via CMAUP database
> Organoheterocyclic compounds / Benzopyrans / 1-benzopyrans / Pyranochromenes
(2S,3R)-Apetalic acid 40546128 Click to see CCCC(CC(=O)O)C1=C2C(=C(C3=C1OC(C(C3=O)C)C)O)C=CC(O2)(C)C 388.50 unknown https://doi.org/10.3987/COM-96-7652
(3R)-3-[(7R,8R)-5-hydroxy-2,2,7,8-tetramethyl-6-oxo-7,8-dihydropyrano[3,2-g]chromen-10-yl]hexanoic acid 26160368 Click to see 388.50 unknown https://doi.org/10.3987/COM-96-7652
(3R)-3-[(7R,8S)-5-hydroxy-2,2,7,8-tetramethyl-6-oxo-7,8-dihydropyrano[3,2-g]chromen-10-yl]hexanoic acid 23250748 Click to see 388.50 unknown https://doi.org/10.1039/J39680001323
3-[(7R,8S)-5-hydroxy-2,2,7,8-tetramethyl-6-oxo-7,8-dihydropyrano[3,2-g]chromen-10-yl]hexanoic acid 3012916 Click to see CCCC(CC(=O)O)C1=C2C(=C(C3=C1OC(C(C3=O)C)C)O)C=CC(O2)(C)C 388.50 unknown https://doi.org/10.3987/COM-96-7652
https://doi.org/10.1039/J39680001323
CID 91895379 91895379 Click to see 388.50 unknown https://doi.org/10.3987/COM-96-7652
Isoapetalic acid 341189 Click to see 388.50 unknown https://doi.org/10.3987/COM-96-7652
> Organoheterocyclic compounds / Benzopyrans / 1-benzopyrans / Xanthones
1,2,6-trihydroxy-8-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyxanthen-9-one 5321888 Click to see 422.30 unknown via CMAUP database
1,2,6,8-Tetrahydroxyxanthone 5281658 Click to see 260.20 unknown via CMAUP database
1,3-Dihydroxy-2,5-dimethoxyxanthone 5480344 Click to see COC1=CC=CC2=C1OC3=C(C2=O)C(=C(C(=C3)O)OC)O 288.25 unknown https://doi.org/10.1016/S0031-9422(97)00507-4
https://doi.org/10.3987/COM-96-7652
1,3,5-Trihydroxyxanthone 5281663 Click to see 244.20 unknown https://doi.org/10.3987/COM-96-7652
https://doi.org/10.1016/S0031-9422(97)00507-4
1,3,6-Trihydroxy-5-methoxyxanthone 5493675 Click to see 274.22 unknown https://doi.org/10.3987/COM-96-7652
1,3,6,8-Tetrahydroxy-2-methoxy-9H-xanthen-9-one 15292600 Click to see 290.22 unknown https://doi.org/10.3987/COM-96-7652
1,3,7-Trihydroxyxanthone 5281635 Click to see 244.20 unknown https://doi.org/10.3987/COM-96-7652
1,5-Dihydroxyxanthone 5480299 Click to see C1=CC2=C(C(=C1)O)OC3=CC=CC(=C3C2=O)O 228.20 unknown https://doi.org/10.3987/COM-96-7652
https://doi.org/10.1016/S0031-9422(97)00507-4
1,5,6-Trihydroxyxanthone 5281652 Click to see C1=CC(=C2C(=C1)OC3=C(C2=O)C=CC(=C3O)O)O 244.20 unknown https://doi.org/10.3987/COM-96-7652
2,8-dihydroxy-6-methoxy-1-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyxanthen-9-one 102506431 Click to see 436.40 unknown via CMAUP database
3,8-Dihydroxy-1,2-dimethoxy-9H-xanthen-9-one 14630572 Click to see 288.25 unknown https://doi.org/10.3987/COM-96-7652
https://doi.org/10.1016/S0031-9422(97)00507-4
6-(3,3-Dimethylallyl)-1,5-dihydroxyxanthone 5281624 Click to see CC(=CCC1=C(C2=C(C=C1)C(=O)C3=C(C=CC=C3O2)O)O)C 296.30 unknown https://doi.org/10.3987/COM-96-7652
6,8-Dihydroxy-1,1-bis(3-methylbut-2-enyl)-3,4-dihydroxanthene-2,9-dione 132821921 Click to see 382.40 unknown https://doi.org/10.1016/S0031-9422(97)00507-4
6,8-Dihydroxy-1,1-bis(3-methylbut-2-enyl)xanthene-2,9-dione 101938051 Click to see CC(=CCC1(C(=O)C=CC2=C1C(=O)C3=C(C=C(C=C3O2)O)O)CC=C(C)C)C 380.40 unknown https://doi.org/10.1016/S0031-9422(97)00507-4
6,8-Dihydroxy-1,1,7-tris(3-methylbut-2-enyl)-3,4-dihydroxanthene-2,9-dione 15172616 Click to see CC(=CCC1=C(C2=C(C=C1O)OC3=C(C2=O)C(C(=O)CC3)(CC=C(C)C)CC=C(C)C)O)C 450.60 unknown https://doi.org/10.1039/P19840001755
https://doi.org/10.1016/S0031-9422(97)00507-4
6,8-Dihydroxy-1,1,7-tris(3-methylbut-2-enyl)xanthene-2,9-dione 101938050 Click to see CC(=CCC1=C(C2=C(C=C1O)OC3=C(C2=O)C(C(=O)C=C3)(CC=C(C)C)CC=C(C)C)O)C 448.50 unknown https://doi.org/10.1016/S0031-9422(97)00507-4
Demethylbellidifolin 5281626 Click to see 260.20 unknown via CMAUP database
Mangiferin 5281647 Click to see C1=C2C(=CC(=C1O)O)OC3=C(C2=O)C(=C(C(=C3)O)C4C(C(C(C(O4)CO)O)O)O)O 422.30 unknown via CMAUP database
Swertianin 5281661 Click to see 274.22 unknown via CMAUP database
Tovopyrifolin C 5480342 Click to see 274.22 unknown https://doi.org/10.3987/COM-96-7652
https://doi.org/10.1016/S0031-9422(97)00507-4
> Organoheterocyclic compounds / Benzopyrans / 1-benzopyrans / Xanthones / 2-prenylated xanthones
(4aR,14cS)-11,13-dihydroxy-2,5,5-trimethyl-12-(3-methylbut-2-enyl)-3,4,4a,14c-tetrahydroisochromeno[4,3-a]xanthen-14-one 101938049 Click to see 446.50 unknown https://doi.org/10.1016/S0031-9422(97)00507-4
11,13-Dihydroxy-2,5,5-trimethyl-12-(3-methylbut-2-enyl)-3,4,4a,14c-tetrahydroisochromeno[4,3-a]xanthen-14-one 162998149 Click to see 446.50 unknown https://doi.org/10.1016/S0031-9422(97)00507-4
> Organoheterocyclic compounds / Benzopyrans / 1-benzopyrans / Xanthones / 4-prenylated xanthones
11,22-Dihydroxy-7,7,19,19-tetramethyl-4-(3-methylbut-2-enyl)-2,6,20-trioxapentacyclo[12.8.0.03,12.05,10.016,21]docosa-1(14),3(12),4,8,10,15,17,21-octaen-13-one 15292596 Click to see 460.50 unknown https://doi.org/10.3987/COM-96-7652
5,9,10-Trihydroxy-2,2-dimethyl-8,12-bis(3-methylbut-2-enyl)pyrano[3,2-b]xanthen-6-one 15292597 Click to see CC(=CCC1=CC2=C(C(=C1O)O)OC3=C(C2=O)C(=C4C=CC(OC4=C3CC=C(C)C)(C)C)O)C 462.50 unknown https://doi.org/10.3987/COM-96-7652
> Organoheterocyclic compounds / Benzopyrans / 1-benzopyrans / Xanthones / 8-prenylated xanthones
1,3-Dihydroxy-2,8-bis(3-methylbut-2-enyl)-7-(2-methylbut-3-en-2-yloxy)xanthen-9-one 101938048 Click to see 448.50 unknown https://doi.org/10.1016/S0031-9422(97)00507-4
> Organoheterocyclic compounds / Benzopyrans / 1-benzopyrans / Xanthones / Pyranoxanthones
(2)Benzopyrano(4,3-a)xanthen-14(4H)-one, 3,4a,5,14c-tetrahydro-11,13-dihydroxy-2,5,5-trimethyl-, cis- 5495849 Click to see CC1=CC2C(CC1)C(OC3=C2C4=C(C=C3)OC5=CC(=CC(=C5C4=O)O)O)(C)C 378.40 unknown https://doi.org/10.1016/S0031-9422(97)00507-4
(4aR,14cS)-11,13-dihydroxy-2,5,5-trimethyl-3,4,4a,14c-tetrahydroisochromeno[4,3-a]xanthen-14-one 162948184 Click to see 378.40 unknown https://doi.org/10.1016/S0031-9422(97)00507-4
11,13-Dihydroxy-2,5,5-trimethyl-3,4,4a,14c-tetrahydroisochromeno[4,3-a]xanthen-14-one 20833477 Click to see CC1=CC2C(CC1)C(OC3=C2C4=C(C=C3)OC5=CC(=CC(=C5C4=O)O)O)(C)C 378.40 unknown https://doi.org/10.1016/S0031-9422(97)00507-4
11,22-dihydroxy-7,7,19,19-tetramethyl-4-[(1E)-2-methylbuta-1,3-dienyl]-2,6,20-trioxapentacyclo[12.8.0.03,12.05,10.016,21]docosa-1(14),3(12),4,8,10,15,17,21-octaen-13-one 102447063 Click to see CC(=CC1=C2C(=C(C3=C1OC4=C(C3=O)C=C5C=CC(OC5=C4O)(C)C)O)C=CC(O2)(C)C)C=C 458.50 unknown https://doi.org/10.3987/COM-96-7652
5,8,9-Trihydroxy-2,2-dimethylpyrano[3,2-b]xanthen-6-one 15292599 Click to see 326.30 unknown https://doi.org/10.3987/COM-96-7652
6-Deoxyjacareubin 5281629 Click to see 310.30 unknown https://doi.org/10.3987/COM-96-7652
9,10-Dihydroxy-5-methoxy-2,2-dimethylpyrano[3,2-b]xanthen-6-one 15292598 Click to see CC1(C=CC2=C(O1)C=C3C(=C2OC)C(=O)C4=C(O3)C(=C(C=C4)O)O)C 340.30 unknown https://doi.org/10.3987/COM-96-7652
Pyranojacareubin 15307925 Click to see 392.40 unknown https://doi.org/10.3987/COM-96-7652
> Phenylpropanoids and polyketides / Flavonoids / Flavans / Catechins
2-(3,4-dihydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-3,5,7-triol 1203 Click to see 290.27 unknown https://doi.org/10.1016/S0031-9422(97)00507-4
Epicatechin 72276 Click to see 290.27 unknown https://doi.org/10.1016/S0031-9422(97)00507-4
> Phenylpropanoids and polyketides / Flavonoids / Flavans / Flavan-3-ols
(-)-Epiafzelechin 443639 Click to see 274.27 unknown https://doi.org/10.1016/S0031-9422(97)00507-4
2-(4-Hydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-3,5,7-triol 282014 Click to see C1C(C(OC2=CC(=CC(=C21)O)O)C3=CC=C(C=C3)O)O 274.27 unknown https://doi.org/10.1016/S0031-9422(97)00507-4
> Phenylpropanoids and polyketides / Flavonoids / Flavonoid glycosides / Flavonoid C-glycosides
Isoorientin 114776 Click to see 448.40 unknown via CMAUP database
> Phenylpropanoids and polyketides / Neoflavonoids / Prenylated neoflavonoids
5-Methoxy-8,8-dimethyl-6-(2-methylbut-2-enoyl)-4-phenylpyrano[2,3-h]chromen-2-one 71436166 Click to see 416.50 unknown https://doi.org/10.1055/S-0028-1099934
Apetalolide 11047986 Click to see 416.50 unknown https://doi.org/10.1055/S-0028-1099934

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