Goniothalamus griffithii is a species of plant in the family Annonaceae native to Myanmar and Thailand. It was named in honor of British botanist William Griffith by Joseph Dalton Hooker and Thomas Thomson. It has rough, dark gray branches and oblong, hairless, leathery leaves. Its petioles and peduncles are 1.3 centimeters long and its sepals are 1.8 centimeters long and united at their base. Its flowers have 6 petals in two rows of 3, with smooth, linear-oblong outer petals and inner petals that are joined at their margins. Its stamen have a fleshy tip that extends above the anthers and its gynoecium have ovaries that are covered in short rigid hairs and styles with fluted ends. Pollen is shed as permanent tetrads and bioactive molecules isolated from its roots have been reported to have cytotoxic activity in tests with cultured human cancer cells.

Synonyms Top

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Language	Common/alternative name
Chinese	大花哥纳香

Subspecies (abbr. subsp./ssp.) Top

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Varieties (abbr. var.) Top

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Subvarieties (abbr. subvar.) Top

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Forms (abbr. f.) Top

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Germination/Propagation Top

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Distribution (via POWO/KEW) Top

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Legend for the distribution data:

- Doubtful data

- Extinct

- Introduced

- Native

Asia-tropical click to expand
- Indo-China
  - Andaman Islands
  - Myanmar
  - Thailand

Links to other databases Top

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Database	ID/link to page
World Flora Online	wfo-0000706491
Tropicos	1602800
KEW	urn:lsid:ipni.org:names:73199-1
The Plant List	kew-2829684
Open Tree Of Life	134100
NCBI Taxonomy	296850
IPNI	73199-1
GBIF	3154519
EOL	1054090
Wikipedia	Goniothalamus_griffithii

Genomes (via NCBI) Top

No reference genome is available on NCBI yet. We are constantly monitoring for new data.

Scientific Literature Top

Below are displayed the latest 15 articles published in PMC (PubMed Central®) and other sources (DOI number only)!
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Title

Authors

Publication

Released

IDs

Hydroxypropyl-β-Cyclodextrin Complexes of Styryllactones Enhance the Anti-Tumor Effect in SW1116 Cell Line

Ma R, Chen JT, Ji XY, Xu XL, Mu Q

Front Pharmacol

22-Apr-2020

PMCID:	PMC7188779
doi:	10.3389/fphar.2020.00484
PMID:	32390840

Photoelectrocyclization Reactions of Amidonaphthoquinones

Yin J, Landward MB, Rainier JD

J Org Chem

05-Mar-2020

PMCID:	PMC7164668
doi:	10.1021/acs.joc.9b03417
PMID:	32072812

Goniothalamin Induces Necroptosis and Anoikis in Human Invasive Breast Cancer MDA-MB-231 Cells

Khaw-on P, Pompimon W, Banjerdpongchai R

Int J Mol Sci

14-Aug-2019

PMCID:	PMC6720804
doi:	10.3390/ijms20163953
PMID:	31416203

Apoptosis Induction via ATM Phosphorylation, Cell Cycle Arrest, and ER Stress by Goniothalamin and Chemodrugs Combined Effects on Breast Cancer-Derived MDA-MB-231 Cells

Khaw-on P, Pompimon W, Banjerdpongchai R

Biomed Res Int

26-Nov-2018

PMCID:	PMC6287143
doi:	10.1155/2018/7049053
PMID:	30598998

Molecular and morphological data supporting phylogenetic reconstruction of the genus Goniothalamus (Annonaceae), including a reassessment of previous infrageneric classifications

Tang CC, Thomas DC, Saunders RM

Data Brief

09-Jul-2015

PMCID:	PMC4532731
doi:	10.1016/j.dib.2015.06.021
PMID:	26286044

The cytotoxicity of naturally occurring styryl lactones.

Tian Z, Chen S, Zhang Y, Huang M, Shi L, Huang F, Fong C, Yang M, Xiao P

Phytomedicine

01-Feb-2006

doi:	10.1016/J.PHYMED.2004.07.010
PMID:	16428026

Constituents from the stems of Goniothalamus griffithii.

Mu Q, Tang WD, Liu RY, Li CM, Lou LG, Sun HD, Hu CQ

Planta Med

01-Sep-2003

doi:	10.1055/S-2003-43219
PMID:	14598208

Alkaloids from the roots of goniothalamus griffithii.

Zhang YJ, Kong M, Chen RY, Yu DQ

J Nat Prod

01-Jul-1999

doi:	10.1021/NP990004L
PMID:	10425141

Styryllactones from the rhizomes of Goniothalamus griffithii.

Zhang YJ, Zhou GX, Chen RY, Yu DQ

J Asian Nat Prod Res

01-Jan-1999

doi:	10.1080/10286029908039864
PMID:	11254031

Phytochemical Profile Top

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Below are displayed the proven (via scientific papers) natural compounds!
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Name	PubChem ID	Canonical SMILES	MW	Found in	Proof
> Alkaloids and derivatives / Aporphines / 4,5-dioxoaporphines
15,16-Dimethoxy-8-methyl-10-azatetracyclo[7.7.1.02,7.013,17]heptadeca-1(17),2,4,6,8,13,15-heptaene-11,12-dione	10495999	Click to see CC1=C2C3=C(C4=CC=CC=C14)C(=C(C=C3C(=O)C(=O)N2)OC)OC	321.30	unknown	https://doi.org/10.1055/S-2003-43219 https://doi.org/10.1021/NP990004L
> Alkaloids and derivatives / Aristolactams
6,14,15-Trimethoxy-10-azatetracyclo[7.6.1.02,7.012,16]hexadeca-1,3,5,7,9(16),12,14-heptaen-11-one	10859838	Click to see COC1=CC=CC2=C3C4=C(C=C21)NC(=O)C4=CC(=C3OC)OC	309.30	unknown	https://doi.org/10.1021/NP990004L
Aristolactam AII	148657	Click to see COC1=C(C=C2C3=C1C4=CC=CC=C4C=C3NC2=O)O	265.26	unknown	https://doi.org/10.1021/NP990004L
Aristolactam BII	162739	Click to see COC1=C(C2=C3C(=C1)C(=O)NC3=CC4=CC=CC=C42)OC	279.29	unknown	https://doi.org/10.1021/NP990004L
Griffithinam	5317823	Click to see COC1=CC=CC2=C3C4=C(C=C21)NC(=O)C4=CC(=C3O)OC	295.29	unknown	https://doi.org/10.1021/NP990004L https://doi.org/10.1055/S-2003-43219
Velutinam	9994639	Click to see COC1=C(C2=C3C=CC=C(C3=CC4=C2C(=C1)C(=O)N4)O)OC	295.29	unknown	https://doi.org/10.1021/NP990004L
> Benzenoids / Benzene and substituted derivatives / Styrenes
Goniothalamin	6440856	Click to see C1C=CC(=O)OC1C=CC2=CC=CC=C2	200.23	unknown	https://doi.org/10.1080/10286029908039864 https://doi.org/10.1055/S-2003-43219 https://doi.org/10.1016/J.PHYMED.2004.07.010
> Organic oxygen compounds / Organooxygen compounds / Carbohydrates and carbohydrate conjugates / Glycosyl compounds / C-glycosyl compounds
8,9-Dihydroxy-7-phenyl-2,6-dioxabicyclo[3.3.1]nonan-3-one	14777899	Click to see C1C2C(C(C(C(O2)C3=CC=CC=C3)O)OC1=O)O	250.25	unknown	https://doi.org/10.1080/10286029908039864
Goniopypyrone	164274	Click to see C1C2C(C(C(C(O2)C3=CC=CC=C3)O)OC1=O)O	250.25	unknown	https://doi.org/10.1080/10286029908039864
> Organoheterocyclic compounds / Benzopyrans / 1-benzopyrans / Xanthones
Euxanthone	5281631	Click to see C1=CC(=C2C(=C1)OC3=C(C2=O)C=C(C=C3)O)O	228.20	unknown	https://doi.org/10.1055/S-2003-43219
> Organoheterocyclic compounds / Furofurans
3-hydroxy-2-[hydroxy(phenyl)methyl]-3,3a,6,6a-tetrahydro-2H-furo[3,2-b]furan-5-one	14777896	Click to see C1C2C(C(C(O2)C(C3=CC=CC=C3)O)O)OC1=O	250.25	unknown	https://doi.org/10.1080/10286029908039864
> Organoheterocyclic compounds / Furopyrans
Altholactone	442513	Click to see C1=CC=C(C=C1)C2C(C3C(O2)C=CC(=O)O3)O	232.23	unknown	https://doi.org/10.1016/J.PHYMED.2004.07.010
Isoaltholactone	10399033	Click to see C1=CC=C(C=C1)C2C(C3C(O2)C=CC(=O)O3)O	232.23	unknown	https://doi.org/10.1080/10286029908039864
> Organoheterocyclic compounds / Pyrans / Pyranones and derivatives / Dihydropyranones
(2R)-2-(1,2-dihydroxy-2-phenylethyl)-3-hydroxy-2,3-dihydropyran-6-one	138113869	Click to see C1=CC=C(C=C1)C(C(C2C(C=CC(=O)O2)O)O)O	250.25	unknown	https://doi.org/10.1080/10286029908039864
Goniodiol	180702	Click to see C1C=CC(=O)OC1C(C(C2=CC=CC=C2)O)O	234.25	unknown	https://doi.org/10.1016/J.PHYMED.2004.07.010 https://doi.org/10.1080/10286029908039864
Goniodiol 7-acetate	126414	Click to see CC(=O)OC(C1CC=CC(=O)O1)C(C2=CC=CC=C2)O	276.28	unknown	https://doi.org/10.1080/10286029908039864
Goniotriol	125950	Click to see C1=CC=C(C=C1)C(C(C2C(C=CC(=O)O2)O)O)O	250.25	unknown	https://doi.org/10.1080/10286029908039864
> Organoheterocyclic compounds / Quinolines and derivatives / Benzoquinolines
CID 85239741	85239741	Click to see CC1C(C(=O)NC2=C1C(=O)C3=CC=CC=C3C2=O)O	257.24	unknown	https://doi.org/10.1021/NP990004L
Griffithazanone A	10706277	Click to see CC1C(C(=O)NC2=C1C(=O)C3=CC=CC=C3C2=O)O	257.24	unknown	https://doi.org/10.1021/NP990004L
Marcanine A	10105653	Click to see CC1=CC(=O)NC2=C1C(=O)C3=CC=CC=C3C2=O	239.23	unknown	https://doi.org/10.1021/NP990004L
> Phenylpropanoids and polyketides / Flavonoids / Flavans / Flavanones
Pinocembrin	68071	Click to see C1C(OC2=CC(=CC(=C2C1=O)O)O)C3=CC=CC=C3	256.25	unknown	https://doi.org/10.1055/S-2003-43219

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Goniothalamus griffithii

Table of Contents

Details Top

Description Top

Synonyms Top

Common names Top

Subspecies (abbr. subsp./ssp.) Top

Varieties (abbr. var.) Top

Subvarieties (abbr. subvar.) Top

Forms (abbr. f.) Top

Germination/Propagation Top

Distribution (via POWO/KEW) Top

Area

Links to other databases Top

Genomes (via NCBI) Top

Scientific Literature Top

Phytochemical Profile Top

Biological Material Top

Contributors Top

Collections Top