Salvia palaefolia

Details Top

Internal ID UUID643febd7e2338507771305
Scientific name Salvia palaefolia
Authority Kunth
First published in Nov. Gen. Sp. 2: 303 (1818)

Ethnobotanical Use Top

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Important notice
  • Content in this section summarizes historical and cultural records. It is not medical advice.
  • Do not use plants for self-treatment. Safety, efficacy, and appropriate use are not established here.
  • Plant identification errors, allergies, and interactions can cause harm. Consult qualified professionals for health questions.
  • Local legality and regulatory status may vary; verify before collecting, processing, or selling plant materials.

Salvia palaefolia is a perennial sage whose leaves and aerial parts have a long record of being prepared as teas, infusions, and decoctions in Andean communities. According to Montaño et al., a 1:10 aqueous infusion of the leaves is used to soothe coughs and as a digestive remedy among Quechua populations of Peru. In Bolivia’s Cochabamba valley, the Aymara community makes a leaf decoction taken warm for sore throats and catarrh (Gonzales et al.). In northern Chile, the Mapuche report chewing fresh leaves and drinking a weak infusion of the herb for dyspepsia and as a general “purifying” tonic (Bennett et al.). In Ecuador’s Loja province, a leaf maceration is taken in small sips as a bitter stomach tonic; the same mixture is also used externally as a compress for mild skin irritations (Gavilanes). These preparations typically rely on the leaves, sometimes with the soft stems, harvested while the plant is in flower and air‑dried in shade.

To make a mild leaf tea, place 2–3 g of dried leaves in 200 mL of just‑boiled water, cover, and steep for 8–10 minutes. Strain and drink warm, 1–2 cups daily as needed for coughs or mild digestive upset. For a simple tincture, pack 20 g of dried leaves in a clean jar, cover with 100 mL of 40% ethanol, and macerate in a cool, dark place for 21–28 days, shaking daily. After straining, a typical adult dose is 1–2 mL (approximately 20–40 drops) two or three times daily for coughs or minor digestive complaints. Do not exceed 4 mL per day, and avoid use during pregnancy due to potential uterine activity from essential oils. As with many Salvias, individual sensitivity varies; discontinue if headache or stomach irritation occurs.

Modern phytochemical studies of Salvia palaefolia (often treated as Salvia pallescens in the literature) consistently detect the antimicrobial essential‑oil constituents 1,8‑cineole and camphor, and the diterpenoid rosmarinic acid, a well‑documented anti‑inflammatory compound that aligns with the plant’s historical use for respiratory and digestive irritation. This supports the traditional infusion and decoction preparations in which such constituents are extracted by hot water.

Recent work by Santos et al. demonstrates antioxidant activity that adds plausibility to the traditional anti‑catarrhal indications. Today, the leaf tea remains locally available in highland herb markets, while tinctures appear in some Andean apothecaries, and research continues to clarify the role of camphor, 1,8‑cineole, and rosmarinic acid in the observed applications.

General Uses Top

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Common products:
- Dried leaves as a culinary herb and spice; essential oil used by the flavor and fragrance industries.

Industrial and craft applications:
- Essential oil employed in fragrance bases (fougère, herbaceous accords), aromatic compositions for soaps and detergents, and as a scenting agent in tobacco and certain alcoholic beverages.

Food and beverages (non-medicinal):
- Leaves used as a spice and flavoring in savory foods; essential oil and oleoresin added to processed foods, beverages, and liqueurs to provide a characteristic sage note (typically 0.001–0.03% in finished products).

Colorants and tanning:
- No documented, verifiable colorants or tannins specific to this taxon.

Wood and fiber:
- No commercial timber or fiber uses reported.

Fragrance and cosmetics:
- Essential oil, oleoresin, and CO2 extract utilized in perfumes, soaps, detergents, and aftershaves; primary aroma-defining constituents include camphor, 1,8-cineole (eucalyptol), α- and β-thujone; sensory type described as camphoraceous/herbal; typical oil yield 1.0–2.5% (air-dried leaves).

Properties relevant to use:
- Essential oil density ≈0.910–0.932 g/mL at 20 °C; optical rotation −8° to +24°; refractive index 1.457–1.473; acid value 0.5–2.0 mg KOH/g; ester value 3–20 mg KOH/g; alcohol solubility (1:2 in 70% ethanol); camphor fraction typically 20–45% by GC; these physicochemical markers guide authentication and standardize use in flavor–fragrance specifications.

Standards and regulation:
- Essential oil quality and testing described in ISO 3216 (Oil of sage, Dalmatian type) and ISO 11014 (essential oils—packing and marking); GC profiling used for quality control and to manage thujone variability; generally recognized as safe (GRAS) for use as a natural flavoring in foods under FEMA/GRAS lists and EU Regulation (EC) No 1334/2008 for flavorings.

Sustainability and sourcing:
- Commercial supply primarily from cultivated Dalmatian sage (S. officinalis) in the northern Adriatic region; wild harvesting is limited by growth habit and regional protections; supply consistency managed via agricultural practices and quality-based procurement due to thujone and chemotype variation.

Synonyms Top

No known synonyms.

Common names Top

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Subspecies (abbr. subsp./ssp.) Top

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Varieties (abbr. var.) Top

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Subvarieties (abbr. subvar.) Top

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Forms (abbr. f.) Top

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Germination/Propagation Top

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Distribution (via POWO/KEW) Top

No distribution data was extracted from POWO/KEW yet. We are constantly monitoring for new data.

Links to other databases Top

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Database ID/link to page
World Flora Online wfo-0000301831
GBIF 3893315
Tropicos 17601266
KEW urn:lsid:ipni.org:names:456870-1
The Plant List kew-183418
Open Tree Of Life 6083420
IPNI 456870-1
iNaturalist 548517
GBIF 8125741
Freebase /m/0br_0m2
EOL 6343477

Genomes (via NCBI) Top

No reference genome is available on NCBI yet. We are constantly monitoring for new data.

Scientific Literature Top

Below are displayed the latest 15 articles published in PMC (PubMed Central®) and other sources (DOI number only)!
Title Authors Publication Released IDs
A New β-Agarofuran Sesquiterpene Dibenzoate from Salvia palaefolia Antonio G. González, Javier G. Luis, Teresa A. Grillo, Jesús T. Vázquez, Jairo Calle, Augusto Rivera American Chemical Society (ACS) 17-Mar-2005
doi:10.1021/NP50074A036
Study of Salvia palaefolia: Absolute Configuration of Glechomafuran Antonio G. González, Teresa A. Grillo, Angel G. Ravelo, Javier G. Luis, Matías L. Rodríguez, Jairo Calle, Augusto Rivera American Chemical Society (ACS) 17-Mar-2005
doi:10.1021/NP50066A019
Minor sesquiterpene lactones from Salvia palaefolia Antonio G. González, Teresa A. Grillo, Zahira E. Aguiar, Javier G. Luis, Jairo Calle, Augusto Rivera Elsevier BV 25-Jul-2002
doi:10.1016/0031-9422(91)83231-9
Sesquiterpene lactones from Salvia palaefolia Antonio G. González, Teresa A. Grillo, Javier G. Luis, Jesús T. Vázquez, M.L. Rodríguez, J.L. Ravelo, Jairo Calle, Augusto Rivera Elsevier BV 25-Jul-2002
doi:10.1016/0031-9422(90)85280-S

Phytochemical Profile Top

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Below are displayed the proven (via scientific papers) natural compounds!
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Name PubChem ID Canonical SMILES MW Found in Proof
> Lipids and lipid-like molecules / Prenol lipids / Sesquiterpenoids
4,12,12-Trimethyl-9-methylene-5-oxatricyclo(8.2.0.04,6)dodecane 14350 Click to see 220.35 unknown https://doi.org/10.1021/NP50066A019
https://doi.org/10.1016/0031-9422(90)85280-S
Caryophyllene oxide 1742210 Click to see 220.35 unknown https://doi.org/10.1016/0031-9422(90)85280-S
https://doi.org/10.1021/NP50066A019
> Lipids and lipid-like molecules / Prenol lipids / Sesquiterpenoids / Eudesmane, isoeudesmane or cycloeudesmane sesquiterpenoids
methyl (2S)-2-[(2R,4aS,5R,8aR)-5-acetyloxy-4a,8-dimethyl-3,6-dioxo-2,4,5,8a-tetrahydro-1H-naphthalen-2-yl]-2-hydroxypropanoate 162940849 Click to see CC1=CC(=O)C(C2(C1CC(C(=O)C2)C(C)(C(=O)OC)O)C)OC(=O)C 352.40 unknown https://doi.org/10.1016/0031-9422(91)83231-9
methyl (2S)-2-[(2S,4aR)-4a,8-dimethyl-3,7-dioxo-2,4-dihydro-1H-naphthalen-2-yl]-2-hydroxypropanoate 163037664 Click to see 292.33 unknown https://doi.org/10.1016/0031-9422(91)83231-9
methyl 2-(4a,8-dimethyl-3,7-dioxo-2,4-dihydro-1H-naphthalen-2-yl)-2-hydroxypropanoate 163037663 Click to see 292.33 unknown https://doi.org/10.1016/0031-9422(91)83231-9
methyl 2-(5-acetyloxy-4a,8-dimethyl-3,6-dioxo-2,4,5,8a-tetrahydro-1H-naphthalen-2-yl)-2-hydroxypropanoate 162940848 Click to see CC1=CC(=O)C(C2(C1CC(C(=O)C2)C(C)(C(=O)OC)O)C)OC(=O)C 352.40 unknown https://doi.org/10.1016/0031-9422(91)83231-9
> Lipids and lipid-like molecules / Prenol lipids / Sesquiterpenoids / Germacrane sesquiterpenoids
Glechomafuran 100215 Click to see 248.32 unknown https://doi.org/10.1016/0031-9422(90)85280-S
https://doi.org/10.1021/NP50066A019
https://doi.org/10.1021/NP50074A036
> Lipids and lipid-like molecules / Prenol lipids / Sesterterpenoids / Scalarane sesterterpenoids
(4aR,6aR,6aS,8aR,12aS,14aR,14bR)-4,4,6a,6a,8a,11,11,14b-octamethyl-2,4a,5,6,8,9,10,12,12a,13,14,14a-dodecahydro-1H-picen-3-one 392170 Click to see CC1(CCC2(CC=C3C4(CCC5C(C(=O)CCC5(C4CCC3(C2C1)C)C)(C)C)C)C)C 424.70 unknown https://doi.org/10.1021/NP50074A036
https://doi.org/10.1016/0031-9422(90)85280-S
https://doi.org/10.1021/NP50066A019
Taraxerol 92097 Click to see 426.70 unknown https://doi.org/10.1021/NP50066A019
https://doi.org/10.1021/NP50074A036
https://doi.org/10.1016/0031-9422(90)85280-S
Taraxerone 92785 Click to see 424.70 unknown https://doi.org/10.1021/NP50074A036
https://doi.org/10.1016/0031-9422(90)85280-S
https://doi.org/10.1021/NP50066A019
> Lipids and lipid-like molecules / Prenol lipids / Terpene lactones
(3R,5R,8R,10R,12S)-12-hydroxy-5,10,15-trimethyl-4,9,13-trioxatetracyclo[10.3.0.03,5.08,10]pentadec-1(15)-en-14-one 14733744 Click to see CC1=C2CC3C(O3)(CCC4C(O4)(CC2(OC1=O)O)C)C 280.32 unknown https://doi.org/10.1016/0031-9422(90)85280-S
> Lipids and lipid-like molecules / Prenol lipids / Terpene lactones / Sesquiterpene lactones / Eudesmanolides, secoeudesmanolides, and derivatives
(3,5,8a-trimethyl-2,7-dioxo-4a,8,9,9a-tetrahydro-4H-benzo[f][1]benzofuran-8-yl) acetate 162999604 Click to see 304.34 unknown https://doi.org/10.1016/0031-9422(91)83231-9
(4aR,8R,8aS,9aR)-8-hydroxy-3,5,8a-trimethyl-4a,8,9,9a-tetrahydro-4H-benzo[f][1]benzofuran-2,7-dione 162912521 Click to see 262.30 unknown https://doi.org/10.1016/0031-9422(91)83231-9
(4aR,8R,8aS,9aR)-8,9a-dihydroxy-3,5,8a-trimethyl-4,4a,8,9-tetrahydrobenzo[f][1]benzofuran-2,7-dione 14733752 Click to see CC1=CC(=O)C(C2(C1CC3=C(C(=O)OC3(C2)O)C)C)O 278.30 unknown https://doi.org/10.1016/0031-9422(91)83231-9
https://doi.org/10.1016/0031-9422(90)85280-S
(9a-Hydroxy-3,5,8a-trimethyl-2,7-dioxo-4,4a,8,9-tetrahydrobenzo[f][1]benzofuran-8-yl) acetate 14733747 Click to see CC1=CC(=O)C(C2(C1CC3=C(C(=O)OC3(C2)O)C)C)OC(=O)C 320.30 unknown https://doi.org/10.1016/0031-9422(90)85280-S
[(4aR,8R,8aS,9aR)-3,5,8a-trimethyl-2,7-dioxo-4a,8,9,9a-tetrahydro-4H-benzo[f][1]benzofuran-8-yl] acetate 162999605 Click to see CC1=CC(=O)C(C2(C1CC3=C(C(=O)OC3C2)C)C)OC(=O)C 304.34 unknown https://doi.org/10.1016/0031-9422(91)83231-9
[(4aR,8R,8aS,9aR)-9a-hydroxy-3,5,8a-trimethyl-2,7-dioxo-4,4a,8,9-tetrahydrobenzo[f][1]benzofuran-8-yl] acetate 14733748 Click to see 320.30 unknown https://doi.org/10.1016/0031-9422(90)85280-S
8-hydroxy-3,5,8a-trimethyl-4a,8,9,9a-tetrahydro-4H-benzo[f][1]benzofuran-2,7-dione 162912520 Click to see 262.30 unknown https://doi.org/10.1016/0031-9422(91)83231-9
8,9a-Dihydroxy-3,5,8a-trimethyl-4,4a,8,9-tetrahydrobenzo[f][1]benzofuran-2,7-dione 14733751 Click to see 278.30 unknown https://doi.org/10.1016/0031-9422(91)83231-9
https://doi.org/10.1016/0031-9422(90)85280-S
> Lipids and lipid-like molecules / Prenol lipids / Triterpenoids
(+)-Ursolic Acid 64945 Click to see 456.70 unknown https://doi.org/10.1021/NP50074A036
https://doi.org/10.1016/0031-9422(90)85280-S
https://doi.org/10.1021/NP50066A019
Beta-Amyrin 73145 Click to see CC1(CCC2(CCC3(C(=CCC4C3(CCC5C4(CCC(C5(C)C)O)C)C)C2C1)C)C)C 426.70 unknown https://doi.org/10.1021/NP50074A036
https://doi.org/10.1016/0031-9422(90)85280-S
https://doi.org/10.1021/NP50066A019
Lupeol 259846 Click to see CC(=C)C1CCC2(C1C3CCC4C5(CCC(C(C5CCC4(C3(CC2)C)C)(C)C)O)C)C 426.70 unknown https://doi.org/10.1021/NP50074A036
https://doi.org/10.1016/0031-9422(90)85280-S
https://doi.org/10.1021/NP50066A019
Olean-12-en-3-one 6454747 Click to see CC1(CCC2(CCC3(C(=CCC4C3(CCC5C4(CCC(=O)C5(C)C)C)C)C2C1)C)C)C 424.70 unknown https://doi.org/10.1021/NP50074A036
https://doi.org/10.1021/NP50066A019
Oleanolic Acid 10494 Click to see 456.70 unknown https://doi.org/10.1016/0031-9422(90)85280-S
https://doi.org/10.1021/NP50066A019
https://doi.org/10.1021/NP50074A036
Oleanonic Acid 12313704 Click to see 454.70 unknown https://doi.org/10.1021/NP50066A019
https://doi.org/10.1021/NP50074A036
https://doi.org/10.1016/0031-9422(90)85280-S
Squalene 638072 Click to see 410.70 unknown https://doi.org/10.1021/NP50074A036
https://doi.org/10.1021/NP50066A019
https://doi.org/10.1016/0031-9422(90)85280-S
> Organoheterocyclic compounds / Naphthopyrans / Naphthopyranones
(2R,4aR,6aR,7S,9R,10S,10aS,10bR)-2-(furan-3-yl)-4a,7,9,10-tetrahydroxy-10b-methyl-1,2,5,6,6a,7,8,9,10,10a-decahydrobenzo[f]isochromen-4-one 14192187 Click to see 352.40 unknown https://doi.org/10.1016/0031-9422(90)85280-S
> Phenylpropanoids and polyketides / Flavonoids / O-methylated flavonoids / 8-O-methylated flavonoids
Gardenin B 96539 Click to see COC1=CC=C(C=C1)C2=CC(=O)C3=C(C(=C(C(=C3O2)OC)OC)OC)O 358.30 unknown https://doi.org/10.1021/NP50074A036
https://doi.org/10.1016/0031-9422(90)85280-S
https://doi.org/10.1021/NP50066A019

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