Salvia multicaulis

Details Top

Internal ID UUID643febd014524160613840
Scientific name Salvia multicaulis
Authority Vahl
First published in Enum. Pl. Obs. 1: 225 (1804)

Ethnobotanical Use Top

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Important notice
  • Content in this section summarizes historical and cultural records. It is not medical advice.
  • Do not use plants for self-treatment. Safety, efficacy, and appropriate use are not established here.
  • Plant identification errors, allergies, and interactions can cause harm. Consult qualified professionals for health questions.
  • Local legality and regulatory status may vary; verify before collecting, processing, or selling plant materials.

Salvia multicaulis has been reported as an herbal tea or infusion across the eastern Mediterranean and adjacent regions. In central and western Turkey, Ghirardini recorded leaf infusions taken for colds and stomach complaints. Across Iran and the Kurdish region, Sadeghi et al. and Amiri et al. describe leaves steeped in hot water for coughs and digestive ailments, while Naghibi et al. note a decoction of roots used for fever and colic. In the South Caucasus (Azerbaijan, Armenia), the pharmacopoeia cited by Khanina records leaf infusions for throat inflammation and cough, and Macit et al. document a similar use among Turkish communities. Most sources specify the aerial parts—leaves and young shoots—and distinguish leaf teas from root decoctions when describing the preparation. The preparation is typically brief and mild; in Kerman province, leaf infusion is prepared by pouring hot water over 5–10 g of fresh leaves, straining after 10–15 minutes, and drinking one cup two to three times daily. For a stronger preparation, leaves are boiled for about five minutes, cooled, and taken as needed for cough and sore throat.

A common recommendation is to steep 1–2 teaspoons of dried leaf in 250 mL of hot water for 10–15 minutes and sip slowly. Because the species contains constituents that can be irritant at high doses, most manuals advise avoiding long, concentrated decoctions and advise moderation in frequency. Pregnant or nursing people should avoid use, and it is not recommended for children. If an ethanol tincture is preferred in regions where a leaf tincture is made, use fresh leaves at a ratio of 1 part herb to 5 parts 40–50% alcohol by weight/volume, macerate in a dark bottle for 2–3 weeks with daily shaking, and then press and filter. As the plant contains thujone-related terpenes, use small volumes and short courses, stopping if stomach upset or dizziness occurs.

The essential oil is dominated by camphor and related monoterpenes, with frequent reports of 1,8-cineole, α- and β-thujone, borneol, and α-pinene; carnosol and carnosic acid occur at lower levels. Phenolics such as rosmarinic acid and luteolin derivatives have also been quantified. These classes of compounds plausibly explain the antimicrobial, spasmolytic, and tonic actions reported for the infusions and decoctions.

Interest in Salvia multicaulis remains active: commercial teas are available in some Turkish markets, and several recent phytochemical studies continue to investigate its antioxidant and antimicrobial properties alongside ongoing ethnobotanical surveys across Iran, Turkey, and the Caucasus.

General Uses Top

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Common products:
Essential oil obtained by hydrodistillation of the aerial parts is the primary commercial product. Commercial applications include fragrance and flavor uses where the oil is used in perfumery and as a natural flavoring component.

Industrial and craft applications:
The essential oil is employed as a fragrance material in soaps and detergents and as a flavoring agent in processed foods and beverages where Salvia-derived sage notes are desired. The phenolic-rich extract is used as a natural antioxidant in food packaging to inhibit oxidation of lipids in fatty foods.

Properties relevant to use:
Essential-oil chemotypes contain high levels of monoterpenes such as 1,8-cineole and camphor, conferring characteristic medicinal-sage odors and volatility appropriate for fragrance uses. Polar phenolic extracts (flavonoids and phenolic acids) show antioxidant activity that delays lipid oxidation in food matrices.

Standards and regulation:
Essential oils for flavor use are regulated under national flavor standards, and cosmetic applications must comply with relevant cosmetic safety regulations and any ISO/ASTM specifications for essential-oil testing (e.g., refractive index, specific gravity, and gas-chromatographic identification limits).

Sustainability and sourcing:
The plant is collected in the wild from rocky, mountainous habitats across the Near East and Central Asia. Sustainable harvesting and geographic chemotype profiling are emphasized to maintain oil quality and prevent overharvest. Seasonal phenology affects yield, with flowering stage harvesting producing higher oil concentrations. In some regions, cultivation or agronomic trials are explored to reduce pressure on wild populations.

Synonyms Top

Scientific name Authority First published in
Arischrada multicaulis (Vahl) Pobed. Novosti Sist. Vyssh. Rast. 9: 247 (1972)
Salvia bodeana Bunge Labiat. Persic. : 42 (1873)
Salvia pinardi Boiss. Diagn. Pl. Orient. 12: 59 (1853)
Salvia rascheyana Boiss. Diagn. Pl. Orient. 12: 58 (1853)
Salvia szovitsiana Bunge Labiat. Persic. : 43 (1873)
Schraderia acetabulosa (Vahl) Pobed. Fl. URSS 21: 369 (1954)
Stiefia multicaulis (Vahl) Soják Cas. Nár. Mus., Odd. Prír. 152: 22 (1983)

Common names Top

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Language Common/alternative name
Arabic قصعين متعدد السوق
Persian مریمگلی پرساقه
Hebrew מרווה רחבת-גביע

Subspecies (abbr. subsp./ssp.) Top

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Varieties (abbr. var.) Top

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Subvarieties (abbr. subvar.) Top

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Forms (abbr. f.) Top

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Germination/Propagation Top

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No germination or propagation data was added yet.

Distribution (via POWO/KEW) Top

Legend for the distribution data:
- Doubtful data
- Extinct
- Introduced
- Native
  • Asia-temperate
    • Western Asia
      • Iran
      • Iraq
      • Lebanon-Syria
      • Palestine
      • Sinai
      • Turkey

Links to other databases Top

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Database ID/link to page
World Flora Online wfo-0000301657
Tropicos 17600598
KEW urn:lsid:ipni.org:names:456747-1
The Plant List kew-183253
Open Tree Of Life 5921568
Observations.org 134998
NCBI Taxonomy 1685714
IPNI 456747-1
iNaturalist 493013
GBIF 3895293
Freebase /m/0bxzj4h
EOL 6342652
Elurikkus 435566
Wikipedia Salvia_multicaulis

Genomes (via NCBI) Top

No reference genome is available on NCBI yet. We are constantly monitoring for new data.

Scientific Literature Top

Below are displayed the latest 15 articles published in PMC (PubMed Central®) and other sources (DOI number only)!
If you wish to see all the related articles click here.
Title Authors Publication Released IDs
Salvimulticanol from Salvia multicaulis suppresses LPS-induced inflammation in RAW264.7 macrophages: in vitro and in silico studies Hamed AR, Nabih HK, El-Rashedy AA, Mohamed TA, Mostafa OE, K. Ali S, Efferth T, Hegazy ME 3 Biotech 02-May-2024
PMCID:PMC11065832
doi:10.1007/s13205-024-03987-8
PMID:38706927
Chromosome Doubling Enhances Biomass and Carotenoid Content in Lycium chinense Zhang R, Rao S, Wang Y, Qin Y, Qin K, Chen J Plants (Basel) 02-Feb-2024
PMCID:PMC10857560
doi:10.3390/plants13030439
PMID:38337972
In Vitro Antibacterial, Antioxidant, Anticholinesterase, and Antidiabetic Activities and Chemical Composition of Salvia balansae Mokhtar A, Souhila T, Nacéra B, Amina B, Alghonaim MI, Öztürk M, Alsalamah SA, Miara MD, Boufahja F, Bendif H Molecules 27-Nov-2023
PMCID:PMC10708212
doi:10.3390/molecules28237801
PMID:38067531
Establishing the Relationship Between Flavonoid Content, Mycorrhization, and Soil Nutritional Content in Different Species of the Genus Passiflora in Colombia Hernández-Martínez AX, Lozano-Puentes HS, Camacho-Montealegre CM, Costa GM, Díaz-Ariza LA ACS Omega 19-Oct-2023
PMCID:PMC10620891
doi:10.1021/acsomega.3c05606
PMID:37929148
Screening of 20 species from Lamiaceae family based on phytochemical analysis, antioxidant activity and HPLC profiling Moshari-Nasirkandi A, Alirezalu A, Alipour H, Amato J Sci Rep 09-Oct-2023
PMCID:PMC10562417
doi:10.1038/s41598-023-44337-7
PMID:37813985
Current State of Knowledge Regarding WHO High Priority Pathogens—Resistance Mechanisms and Proposed Solutions through Candidates Such as Essential Oils: A Systematic Review Romanescu M, Oprean C, Lombrea A, Badescu B, Teodor A, Constantin GD, Andor M, Folescu R, Muntean D, Danciu C, Dalleur O, Batrina SL, Cretu O, Buda VO Int J Mol Sci 04-Jun-2023
PMCID:PMC10253476
doi:10.3390/ijms24119727
PMID:37298678
Chemical composition, cholinesterase, and α-glucosidase inhibitory activity of the essential oils of some Iranian native Salvia species Gharehbagh HJ, Ebrahimi M, Dabaghian F, Mojtabavi S, Hariri R, Saeedi M, Faramarzi MA, Khanavi M BMC Complement Med Ther 03-Jun-2023
PMCID:PMC10239571
doi:10.1186/s12906-023-04004-w
PMID:37270541
Drying temperatures affect the qualitative–quantitative variation of aromatic profiling in Anethum graveolens L. ecotypes as an industrial–medicinal–vegetable plant Farmanpour Kalalagh K, Mohebodini M, Fattahi R, Beyraghdar Kashkooli A, Davarpanah Dizaj S, Salehifar F, Mokhtari AM Front Plant Sci 12-May-2023
PMCID:PMC10214840
doi:10.3389/fpls.2023.1137840
PMID:37251761
The variability of phenolic constituents and antioxidant properties among wild populations of Ziziphora clinopodioides Lam Taheri A, Ganjeali A, Arefi-Oskouie A, Çirak C, Cheniany M Physiol Mol Biol Plants 30-Jan-2023
PMCID:PMC9981857
doi:10.1007/s12298-023-01283-y
PMID:36875730
Comparison of antibacterial and antioxidant potentials of pure and nanoemulsified Nepeta pogonosperma essential oil Sharifi K, Sharifi A Food Sci Nutr 28-Dec-2022
PMCID:PMC10084963
doi:10.1002/fsn3.3210
PMID:37051348
Preparation and characterization of geraniol nanoemulsions and its antibacterial activity Feng X, Feng K, Zheng Q, Tan W, Zhong W, Liao C, Liu Y, Li S, Hu W Front Microbiol 29-Nov-2022
PMCID:PMC9745324
doi:10.3389/fmicb.2022.1080300
PMID:36523845
New Diterpenes with Potential Antitumoral Activity Isolated from Plants in the Years 2017–2022 Forzato C, Nitti P Plants (Basel) 29-Aug-2022
PMCID:PMC9460660
doi:10.3390/plants11172240
PMID:36079622
7-Acetoxyhorminone from Salvia multicaulis Vahl. as Promising Inhibitor of 3-Hydroxy-3-methylglutaryl Coenzyme A (HMG-CoA) Reductase Yigitkan S, Ertas A, Salmas RE, Firat M, Orhan IE Pharmaceuticals (Basel) 04-Feb-2022
PMCID:PMC8880194
doi:10.3390/ph15020198
PMID:35215310
Ethnomedicinal Plants of Hasankeyf (Batman-Turkey) Yeşil Y, İnal İ Front Pharmacol 11-Mar-2021
PMCID:PMC7990790
doi:10.3389/fphar.2020.624710
PMID:33776756
Phytotoxic Effects of Plant Essential Oils: A Systematic Review and Structure-Activity Relationship Based on Chemometric Analyses Abd-ElGawad AM, El Gendy AE, Assaeed AM, Al-Rowaily SL, Alharthi AS, Mohamed TA, Nassar MI, Dewir YH, Elshamy AI Plants (Basel) 25-Dec-2020
PMCID:PMC7823517
doi:10.3390/plants10010036
PMID:33375618

Phytochemical Profile Top

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Below are displayed the proven (via scientific papers) natural compounds!
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Name PubChem ID Canonical SMILES MW Found in Proof
> Benzenoids / Benzene and substituted derivatives / Biphenyls and derivatives
Heptyl 4-(4-heptoxycarbonylphenyl)benzoate 15378965 Click to see CCCCCCCOC(=O)C1=CC=C(C=C1)C2=CC=C(C=C2)C(=O)OCCCCCCC 438.60 unknown https://doi.org/10.1016/S0031-9422(97)00540-2
> Benzenoids / Benzene and substituted derivatives / Cumenes
8-Hydroxy-3,3-dimethyl-7-propan-2-yl-2,3a,4,5-tetrahydrobenzo[g]azulen-1-one 85273221 Click to see 284.40 unknown https://doi.org/10.1021/NP990458I
Salvimultine 10803003 Click to see 284.40 unknown https://doi.org/10.1021/NP990458I
> Benzenoids / Phenanthrenes and derivatives / Hydrophenanthrenes
(4As,4br,7r,9r)-4b,9-dihydroxy-1,1,4a,7-tetramethyl-7-vinyl-3,4,6,9,10,10a-hexahydrophenanthrene-2,5-dione 467788 Click to see 332.40 unknown https://doi.org/10.1021/NP9700681
7-Ethenyl-4b,9-dihydroxy-1,1,4a,7-tetramethyl-3,4,6,9,10,10a-hexahydrophenanthrene-2,5-dione 73805598 Click to see CC1(C2CC(C3=CC(CC(=O)C3(C2(CCC1=O)C)O)(C)C=C)O)C 332.40 unknown https://doi.org/10.1021/NP9700681
Salvipimarone 21582617 Click to see CC1(C2CC(C3=CC(CC(=O)C3(C2(CCC1=O)C)O)(C)C=C)O)C 332.40 unknown https://doi.org/10.1021/NP9700681
> Benzenoids / Tetralins
CID 9906686 9906686 Click to see CC1(CC2=C(C(=O)C1)C34C(C5=C(C(C3(O4)C=C2)O)C(=CC=C5)OC)O)O 356.40 unknown https://doi.org/10.1016/S0031-9422(97)00540-2
> Lipids and lipid-like molecules / Prenol lipids / Diterpenoids
(+)-Pisiferal 13785026 Click to see CC(C)C1=C(C=C2C(=C1)CCC3C2(CCCC3(C)C)C=O)O 300.40 unknown https://doi.org/10.1021/NP9700681
(1S,4aS,10aR)-6-hydroxy-1,4a-dimethyl-7-propan-2-yl-2,3,4,9,10,10a-hexahydrophenanthrene-1-carbaldehyde 101103460 Click to see CC(C)C1=C(C=C2C(=C1)CCC3C2(CCCC3(C)C=O)C)O 300.40 unknown https://doi.org/10.1016/S0031-9422(97)00540-2
(4aS,10aR)-6-hydroxy-1,1,4a-trimethyl-7-propan-2-yl-4,9,10,10a-tetrahydro-3H-phenanthren-2-one 11700871 Click to see CC(C)C1=C(C=C2C(=C1)CCC3C2(CCC(=O)C3(C)C)C)O 300.40 unknown https://doi.org/10.1021/NP9700681
(4aS,10aR)-8-hydroxy-6-methoxy-1,1,4a-trimethyl-7-propan-2-yl-4,9,10,10a-tetrahydro-3H-phenanthren-2-one 15378963 Click to see 330.50 unknown https://doi.org/10.1016/S0031-9422(97)00540-2
(4aS,10aS)-6-hydroxy-1,1,4a-trimethyl-7-propan-2-yl-3,9,10,10a-tetrahydro-2H-phenanthren-4-one 15241260 Click to see 300.40 unknown https://doi.org/10.1021/NP9700681
(4bR,8aR)-4b,8,8-trimethyl-2-propan-2-yl-5,6,7,8a-tetrahydrophenanthrene-1,3,4-triol 101219048 Click to see 316.40 unknown https://doi.org/10.1016/S0031-9422(97)00540-2
(4bS,8aS)-3-hydroxy-4b,8,8-trimethyl-2-propan-2-yl-6,7,8a,10-tetrahydro-5H-phenanthren-9-one 14165057 Click to see 300.40 unknown https://doi.org/10.1016/S0031-9422(97)00540-2
10-Hydroxy-3-methoxy-4b,8,8-trimethyl-2-propan-2-yl-5,6,7,10-tetrahydrophenanthrene-1,4-dione 78187759 Click to see 344.40 unknown https://doi.org/10.1021/NP9700681
12-Demethylmulticaulin 467783 Click to see 264.40 unknown https://doi.org/10.1021/NP9700681
12-Methyl-5-dehydroacetylhorminone 467787 Click to see CC(C)C1=C(C(=O)C2=C(C1=O)C(C=C3C2(CCCC3(C)C)C)OC(=O)C)OC 386.50 unknown https://doi.org/10.1021/NP9700681
12-Methyl-5-dehydrohorminone 467786 Click to see 344.40 unknown https://doi.org/10.1021/NP9700681
18-Oxoferruginol 52946772 Click to see 300.40 unknown https://doi.org/10.1021/NP9700681
6-Hydroxy-1,4a-dimethyl-7-propan-2-yl-2,3,4,9,10,10a-hexahydrophenanthrene-1-carbaldehyde 14323964 Click to see CC(C)C1=C(C=C2C(=C1)CCC3C2(CCCC3(C)C=O)C)O 300.40 unknown https://doi.org/10.1016/S0031-9422(97)00540-2
8-hydroxy-6-methoxy-1,1,4a-trimethyl-7-propan-2-yl-4,9,10,10a-tetrahydro-3H-phenanthren-2-one 73193330 Click to see 330.50 unknown https://doi.org/10.1016/S0031-9422(97)00540-2
Abieta-9(11),8(14),12-trien-12-ol 521330 Click to see CC(C)C1=C(C=C2C(=C1)CCC3C2(CCCC3(C)C)C)O 286.50 unknown https://doi.org/10.1016/S0031-9422(97)00540-2
Cryptanol 184179 Click to see 316.40 unknown https://doi.org/10.1016/S0031-9422(97)00540-2
Ferruginol 442027 Click to see CC(C)C1=C(C=C2C(=C1)CCC3C2(CCCC3(C)C)C)O 286.50 unknown https://doi.org/10.1016/S0031-9422(97)00540-2
Horminone 2751795 Click to see 332.40 unknown https://doi.org/10.1021/NP9700681
Indigoferabietone 504479 Click to see CC(C)C1=C(C(=O)C2=C(C1=O)C(C=C3C2(CCCC3(C)C)C)OC(=O)C)OC 386.50 unknown https://doi.org/10.1021/NP9700681
Manool 3034394 Click to see 290.50 unknown https://doi.org/10.1021/NP9700681
Multicaulin 467782 Click to see 278.40 unknown https://doi.org/10.1021/NP9700681
Sempervirol 12442761 Click to see CC(C)C1=C(C=C2CCC3C(CCCC3(C2=C1)C)(C)C)O 286.50 unknown https://doi.org/10.1021/NP9700681
Taxoquinone 99965 Click to see CC(C)C1=C(C2=C(C(=O)C1=O)C3(CCCC(C3CC2O)(C)C)C)O 332.40 unknown https://doi.org/10.1021/NP9700681
> Lipids and lipid-like molecules / Prenol lipids / Diterpenoids / Tanshinones, isotanshinones, and derivatives
12-Demethylmultiorthoquinone 467785 Click to see 294.30 unknown https://doi.org/10.1021/NP9700681
Multiorthoquinone 467784 Click to see CC1=C2C=CC3=C(C2=CC(=C1C)OC)C(=O)C(=O)C(=C3)C(C)C 308.40 unknown https://doi.org/10.1021/NP9700681
> Lipids and lipid-like molecules / Prenol lipids / Terpene lactones / Diterpene lactones
8-Hydroxy-12-oxoabieta-9(11),13-dien-20-oic 8,20-lactone 70698284 Click to see CC(C)C1=CC23CCC4C(CCCC4(C2=CC1=O)C(=O)O3)(C)C 314.40 unknown https://doi.org/10.1016/S0031-9422(97)00540-2
> Lipids and lipid-like molecules / Prenol lipids / Triterpenoids
alpha-Amyrenol 225688 Click to see 426.70 unknown https://doi.org/10.1016/S0031-9422(97)00540-2
Alpha-Amyrin 73170 Click to see 426.70 unknown https://doi.org/10.1016/S0031-9422(97)00540-2
https://doi.org/10.1021/NP9700681
alpha-Amyrin acetate 92842 Click to see 468.80 unknown https://doi.org/10.1016/S0031-9422(97)00540-2
Lup-20(29)-en-3-ol, (3beta)- 521518 Click to see CC(=C)C1CCC2(C1C3CCC4C5(CCC(C(C5CCC4(C3(CC2)C)C)(C)C)O)C)C 426.70 unknown https://doi.org/10.1016/S0031-9422(97)00540-2
Lup-20(29)-en-3-one 323075 Click to see CC(=C)C1CCC2(C1C3CCC4C5(CCC(=O)C(C5CCC4(C3(CC2)C)C)(C)C)C)C 424.70 unknown https://doi.org/10.1016/S0031-9422(97)00540-2
Lupenone 92158 Click to see CC(=C)C1CCC2(C1C3CCC4C5(CCC(=O)C(C5CCC4(C3(CC2)C)C)(C)C)C)C 424.70 unknown https://doi.org/10.1016/S0031-9422(97)00540-2
Lupeol 259846 Click to see CC(=C)C1CCC2(C1C3CCC4C5(CCC(C(C5CCC4(C3(CC2)C)C)(C)C)O)C)C 426.70 unknown https://doi.org/10.1021/NP9700681
https://doi.org/10.1016/S0031-9422(97)00540-2
Npc25529 293754 Click to see 468.80 unknown https://doi.org/10.1016/S0031-9422(97)00540-2
> Lipids and lipid-like molecules / Steroids and steroid derivatives / Ergostane steroids / Ergosterols and derivatives
(22e)-Ergosta-5,22-dien-3-one 134691564 Click to see CC(C)C(C)C=CC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(=O)C4)C)C 396.60 unknown https://doi.org/10.1016/S0031-9422(97)00540-2
17-(5,6-Dimethylhept-3-en-2-yl)-10,13-dimethyl-1,2,4,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one 85632475 Click to see 396.60 unknown https://doi.org/10.1016/S0031-9422(97)00540-2
Brassicasterone 133655762 Click to see CC(C)C(C)C=CC(C)C1CCC2C1(CCC3C2CCC4=CC(=O)CCC34C)C 396.60 unknown https://doi.org/10.1016/S0031-9422(97)00540-2
> Lipids and lipid-like molecules / Steroids and steroid derivatives / Stigmastanes and derivatives
(-)-beta-Sitosterol 222284 Click to see 414.70 unknown https://doi.org/10.1016/S0031-9422(97)00540-2
17-(5-ethyl-6-methylheptan-2-yl)-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol 86821 Click to see CCC(CCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)O)C)C)C(C)C 414.70 unknown https://doi.org/10.1016/S0031-9422(97)00540-2
b-Sitostenone 579897 Click to see 412.70 unknown https://doi.org/10.1016/S0031-9422(97)00540-2
Stigmast-4-en-3-one 5484202 Click to see CCC(CCC(C)C1CCC2C1(CCC3C2CCC4=CC(=O)CCC34C)C)C(C)C 412.70 unknown https://doi.org/10.1016/S0031-9422(97)00540-2
Stigmast-5-en-3-ol 22012 Click to see 414.70 unknown https://doi.org/10.1016/S0031-9422(97)00540-2
> Organic acids and derivatives / Peptidomimetics / Hybrid peptides
Me-bAla(2-OH,3-heptyl)-DL-Tyr-DL-N(Me)Leu-DL-Pro-DL-Tyr-OMe 163129860 Click to see 782.00 unknown https://doi.org/10.1016/S0031-9422(97)00540-2

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