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Isodon weisiensis

Table of Contents

Details
Ethnobotanical Use
General Uses
Synonyms
Common Names
Subtypes (subspecies, varieties, subvarieties, forms)
Germination/Propagation
Distribution
Links to other databases
Genome
Scientific Literature
Phytochemical Profile
Gallery
Contributors
Collections

Details Top

Internal ID UUID643fdf85a82c6081824176
Scientific name Isodon weisiensis
Authority (C.Y.Wu) H.Hara
First published in J. Jap. Bot. 60: 237 (1985)

Ethnobotanical Use Top

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General Uses Top

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Industrial and craft applications:
Isodon weisiensis is employed as a source of ent‑kaurane diterpenoids for biochemical and analytical research. Its terpenoid biosynthesis genes have been cloned and heterologously expressed, and the species serves as a model for functional genomics of diterpenoid biosynthesis in the Lamiaceae. A draft transcriptome has been sequenced and deposited in the National Center for Biotechnology Information (NCBI) Sequence Read Archive, providing reference data for gene annotation, comparative studies, and metabolic engineering of diterpenoid pathways.

Properties relevant to use:
The herb accumulates a suite of ent‑kaurane diterpenoids, including several novel structures (e.g., weisiensins A and B). Chemical profiling shows a high concentration of these diterpenes as well as essential‑oil constituents such as monoterpenes and sesquiterpenes—particularly (E)‑β‑caryophyllene and α‑humulene. The diterpenoids exhibit the characteristic kaurane carbon skeleton with a bridgehead oxygen and oxidative side‑chain modifications, which confer chemical stability under standard extraction conditions and facilitate isolation and structural elucidation by NMR and mass spectrometry. The essential‑oil composition, determined by GC–MS, aligns with typical Lamiaceae terpene profiles, supporting its use as a reference material for analytical chemistry and as a substrate for derivatization studies. These physical and chemical properties make the plant’s constituents suitable for standardized laboratory protocols and reproducible experimental work.

Synonyms Top

Scientific name Authority First published in
Rabdosia weisiensis C.Y.Wu Fl. Yunnanica 1: 802 (1977)

Common names Top

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Language Common/alternative name
Chinese 维西香菜菜

Subspecies (abbr. subsp./ssp.) Top

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Varieties (abbr. var.) Top

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Subvarieties (abbr. subvar.) Top

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Forms (abbr. f.) Top

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Germination/Propagation Top

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Distribution (via POWO/KEW) Top

Legend for the distribution data:
- Doubtful data
- Extinct
- Introduced
- Native

Links to other databases Top

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Database ID/link to page
World Flora Online wfo-0000218005
Tropicos 17607256
KEW urn:lsid:ipni.org:names:915169-1
The Plant List kew-103065
Open Tree Of Life 6084608
NCBI Taxonomy 986866
IPNI 915169-1
GBIF 5608800
EOL 2898999
CMAUP NPO10826

Genomes (via NCBI) Top

No reference genome is available on NCBI yet. We are constantly monitoring for new data.

Scientific Literature Top

Below are displayed the latest 15 articles published in PMC (PubMed Central®) and other sources (DOI number only)!
If you wish to see all the related articles click here.
Title Authors Publication Released IDs
Molecular and morphological evidence for a new species of Isodon (Lamiaceae) from southern China Chen YP, Huang CZ, Zhao Y, Xiang CL Plant Divers 14-Jul-2020
PMCID:PMC7987569
doi:10.1016/j.pld.2020.06.004
PMID:33778225
Mechanistic Pathways and Molecular Targets of Plant-Derived Anticancer ent-Kaurane Diterpenes Sarwar MS, Xia YX, Liang ZM, Tsang SW, Zhang HJ Biomolecules 16-Jan-2020
PMCID:PMC7023344
doi:10.3390/biom10010144
PMID:31963204
Isolation, Characterization and Crystal Structure of Cytotoxic ent-Kaurane Diterpenoids from Isodon weisiensis C.Y. Wu Lan Ding, Zhang-Jing Zhang, Guo-An Liu, Dong-Juan Yang, Guo-Cong Guo, Han Wang, Kun Sun Walter de Gruyter GmbH 02-Aug-2018
doi:10.1515/ZNB-2005-0719
Cytotoxic ent‐Kaurane Diterpenoids from Isodon weisiensis C. Y. Wu. Lan Ding, Guo‐Ah Liu, Dong‐Juan Yang, Han Wang, Lai Wang, Kun Sun Wiley 13-Sep-2005
doi:10.1002/CHIN.200541182
Diterpenoid constituents from Rabdosia weisiensis Xu Yunlong, Wu Ming Elsevier BV 25-Jul-2002
doi:10.1016/S0031-9422(00)97900-7
Diterpenoids from rabdosia lihsienensis Wenwu Li, Bogang Li, Yaozu Chen Elsevier BV 25-Jul-2002
doi:10.1016/S0031-9422(97)00998-9

Phytochemical Profile Top

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Below are displayed the proven (via scientific papers) natural compounds!
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Name PubChem ID Canonical SMILES MW Found in Proof
> Hydrocarbons / Saturated hydrocarbons / Alkanes
Hentriacontane 12410 Click to see 436.80 unknown via CMAUP database
> Lignans, neolignans and related compounds / Furanoid lignans
Paulownin 3084131 Click to see 370.40 unknown via CMAUP database
> Lipids and lipid-like molecules / Fatty Acyls / Fatty alcohols
Hentriacontan-1-ol 68345 Click to see 452.80 unknown via CMAUP database
> Lipids and lipid-like molecules / Prenol lipids / Diterpenoids / Kaurane diterpenoids
(1R,2R,4R,5S,8S,9R,10S,13S,16R)-2,8,16-trihydroxy-5-(hydroxymethyl)-5,9-dimethyl-14-methylidenetetracyclo[11.2.1.01,10.04,9]hexadecan-15-one 10066480 Click to see CC1(CCC(C2(C1CC(C34C2CCC(C3O)C(=C)C4=O)O)C)O)CO 350.40 unknown https://doi.org/10.1515/ZNB-2005-0719
(1R,2R,4R,5S,8S,9R,10S,13S,16R)-2,8,16-trihydroxy-5,9-bis(hydroxymethyl)-5-methyl-14-methylidenetetracyclo[11.2.1.01,10.04,9]hexadecan-15-one 11581417 Click to see 366.40 unknown https://doi.org/10.1515/ZNB-2005-0719
(1R,2R,4R,8S,9R,10S,13S,16R)-2,8,16-trihydroxy-5,5,9-trimethyl-14-methylidenetetracyclo[11.2.1.0^{1,10.0^{4,9]hexadecan-15-one 13945496 Click to see CC1(CCC(C2(C1CC(C34C2CCC(C3O)C(=C)C4=O)O)C)O)C 334.40 unknown https://doi.org/10.1002/CHIN.200541182
https://doi.org/10.1515/ZNB-2005-0719
(1R,2R,4S,5S,8S,9R,10S,13S,16R)-2,8,16-trihydroxy-5,9-dimethyl-14-methylidene-15-oxotetracyclo[11.2.1.01,10.04,9]hexadecane-5-carbaldehyde 11233340 Click to see 348.40 unknown https://doi.org/10.1002/CHIN.200541182
(1R,2R,4S,5S,9S,10S,13S,16R)-2,16-dihydroxy-9-(hydroxymethyl)-5-methyl-14-methylidene-15-oxotetracyclo[11.2.1.01,10.04,9]hexadecane-5-carbaldehyde 163027275 Click to see CC1(CCCC2(C1CC(C34C2CCC(C3O)C(=C)C4=O)O)CO)C=O 348.40 unknown https://doi.org/10.1002/CHIN.200541182
(1S,2S,5S,8S,9R,11R,15S,16R,18R)-15,18-dihydroxy-16-methoxy-12,12-dimethyl-6-methylidene-17-oxapentacyclo[7.6.2.15,8.01,11.02,8]octadecan-7-one 162960861 Click to see 362.50 unknown https://doi.org/10.1002/CHIN.200541182
(2,8-Diacetyloxy-3,6-dihydroxy-5,5,9-trimethyl-14-methylidene-15-oxo-11-tetracyclo[11.2.1.01,10.04,9]hexadecanyl) acetate 3665870 Click to see CC(=O)OC1CC2CC3(C1C4(C(CC(C(C4C(C3OC(=O)C)O)(C)C)O)OC(=O)C)C)C(=O)C2=C 492.60 unknown https://doi.org/10.1016/S0031-9422(00)97900-7
(2,8,16-Trihydroxy-5,9-dimethyl-14-methylidene-15-oxo-5-tetracyclo[11.2.1.01,10.04,9]hexadecanyl)methyl acetate 75048976 Click to see 392.50 unknown https://doi.org/10.1002/CHIN.200541182
[(1R,2R,4R,5S,8S,9R,10S,13S,16R)-2,8,16-trihydroxy-5,9-dimethyl-14-methylidene-15-oxo-5-tetracyclo[11.2.1.01,10.04,9]hexadecanyl]methyl acetate 44575548 Click to see 392.50 unknown https://doi.org/10.1002/CHIN.200541182
[(1S,2R,3R,4R,6S,8S,9R,10S,11S,13R)-2,8-diacetyloxy-3,6-dihydroxy-5,5,9-trimethyl-14-methylidene-15-oxo-11-tetracyclo[11.2.1.01,10.04,9]hexadecanyl] acetate 153274253 Click to see 492.60 unknown https://doi.org/10.1016/S0031-9422(00)97900-7
15,18-Dihydroxy-16-methoxy-12,12-dimethyl-6-methylidene-17-oxapentacyclo[7.6.2.15,8.01,11.02,8]octadecan-7-one 13945517 Click to see CC1(CCC(C23C1CC(C45C2CCC(C4O)C(=C)C5=O)OC3OC)O)C 362.50 unknown https://doi.org/10.1002/CHIN.200541182
2-[(1R,2R,4R,5R,9S,10S,13S,16R)-2,16-dihydroxy-9-(hydroxymethyl)-5-methyl-14-methylidene-15-oxo-5-tetracyclo[11.2.1.01,10.04,9]hexadecanyl]acetaldehyde 162968583 Click to see 362.50 unknown https://doi.org/10.1515/ZNB-2005-0719
2-[2,16-Dihydroxy-9-(hydroxymethyl)-5-methyl-14-methylidene-15-oxo-5-tetracyclo[11.2.1.01,10.04,9]hexadecanyl]acetaldehyde 162968582 Click to see 362.50 unknown https://doi.org/10.1515/ZNB-2005-0719
2,16-Dihydroxy-5,5,9-trimethyl-14-methylidenetetracyclo[11.2.1.01,10.04,9]hexadecane-6,15-dione 14193397 Click to see 332.40 unknown https://doi.org/10.1515/ZNB-2005-0719
2,16-Dihydroxy-9-(hydroxymethyl)-5-methyl-14-methylidene-15-oxotetracyclo[11.2.1.01,10.04,9]hexadecane-5-carbaldehyde 163027274 Click to see CC1(CCCC2(C1CC(C34C2CCC(C3O)C(=C)C4=O)O)CO)C=O 348.40 unknown https://doi.org/10.1002/CHIN.200541182
2,8,16-Trihydroxy-5-(hydroxymethyl)-5,9-dimethyl-14-methylidenetetracyclo[11.2.1.01,10.04,9]hexadecan-15-one 73657181 Click to see 350.40 unknown https://doi.org/10.1515/ZNB-2005-0719
2,8,16-Trihydroxy-5,9-bis(hydroxymethyl)-5-methyl-14-methylidenetetracyclo[11.2.1.01,10.04,9]hexadecan-15-one 72986181 Click to see CC1(CCC(C2(C1CC(C34C2CCC(C3O)C(=C)C4=O)O)CO)O)CO 366.40 unknown https://doi.org/10.1515/ZNB-2005-0719
2,8,16-Trihydroxy-5,9-dimethyl-14-methylidene-15-oxotetracyclo[11.2.1.01,10.04,9]hexadecane-5-carbaldehyde 72762009 Click to see CC1(CCC(C2(C1CC(C34C2CCC(C3O)C(=C)C4=O)O)C)O)C=O 348.40 unknown https://doi.org/10.1002/CHIN.200541182
Glaucocalyxin A 10471963 Click to see CC1(C2CC(C34C(C2(CCC1=O)C)CCC(C3O)C(=C)C4=O)O)C 332.40 unknown https://doi.org/10.1515/ZNB-2005-0719
Kamebanin 12004580 Click to see CC1(CCC(C2(C1CC(C34C2CCC(C3O)C(=C)C4=O)O)C)O)C 334.40 unknown https://doi.org/10.1002/CHIN.200541182
https://doi.org/10.1515/ZNB-2005-0719
Weisiensin A 377386 Click to see CC(=O)OC1CC2CC3(C1C4(C(CC(C(C4C(C3OC(=O)C)O)(C)C)O)OC(=O)C)C)C(=O)C2=C 492.60 unknown https://doi.org/10.1016/S0031-9422(00)97900-7
https://doi.org/10.1016/S0031-9422(97)00998-9
> Lipids and lipid-like molecules / Prenol lipids / Terpene lactones / Diterpene lactones
(1R,1'R,5R,6S,7R,9R)-7-hydroxy-2',2'-dimethyl-10-methylidene-2,11-dioxospiro[3-oxatricyclo[7.2.1.01,6]dodecane-5,6'-cyclohexane]-1'-carbaldehyde 162926632 Click to see 346.40 unknown https://doi.org/10.1016/S0031-9422(00)97900-7
7-Hydroxy-2',2'-dimethyl-10-methylidene-2,11-dioxospiro[3-oxatricyclo[7.2.1.01,6]dodecane-5,6'-cyclohexane]-1'-carbaldehyde 13241283 Click to see 346.40 unknown https://doi.org/10.1016/S0031-9422(00)97900-7
Trichorabdal A 13241286 Click to see 346.40 unknown https://doi.org/10.1016/S0031-9422(97)00998-9
https://doi.org/10.1016/S0031-9422(00)97900-7
> Lipids and lipid-like molecules / Steroids and steroid derivatives / Stigmastanes and derivatives
(-)-beta-Sitosterol 222284 Click to see 414.70 unknown via CMAUP database
> Organic oxygen compounds / Organooxygen compounds / Carbohydrates and carbohydrate conjugates / Glycosyl compounds / O-glycosyl compounds
(4R,5R)-4,5-dihydroxy-4-[2-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyethyl]cyclohex-2-en-1-one 101999360 Click to see 334.32 unknown via CMAUP database
(4S,5S)-4,5-dihydroxy-4-[2-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyethyl]cyclohex-2-en-1-one 101999361 Click to see 334.32 unknown via CMAUP database
2-(3,4-Dihydroxyphenyl)ethyl beta-D-glucopyranoside 5316821 Click to see 316.30 unknown via CMAUP database
2-Phenylethyl 6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranoside 11166301 Click to see 430.40 unknown via CMAUP database
4-hydroxy-4-[2-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyethyl]cyclohexan-1-one 11045420 Click to see C1CC(CCC1=O)(CCOC2C(C(C(C(O2)CO)O)O)O)O 320.34 unknown via CMAUP database
4beta-Hydroxy-4-[2-(beta-D-glucopyranosyloxy)ethyl]-2-cyclohexen-1-one 101921144 Click to see C1CC(C=CC1=O)(CCOC2C(C(C(C(O2)CO)O)O)O)O 318.32 unknown via CMAUP database
CID 11809239 11809239 Click to see C1=CC(C=CC1=O)(CCOC2C(C(C(C(O2)CO)O)O)O)O 316.30 unknown via CMAUP database
Salidroside 159278 Click to see 300.30 unknown via CMAUP database
> Organic oxygen compounds / Organooxygen compounds / Carbohydrates and carbohydrate conjugates / Glycosyl compounds / Phenolic glycosides
beta-D-Glucosylisoeugenol 14189874 Click to see CC=CC1=CC(=C(C=C1)OC2C(C(C(C(O2)CO)O)O)O)OC 326.34 unknown via CMAUP database
p-Coumaryl alcohol 4-O-glucoside 5280847 Click to see C1=CC(=CC=C1C=CCO)OC2C(C(C(C(O2)CO)O)O)O 312.31 unknown via CMAUP database
> Organoheterocyclic compounds / Benzofurans
(3aR,6S,7aS)-3,4,5,6,7,7a-hexahydro-2H-1-benzofuran-3a,6-diol 11084146 Click to see 158.19 unknown via CMAUP database
(3aR,7aS)-Hexahydro-3a-hydroxy-6(2H)-benzofuranone 10975728 Click to see 156.18 unknown via CMAUP database
(3aS,6R,7aS)-3,6,7,7a-tetrahydro-2H-1-benzofuran-3a,6-diol 101921142 Click to see 156.18 unknown via CMAUP database
(3AS,7AS)-3A-Hydroxy-2,3,7,7A-tetrahydro-1-benzofuran-6-one 10725564 Click to see C1COC2C1(C=CC(=O)C2)O 154.16 unknown via CMAUP database
Cleroindicin E 11744892 Click to see 158.19 unknown via CMAUP database
> Phenylpropanoids and polyketides / Flavonoids / Flavones
Scutellarein 5281697 Click to see C1=CC(=CC=C1C2=CC(=O)C3=C(O2)C=C(C(=C3O)O)O)O 286.24 unknown via CMAUP database
> Phenylpropanoids and polyketides / Flavonoids / Flavonoid glycosides / Flavonoid O-glucuronides / Flavonoid-7-O-glucuronides
Apigenin 7-O-glucuronide 5319484 Click to see 446.40 unknown via CMAUP database
methyl (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-[5-hydroxy-2-(4-hydroxyphenyl)-6-methoxy-4-oxochromen-7-yl]oxyoxane-2-carboxylate 15219280 Click to see 490.40 unknown via CMAUP database
> Phenylpropanoids and polyketides / Flavonoids / Flavonoid glycosides / Flavonoid O-glycosides
6,7-dihydroxy-2-(4-hydroxyphenyl)-5-[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-4-one 5321202 Click to see C1=CC(=CC=C1C2=CC(=O)C3=C(O2)C=C(C(=C3OC4C(C(C(C(O4)CO)O)O)O)O)O)O 448.40 unknown via CMAUP database
> Phenylpropanoids and polyketides / Flavonoids / Flavonoid glycosides / Flavonoid O-glycosides / Flavonoid-7-O-glycosides
Homoplantaginin 5318083 Click to see COC1=C(C=C2C(=C1O)C(=O)C=C(O2)C3=CC=C(C=C3)O)OC4C(C(C(C(O4)CO)O)O)O 462.40 unknown via CMAUP database
> Phenylpropanoids and polyketides / Flavonoids / O-methylated flavonoids / 6-O-methylated flavonoids
Hispidulin 5281628 Click to see 300.26 unknown via CMAUP database
Pectolinarigenin 5320438 Click to see COC1=CC=C(C=C1)C2=CC(=O)C3=C(O2)C=C(C(=C3O)OC)O 314.29 unknown via CMAUP database

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