Isodon scoparius

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Common products:
- Dried aerial parts (leaves and stems) of Isodon scoparius are supplied to research laboratories as a source of ent‑kaurane diterpenoids, used as model substrates for biosynthetic pathway investigations, as authentic standards for chromatographic analyses, and as building blocks for synthetic derivatization in chemical‑library construction.
- Botanical reference specimens of I. scoparius are offered by herbarium networks for taxonomic verification and as voucher material in phytochemical studies.
- Commercial suppliers offer research‑grade extracts or purified diterpenoids from I. scoparius for high‑throughput screening and synthetic chemistry libraries.
- The ent‑kaurane diterpenoids isolated from I. scoparius are catalogued in the Dictionary of Natural Products (DNP) and assigned CAS numbers for computational reference.

Properties relevant to use:
- The plant accumulates ent‑kaurane diterpenoids with highly oxygenated, tetracyclic carbon skeletons. These molecules exhibit strong UV absorbance (λmax ≈ 210–260 nm) due to conjugated carbonyl groups, facilitating low‑level detection by HPLC and MS.
- Isolated diterpenoids from I. scoparius display melting points typical of ent‑kaurane diterpenoids (generally above 150 °C), indicating good crystallinity and stability under ambient laboratory conditions.
- The compounds are readily soluble in common organic solvents such as methanol, ethyl acetate, and chloroform, allowing efficient extraction and purification by liquid‑liquid partitioning.
- Minor flavonoids and phenolic acids present in the extract provide additional chromophoric groups, useful as internal standards for quantitative analyses.
- Phenolic acids in the extract have pKa values around 5–7, enabling selective extraction under acidic or basic conditions.

Standards and regulation:
- No plant‑specific food, cosmetic, or timber standards exist for Isodon scoparius. Research extracts and isolated compounds are subject to general chemical safety legislation (e.g., OECD guidelines for testing of chemicals, EU REACH, US TSCA) when produced or handled in quantity.
- Institutional biosafety and laboratory‑safety protocols govern the handling of the plant material and its extracts.
- If produced in quantities exceeding 1 ton per year, the diterpenoids fall under EU REACH registration requirements.

Sustainability and sourcing:
- Isodon scoparius occurs naturally in forested habitats of southwestern China. Commercial harvesting is limited to small, non‑destructive collection of aerial biomass for research; no large‑scale cultivation programs have been established.
- The low commercial demand and limited geographic range suggest that population impacts are minimal, and collection typically follows local guidelines for sustainable wild‑collection of forest plants.
- Herbarium specimens and dried plant material are supplied through botanical specimen networks, which maintain voucher samples for long‑term reference.
- No CITES restrictions apply to I. scoparius, reflecting its limited commercial trade.

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No reference genome is available on NCBI yet. We are constantly monitoring for new data.

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