Isodon rosthornii

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Internal ID UUID643fdf82422f8250096582
Scientific name Isodon rosthornii
Authority Kudô
First published in Mem. Fac. Sci. Taihoku Imp. Univ. 2: 135 (1929)

Ethnobotanical Use Top

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General Uses Top

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Common products:
• Dried aerial parts used in phytochemical analysis; isolated natural products serve as certified analytical standards in chromatography and spectrometry for diterpenoid authentication.

Scientific and model-organism uses:
• Ent-kaurane diterpenoids (rosthornins A–G and analogues) from I. rosthornii are studied in natural products chemistry and chemotaxonomy. They are used as test analytes in method development and validation for LC–MS/MS, GC–MS, HPLC, and NMR, enabling calibration curves and reference spectra for diterpene profiling. Specimens are preserved in herbaria and indexed in databases (e.g., Tropicos, GBIF, IPNI, Plants of the World Online) supporting taxonomic identity and traceability for research. I. rosthornii contributes comparative chemical data for reconstructing ent-kaurane biosynthetic pathways in Lamiaceae; its metabolites have been utilized in bioactivity screening as chemical probes (non-medicinal).

Synonyms Top

Scientific name Authority First published in
Plectranthus rosthornii Diels Bot. Jahrb. Syst. 29: 562 (1900)
Rabdosia rosthornii (Diels) H.Hara J. Jap. Bot. 47: 199 (1972)

Common names Top

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Language Common/alternative name
Chinese 瘿花香茶菜

Subspecies (abbr. subsp./ssp.) Top

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Varieties (abbr. var.) Top

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Subvarieties (abbr. subvar.) Top

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Forms (abbr. f.) Top

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Germination/Propagation Top

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Distribution (via POWO/KEW) Top

Legend for the distribution data:
- Doubtful data
- Extinct
- Introduced
- Native

Links to other databases Top

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Database ID/link to page
World Flora Online wfo-0000217953
Tropicos 17607250
KEW urn:lsid:ipni.org:names:448610-1
The Plant List kew-103018
Open Tree Of Life 1017559
NCBI Taxonomy 662925
IPNI 448610-1
GBIF 5608864
EOL 2898982

Genomes (via NCBI) Top

No reference genome is available on NCBI yet. We are constantly monitoring for new data.

Scientific Literature Top

Below are displayed the latest 15 articles published in PMC (PubMed Central®) and other sources (DOI number only)!
If you wish to see all the related articles click here.
Title Authors Publication Released IDs
A Comprehensive Review of the Classification, Sources, Phytochemistry, and Pharmacology of Norditerpenes Zeng N, Zhang Q, Yao Q, Fu G, Su W, Wang W, Li B Molecules 21-Dec-2023
PMCID:PMC10780140
doi:10.3390/molecules29010060
PMID:38202643
Molecular and morphological evidence for a new species of Isodon (Lamiaceae) from southern China Chen YP, Huang CZ, Zhao Y, Xiang CL Plant Divers 14-Jul-2020
PMCID:PMC7987569
doi:10.1016/j.pld.2020.06.004
PMID:33778225
Mechanistic Pathways and Molecular Targets of Plant-Derived Anticancer ent-Kaurane Diterpenes Sarwar MS, Xia YX, Liang ZM, Tsang SW, Zhang HJ Biomolecules 16-Jan-2020
PMCID:PMC7023344
doi:10.3390/biom10010144
PMID:31963204
Two Natural ent-kauranoids as Novel Wnt Signaling Inhibitors Zhang J, Kong LM, Zhan R, Ye ZN, Pu JX, Sun HD, Li Y Nat Prod Bioprospect 24-Apr-2014
PMCID:PMC4050307
doi:10.1007/s13659-014-0016-4
PMID:24955294
Bioactive ent-kaurane diterpenoids from Isodon rosthornii. Zhan R, Li XN, Du X, Wang WG, Dong K, Su J, Li Y, Pu JX, Sun HD J Nat Prod 26-Jul-2013
doi:10.1021/NP400190N
PMID:23819871
Isorosthornins A-C, new ent-kaurane diterpenoids from Isodon rosthornii Zhan R, Du X, Su J, Li XN, Wang WG, Liang CQ, Yang JH, Li Y, Pu JX, Sun HD Nat Prod Bioprospect 12-Dec-2011
PMCID:PMC4131646
doi:10.1007/s13659-011-0031-7
Diterpenoid constituents from Rabdosia rosthornii Xu Yunlong, Ma Yunbao Elsevier BV 25-Jul-2002
doi:10.1016/0031-9422(89)80316-4
Enmein type diterpenoids from Isodon japonica. Li B, Tian X Phytochemistry 01-Oct-2001
doi:10.1016/S0031-9422(01)00245-X
PMID:11576594

Phytochemical Profile Top

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Below are displayed the proven (via scientific papers) natural compounds!
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Name PubChem ID Canonical SMILES MW Found in Proof
> Lipids and lipid-like molecules / Prenol lipids / Diterpenoids / Kaurane diterpenoids
(11-Acetyloxy-2,13-dihydroxy-5,9-dimethyl-14-methylidene-15-oxo-5-tetracyclo[11.2.1.01,10.04,9]hexadecanyl)methyl acetate 14414483 Click to see 434.50 unknown https://doi.org/10.1016/0031-9422(89)80316-4
(1R,2S,3R,5S,8R,9S,10S,11R,18R)-3,9,10,18-tetrahydroxy-12,12-dimethyl-6-methylidene-17-oxapentacyclo[7.6.2.15,8.01,11.02,8]octadecan-7-one 73345999 Click to see CC1(CCCC23C1C(C(C45C2C(CC(C4O)C(=C)C5=O)O)(OC3)O)O)C 364.40 unknown https://doi.org/10.1021/NP400190N
(1R,2S,3S,5R,8S,9S,10S,11R,18S)-3,9,10,18-tetrahydroxy-12,12-dimethyl-6-methylidene-17-oxapentacyclo[7.6.2.15,8.01,11.02,8]octadecan-7-one 162912129 Click to see 364.40 unknown https://doi.org/10.1016/S0031-9422(01)00245-X
(1R,2S,3S,5S,6R,7R,8S,9R,10S,11R,18R)-6,12,12-trimethyl-17-oxapentacyclo[7.6.2.15,8.01,11.02,8]octadecane-3,7,9,10,18-pentol 71745895 Click to see 368.50 unknown https://doi.org/10.1021/NP400190N
(1R,2S,3S,5S,8R,9R,13S,14S,15R)-3,14-dihydroxy-11,11,16,16-tetramethyl-6-methylidene-10,12,21-trioxahexacyclo[11.6.2.01,15.02,8.05,9.08,13]henicosan-7-one 73356654 Click to see 404.50 unknown https://doi.org/10.1021/NP400190N
(1R,2S,5S,7R,8R,9S,10S,11R,15S,18R)-16-methoxy-12,12-dimethyl-6-methylidene-17-oxapentacyclo[7.6.2.15,8.01,11.02,8]octadecane-7,9,10,15,18-pentol 73353585 Click to see 396.50 unknown https://doi.org/10.1021/NP400190N
(1R,2S,5S,8R,9R,10S,11R,15S,16R,18R)-16-ethoxy-9,10,15,18-tetrahydroxy-12,12-dimethyl-6-methylidene-17-oxapentacyclo[7.6.2.15,8.01,11.02,8]octadecan-7-one 73353584 Click to see 408.50 unknown https://doi.org/10.1021/NP400190N
(1R,2S,5S,8R,9R,10S,11R,15S,16S,18R)-16-butoxy-9,10,15,18-tetrahydroxy-12,12-dimethyl-6-methylidene-17-oxapentacyclo[7.6.2.15,8.01,11.02,8]octadecan-7-one 11561169 Click to see CCCCOC1C23C4CCC5C(C4(C(=O)C5=C)C(O1)(C(C2C(CCC3O)(C)C)O)O)O 436.50 unknown https://doi.org/10.1021/NP400190N
(1R,2S,5S,8R,9S,10S,11R,15S,16S,18R)-9,10,15,18-tetrahydroxy-16-methoxy-12,12-dimethyl-6-methylidene-17-oxapentacyclo[7.6.2.15,8.01,11.02,8]octadecan-7-one 73356653 Click to see CC1(CCC(C23C1C(C(C45C2CCC(C4O)C(=C)C5=O)(OC3OC)O)O)O)C 394.50 unknown https://doi.org/10.1021/NP400190N
(1R,5R,8S,9R,10S,11R,15S)-9,10,15-trihydroxy-12,12-dimethyl-6-methylidene-17-oxapentacyclo[7.6.2.15,8.01,11.02,8]octadec-2-en-7-one 71745898 Click to see CC1(CCC(C23C1C(C(C45C2=CCC(C4)C(=C)C5=O)(OC3)O)O)O)C 346.40 unknown https://doi.org/10.1021/NP400190N
(1R,5S,7R,8R,9R,10S,11R,15S,18R)-12,12-dimethyl-6-methylidene-17-oxapentacyclo[7.6.2.15,8.01,11.02,8]octadec-2-ene-7,9,10,15,18-pentol 71745897 Click to see 364.40 unknown https://doi.org/10.1021/NP400190N
[(1S,2S,3S,5S,8R,9R,10S,11R,18R)-18-acetyloxy-9,10-dihydroxy-12,12-dimethyl-6-methylidene-7-oxo-17-oxapentacyclo[7.6.2.15,8.01,11.02,8]octadecan-3-yl] acetate 71745711 Click to see CC(=O)OC1CC2C(C3(C1C45CCCC(C4C(C3(OC5)O)O)(C)C)C(=O)C2=C)OC(=O)C 448.50 unknown https://doi.org/10.1021/NP400190N
[(1S,2S,5R,10S,11R,15S,18R)-9,10,18-trihydroxy-12,12-dimethyl-6-methylidene-7-oxo-17-oxapentacyclo[7.6.2.15,8.01,11.02,8]octadecan-15-yl] acetate 6325508 Click to see CC(=O)OC1CCC(C2C13COC(C2O)(C45C3CCC(C4O)C(=C)C5=O)O)(C)C 406.50 unknown https://doi.org/10.1021/NP400190N
[(1S,2S,5R,6R,8S,9R,10S,11R,12S,13S,15R)-9,10,13,15-tetrahydroxy-6,12-dimethyl-7-oxo-17-oxapentacyclo[7.6.2.15,8.01,11.02,8]octadecan-12-yl] acetate 73350630 Click to see CC1C2CCC3C(C2)(C1=O)C4(C(C5C3(CO4)C(CC(C5(C)OC(=O)C)O)O)O)O 410.50 unknown https://doi.org/10.1021/NP400190N
[(1S,2S,5S,6R,8R,9R,10S,11R,12R,15R,18R)-9,10,15,18-tetrahydroxy-6,12-dimethyl-7-oxo-17-oxapentacyclo[7.6.2.15,8.01,11.02,8]octadecan-12-yl] acetate 73347532 Click to see 410.50 unknown https://doi.org/10.1021/NP400190N
[13-Hydroxy-5-(hydroxymethyl)-5,9-dimethyl-14-methylidene-15-oxo-11-tetracyclo[11.2.1.01,10.04,9]hexadecanyl] acetate 14414481 Click to see 376.50 unknown https://doi.org/10.1016/0031-9422(89)80316-4
Effusanin A 34174827 Click to see 348.40 unknown https://doi.org/10.1021/NP400190N
Lasiokaurin 73348360 Click to see CC(=O)OC1CCC(C2C13COC(C2O)(C45C3CCC(C4O)C(=C)C5=O)O)(C)C 406.50 unknown https://doi.org/10.1021/NP400190N
Oridonin 5321010 Click to see CC1(CCC(C23C1C(C(C45C2CCC(C4O)C(=C)C5=O)(OC3)O)O)O)C 364.40 unknown https://doi.org/10.1021/NP400190N
rabdoternin E 44445766 Click to see 394.50 unknown https://doi.org/10.1021/NP400190N
Rosthornin A 14414480 Click to see CC(=O)OC1CC2(CC3(C1C4(CCCC(C4CC3)(C)CO)C)C(=O)C2=C)O 376.50 unknown https://doi.org/10.1016/0031-9422(89)80316-4
Rosthornin B 91895327 Click to see 434.50 unknown https://doi.org/10.1016/0031-9422(89)80316-4
> Lipids and lipid-like molecules / Prenol lipids / Terpene lactones / Diterpene lactones
(1R,2R,5S,6R,7R,8S,9R,10S,11R,18R)-7,9,10,18-tetrahydroxy-6,12,12-trimethyl-17-oxapentacyclo[7.6.2.15,8.01,11.02,8]octadecan-16-one 71745896 Click to see 366.40 unknown https://doi.org/10.1021/NP400190N
(1S,2R,4R,6S,9R,13S,16S,17R)-2-hydroxy-10,10-dimethyl-3-methylidene-8,15-dioxo-7,14-dioxapentacyclo[7.6.2.11,4.06,16.013,17]octadecane-17-carbaldehyde 73352131 Click to see CC1(CCC2C3(C1C(=O)OC4C3C5(CC(C4)C(=C)C5O)C(=O)O2)C=O)C 360.40 unknown https://doi.org/10.1021/NP400190N
[(1S,4R,8R,9R,11R,12R,13S,16S,18R)-9-hydroxy-11-methoxy-7,7-dimethyl-17-methylidene-2-oxo-3,10-dioxapentacyclo[14.2.1.01,13.04,12.08,12]nonadecan-18-yl] acetate 73356656 Click to see 420.50 unknown https://doi.org/10.1021/NP400190N
[(1S,4R,8R,9R,11S,12R,13S,14S,16R,18R)-9,14-dihydroxy-11-methoxy-7,7-dimethyl-17-methylidene-2-oxo-3,10-dioxapentacyclo[14.2.1.01,13.04,12.08,12]nonadecan-18-yl] acetate 73353586 Click to see 436.50 unknown https://doi.org/10.1021/NP400190N
Rabdoternin B 3086623 Click to see CC1(CCC(C23C1C(C(C45C2CCC(C4O)C(=C)C5O)(OC3=O)O)O)O)C 380.40 unknown https://doi.org/10.1021/NP400190N
> Lipids and lipid-like molecules / Steroids and steroid derivatives / Oxosteroids
Methyl 9-hydroxy-7-[2-[2-hydroxyethyl(methyl)amino]-2-oxoethylidene]-2-[2-(10-hydroxy-8-methoxycarbonyl-1,4b,8-trimethyl-9-oxo-1,3,4,4a,5,6,7,8a,10,10a-decahydrophenanthren-2-ylidene)acetyl]oxy-1,4a,8-trimethyl-10-oxo-2,3,4,4b,5,6,8,8a,9,10a-decahydrophenanthrene-1-carboxylate 74946683 Click to see CC1C2C(CCC1=CC(=O)N(C)CCO)C3(CCC(C(C3C(=O)C2O)(C)C(=O)OC)OC(=O)C=C4CCC5C(C4C)C(C(=O)C6C5(CCCC6(C)C(=O)OC)C)O)C 812.00 unknown https://doi.org/10.1016/0031-9422(89)80316-4
> Organoheterocyclic compounds / Lactones / Delta valerolactones
[(1S,2R,4R,8S,9R,13S,17S)-17-formyl-8-hydroxy-10,10-dimethyl-3-methylidene-15-oxo-7,14-dioxapentacyclo[7.6.2.11,4.06,16.013,17]octadec-6(16)-en-2-yl] acetate 73356655 Click to see 402.40 unknown https://doi.org/10.1021/NP400190N

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