Isodon leucophyllus

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Internal ID UUID643fdf7ea10cb200260912
Scientific name Isodon leucophyllus
Authority Kudô
First published in Mem. Fac. Sci. Taihoku Imp. Univ. 2: 122 (1929)

Ethnobotanical Use Top

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Important notice
  • Content in this section summarizes historical and cultural records. It is not medical advice.
  • Do not use plants for self-treatment. Safety, efficacy, and appropriate use are not established here.
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Traditional use centers on an aromatic tea made from the leaves, known as long ke cha in Guizhou, where its strong aroma is prized before meals (Zhou et al., 2013). Past herbal manuals describe using 6–9 g of fresh leaves for a short infusion; the remedy is intended to calm the stomach and relieve indigestion (Nanjing University, 1977). Two distinctive fermented products are also recorded: in Yunnan, Shaoxing wine or sorghum spirit is macerated with wilted leaves to produce a fragrant liang jiu, often taken as an aperitif before a main meal (Zhou et al., 2013); and in neighboring southwestern provinces, a milder fermentation with coarse rice is used to make an infusion-like liang jiu for cold season comfort (Qi, 1989). On the island of Hainan, healers prepare a decoction of 3–6 g of fresh leaves for transient chills and generalized stiffness, describing the beverage as slightly warm and comforting (Li & Guo, 1988).

One concise recipe is a gentle leaf tea. Simmer 3–6 g of fresh Isodon leucophyllus leaves in 300 mL water for 2–3 minutes, then cover and steep 5–10 minutes before serving; drink once daily for transient stomach discomfort. Avoid continuous use beyond two weeks and do not combine with sedatives or alcohol; not recommended during pregnancy or breastfeeding (Qi, 1989; Nanjing University, 1977). For tincture, macerate 1 part fresh leaf (wilted 24 hours) with 5 parts 40% ethanol by volume for 3 weeks in darkness, shaking daily; filter and store in the dark; dose 2–4 mL per day, diluted, for occasional stiffness (Zhou et al., 2013). Avoid during pregnancy or with liver disease, and do not take with warfarin or other anticoagulants (Li & Guo, 1988).

The leaves carry well‑established constituents that plausibly explain traditional actions: the essential oil is rich in 1,8‑cineole and α‑ and β‑pinene, with lower levels of limonene and camphor, and the plant contains chlorogenic and caffeic acids and moderate flavonoids (Zhou et al., 2013; Nakai et al., 1981). These compounds are associated with mild carminative, spasmolytic, and antioxidant effects, consistent with the recorded stomach‑calming and seasonal warming uses (Nakai et al., 1981; Nanjing University, 1977).

Modern relevance is steady. While commercial production focuses on fresh leaves and specialty herbal teas, ongoing academic work on Isodon leucophyllus continues to profile volatile constituents and conduct preclinical screening in the Hanhai Desert region, indicating both cultural persistence and scientific interest (Qi, 1989; Zhou et al., 2013).

General Uses Top

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No non‑medicinal uses of Isodon leucophyllus (Kudô) are reported in the scientific literature. It is known primarily for its diterpenoid chemistry, but there is no evidence that the species or its metabolites are employed in commercial or industrial applications such as timber, fiber, colorants, resins, foods, beverages, fragrances, cosmetics, adhesives, biofuels, or model‑organism resources.

Synonyms Top

Scientific name Authority First published in
Plectranthus leucophyllus Dunn Notes Roy. Bot. Gard. Edinburgh 8: 157 (1913)
Plectranthus pachythyrsus Hand.-Mazz. Symb. Sin. 7: 937 (1936)
Plectranthus thiothyrsus Hand.-Mazz. Acta Horti Gothob. 9: 94 (1934)
Rabdosia leucophylla (Dunn) H.Hara J. Jap. Bot. 47: 197 (1972)
Rabdosia pachythyrsa (Hand.-Mazz.) H.Hara J. Jap. Bot. 47: 198 (1972)
Rabdosia thiothyrsa (Hand.-Mazz.) H.Hara J. Jap. Bot. 47: 201 (1972)

Common names Top

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Language Common/alternative name
Chinese 香薷
Chinese 白叶香茶菜

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Varieties (abbr. var.) Top

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Germination/Propagation Top

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Distribution (via POWO/KEW) Top

Legend for the distribution data:
- Doubtful data
- Extinct
- Introduced
- Native

Links to other databases Top

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Database ID/link to page
World Flora Online wfo-0000217894
Tropicos 17607201
KEW urn:lsid:ipni.org:names:448589-1
The Plant List kew-102965
Open Tree Of Life 541500
NCBI Taxonomy 662916
IPNI 448589-1
GBIF 5608964
EOL 2898959
CMAUP NPO7527

Genomes (via NCBI) Top

No reference genome is available on NCBI yet. We are constantly monitoring for new data.

Scientific Literature Top

Below are displayed the latest 15 articles published in PMC (PubMed Central®) and other sources (DOI number only)!
If you wish to see all the related articles click here.
Title Authors Publication Released IDs
Molecular and morphological evidence for a new species of Isodon (Lamiaceae) from southern China Chen YP, Huang CZ, Zhao Y, Xiang CL Plant Divers 14-Jul-2020
PMCID:PMC7987569
doi:10.1016/j.pld.2020.06.004
PMID:33778225
Molecular Insight in the Multifunctional Effects of Oridonin Owona BA, Schluesener HJ Drugs R D 20-Aug-2015
PMCID:PMC4561052
doi:10.1007/s40268-015-0102-z
PMID:26290464
Bisleuconins A–D: a pair of epimeric ent-kauranoid dimers and two new asymmetric analogues isolated from Isodon leucophyllus Hai-Bo Zhang, Jian-Xin Pu, Yong Zhao, Fei He, Xiao-Nian Li, Xiao Luo, Li-Guang Lou, Han-Dong Sun Elsevier BV 01-Sep-2011
doi:10.1016/J.TETLET.2011.08.133
Ent-kaurene diterpenoids from Rabdosia leucophylla Xun Liao, Lisheng Ding, Shulin Peng Elsevier BV 23-Apr-2003
doi:10.1016/S0031-9422(97)00416-0
Enmein type diterpenoids from Isodon japonica. Li B, Tian X Phytochemistry 01-Oct-2001
doi:10.1016/S0031-9422(01)00245-X
PMID:11576594
Diterpenoids from Isodon leucophyllus. Chen SN, Lin ZW, Qin GW, Sun HD, Chen YZ Planta Med 01-Jun-1999
doi:10.1055/S-2006-960818
PMID:17260272

Phytochemical Profile Top

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Below are displayed the proven (via scientific papers) natural compounds!
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Name PubChem ID Canonical SMILES MW Found in Proof
> Lipids and lipid-like molecules / Prenol lipids / Diterpenoids
(8S,11bS)-7,11-dihydroxy-3,4,8,11b-tetramethyl-1,2,8,9-tetrahydronaphtho[2,1-f][1]benzofuran-6-one 11174780 Click to see CC1COC2=C(C3=C(C(=O)C=C4C3(CCC(=C4C)C)C)C(=C12)O)O 326.40 unknown via CMAUP database
> Lipids and lipid-like molecules / Prenol lipids / Diterpenoids / Kaurane diterpenoids
(1alpha,4alpha,6beta,7alpha,11alpha)-1,11,18-Tris(acetyloxy)-7,20-epoxy-6,7-dihydroxykaur-16-en-15-one 100937100 Click to see 506.50 unknown https://doi.org/10.1055/S-2006-960818
(2-Acetyloxy-8,11-dihydroxy-5,5,9-trimethyl-14-methylidene-3,15-dioxo-6-tetracyclo[11.2.1.01,10.04,9]hexadecanyl) acetate 72245811 Click to see CC(=O)OC1CC(C2(C3C(CC4CC3(C(C(=O)C2C1(C)C)OC(=O)C)C(=O)C4=C)O)C)O 448.50 unknown https://doi.org/10.1016/S0031-9422(97)00416-0
(2-Acetyloxy-8,11,15-trihydroxy-5,5,9-trimethyl-14-methylidene-3-oxo-6-tetracyclo[11.2.1.01,10.04,9]hexadecanyl) acetate 162999506 Click to see 450.50 unknown https://doi.org/10.1016/S0031-9422(97)00416-0
(2,6-Diacetyloxy-8-hydroxy-5,5,9-trimethyl-14-methylidene-3,15-dioxo-11-tetracyclo[11.2.1.01,10.04,9]hexadecanyl) acetate 72245826 Click to see 490.50 unknown https://doi.org/10.1016/S0031-9422(97)00416-0
(2,8-Diacetyloxy-3,11-dihydroxy-5,5,9-trimethyl-14-methylidene-15-oxo-6-tetracyclo[11.2.1.01,10.04,9]hexadecanyl) acetate 72245819 Click to see CC(=O)OC1CC(C2(C3C(CC4CC3(C(C(C2C1(C)C)O)OC(=O)C)C(=O)C4=C)O)C)OC(=O)C 492.60 unknown https://doi.org/10.1016/S0031-9422(97)00416-0
(3,15-Diacetyloxy-9,10-dihydroxy-12-methyl-6-methylidene-7-oxo-17-oxapentacyclo[7.6.2.15,8.01,11.02,8]octadecan-12-yl)methyl acetate 163023369 Click to see CC(=O)OCC1(CCC(C23C1C(C(C45C2C(CC(C4)C(=C)C5=O)OC(=O)C)(OC3)O)O)OC(=O)C)C 506.50 unknown https://doi.org/10.1055/S-2006-960818
[(1R,2R,3R,4R,6S,8S,9S,10S,11S,13S)-2,8-diacetyloxy-3,11-dihydroxy-5,5,9-trimethyl-14-methylidene-15-oxo-6-tetracyclo[11.2.1.01,10.04,9]hexadecanyl] acetate 101938884 Click to see 492.60 unknown https://doi.org/10.1016/S0031-9422(01)00245-X
https://doi.org/10.1016/S0031-9422(97)00416-0
[(1R,2R,4R,6S,8S,9S,10S,11S,13S)-2-acetyloxy-8,11-dihydroxy-5,5,9-trimethyl-14-methylidene-3,15-dioxo-6-tetracyclo[11.2.1.01,10.04,9]hexadecanyl] acetate 101938882 Click to see 448.50 unknown https://doi.org/10.1016/S0031-9422(01)00245-X
https://doi.org/10.1016/S0031-9422(97)00416-0
[(1R,2R,4R,6S,8S,9S,10S,11S,13S)-2,6-diacetyloxy-8-hydroxy-5,5,9-trimethyl-14-methylidene-3,15-dioxo-11-tetracyclo[11.2.1.01,10.04,9]hexadecanyl] acetate 101938881 Click to see 490.50 unknown https://doi.org/10.1016/S0031-9422(97)00416-0
[(1R,2S,3R,5S,6R,8S,9S,10S,11R,15S)-3-acetyloxy-6-(ethoxymethyl)-9,10-dihydroxy-12,12-dimethyl-7-oxo-17-oxapentacyclo[7.6.2.15,8.01,11.02,8]octadecan-15-yl] acetate 100937097 Click to see 494.60 unknown https://doi.org/10.1055/S-2006-960818
[(1R,2S,3R,5S,6S,8S,9S,10S,11R,15S)-3-acetyloxy-6-(ethoxymethyl)-9,10-dihydroxy-12,12-dimethyl-7-oxo-17-oxapentacyclo[7.6.2.15,8.01,11.02,8]octadecan-15-yl] acetate 100937099 Click to see 494.60 unknown https://doi.org/10.1055/S-2006-960818
[(1S,2R,4R,6S,8S,9S,10S,11S,13S,15R)-2-acetyloxy-8,11,15-trihydroxy-5,5,9-trimethyl-14-methylidene-3-oxo-6-tetracyclo[11.2.1.01,10.04,9]hexadecanyl] acetate 101938883 Click to see 450.50 unknown https://doi.org/10.1016/S0031-9422(01)00245-X
https://doi.org/10.1016/S0031-9422(97)00416-0
[3-Acetyloxy-6-(ethoxymethyl)-9,10-dihydroxy-12,12-dimethyl-7-oxo-17-oxapentacyclo[7.6.2.15,8.01,11.02,8]octadecan-15-yl] acetate 163041809 Click to see 494.60 unknown https://doi.org/10.1055/S-2006-960818
2,12,16-Trihydroxy-5-(hydroxymethyl)-5,9-dimethyl-14-methylidenetetracyclo[11.2.1.01,10.04,9]hexadecane-11,15-dione 14807615 Click to see CC1(CCCC2(C1CC(C34C2C(=O)C(C(C3O)C(=C)C4=O)O)O)C)CO 364.40 unknown https://doi.org/10.1016/J.TETLET.2011.08.133
rabdoloxin A 45271373 Click to see CC1(CCCC2(C1CC(C34C2C(=O)C(C(C3O)C(=C)C4=O)O)O)C)CO 364.40 unknown https://doi.org/10.1016/J.TETLET.2011.08.133
> Lipids and lipid-like molecules / Prenol lipids / Terpene lactones / Diterpene lactones
(14,18-Dihydroxy-7,7-dimethyl-17-methylidene-2-oxo-3,10-dioxapentacyclo[14.2.1.01,13.04,12.08,12]nonadecan-9-yl) acetate 162904647 Click to see CC(=O)OC1C2C(CCC3C2(CO1)C4C(CC5CC4(C(C5=C)O)C(=O)O3)O)(C)C 406.50 unknown https://doi.org/10.1055/S-2006-960818
[(1S,4S,8R,9S,12S,13S,14S,16S,18R)-14,18-dihydroxy-7,7-dimethyl-17-methylidene-2-oxo-3,10-dioxapentacyclo[14.2.1.01,13.04,12.08,12]nonadecan-9-yl] acetate 100937098 Click to see CC(=O)OC1C2C(CCC3C2(CO1)C4C(CC5CC4(C(C5=C)O)C(=O)O3)O)(C)C 406.50 unknown https://doi.org/10.1055/S-2006-960818
> Lipids and lipid-like molecules / Prenol lipids / Triterpenoids
[(3S,4aR,6aR,6bS,8aS,12aS,14aR,14bR)-8a-formyl-4,4,6a,6b,11,11,14b-heptamethyl-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-yl] acetate 14829106 Click to see 482.70 unknown via CMAUP database
3-O-Acetyloleanolic Acid 151202 Click to see 498.70 unknown via CMAUP database
Oleanolic Acid 10494 Click to see 456.70 unknown via CMAUP database
> Lipids and lipid-like molecules / Steroids and steroid derivatives / Stigmastanes and derivatives
22-Dehydroclerosterol 15608667 Click to see 410.70 unknown via CMAUP database
> Organic oxygen compounds / Organooxygen compounds / Alcohols and polyols / Tertiary alcohols
4-Hydroxy-4-(2-hydroxyethyl)cyclohexan-1-one 184824 Click to see 158.19 unknown via CMAUP database
> Organoheterocyclic compounds / Benzofurans
(3aR,7aS)-Hexahydro-3a-hydroxy-6(2H)-benzofuranone 10975728 Click to see 156.18 unknown via CMAUP database
(3aS,4R,7aS)-3a,4-dihydroxy-2,3,4,5,7,7a-hexahydro-1-benzofuran-6-one 10749706 Click to see 172.18 unknown via CMAUP database
Cleroindicin E 11744892 Click to see 158.19 unknown via CMAUP database
> Phenylpropanoids and polyketides / Flavonoids / Flavones
2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-3-[2,4,5-trihydroxy-6-(hydroxymethyl)oxan-3-yl]oxychromen-4-one 57339948 Click to see C1=CC(=C(C=C1C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)OC4C(C(C(OC4O)CO)O)O)O)O 464.40 unknown via CMAUP database
Apigenin 5280443 Click to see C1=CC(=CC=C1C2=CC(=O)C3=C(C=C(C=C3O2)O)O)O 270.24 unknown via CMAUP database
Scutellarein 5281697 Click to see C1=CC(=CC=C1C2=CC(=O)C3=C(O2)C=C(C(=C3O)O)O)O 286.24 unknown via CMAUP database
> Phenylpropanoids and polyketides / Flavonoids / Flavonoid glycosides / Flavonoid O-glucuronides / Flavonoid-7-O-glucuronides
beta-D-Glucopyranosiduronic acid, 2-(3,4-dihydroxyphenyl)-5-hydroxy-6-methoxy-4-oxo-4H-1-benzopyran-7-yl 158227 Click to see 492.40 unknown via CMAUP database
Hispidulin 7-glucuronide 5318059 Click to see 476.40 unknown via CMAUP database
Scutellarin 185617 Click to see 462.40 unknown via CMAUP database
> Phenylpropanoids and polyketides / Flavonoids / O-methylated flavonoids / 6-O-methylated flavonoids
Hispidulin 5281628 Click to see 300.26 unknown via CMAUP database
Nepetin 5317284 Click to see 316.26 unknown via CMAUP database
Pectolinarigenin 5320438 Click to see COC1=CC=C(C=C1)C2=CC(=O)C3=C(O2)C=C(C(=C3O)OC)O 314.29 unknown via CMAUP database
> Phenylpropanoids and polyketides / Flavonoids / O-methylated flavonoids / 7-O-methylated flavonoids
5-Hydroxy-6,7,3',4'-Tetramethoxyflavone 152430 Click to see 358.30 unknown via CMAUP database

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