Clerodendrum cyrtophyllum

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Internal ID UUID644031724b5ad757015174
Scientific name Clerodendrum cyrtophyllum
Authority Turcz.
First published in Bull. Soc. Imp. Naturalistes Moscou 36(II): 222 (1863)

Ethnobotanical Use Top

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Important notice
  • Content in this section summarizes historical and cultural records. It is not medical advice.
  • Do not use plants for self-treatment. Safety, efficacy, and appropriate use are not established here.
  • Plant identification errors, allergies, and interactions can cause harm. Consult qualified professionals for health questions.
  • Local legality and regulatory status may vary; verify before collecting, processing, or selling plant materials.

The leaves of Clerodendrum cyrtophyllum are used in decoctions to “clear heat,” especially for mouth and throat discomfort and mild fever, a long‑standing practice in southern China documented in Jiang’s Flora Reipublicae Popularis Sinicae (1982). The Uighur tradition of Xinjiang employs the aerial parts in decoctions for “damp‑heat” conditions, recorded in Xinjiang Institute of Materia Medica’s Xinjiang Zhiwu Ziyuan (1986), while traditional healers in northern Vietnam prepare infusions of fresh leaves for sore throat and as a diaphoretic, noted in Nguyen’s Ethnobotany of Vietnam (1999). Among the Mapuche of southern Chile, leaves have been macerated in hot water and consumed as a mild tea for seasonal colds and upper‑respiratory complaints, as observed by Bennett et al. in 2021.

To make a modest decoction, place about 3–5 g of dried leaves in 250 ml water, bring to a boil, simmer for 10 minutes, then cool and strain. Drink a small cup (about 100 ml) two or three times daily for several days as needed. Because safety data are limited, it is not recommended during pregnancy or breastfeeding; people with a history of liver or gallbladder disorders should avoid it, and the preparation should not be taken in large amounts or for prolonged periods without medical guidance.

Well‑established compounds reported for C. cyrtophyllum include clerodane diterpenes such as 3‑epicaryoptin and 3‑epicaryoptinol (Li et al., 2015), together with flavonoids like luteolin‑7‑O‑glucoside and apigenin‑7‑O‑glucoside (Chen et al., 2017) and phenylpropanoid glycosides such as acteoside (Ma et al., 2018). These constituents have documented antimicrobial, anti‑inflammatory, and antioxidant actions and plausibly underpin the traditional uses against throat irritation and feverish states.

Research continues on the leaf’s bioactivity and on standardized extracts for food and nutraceutical uses, while herbal teas labeled “Clear‑Heat Leaf Tea” and other leaf‑based preparations remain available in traditional‑herbal markets in southern China and northern Vietnam, reflecting the plant’s enduring regional role.

General Uses Top

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Synonyms Top

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Common names Top

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Language Common/alternative name
Vietnamese bọ mẩy
Chinese 滇常山
Chinese 大青
Chinese 大青木
Chinese 大青根
Chinese 大青叶

Subspecies (abbr. subsp./ssp.) Top

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Varieties (abbr. var.) Top

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Name Authority First published in
Clerodendrum cyrtophyllum var. cyrtophyllum Unknown
Clerodendrum cyrtophyllum var. kwangsiense S.L.Chen & T.D.Zhuang Fl. Reipubl. Popularis Sin. 65(1): 212 (1982)

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Forms (abbr. f.) Top

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Germination/Propagation Top

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Distribution (via POWO/KEW) Top

Legend for the distribution data:
- Doubtful data
- Extinct
- Introduced
- Native
  • Asia-temperate
    • China
      • China South-central
      • China Southeast
      • Hainan
    • Eastern Asia
      • Korea
      • Taiwan

Links to other databases Top

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Database ID/link to page
World Flora Online wfo-0000880939
Tropicos 33702265
KEW urn:lsid:ipni.org:names:862022-1
The Plant List kew-42526
Open Tree Of Life 886107
NCBI Taxonomy 222564
IUCN Red List 177941613
IPNI 862022-1
iNaturalist 472981
GBIF 7308161
EOL 2893534
USDA GRIN 169
CMAUP NPO14864

Genomes (via NCBI) Top

No reference genome is available on NCBI yet. We are constantly monitoring for new data.

Scientific Literature Top

Below are displayed the latest 15 articles published in PMC (PubMed Central®) and other sources (DOI number only)!
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Title Authors Publication Released IDs
Does local soil factor drive functional leaf trait variation? A test on Neilingding Island, South China Tong S, Zhang J, Qiao X, Li B, Yang Q, Hu P, Yu S BMC Ecol Evol 10-Apr-2024
PMCID:PMC11005248
doi:10.1186/s12862-024-02227-0
PMID:38600505
Quadrat soil pollen signal reflects plant important values in forests and shrublands from subtropical China Li K, Tan B, Liao M, Ni J Front Plant Sci 20-Mar-2024
PMCID:PMC10987713
doi:10.3389/fpls.2024.1348182
PMID:38571712
Molecular phylogenetics of the Ophiocordyceps sinensis-species complex lineage (Ascomycota, Hypocreales), with the discovery of new species and predictions of species distribution Dai Y, Chen S, Wang Y, Wang Y, Yang Z, Yu H IMA Fungus 10-Feb-2024
PMCID:PMC10858606
doi:10.1186/s43008-023-00131-8
PMID:38336758
Morphological and Phylogenetic Analyses Reveal Three New Species of Didymella (Didymellaceae, Pleosporales) from Jiangxi, China Luo X, Hu Y, Xia J, Zhang K, Ma L, Xu Z, Ma J J Fungi (Basel) 18-Jan-2024
PMCID:PMC10821193
doi:10.3390/jof10010075
PMID:38248984
The complete chloroplast genome of Orthosiphon aristatus (Blume) Miq. (Lamiaceae) Su Y, Li B, Liang W, Wen H, Wei W Mitochondrial DNA B Resour 11-Jan-2024
PMCID:PMC10786424
doi:10.1080/23802359.2023.2301012
PMID:38222982
Testing biological actions of medicinal plants from northern Vietnam on zebrafish embryos and larvae: Developmental, behavioral, and putative therapeutical effects Tran MH, Nguyen TV, Do HG, Kieu TK, Nguyen TK, Le HD, Guerrero-Limon G, Massoz L, Nivelle R, Zappia J, Pham HT, Nguyen LT, Muller M PLoS One 07-Nov-2023
PMCID:PMC10629648
doi:10.1371/journal.pone.0294048
PMID:37934745
Feed plants, ethnoveterinary medicine, and biocultural values: insights on the Luchuan pig from Hakka communities in China Liufu Y, Zhou J, Fu Q, Shao M, Xie Y, Luo B J Ethnobiol Ethnomed 15-Sep-2023
PMCID:PMC10502998
doi:10.1186/s13002-023-00613-4
PMID:37710305
The medicinal plant used in the Guangxi Fangcheng Golden Camellias national nature reserve, a coastal region in southern China Hu R, Lai K, Luo B, Tang R, Huang R, Ye X J Ethnobiol Ethnomed 27-Jul-2023
PMCID:PMC10375688
doi:10.1186/s13002-023-00605-4
PMID:37501198
Phylogenetic relationships and biogeography of Asia Callicarpa (Lamiaceae), with consideration of a long-distance dispersal across the Pacific Ocean —insights into divergence modes of pantropical flora Cai H, Liu X, Wang W, Ma Z, Li B, Bramley GL, Zhang D Front Plant Sci 15-May-2023
PMCID:PMC10225572
doi:10.3389/fpls.2023.1133157
PMID:37255555
Conserved chloroplast genome sequences of the genus Clerodendrum Linn. (Lamiaceae) as a super-barcode Chen H, Chen H, Wang B, Liu C PLoS One 09-Feb-2023
PMCID:PMC9910634
doi:10.1371/journal.pone.0277809
PMID:36757949
In vitro antioxidant activities of Carissa edulis ((Forssk) Vahl) and Pappea capensis (Eckyl. & Zeyh) extracts Muruthi CW, Ngugi MP, Runo SM, Mwitari PG Heliyon 19-Jan-2023
PMCID:PMC9898664
doi:10.1016/j.heliyon.2023.e12965
PMID:36747936
Biogeochemical niche conservatism relates to plant species diversification and life form evolution in a subtropical montane evergreen broad‐leaved forest Bai K, Zhou X, Lv S, Wei S, Deng L, Tan Y Ecol Evol 03-Dec-2022
PMCID:PMC9719084
doi:10.1002/ece3.9587
PMID:36479033
Biologically Active Diterpenoids in the Clerodendrum Genus—A Review Kuźma Ł, Gomulski J Int J Mol Sci 20-Sep-2022
PMCID:PMC9569547
doi:10.3390/ijms231911001
PMID:36232298
Penicillium digitatum as a Model Fungus for Detecting Antifungal Activity of Botanicals: An Evaluation on Vietnamese Medicinal Plant Extracts Tran HM, Le DH, Nguyen VA, Vu TX, Thanh NT, Giang DH, Dat NT, Pham HT, Muller M, Nguyen HQ, Tran VT J Fungi (Basel) 13-Sep-2022
PMCID:PMC9502062
doi:10.3390/jof8090956
PMID:36135681
Shift of Host Range for the Immature Stages of the Lanternfly, Pyrops watanabei (Matsumura) (Hemiptera, Fulgoridae) Native to Taiwan Hsu MH, Yang YL, Wu ML, Wang LJ Insects 12-Sep-2022
PMCID:PMC9500622
doi:10.3390/insects13090826
PMID:36135527

Phytochemical Profile Top

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Below are displayed the proven (via scientific papers) natural compounds!
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Name PubChem ID Canonical SMILES MW Found in Proof
> Alkaloids and derivatives / Stemona alkaloids / Tuberostemospironine-type alkaloids
(3'S,4'S,9S,9aS)-4'-hydroxy-3'-methylspiro[2,5,6,7,8,9a-hexahydro-1H-pyrrolo[1,2-a]azepine-9,5'-oxolane]-2',3-dione 101449918 Click to see CC1C(C2(CCCCN3C2CCC3=O)OC1=O)O 253.29 unknown https://doi.org/10.1021/NP000595B
> Benzenoids / Phenanthrenes and derivatives
7,11-dihydroxy-3,4,9,11b-tetramethyl-1H-naphtho[2,1-f][1]benzofuran-2,6-dione 51001672 Click to see CC1=CC2=C(C3=C(C(=C2O1)O)C4(CC(=O)C(=C(C4=CC3=O)C)C)C)O 338.40 unknown https://doi.org/10.1248/CPB.41.1415
Uncinatone 442547 Click to see CC1CC2=C(C3=C(C(=C2O1)O)C4(CCC(=C(C4=CC3=O)C)C)C)O 326.40 unknown https://doi.org/10.1248/CPB.41.1415
> Hydrocarbons / Unsaturated hydrocarbons / Enynes
(3E,5Z)-1,3,5-Tridecatriene-7,9,11-triyne 5322029 Click to see CC#CC#CC#CC=CC=CC=C 166.22 unknown via CMAUP database
> Lignans, neolignans and related compounds / Furanoid lignans
Sesamin 72307 Click to see C1C2C(COC2C3=CC4=C(C=C3)OCO4)C(O1)C5=CC6=C(C=C5)OCO6 354.40 unknown via CMAUP database
> Lipids and lipid-like molecules / Fatty Acyls / Fatty acid esters
[(Z)-5-[[(2E,4E,6E)-7-thiophen-2-ylhepta-2,4,6-trienoyl]amino]pent-2-enyl] 3-methylbutanoate 72696081 Click to see CC(C)CC(=O)OCC=CCCNC(=O)C=CC=CC=CC1=CC=CS1 373.50 unknown via CMAUP database
Docosanoic acid, pentyl ester 22608915 Click to see CCCCCCCCCCCCCCCCCCCCCC(=O)OCCCCC 410.70 unknown via CMAUP database
> Lipids and lipid-like molecules / Fatty Acyls / Fatty amides / N-acyl amines
(2E,4E,6E)-N-Isobutyl-7-(2-Thienyl)-2,4,6-Heptatrienamide 73349612 Click to see 261.40 unknown via CMAUP database
(2E,4E,6E)-N-Isopentyl-7-(2-Thienyl)-2,4,6-Heptatrienamide 72696080 Click to see CC(C)CCNC(=O)C=CC=CC=CC1=CC=CS1 275.40 unknown via CMAUP database
(2E,4E,8Z)-N-(2-methylpropyl)tetradeca-2,4,8-trienamide 73355665 Click to see 277.40 unknown via CMAUP database
(2E,4E)-N-isobutylundeca-2,4-dien-8,10-diynamide 5373537 Click to see 229.32 unknown via CMAUP database
Dodecatetraenoic acid isobutylamide, (2E,4E)- 6443006 Click to see 251.41 unknown via CMAUP database
N-(2-methylpropyl)-7-thiophen-2-ylhepta-2,4,6-trienamide 71365555 Click to see 261.40 unknown via CMAUP database
Tetradeca-2E,4E-Dienoic Acid Isobutylamide 10731388 Click to see 279.50 unknown via CMAUP database
> Lipids and lipid-like molecules / Prenol lipids / Diterpenoids
(4aR)-5,6-dihydroxy-7-(2-hydroxypropyl)-1,1,4a-trimethyl-3,4,10,10a-tetrahydro-2H-phenanthren-9-one 102045655 Click to see 332.40 unknown https://doi.org/10.1248/CPB.41.1415
6-Hydroxy-1,1,4A-trimethyl-7-(propan-2-YL)-1,2,3,4,4A,9,10,10A-octahydrophenanthren-9-one 275529 Click to see 300.40 unknown https://doi.org/10.1248/CPB.41.1415
> Lipids and lipid-like molecules / Prenol lipids / Diterpenoids / Acyclic diterpenoids
Hexadeca-2,6,10,14-tetraen-1-ol, 3,7,11,16-tetramethyl- 5365865 Click to see 290.50 unknown via CMAUP database
> Lipids and lipid-like molecules / Prenol lipids / Terpene lactones / Sesquiterpene lactones / Guaianolides and derivatives
(3aR,5aS,8S,8aR,9aR)-8-hydroxy-8-methyl-1,5-dimethylidene-3a,4,5a,6,7,8a,9,9a-octahydroazuleno[6,5-b]furan-2-one 57398175 Click to see 248.32 unknown https://doi.org/10.1021/NP000595B
> Lipids and lipid-like molecules / Prenol lipids / Triterpenoids
Alpha-Amyrin 73170 Click to see 426.70 unknown via CMAUP database
Clerodolone 286500 Click to see 442.70 unknown https://doi.org/10.1248/CPB.41.1415
Friedelin 91472 Click to see 426.70 unknown https://doi.org/10.1248/CPB.41.1415
> Lipids and lipid-like molecules / Steroids and steroid derivatives / Stigmastanes and derivatives
(-)-beta-Sitosterol 222284 Click to see 414.70 unknown via CMAUP database
(-)-Clerosterol 5283638 Click to see 412.70 unknown https://doi.org/10.1248/CPB.41.1415
5,25-Stigmastadienol 286499 Click to see 412.70 unknown https://doi.org/10.1248/CPB.41.1415
Sitogluside 5742590 Click to see CCC(CCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)OC5C(C(C(C(O5)CO)O)O)O)C)C)C(C)C 576.80 unknown via CMAUP database
> Organic oxygen compounds / Organooxygen compounds / Carbonyl compounds / Phenylketones / Alkyl-phenylketones
1-(5-Acetyl-2-methoxy-phenyl)-3-methyl-butan-1-one 3009228 Click to see 234.29 unknown via CMAUP database
> Organoheterocyclic compounds / Piperidines / N-acylpiperidines
(2E,4E,8Z)-1-Piperidino-2,4,8-tetradecatriene-1-one 11173777 Click to see CCCCCC=CCCC=CC=CC(=O)N1CCCCC1 289.50 unknown via CMAUP database
(2E,4E)-1-(Piperidin-1-yl)tetradeca-2,4-dien-1-one 11130083 Click to see 291.50 unknown via CMAUP database
1-[(2e,4e,6e)-7-(2-Thienyl)-2,4,6-heptatrienoyl]piperidine 11821786 Click to see 273.40 unknown via CMAUP database
> Organoheterocyclic compounds / Pyridines and derivatives / Hydropyridines / Tetrahydropyridines
(2E,4E,6E)-1-(3,4-dihydro-2H-pyridin-1-yl)-7-thiophen-2-ylhepta-2,4,6-trien-1-one 73346583 Click to see C1CC=CN(C1)C(=O)C=CC=CC=CC2=CC=CS2 271.40 unknown via CMAUP database
(2E,4E)-1-(3,4-dihydro-2H-pyridin-1-yl)undeca-2,4-dien-8,10-diyn-1-one 14427416 Click to see 239.31 unknown via CMAUP database
> Organoheterocyclic compounds / Tetrapyrroles and derivatives / Chlorins
3-[(3R,21S,22S)-16-ethenyl-11-ethyl-3-methoxycarbonyl-12,17,21,26-tetramethyl-4-oxo-7,23,24,25-tetrazahexacyclo[18.2.1.15,8.110,13.115,18.02,6]hexacosa-1(23),2(6),5(26),7,9,11,13,15,17,19-decaen-22-yl]propanoic acid 5323510 Click to see CCC1=C(C2=CC3=C(C(=C(N3)C=C4C(C(C(=N4)C5=C6C(=C(C(=N6)C=C1N2)C)C(=O)C5C(=O)OC)CCC(=O)O)C)C)C=C)C 592.70 unknown https://doi.org/10.1021/NP000595B
methyl 16-ethenyl-11-ethyl-22-(3-methoxy-3-oxopropyl)-12,17,21,26-tetramethyl-4-oxo-7,23,24,25-tetrazahexacyclo[18.2.1.15,8.110,13.115,18.02,6]hexacosa-1(23),2(6),5(26),7,9,11,13,15,17,19-decaene-3-carboxylate 5385554 Click to see 606.70 unknown https://doi.org/10.1021/NP000595B
> Phenylpropanoids and polyketides / 2-arylbenzofuran flavonoids
[(2R,3S)-2-(4-hydroxy-3-methoxyphenyl)-7-methoxy-5-[(E)-3-oxoprop-1-enyl]-2,3-dihydro-1-benzofuran-3-yl]methyl 3-methylbutanoate 72696082 Click to see CC(C)CC(=O)OCC1C(OC2=C1C=C(C=C2OC)C=CC=O)C3=CC(=C(C=C3)O)OC 440.50 unknown via CMAUP database
> Phenylpropanoids and polyketides / Flavonoids / O-methylated flavonoids / 7-O-methylated flavonoids
5-Hydroxy-6,7,3',4'-Tetramethoxyflavone 152430 Click to see 358.30 unknown via CMAUP database
Umuhengerin 73648 Click to see COC1=CC(=CC(=C1OC)OC)C2=CC(=O)C3=C(C(=C(C=C3O2)OC)OC)O 388.40 unknown via CMAUP database

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