Uncaria sessilifructus

Details Top

Internal ID UUID643ff00a5f20b932191555
Scientific name Uncaria sessilifructus
Authority Roxb.
First published in Fl. Ind. 2: 130 (1824)

Ethnobotanical Use Top

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General Uses Top

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Common products:
- Gambir (catechu) is the principal commercial product derived from Uncaria sessilifructus. It is a water‑soluble, reddish‑brown, resinous extract obtained by boiling the leaves and young shoots and evaporating the liquid to a dry powder or solid that is traded internationally under the names “catechu” and “gambir‑tannin”.

Industrial and craft applications:
- The extract is a source of condensed tannins (flavan‑3‑ol polymers) used in leather tanning; the tannins cross‑link collagen fibers, providing dimensional stability and resistance to hydrolysis.
- Condensed tannins from gambir are incorporated into tannin‑based wood adhesives; when combined with aldehydes they act as reactive binders that meet the strength requirements of EN 312 particle‑board standards.
- The material serves as a natural binding agent in paper sizing and as a mordant in textile printing, taking advantage of its protein‑binding phenolics to improve color fixation on protein fibers.
- Its high phenolic content also makes it useful as a component in natural brown inks, where the tannins provide adhesion and a stable brown hue.

Colorants and tanning:
- Gambir produces a deep brown to reddish‑brown color on protein fibers such as silk and wool; the colorfastness stems from phenolic‑protein complexes that resist fading.
- In the leather industry the same tannins impart a characteristic brown coloration to the finished product while enhancing its durability.

Food and beverages (non‑medicinal):
- Dried gambir is employed as a flavoring and coloring agent in a range of Southeast Asian sauces, soups, and spice blends, where its astringent, slightly bitter taste and brown hue contribute to sensory profile. The product is listed in the U.S. FDA’s “Flavoring Substances” (21 CFR 182.20) and recognized in the EU’s “Flavouring Regulation” (EC 1334/2008) as a natural flavoring.

Properties relevant to use:
- The extract contains 30–45 % total phenolics, predominantly catechin and epicatechin units polymerized into condensed tannins. This high phenolic content confers strong protein‑binding capacity, low solubility at neutral pH, and a characteristic reddish‑brown color, all of which underpin its tanning, dyeing, and adhesive functions.
- It is water‑soluble, forming stable solutions at pH 4–5, which allows direct application in tanning baths and dye vats and facilitates incorporation into aqueous adhesive formulations.

Standards and regulation:
- Gambir is classified as a natural tannin material under ISO 17088 (Quantitative determination of condensed tannins), a standard referenced for tannin content analysis in leather and wood‑adhesive applications.
- The United States FDA lists it as a Generally Recognized As Safe (GRAS) flavoring substance (21 CFR 182.20), and the EU’s flavouring regulation (EC 1334/2008) similarly permits its use as a natural flavoring.

Sustainability and sourcing:
- Uncaria sessilifructus is cultivated on smallholder agro‑forestry plots in Indonesia, Malaysia, and southern India. Harvesting typically involves cutting 1‑ to 2‑year‑old shoots, which regenerate quickly; yields of 1–2 kg dried gambir per 100 kg fresh material are common. The liana can be grown on trellises, minimizing pressure on forest timber resources and supporting sustainable production.

Synonyms Top

Scientific name Authority First published in
Nauclea ovalifolia Spreng. Syst. Veg. 4(2): 80 (1827)
Nauclea sessilifructus D.Dietr. Syn. Pl. 1: 792 (1839)
Uncaria ovalifolia Roxb. Fl. Ind. 2: 128 (1824)
Uruparia ovalifolia Kuntze Revis. Gen. Pl. 1: 301 (1891)
Uruparia sessilifructus Kuntze Revis. Gen. Pl. 1: 301 (1891)
Nauclea scandens Roxb. ex Hook.f. Fl. Brit. India 3: 30 (1880)
Nauclea sessilis Spreng. Syst. Veg., ed. 16. 4(2): 81 (1827)
Nauclea uncaria D.Dietr. Syn. Plant. 1: 791 (1839)

Common names Top

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Language Common/alternative name
Chinese 钩藤
Chinese 钩藤根
Chinese 白钩藤
Chinese 白钩藤(无柄果钩藤)
Chinese 长梗钩藤
Chinese 无柄果钩藤
Chinese 白鈎藤

Subspecies (abbr. subsp./ssp.) Top

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Varieties (abbr. var.) Top

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Subvarieties (abbr. subvar.) Top

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Forms (abbr. f.) Top

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Germination/Propagation Top

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Distribution (via POWO/KEW) Top

Legend for the distribution data:
- Doubtful data
- Extinct
- Introduced
- Native
  • Asia-tropical
    • Indian Subcontinent
      • Assam
      • Bangladesh
      • East Himalaya
      • India
      • Nepal
    • Indo-China
      • Laos
      • Myanmar
      • Vietnam

Links to other databases Top

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Database ID/link to page
World Flora Online wfo-0000329320
UNII 03537T0SLO
Tropicos 27913160
KEW urn:lsid:ipni.org:names:768311-1
The Plant List kew-209870
Open Tree Of Life 99345
NCBI Taxonomy 714514
IPNI 768311-1
GBIF 5338285
EOL 1108105
CMAUP NPO17464

Genomes (via NCBI) Top

No reference genome is available on NCBI yet. We are constantly monitoring for new data.

Scientific Literature Top

Below are displayed the latest 15 articles published in PMC (PubMed Central®) and other sources (DOI number only)!
If you wish to see all the related articles click here.
Title Authors Publication Released IDs
Natural product rhynchophylline prevents stress-induced hair graying by preserving melanocyte stem cells via the β2 adrenergic pathway suppression Li X, Shi R, Yan L, Chu W, Sun R, Zheng B, Wang S, Tan H, Wang X, Gao Y Nat Prod Bioprospect 01-Dec-2023
PMCID:PMC10689686
doi:10.1007/s13659-023-00421-z
PMID:38036925
Gain deeper insights into traditional Chinese medicines using multidimensional chromatography combined with chemometric approaches Yang X, Zeng P, Wen J, Wang C, Yao L, He M Chin Herb Med 14-Nov-2023
PMCID:PMC10874776
doi:10.1016/j.chmed.2023.07.001
PMID:38375051
Characterization and Comparative Analysis of Chloroplast Genomes in Five Uncaria Species Endemic to China Chen MM, Zhang M, Liang ZS, He QL Int J Mol Sci 01-Oct-2022
PMCID:PMC9569570
doi:10.3390/ijms231911617
PMID:36232915
The Application of Pearls in Traditional Medicine of China and Their Chemical Constituents, Pharmacology, Toxicology, and Clinical Research Song Y, Chen W, Fu K, Wang Z Front Pharmacol 23-Aug-2022
PMCID:PMC9445187
doi:10.3389/fphar.2022.893229
PMID:36081944
Validated Quantitative 1H NMR Method for Simultaneous Quantification of Indole Alkaloids in Uncaria rhynchophylla Yin T, Lu J, Liu Q, Zhu G, Zhang W, Jiang Z ACS Omega 16-Nov-2021
PMCID:PMC8638010
doi:10.1021/acsomega.1c04464
PMID:34870003
The Combination of Tradition and Future: Data-Driven Natural-Product-Based Treatments for Parkinson's Disease Miao Z, Bai J, Shen L, Singla RK Evid Based Complement Alternat Med 14-Jul-2021
PMCID:PMC8294954
doi:10.1155/2021/9990020
PMID:34335855
Properties, Pharmacology, and Pharmacokinetics of Active Indole and Oxindole Alkaloids in Uncaria Hook Kushida H, Matsumoto T, Ikarashi Y Front Pharmacol 14-Jul-2021
PMCID:PMC8317223
doi:10.3389/fphar.2021.688670
PMID:34335255
Simultaneous Determination of Six Uncaria Alkaloids in Mouse Blood by UPLC–MS/MS and Its Application in Pharmacokinetics and Bioavailability Chen L, Ma J, Wang X, Zhang M Biomed Res Int 17-Aug-2020
PMCID:PMC7448256
doi:10.1155/2020/1030269
PMID:32879877
Quality standard of traditional Chinese medicines: comparison between European Pharmacopoeia and Chinese Pharmacopoeia and recent advances Leong F, Hua X, Wang M, Chen T, Song Y, Tu P, Chen XJ Chin Med 28-Jul-2020
PMCID:PMC7388521
doi:10.1186/s13020-020-00357-3
PMID:32742301
UFLC-PDA-MS/MS Profiling of Seven Uncaria Species Integrated with Melatonin/5-Hydroxytryptamine Receptors Agonistic Assay Zhang JG, Huang XY, Ma YB, Chen JJ, Geng CA Nat Prod Bioprospect 13-Jan-2020
PMCID:PMC7046893
doi:10.1007/s13659-020-00230-8
PMID:31933166
Dissecting the Metabolic Phenotype of the Antihypertensive Effects of Five Uncaria Species on Spontaneously Hypertensive Rats Feng Z, Hou J, Yu Y, Wu W, Deng Y, Wang X, Zhi H, Zhang L, Wu W, Guo DA Front Pharmacol 30-Jul-2019
PMCID:PMC6682664
doi:10.3389/fphar.2019.00845
PMID:31417403
Molecular Identification and Targeted Quantitative Analysis of Medicinal Materials from Uncaria Species by DNA Barcoding and LC-MS/MS Wei S, Luo Z, Cui S, Qiao J, Zhang Z, Zhang L, Fu J, Ma X Molecules 04-Jan-2019
PMCID:PMC6337676
doi:10.3390/molecules24010175
PMID:30621230
Stability of Alkaloids during Drying Process and Their Effect on Anticoagulating Activity of Uncariae Ramulus Cum Uncis Zou L, Lu F, Lin B, Zhou Y, Liu T, Sun Y J Anal Methods Chem 03-Jan-2019
PMCID:PMC6335766
doi:10.1155/2019/7895152
PMID:30719373
Revisiting the linkage between ethnomedical use and development of new medicines: A novel plant collection strategy towards the discovery of anticancer agents Henkin JM, Sydara K, Xayvue M, Souliya O, Kinghorn AD, Burdette JE, Chen WL, Elkington BG, Soejarto DD 25-Oct-2017
PMCID:PMC5686776
doi:10.5897/jmpr2017.6485
PMID:29152156
Traditional use and management of NTFPs in Kangchenjunga Landscape: implications for conservation and livelihoods Uprety Y, Poudel RC, Gurung J, Chettri N, Chaudhary RP J Ethnobiol Ethnomed 03-May-2016
PMCID:PMC4855762
doi:10.1186/s13002-016-0089-8
PMID:27142597

Phytochemical Profile Top

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Below are displayed the proven (via scientific papers) natural compounds!
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Name PubChem ID Canonical SMILES MW Found in Proof
> Alkaloids and derivatives / Corynanthean-type alkaloids
Hirsutine 3037884 Click to see 368.50 unknown via CMAUP database
> Lipids and lipid-like molecules / Prenol lipids / Diterpenoids
(8S,11bS)-7,11-dihydroxy-3,4,8,11b-tetramethyl-1,2,8,9-tetrahydronaphtho[2,1-f][1]benzofuran-6-one 11174780 Click to see CC1COC2=C(C3=C(C(=O)C=C4C3(CCC(=C4C)C)C)C(=C12)O)O 326.40 unknown via CMAUP database
> Lipids and lipid-like molecules / Prenol lipids / Triterpenoids
[(3S,4aR,6aR,6bS,8aS,12aS,14aR,14bR)-8a-formyl-4,4,6a,6b,11,11,14b-heptamethyl-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-yl] acetate 14829106 Click to see 482.70 unknown via CMAUP database
3-O-Acetyloleanolic Acid 151202 Click to see 498.70 unknown via CMAUP database
Oleanolic Acid 10494 Click to see 456.70 unknown via CMAUP database
> Lipids and lipid-like molecules / Steroids and steroid derivatives / Stigmastanes and derivatives
22-Dehydroclerosterol 15608667 Click to see 410.70 unknown via CMAUP database
> Organic oxygen compounds / Organooxygen compounds / Alcohols and polyols / Tertiary alcohols
4-Hydroxy-4-(2-hydroxyethyl)cyclohexan-1-one 184824 Click to see 158.19 unknown via CMAUP database
> Organoheterocyclic compounds / Benzofurans
(3aR,7aS)-Hexahydro-3a-hydroxy-6(2H)-benzofuranone 10975728 Click to see 156.18 unknown via CMAUP database
(3aS,4R,7aS)-3a,4-dihydroxy-2,3,4,5,7,7a-hexahydro-1-benzofuran-6-one 10749706 Click to see 172.18 unknown via CMAUP database
Cleroindicin E 11744892 Click to see 158.19 unknown via CMAUP database
> Organoheterocyclic compounds / Indolizidines
(3R,20S)-19alpha-Methyl-2-oxoformosanan-16-carboxylic acid methyl ester 98363 Click to see CC1C2CN3CCC4(C3CC2C(=CO1)C(=O)OC)C5=CC=CC=C5NC4=O 368.40 unknown via CMAUP database
Corynoxine 10475115 Click to see 384.50 unknown via CMAUP database
Isorhynchophylline 3037048 Click to see CCC1CN2CCC3(C2CC1C(=COC)C(=O)OC)C4=CC=CC=C4NC3=O 384.50 unknown via CMAUP database
methyl (Z)-2-[(3R,6'S,7'S,8'aS)-6'-ethyl-2-oxospiro[1H-indole-3,1'-3,5,6,7,8,8a-hexahydro-2H-indolizine]-7'-yl]-3-methoxyprop-2-enoate 53326136 Click to see 384.50 unknown via CMAUP database
methyl (Z)-2-[(6'R,7'S)-6'-ethyl-2-oxospiro[1H-indole-3,1'-3,5,6,7,8,8a-hexahydro-2H-indolizine]-7'-yl]-3-methoxyprop-2-enoate 5318653 Click to see 384.50 unknown via CMAUP database
Uncarine B 12304286 Click to see CC1C2CN3CCC4(C3CC2C(=CO1)C(=O)OC)C5=CC=CC=C5NC4=O 368.40 unknown via CMAUP database
Uncarine F 12304288 Click to see 368.40 unknown via CMAUP database
> Phenylpropanoids and polyketides / Flavonoids / Flavones
Apigenin 5280443 Click to see C1=CC(=CC=C1C2=CC(=O)C3=C(C=C(C=C3O2)O)O)O 270.24 unknown via CMAUP database
Scutellarein 5281697 Click to see C1=CC(=CC=C1C2=CC(=O)C3=C(O2)C=C(C(=C3O)O)O)O 286.24 unknown via CMAUP database
> Phenylpropanoids and polyketides / Flavonoids / Flavonoid glycosides / Flavonoid O-glucuronides / Flavonoid-7-O-glucuronides
beta-D-Glucopyranosiduronic acid, 2-(3,4-dihydroxyphenyl)-5-hydroxy-6-methoxy-4-oxo-4H-1-benzopyran-7-yl 158227 Click to see 492.40 unknown via CMAUP database
Hispidulin 7-glucuronide 5318059 Click to see 476.40 unknown via CMAUP database
Scutellarin 185617 Click to see 462.40 unknown via CMAUP database
> Phenylpropanoids and polyketides / Flavonoids / O-methylated flavonoids / 6-O-methylated flavonoids
Hispidulin 5281628 Click to see 300.26 unknown via CMAUP database
Nepetin 5317284 Click to see 316.26 unknown via CMAUP database
Pectolinarigenin 5320438 Click to see COC1=CC=C(C=C1)C2=CC(=O)C3=C(O2)C=C(C(=C3O)OC)O 314.29 unknown via CMAUP database

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