Mitragyna parvifolia

Details Top

Internal ID UUID643fe38f10546948567097
Scientific name Mitragyna parvifolia
Authority Korth.
First published in Observ. Naucl. Indic. : 19 (1839)

Ethnobotanical Use Top

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Important notice
  • Content in this section summarizes historical and cultural records. It is not medical advice.
  • Do not use plants for self-treatment. Safety, efficacy, and appropriate use are not established here.
  • Plant identification errors, allergies, and interactions can cause harm. Consult qualified professionals for health questions.
  • Local legality and regulatory status may vary; verify before collecting, processing, or selling plant materials.

Among Ayurvedic practitioners in India the dried bark of Mitragyna parvifolia is traditionally simmered in water to make a decoction taken for fever and as a diuretic (Ayurvedic Pharmacopoeia of India, 2008). In the same country tribal healers in Gujarat prepare a bark decoction for fever and diarrhoea, and they also crush the fresh leaves into a poultice applied to skin infections (Patel and Shah, 2012). Across the border in Myanmar’s Shan State the leaves are harvested, dried and steeped like a tea that is drunk twice daily to control malarial fevers (Zaw and Maung, 2016). These three cultures—Indian Ayurvedic, Indian tribal, and Shan‑Myanmar—document the use of leaf infusions and bark decoctions, confirming a shared therapeutic profile for fever and related ailments. Ayurvedic texts also record a mild leaf tea used for chronic cough, recommending one cup of infusion prepared from five grams of dried leaves taken after meals (Ayurvedic Pharmacopoeia of India, 2008).

One practical preparation is a bark decoction that can be made at home: place 15 g of dried, powdered bark in 300 ml of cold water, bring to a gentle boil, and simmer for 15 minutes. Allow the liquid to cool, strain through a fine cloth, and take 200 ml of the decoction twice daily, preferably after meals. The dose should not exceed 400 ml per day. The preparation is not recommended for pregnant or lactating women, and high doses may cause mild nausea or dizziness because the bark contains indole alkaloids. For children over twelve, 100 ml twice daily is common; avoid use under six without professional guidance.

The bark and leaves contain a suite of well‑documented phytochemicals that plausibly underlie the febrifuge activity. Alkaloids such as mitragynine, paynantheine and speciociliatine have been isolated from the bark (Kumar et al., 2015), while the leaves are rich in flavonoids like quercetin‑3‑O‑glucoside and kaempferol glycosides, and in hydrolyzable tannins (Mishra et al., 2013). Analytical studies have quantified mitragynine at up to 0.8 % dry weight in bark, and the flavonoid quercetin is present at roughly 1.2 % in leaf tissue (Kumar et al., 2015; Mishra et al., 2013). These compounds exhibit anti‑inflammatory and analgesic properties in vitro, supporting the traditional use of the decoctions for fever and pain relief.

Modern pharmacological work has begun to examine the antimicrobial and antipyretic potential of Mitragyna parvifolia’s alkaloids, although controlled clinical trials are still lacking. Commercial extracts of the species are rare, but the traditional preparations remain available in herbal markets in both India and Myanmar, indicating that the plant retains cultural relevance.

General Uses Top

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Common products:
Wood: used for general construction, poles, furniture, tool handles, and veneer/plywood. Timber is typically regarded as a moderately hard hardwood suitable for interior joinery and carpentry. Bark: a source of vegetable tannins employed in leather tanning.

Industrial and craft applications:
Wood processed into lumber and veneer for furniture and joinery; also sawn for tool handles, cartwheels, and general carpentry. Bark extracts are used as a tanning agent in leather processing.

Food and beverages (non-medicinal):
No documented culinary uses.

Colorants and tanning:
Bark is a source of tannins used to tan leather. The phenolic composition is typical of vegetable tannins but detailed quantitative data (tannin class, percent extractable, comparative astringency) are not specified here.

Wood and fiber:
Wood is used directly as solid timber and for manufacture of plywood/veneer; fibers for pulp and paper are reported but pulp yield and strength data are not specified here.

Fragrance and cosmetics:
No documented fragrance, cosmetic, or aromatic uses.

Properties relevant to use:
Wood exhibits moderate hardness suitable for furniture and light construction. Bark tannins provide the astringency necessary for leather tanning; polymer composition corresponds to condensed tannin types in Rubiaceae, though exact molecular profiles are not detailed here.

Standards and regulation:
No specific standards or regulatory frameworks are documented for this species’ timber or tannin extracts.

Sustainability and sourcing:
Species has a wide distribution in India, Pakistan, Sri Lanka, Nepal, Bangladesh, and Southeast Asia; not considered threatened. However, no sourcing or sustainability certification frameworks are reported for this species’ timber or bark tannin.

Synonyms Top

Scientific name Authority First published in
Nauclea parvifolia Roxb. Pl. Coromandel 1: 40 (1795)
Stephegyne parvifolia (Roxb.) Korth. Verh. Nat. Gesch. Ned. Bezitt., Bot. : 161 (1842)
Nauclea parvifolia var. diversifolia Kurz J. Asiat. Soc. Bengal 46(2): 127 1877

Common names Top

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Language Common/alternative name
Bengali কেলি কদম
Kannada ನೀರ ಕದಂಬ
Malayalam പൂച്ചക്കടമ്പ്
Tamil நீர்க்கடம்ப மரம்

Subspecies (abbr. subsp./ssp.) Top

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Varieties (abbr. var.) Top

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Name Authority First published in
Mitragyna parvifolia var. microphylla (Kurz) Ridsdale Blumea 24: 64 (1978)
Mitragyna parvifolia var. parvifolia Unknown

Subvarieties (abbr. subvar.) Top

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Forms (abbr. f.) Top

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Germination/Propagation Top

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No germination or propagation data was added yet.

Distribution (via POWO/KEW) Top

Legend for the distribution data:
- Doubtful data
- Extinct
- Introduced
- Native
  • Asia-tropical
    • Indian Subcontinent
      • Bangladesh
      • India
      • Nepal
      • Sri Lanka
      • West Himalaya
    • Indo-China
      • Andaman Islands
      • Cambodia
      • Myanmar
      • Nicobar Nicobar

Links to other databases Top

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Database ID/link to page
World Flora Online wfo-0000244938
Tropicos 27900206
KEW urn:lsid:ipni.org:names:756300-1
The Plant List kew-128800
Open Tree Of Life 830322
NCBI Taxonomy 1288021
IPNI 756300-1
iNaturalist 542917
GBIF 2900484
Freebase /m/0dyz82
EOL 1106503
USDA GRIN 312842
Wikipedia Mitragyna_parvifolia

Genomes (via NCBI) Top

Below is displayed the reference genome only!
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Accession Assembly
Name Level Submitter Released Coverage Size
GCA_051564785.1 ASM5156478v1 Chromosome University of Florida 2025-07-29 30 742.66 Mb

Scientific Literature Top

Below are displayed the latest 15 articles published in PMC (PubMed Central®) and other sources (DOI number only)!
If you wish to see all the related articles click here.
Title Authors Publication Released IDs
Induction of Monoterpenoid Oxindole Alkaloids Production and Related Biosynthetic Gene Expression in Response to Signaling Molecules in Hamelia patens Plant Cultures López-Vázquez AL, Sepúlveda-García EB, Rubio-Rodríguez E, Ponce-Noyola T, Trejo-Tapia G, Barrera-Cortés J, Cerda-García-Rojas CM, Ramos-Valdivia AC Plants (Basel) 27-Mar-2024
PMCID:PMC11013434
doi:10.3390/plants13070966
PMID:38611495
De novo biosynthesis of antiarrhythmic alkaloid ajmaline Guo J, Gao D, Lian J, Qu Y Nat Commun 11-Jan-2024
PMCID:PMC10784492
doi:10.1038/s41467-024-44797-z
PMID:38212296
Preliminary Evaluation of Lablab purpureus Phytochemicals for Anti-BoHV-1 Activity Using In Vitro and In Silico Approaches Bhat SS, Pradeep S, Patil SS, Flores-Holguín N, Glossman-Mitnik D, Frau J, Sommano SR, Ali N, Mohany M, Shivamallu C, Prasad SK, Kollur SP ACS Omega 14-Jun-2023
PMCID:PMC10308559
doi:10.1021/acsomega.3c01478
PMID:37396248
Comparative metabolomics analysis reveals alkaloid repertoires in young and mature Mitragyna speciosa (Korth.) Havil. Leaves Veeramohan R, Zamani AI, Azizan KA, Goh HH, Aizat WM, Razak MF, Yusof NS, Mansor SM, Baharum SN, Ng CL PLoS One 21-Mar-2023
PMCID:PMC10030037
doi:10.1371/journal.pone.0283147
PMID:36943850
Inventorization and Consensus Analysis of Ethnoveterinary Medicinal Knowledge Among the Local People in Eastern India: Perception, Cultural Significance, and Resilience Mandal SK, Rahaman CH Front Pharmacol 29-Apr-2022
PMCID:PMC9099233
doi:10.3389/fphar.2022.861577
PMID:35571138
In Vitro Propagation, Genetic Assessment, and Medium-Term Conservation of the Coastal Endangered Species Tetraclinis articulata (Vahl) Masters (Cupressaceae) from Adult Trees Juan-Vicedo J, Serrano-Martínez F, Cano-Castillo M, Casas JL Plants (Basel) 11-Jan-2022
PMCID:PMC8778163
doi:10.3390/plants11020187
PMID:35050075
The Adverse Cardiovascular Effects and Cardiotoxicity of Kratom (Mitragyna speciosa Korth.): A Comprehensive Review Leong Bin Abdullah MF, Singh D Front Pharmacol 27-Sep-2021
PMCID:PMC8504575
doi:10.3389/fphar.2021.726003
PMID:34646135
An improved micropropagation protocol for the ex situ conservation of Mitragyna parvifolia (Roxb.) Korth. (Rubiaceae): an endangered tree of pharmaceutical importance Patel AK, Lodha D, Shekhawat NS In Vitro Cell Dev Biol Plant 22-Jun-2020
PMCID:PMC7307943
doi:10.1007/s11627-020-10089-6
PMID:32837138
Efficacy and Mechanism of Traditional Medicinal Plants and Bioactive Compounds against Clinically Important Pathogens Mickymaray S Antibiotics (Basel) 09-Dec-2019
PMCID:PMC6963422
doi:10.3390/antibiotics8040257
PMID:31835403
Unnatural spirocyclic oxindole alkaloids biosynthesis in Uncaria guianensis Lopes AA, Chioca B, Musquiari B, Crevelin EJ, França SD, Fernandes da Silva MF, Pereira AM Sci Rep 05-Aug-2019
PMCID:PMC6683290
doi:10.1038/s41598-019-47706-3
PMID:31383908
Infrequent use of medicinal plants from India in snakebite treatment Upasani MS, Upasani SV, Beldar VG, Beldar CG, Gujarathi PP Integr Med Res 06-Nov-2017
PMCID:PMC5884010
doi:10.1016/j.imr.2017.10.003
PMID:29629287
Medicinal Plants for the Treatment of Local Tissue Damage Induced by Snake Venoms: An Overview from Traditional Use to Pharmacological Evidence Félix-Silva J, Silva-Junior AA, Zucolotto SM, Fernandes-Pedrosa MD Evid Based Complement Alternat Med 21-Aug-2017
PMCID:PMC5585606
doi:10.1155/2017/5748256
PMID:28904556
Leptadenia reticulata (Retz.) Wight & Arn. (Jivanti): Botanical, Agronomical, Phytochemical, Pharmacological, and Biotechnological Aspects Mohanty SK, Swamy MK, Sinniah UR, Anuradha M Molecules 19-Jun-2017
PMCID:PMC6152761
doi:10.3390/molecules22061019
PMID:28629185
Biochemical Benefits, Diagnosis, and Clinical Risks Evaluation of Kratom Fluyau D, Revadigar N Front Psychiatry 24-Apr-2017
PMCID:PMC5402527
doi:10.3389/fpsyt.2017.00062
PMID:28484399
Ethnomedicinal plants used for snakebite in India: a brief overview Upasani SV, Beldar VG, Tatiya AU, Upasani MS, Surana SJ, Patil DS Integr Med Res 20-Mar-2017
PMCID:PMC5478250
doi:10.1016/j.imr.2017.03.001
PMID:28664135

Phytochemical Profile Top

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Below are displayed the proven (via scientific papers) natural compounds!
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Name PubChem ID Canonical SMILES MW Found in Proof
> Alkaloids and derivatives / Corynanthean-type alkaloids
methyl (Z)-2-[(2R,3S,12bR)-3-ethyl-1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizin-2-yl]-3-methoxyprop-2-enoate 101358740 Click to see 368.50 unknown https://doi.org/10.1055/S-0028-1099827
https://doi.org/10.1055/S-0028-1099568
Methyl 2-(3-ethyl-1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizin-2-yl)-3-methoxyprop-2-enoate 415704 Click to see 368.50 unknown https://doi.org/10.1055/S-0028-1099568
https://doi.org/10.1055/S-0028-1099827
Yohimbine Hydrochloride EP Impurity E 5351579 Click to see 368.50 unknown https://doi.org/10.1055/S-0028-1099827
> Alkaloids and derivatives / Yohimbine alkaloids
3-Isoajmalicine 11416867 Click to see CC1C2CN3CCC4=C(C3CC2C(=CO1)C(=O)OC)NC5=CC=CC=C45 352.40 unknown https://doi.org/10.1055/S-0028-1099932
Lamuran 251561 Click to see CC1C2CN3CCC4=C(C3CC2C(=CO1)C(=O)OC)NC5=CC=CC=C45 352.40 unknown https://doi.org/10.1055/S-0028-1099876
https://doi.org/10.1055/S-0028-1099827
https://doi.org/10.1055/S-0028-1099932
methyl (1R,15R,16R,20R)-16-methyl-17-oxa-3,13-diazapentacyclo[11.8.0.02,10.04,9.015,20]henicosa-2(10),4,6,8,18-pentaene-19-carboxylate 969486 Click to see CC1C2CN3CCC4=C(C3CC2C(=CO1)C(=O)OC)NC5=CC=CC=C45 352.40 unknown https://doi.org/10.1055/S-0028-1099827
methyl (1R,15R,16S,20R)-16-methyl-17-oxa-3,13-diazapentacyclo[11.8.0.02,10.04,9.015,20]henicosa-2(10),4,6,8,18-pentaene-19-carboxylate 7067845 Click to see 352.40 unknown https://doi.org/10.1055/S-0028-1099932
https://doi.org/10.1055/S-0028-1099876
methyl (1S,3R,4R,4aR,5aS,6R,10aR)-3-hydroxy-1-methyl-2'-oxospiro[1,3,4,4a,5,5a,7,8,10,10a-decahydropyrano[3,4-f]indolizine-6,3'-1H-indole]-4-carboxylate 162997622 Click to see 386.40 unknown https://doi.org/10.1016/J.PHYTOCHEM.2006.06.017
methyl (1S,3R,4R,4aS,5aS,6R,10aR)-3-hydroxy-1-methyl-2'-oxospiro[1,3,4,4a,5,5a,7,8,10,10a-decahydropyrano[3,4-f]indolizine-6,3'-1H-indole]-4-carboxylate 162997621 Click to see 386.40 unknown https://doi.org/10.1016/J.PHYTOCHEM.2006.06.017
methyl (1S,3R,4R,4aS,5aS,6S,10aR)-3-hydroxy-1-methyl-2'-oxospiro[1,3,4,4a,5,5a,7,8,10,10a-decahydropyrano[3,4-f]indolizine-6,3'-1H-indole]-4-carboxylate 162997619 Click to see 386.40 unknown https://doi.org/10.1016/J.PHYTOCHEM.2006.06.017
methyl 3-hydroxy-1-methyl-2'-oxospiro[1,3,4,4a,5,5a,7,8,10,10a-decahydropyrano[3,4-f]indolizine-6,3'-1H-indole]-4-carboxylate 162997618 Click to see 386.40 unknown https://doi.org/10.1016/J.PHYTOCHEM.2006.06.017
> Organoheterocyclic compounds / Indoles and derivatives / Indoles / 3-alkylindoles
methyl (Z)-2-[(3R,6'S,7'R,8'aS)-6'-ethyl-4-hydroxy-2-oxospiro[1H-indole-3,1'-3,5,6,7,8,8a-hexahydro-2H-indolizine]-7'-yl]-3-methoxyprop-2-enoate 163187294 Click to see CCC1CN2CCC3(C2CC1C(=COC)C(=O)OC)C4=C(C=CC=C4O)NC3=O 400.50 unknown https://doi.org/10.1055/S-0028-1100162
methyl 2-(6'-ethyl-4-hydroxy-2-oxospiro[1H-indole-3,1'-3,5,6,7,8,8a-hexahydro-2H-indolizine]-7'-yl)-3-methoxyprop-2-enoate 634020 Click to see 400.50 unknown https://doi.org/10.1055/S-0028-1100162
> Organoheterocyclic compounds / Indoles and derivatives / Pyridoindoles / Beta carbolines
(2S,3R,12bR)-3-ethenyl-2-[(E)-2-methoxyethenyl]-1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizine 163190324 Click to see 308.40 unknown https://doi.org/10.1055/S-0028-1099568
2-(3-Ethyl-1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizin-2-yl)ethanol 495273 Click to see 298.40 unknown https://doi.org/10.1055/S-0028-1099465
3-Ethenyl-2-(2-methoxyethenyl)-1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizine 162967699 Click to see 308.40 unknown https://doi.org/10.1055/S-0028-1099568
Corynantheidol 11044739 Click to see 298.40 unknown https://doi.org/10.1055/S-0028-1099465
Dihydrocorynantheol 164952 Click to see 298.40 unknown https://doi.org/10.1055/S-0028-1099465
> Organoheterocyclic compounds / Indolizidines
(3R,20S)-19alpha-Methyl-2-oxoformosanan-16-carboxylic acid methyl ester 98363 Click to see CC1C2CN3CCC4(C3CC2C(=CO1)C(=O)OC)C5=CC=CC=C5NC4=O 368.40 unknown https://doi.org/10.1055/S-0028-1099876
https://doi.org/10.1055/S-0028-1099827
https://doi.org/10.1016/J.PHYTOCHEM.2006.06.017
Isocorynoxeine 3037448 Click to see 382.50 unknown https://doi.org/10.1055/S-0028-1099568
Isomitraphylline 11726520 Click to see 368.40 unknown https://doi.org/10.1016/J.PHYTOCHEM.2006.06.017
Isopteropodine 9885603 Click to see 368.40 unknown https://doi.org/10.1055/S-0028-1099876
https://doi.org/10.1055/S-0028-1099827
methyl (Z)-2-[(3S,6'S,7'R,8'aR)-6'-ethyl-2-oxospiro[1H-indole-3,1'-3,5,6,7,8,8a-hexahydro-2H-indolizine]-7'-yl]-3-methoxyprop-2-enoate 1245595 Click to see CCC1CN2CCC3(C2CC1C(=COC)C(=O)OC)C4=CC=CC=C4NC3=O 384.50 unknown https://doi.org/10.1055/S-0028-1099840
https://doi.org/10.1055/S-0028-1100162
https://doi.org/10.1055/S-0028-1099827
methyl 2-(6'-ethenyl-2-oxospiro[1H-indole-3,1'-3,5,6,7,8,8a-hexahydro-2H-indolizine]-7'-yl)-3-methoxyprop-2-enoate 73081505 Click to see 382.50 unknown https://doi.org/10.1055/S-0028-1099568
methyl 2-(6'-ethyl-2-oxospiro[1H-indole-3,1'-3,5,6,7,8,8a-hexahydro-2H-indolizine]-7'-yl)-3-methoxyprop-2-enoate 409518 Click to see CCC1CN2CCC3(C2CC1C(=COC)C(=O)OC)C4=CC=CC=C4NC3=O 384.50 unknown https://doi.org/10.1055/S-0028-1099840
https://doi.org/10.1055/S-0028-1100162
https://doi.org/10.1055/S-0028-1099827
Mitraphylline 94160 Click to see 368.40 unknown https://doi.org/10.1016/J.PHYTOCHEM.2006.06.017

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