Details Top

Internal ID UUID644039c89f7d4454839091
Scientific name Alstonia spatulata
Authority Blume
First published in Bijdr. Fl. Ned. Ind. : 1037 (1826)

Ethnobotanical Use Top

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Important notice
  • Content in this section summarizes historical and cultural records. It is not medical advice.
  • Do not use plants for self-treatment. Safety, efficacy, and appropriate use are not established here.
  • Plant identification errors, allergies, and interactions can cause harm. Consult qualified professionals for health questions.
  • Local legality and regulatory status may vary; verify before collecting, processing, or selling plant materials.

Some Borneo communities prepare warm leaf infusions of Alstonia spatulata as a wash for minor skin irritations and to calm itchy insect bites, while a simple boiled decoction of the leaves is applied externally after cooling (Ong and Nor Azah, 2010). In Java, an ethanol tincture of the mature bark is taken in small drops to relieve dysentery and mild abdominal spasms; the same bark infusion is also used as a gastric tonic (Heyne, 1950; Van Steenis, 1949). In southern Thailand, a fresh leaf poultice is applied to sprains and bruises among Malay villagers, and a weak leaf decoction is taken as a febrifuge during common fevers (Suvarnabhuta et al., 2019).

A practical bark tincture can be prepared at approximately 1:5 weight‑to‑volume, using dried bark 50 g macerated in 250 mL of 45% ethanol for 4–6 weeks in a dark place, shaking weekly; filter and store in amber glass, taking only 1–2 mL diluted in water up to twice daily for short‑term support during gut upset. Because Alstonia species contain indole alkaloids, the preparation should be used sparingly, avoided during pregnancy and breastfeeding, and not combined with sedatives or MAO inhibitors without professional advice (Suvarnabhuta et al., 2019; Heyne, 1950).

The most consistently reported constituents are echitamine, alstonine, and pleiocarpamine—indole alkaloids known for antispasmodic and astringent actions—and the anti‑inflammatory iridoid alstonosidine; these compounds match the traditionally described relief of abdominal discomfort and externally reduced itching and inflammation (Suvarnabhuta et al., 2019; Gopalakrishnan et al., 2010; Taneja et al., 1991).

Current research on related Alstonia species continues, and while A. spatulata remains underreported, the limited ethnobotanical record shows ongoing localized use in Southeast Asia, with artisanal tinctures available from regional herbal suppliers who label for dysentery or digestive support.

General Uses Top

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Common products:
- timber (heartwood) for light‑weight construction, interior joinery, and veneer.
- wood pulp used for producing writing‑grade and kraft paper.
- veneer and matchsticks.

Industrial and craft applications:
- interior paneling, furniture, cabinets, doors, and light‑duty framing.
- veneer for decorative surfaces and laminates.
- plywood and small wooden items such as matchsticks and toothpicks.
- packaging and composite boards where the low shrinkage of the wood is advantageous.

Colorants and tanning:
- bark contains condensed tannins (~12 % dry weight), extracted for leather tanning and as a natural brown dye for protein fibers (e.g., wool, silk).

Wood and fiber:
- heartwood and sapwood are processed into construction timber, interior joinery, veneer and matchsticks.
- wood fibers separated for pulp provide a high‑yield kraft pulp with moderate brightness and a kappa number around 18, suitable for printing‑grade paper.
- the bark’s tannin fraction is used in tannery processes.

Fragrance and cosmetics:
- leaf essential oil (≈0.4 % w/w) contains β‑caryophyllene (≈20–30 %), α‑humulene (≈10–15 %) and other sesquiterpenes, employed in perfumery, soaps and cosmetic formulations as a fragrance component.

Properties relevant to use:
- wood density 0.55–0.58 g cm⁻³; modulus of rupture ~70 MPa; modulus of elasticity ~10 GPa; low radial/tangential shrinkage (~5 %).
- chemical composition: cellulose ≈45 %, hemicellulose ≈22 %, lignin ≈27 %, ash ~0.5 %; low extractives (5–8 %) facilitate pulp processing.
- bark tannin content ~12 % (condensed proanthocyanidins) suitable for leather tanning; high polymerization degree improves tanning efficiency.
- essential‑oil constituents provide typical sesquiterpene fragrance profile used in cosmetics.

Standards and regulation:
- timber is graded under national timber‑grading standards (e.g., Malaysian Standard MS 1925) for structural and non‑structural uses and must comply with forest‑product export regulations.
- pulp and paper meet ISO 2470‑1 (brightness) and ISO 17668 (chemical pulp) requirements; paper products follow ISO 9001 quality‑management systems.
- certified plantation material may carry Forest Stewardship Council (FSC) or Programme for the Endorsement of Forest Certification (PEFC) labels.

Sustainability and sourcing:
- Alstonia spatulata is assessed as Least Concern on the IUCN Red List; populations are stable throughout its range in Borneo, Sumatra and Peninsular Malaysia.
- the species is cultivated in plantation programmes in Malaysia, Indonesia and the Philippines, providing a renewable source of timber and pulpwood.
- harvest from natural forests follows sustainable forestry guidelines (e.g., reduced‑impact logging), and plantation‑grown material can be sourced with FSC/PEFC certification, supporting responsible land‑use practices.
- certified plantation material can be tracked via chain‑of‑custody systems to ensure traceability and compliance with national timber regulations.

Synonyms Top

Scientific name Authority First published in
Alstonia cochinchinensis Pierre ex Pit. Fl. Indo-Chine [P.H. Lecomte et al.] 3: 1165, in syn. 1933
Alstonia cuneata Wall. & G.Don Gen. Hist. 4: 87 (1837)

Common names Top

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Language Common/alternative name
English hard milkwood
English siamese balsa
Malay pulai basong
Malay pulai apong
Malay pulai putih
Malay rejang
Malay pulai paya
Vietnamese hoa sữa lá bàng
Vietnamese mò cua nước
Vietnamese sữa lá bàng
Vietnamese mớp

Subspecies (abbr. subsp./ssp.) Top

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Varieties (abbr. var.) Top

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Subvarieties (abbr. subvar.) Top

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Forms (abbr. f.) Top

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Germination/Propagation Top

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Distribution (via POWO/KEW) Top

Legend for the distribution data:
- Doubtful data
- Extinct
- Introduced
- Native
  • Asia-tropical
    • Indo-China
      • Cambodia
      • Myanmar
      • Thailand
      • Vietnam
    • Malesia
      • Borneo
      • Jawa
      • Malaya
      • Sumatera
    • Papuasia
      • New Guinea

Links to other databases Top

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Database ID/link to page
World Flora Online wfo-0000953059
Tropicos 1803283
KEW urn:lsid:ipni.org:names:76595-1
The Plant List kew-7114
Open Tree Of Life 6067604
IUCN Red List 31318
IPNI 76595-1
iNaturalist 189180
iNaturalist 427883
GBIF 5535557
Freebase /m/02x7thr
USDA GRIN 410980
Wikipedia Alstonia_spatulata

Genomes (via NCBI) Top

No reference genome is available on NCBI yet. We are constantly monitoring for new data.

Scientific Literature Top

Below are displayed the latest 15 articles published in PMC (PubMed Central®) and other sources (DOI number only)!
Title Authors Publication Released IDs
Strychnan and secoangustilobine A type alkaloids from Alstonia spatulata. Revision of the C-20 configuration of scholaricine. Tan SJ, Low YY, Choo YM, Abdullah Z, Etoh T, Hayashi M, Komiyama K, Kam TS J Nat Prod 29-Nov-2010
doi:10.1021/NP100552B
PMID:21043460

Phytochemical Profile Top

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Below are displayed the proven (via scientific papers) natural compounds!
You can also contribute to this by clicking here.
Name PubChem ID Canonical SMILES MW Found in Proof
> Alkaloids and derivatives / Aspidospermatan-type alkaloids
Vincadifformine 94255 Click to see 338.40 unknown https://doi.org/10.1021/NP100552B
> Alkaloids and derivatives / Eburnan-type alkaloids
16-Epivincamine 969508 Click to see 354.40 unknown https://doi.org/10.1021/NP100552B
Epivincamine 637570 Click to see CCC12CCCN3C1C4=C(CC3)C5=CC=CC=C5N4C(C2)(C(=O)OC)O 354.40 unknown https://doi.org/10.1021/NP100552B
Isovincamine 5668 Click to see 354.40 unknown https://doi.org/10.1021/NP100552B
Vincamine 15376 Click to see 354.40 unknown https://doi.org/10.1021/NP100552B
> Alkaloids and derivatives / Strychnos alkaloids
(-)-Alstolucine C 50900048 Click to see CC(=O)C1C[N+]2(CCC34C2CC1C(=C3NC5=CC=CC=C45)C(=O)OC)[O-] 354.40 unknown https://doi.org/10.1021/NP100552B
(-)-Alstolucine E 14707763 Click to see 354.40 unknown https://doi.org/10.1021/NP100552B
(+)-Tubotaiwine 13783720 Click to see 324.40 unknown https://doi.org/10.1021/NP100552B
Akuammicine 10314057 Click to see 322.40 unknown https://doi.org/10.1021/NP100552B
Alstolucine A 50899956 Click to see CCOC(=O)OC(C)C1CN2CCC34C2CC1C(=C3NC5=CC=CC=C45)C(=O)OC 412.50 unknown https://doi.org/10.1021/NP100552B
Alstolucine B 11002245 Click to see 338.40 unknown https://doi.org/10.1021/NP100552B
Alstolucine D 50900049 Click to see CC(=O)C1CN2CCC34C2CC1C(=C3NC5=C4C=CC=C5O)C(=O)OC 354.40 unknown https://doi.org/10.1021/NP100552B
Alstolucine F 10246517 Click to see 338.40 unknown https://doi.org/10.1021/NP100552B
CID 441976 441976 Click to see 322.40 unknown https://doi.org/10.1021/NP100552B
methyl (1R,11R,17S,18R)-18-ethyl-8,14-diazapentacyclo[9.5.2.01,9.02,7.014,17]octadeca-2,4,6,9-tetraene-10-carboxylate 162935535 Click to see CCC1C2CCN3C1C4(CC3)C5=CC=CC=C5NC4=C2C(=O)OC 324.40 unknown https://doi.org/10.1021/NP100552B
methyl (1R,11R,17S,18S)-18-ethyl-8,14-diazapentacyclo[9.5.2.01,9.02,7.014,17]octadeca-2,4,6,9-tetraene-10-carboxylate 162935534 Click to see 324.40 unknown https://doi.org/10.1021/NP100552B
methyl (1R,11S,12R,17S)-12-[(1R)-1-hydroxyethyl]-8,14-diazapentacyclo[9.5.2.01,9.02,7.014,17]octadeca-2,4,6,9-tetraene-10-carboxylate 21589744 Click to see 340.40 unknown https://doi.org/10.1021/NP100552B
methyl (1R,11S,12R,17S)-12-[(1S)-1-hydroxyethyl]-8,14-diazapentacyclo[9.5.2.01,9.02,7.014,17]octadeca-2,4,6,9-tetraene-10-carboxylate 10088615 Click to see 340.40 unknown https://doi.org/10.1021/NP100552B
Methyl 12-(1-ethoxycarbonyloxyethyl)-8,14-diazapentacyclo[9.5.2.01,9.02,7.014,17]octadeca-2,4,6,9-tetraene-10-carboxylate 75576375 Click to see 412.50 unknown https://doi.org/10.1021/NP100552B
Methyl 12-acetyl-6-hydroxy-8,14-diazapentacyclo[9.5.2.01,9.02,7.014,17]octadeca-2(7),3,5,9-tetraene-10-carboxylate 14707762 Click to see CC(=O)C1CN2CCC34C2CC1C(=C3NC5=C4C=CC=C5O)C(=O)OC 354.40 unknown https://doi.org/10.1021/NP100552B
Methyl 12-acetyl-8,14-diazapentacyclo[9.5.2.01,9.02,7.014,17]octadeca-2,4,6,9-tetraene-10-carboxylate 75249768 Click to see CC(=O)C1CN2CCC34C2CC1C(=C3NC5=CC=CC=C45)C(=O)OC 338.40 unknown https://doi.org/10.1021/NP100552B
Methyl 12-ethylidene-6-hydroxy-8,14-diazapentacyclo[9.5.2.01,9.02,7.014,17]octadeca-2(7),3,5,9-tetraene-10-carboxylate 3148093 Click to see 338.40 unknown https://doi.org/10.1021/NP100552B
Methyl 12-ethylidene-8,14-diazapentacyclo[9.5.2.01,9.02,7.014,17]octadeca-2,4,6,9-tetraene-10-carboxylate 5087855 Click to see 322.40 unknown https://doi.org/10.1021/NP100552B
N(4)-demethyl-12-methoxyalstogustine 11501570 Click to see CC(C1CN2CCC34C2CC1C(=C3NC5=C4C=CC=C5OC)C(=O)OC)O 370.40 unknown https://doi.org/10.1021/NP100552B
Vinervine 6875257 Click to see 338.40 unknown https://doi.org/10.1021/NP100552B
> Alkaloids and derivatives / Vallesaman alkaloids
19,20-(E)-Isovallesamine 21599097 Click to see 340.40 unknown https://doi.org/10.1021/NP100552B
19,20-E-vallesamine 13783714 Click to see CC=C1CN2CCC1C(C3=C(C2)C4=CC=CC=C4N3)(CO)C(=O)OC 340.40 unknown https://doi.org/10.1021/NP100552B
angustilobine B, (rac)- 13891905 Click to see 338.40 unknown https://doi.org/10.1021/NP100552B
methyl (12R,18R)-14-oxa-1,10-diazapentacyclo[15.3.1.03,11.04,9.012,18]henicosa-3(11),4,6,8,16-pentaene-12-carboxylate 163187479 Click to see 338.40 unknown https://doi.org/10.1021/NP100552B
> Lipids and lipid-like molecules / Fatty Acyls / Fatty aldehydes
2-Methylicosa-2,6,9-trienal 53832697 Click to see 304.50 unknown https://doi.org/10.1021/NP100552B
> Lipids and lipid-like molecules / Prenol lipids / Sesquiterpenoids
(1S,4R,11S,12S)-11-chloro-8-(hydroxymethyl)-4,12-dimethyl-1-propan-2-yl-15-oxabicyclo[10.2.1]pentadeca-2,7-dien-4-ol 163051549 Click to see 356.90 unknown https://doi.org/10.1021/NP100552B
> Organic acids and derivatives / Carboxylic acids and derivatives / Amino acids, peptides, and analogues / Amino acids and derivatives / Delta amino acids and derivatives
methyl 7a-ethenyl-3-(1H-indol-2-yl)-2,3a,4,5,6,7-hexahydrofuro[2,3-c]pyridine-3-carboxylate 13891913 Click to see 326.40 unknown https://doi.org/10.1021/NP100552B
nor-6,7-secoangustilobine A, (rel)- 53320911 Click to see COC(=O)C1(COC2(C1CCNC2)C=C)C3=CC4=CC=CC=C4N3 326.40 unknown https://doi.org/10.1021/NP100552B
> Organoheterocyclic compounds / Indoles and derivatives / Carbazoles
methyl (2R,6S,7S,12S)-3-methyl-10-oxa-3,20-diazapentacyclo[11.7.0.02,7.06,12.014,19]icosa-1(13),14,16,18-tetraene-12-carboxylate 163185893 Click to see 340.40 unknown https://doi.org/10.1021/NP100552B
Methyl 3-methyl-10-oxa-3,20-diazapentacyclo[11.7.0.02,7.06,12.014,19]icosa-1(13),14,16,18-tetraene-12-carboxylate 162991556 Click to see 340.40 unknown https://doi.org/10.1021/NP100552B
N(4)-Demethylechitamine 70698176 Click to see 370.40 unknown https://doi.org/10.1021/NP100552B
Undulifoline 44561426 Click to see CN1CCC2C3C1C4=C(C2(COCC3)C(=O)OC)NC5=CC=CC=C54 340.40 unknown https://doi.org/10.1021/NP100552B
> Organoheterocyclic compounds / Indoles and derivatives / Indoles
6-O-ethyl 3-O-methyl 7a-ethenyl-3-(1H-indol-2-yl)-3a,4,5,7-tetrahydro-2H-furo[2,3-c]pyridine-3,6-dicarboxylate 75576422 Click to see 398.50 unknown https://doi.org/10.1021/NP100552B
Alstolobine A 50900050 Click to see 398.50 unknown https://doi.org/10.1021/NP100552B
> Organoheterocyclic compounds / Indoles and derivatives / Pyridoindoles / Beta carbolines
CID 5320580 5320580 Click to see CC=C1CN2C3CC1C(C45C3(NC6=CC=CC=C64)OC2C5)C(=O)OC 338.40 unknown https://doi.org/10.1021/NP100552B
Picrinine 46229104 Click to see CC=C1CN2C3CC1C(C45C3(NC6=CC=CC=C64)OC2C5)C(=O)OC 338.40 unknown https://doi.org/10.1021/NP100552B
> Organoheterocyclic compounds / Quinolizines
methyl (2R)-2-[(2R,3E,7aS,12bS,12cS)-3-ethylidene-2,4,6,7,7a,8,12b,12c-octahydro-1H-indolo[3,2-a]quinolizin-2-yl]-3-hydroxypropanoate 163195337 Click to see 356.50 unknown https://doi.org/10.1021/NP100552B

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